150 research outputs found
sj-docx-1-tai-10.1177_20499361231169429 – Supplemental material for Parents’ expectation of antibiotic prescriptions for respiratory infections in children: a systematic review and meta-analysis
No full textSupplemental material, sj-docx-1-tai-10.1177_20499361231169429 for Parents’ expectation of antibiotic prescriptions for respiratory infections in children: a systematic review and meta-analysis by Muhammad Aaqib Shamim, Bijaya K. Padhi, Prakasini Satapathy, Abdelmonem Siddiq, Subhanwita Manna, Arun K. Aggarwal, Tareq Al-Ahdal, Jagdish Khubchandani, Andrés F. Henao-Martinez and Ranjit Sah in Therapeutic Advances in Infectious Disease</p
Monolithic Newton-Multigrid Solver for Multiphase Flow Problems with Surface Tension
No full text[EN] We have developed a monolithic Newton-multigrid solver for multiphase flow problems which solves velocity, pressure and interface position simultaneously. The main idea of our work is based on the formulations discussed in [1], where it points out the feasibility of a fully implicit monolithic solver for multiphase flow problems via two formulations, a curvature-free level set approach and a curvature-free cutoff material function approach. Both formulations are fully implicit and have the advantages of requiring less regularity, since neither normals nor curvature are explicitly calculated, and no capillary time restriction. Furthermore, standard Navier-Stokes solvers might be used, which do not have to take into account inhomogeneous force terms. The reinitialization issue is integrated with a nonlinear terms within the formulations.The nonlinearity is treated with a Newton-type solver with divided difference evaluation of the Jacobian matrices. The resulting linearized system inside of the outer Newton solver is a typical saddle point problem which is solved using the geometrical multigrid with Vanka-like smoother using higher order stable FEM pair for velocity and pressure and for all other variables. The method is implemented into an existing software packages for the numerical simulation of multiphase flows (FeatFlow). The robustness and accuracy of this solver is tested for two different test cases, i.e. static bubble and oscillating bubble, respectively [2].Muhammad Aaqib Afaq would like to thank Erasmus Mundus INTACT project, funded by the European Union as part of the Erasmus Mundus programme and the National University of Sciences and Technology (NUST) for their financial support. The authors also acknowledge the support by LS3 and LiDO3 team at ITMC, TU Dortmund University.Afaq, MA.; Turek, S.; Ouazzi, A.; Fatima, A. (2022). Monolithic Newton-Multigrid Solver for Multiphase Flow Problems with Surface Tension. En Proceedings of the YIC 2021 - VI ECCOMAS Young Investigators Conference. Editorial Universitat Politècnica de València. 190-199. https://doi.org/10.4995/YIC2021.2021.12390OCS19019
The Debated Issue on Tissue Copper Levels in Colorectal Cancer Patients: A Meta-analysis and Replication Study
No full textColorectal cancer (CRC) is a growing public health problem. Several clinical studies have shown a potentially oncogenic role of copper in CRC progression, but the reports are inconsistent. To examine published evidence on the association between tissue copper status and CRC, we carried out a systematic review and meta-analysis, searching Cochrane Library, EBSCOhost, Embase, ProQuest, PubMed/Medline, Scopus, and Web of Science for studies reporting colon tumor and matched non-cancerous tissue copper concentrations in CRC patients for articles published till June 2023. Based on a random effects model, standardized mean differences (SMD) were assessed. We also completed a replication study on 17 CRC patients that analyzed copper levels in both cancer tissue specimens and healthy mucosa dissected from the same patient. Thirteen studies investigating copper levels (including the replication study) in colorectal specimens from a pooled total of 312 CRC and 298 healthy mucosa were selected. Our meta-analysis estimated a high between-study heterogeneity (I2 = 96%) and lower levels of copper in CRC tissue cancer specimens than in matched healthy mucosa: the decrease was equal to - 0.74 (95% CI, - 2.18; 0.71) but was not significant. The replication study showed a significant decrease in tissue cancer specimens. Sensitivity analyses of the meta-analysis revealed that pre-analytical methodology for tissue preparation significantly reduced the between-study heterogeneity strongly influencing copper levels (p < 0.01), indicating a copper decrease in the cytoplasmic copper pool of the tumor tissue suggesting a rapid turnover of the metal in cancer cells
Health Data Analyst at DGI Clinical
No full textSummer internship - 2017This report discusses the internship undertaken by the author at DGI Clinical, a Halifax based company that provides innovative clinical metric solutions that demonstrate clinically meaningful outcomes of treatments. The author contributed towards the transformation of DGI’s SymptomGuide™ into a mobile health solution for patients suffering from Dementia.
At the end of the internship, the author successfully met the objectives and deliverables of the project, which are
1. Privacy Impact Assessment and Recommendations
2. Database Design
3. Database Migration
4. User Interface Prototype for SymptomGuide™
This internship report introduces background knowledge of the mobile health application in development, details the tasks performed by the author during the internship and its outcomes.DGI Clinica
The Debated Issue on Tissue Copper Levels in Colorectal Cancer Patients: A Meta-analysis and Replication Study
No full textColorectal cancer (CRC) is a growing public health problem. Several clinical studies have shown a potentially oncogenic role of copper in CRC progression, but the reports are inconsistent. To examine published evidence on the association between tissue copper status and CRC, we carried out a systematic review and meta-analysis, searching Cochrane Library, EBSCOhost, Embase, ProQuest, PubMed/Medline, Scopus, and Web of Science for studies reporting colon tumor and matched non-cancerous tissue copper concentrations in CRC patients for articles published till June 2023. Based on a random effects model, standardized mean differences (SMD) were assessed. We also completed a replication study on 17 CRC patients that analyzed copper levels in both cancer tissue specimens and healthy mucosa dissected from the same patient. Thirteen studies investigating copper levels (including the replication study) in colorectal specimens from a pooled total of 312 CRC and 298 healthy mucosa were selected. Our meta-analysis estimated a high between-study heterogeneity (I2 = 96%) and lower levels of copper in CRC tissue cancer specimens than in matched healthy mucosa: the decrease was equal to − 0.74 (95% CI, − 2.18; 0.71) but was not significant. The replication study showed a significant decrease in tissue cancer specimens. Sensitivity analyses of the meta-analysis revealed that pre-analytical methodology for tissue preparation significantly reduced the between-study heterogeneity strongly influencing copper levels (p < 0.01), indicating a copper decrease in the cytoplasmic copper pool of the tumor tissue suggesting a rapid turnover of the metal in cancer cells
Development of Simulation Based p-Multipliers for Laterally Loaded Pile Groups in Granular Soil Using 3D Nonlinear Finite Element Model
No full textThe behavior of laterally loaded pile groups is usually accessed by beam-on-nonlinear-Winkler-foundation (BNWF) approach employing various forms of empirically derived p-y curves and p-multipliers. Averaged p-multiplier for a particular pile group is termed as the group effect parameter. In practice, the p-y curve presented by the American Petroleum Institute (API) is most often utilized for piles in granular soils, although its shortcomings are recognized. In this study, we performed 3D finite element analysis to develop p-multipliers and group effect parameters for 3 × 3 to 5 × 5 vertically squared pile groups. The effect of the ratio of spacing to pile diameter (S/D), number of group piles, varying friction angle (φ), and pile fixity conditions on p-multipliers and group effect parameters are evaluated and quantified. Based on the simulation outcomes, a new functional form to calculate p-multipliers is proposed for pile groups. Extensive comparisons with the experimental measurements reveal that the calculated p-multipliers and group effect parameters are within the recorded range. Comparisons with two design guidelines which do not account for the pile fixity condition demonstrate that they overestimate the p-multipliers for fixed-head condition
Mutual Funds Volatility and Risk-Adjusted Returns: Evidence from the Pakistani Open-Ended Fund Market
No full textPurpose: This study examines the volatility and risk-adjusted returns of all open-ended mutual funds in Pakistan over the short-term (90 days) and long-term (365 days) periods. It uses the Sharpe ratio as the primary performance metric. Its purpose is to analyze the open-ended fund behavior across different time horizons and categories.
Design/Methodology/Approach: The data is extracted from the MUFAP for the year 2024 and utilizes the Sharpe Ratio for the comparison of the risk-adjusted performance among fund types, including equity and allocation funds.
Findings: The findings show that generally long-term investments give higher and more stable risk-adjusted returns as compared to short-term, which are marked by high volatility. Equity funds display the widest performance range, with outcomes ranging from exceptional gains to heavy losses. Allocation funds give moderate and more consistent returns, whereas cash funds and fixed income offer low but stable performance.
Implications/Originality/Value: The results show the significance of long-term investing and informed fund selection in emerging markets like Pakistan. This study contributes to the existing literature on mutual fund performance in Pakistan by comparing the performance over short and long-term periods and provides practical insights for investors and policymakers
Evaluate the use of recycled aggregate in concrete
No full textRecycling is a key component of modern waste reduction. The application of recycled aggregate has been started in many construction projects in Australia, America and other Asian countries. This research is an attempt to study the basic properties of recycled aggregate. The properties of the recycled aggregate were also compared with natural aggregates. Additionally, the properties of recycled aggregate. Concrete were also determined and explained here. Concrete cylinders were cast at different replacement of fresh aggregate such as 20%, 40%, 60% and 80%. A total of 45 concrete cylinders of standard size were produced comp rising of 36 cylinders with recycled aggregate and 9 cylinder with fresh aggregates. The basic concrete properties were determined. The compressive strength, UPV and Rebound Hammer test were performed at the age of 7, 14 and 28 day s. Furthermore, the recycled aggregate concrete cylinders properties were also compared with the fresh aggregate concrete cylinders specimen’s properties.peer-reviewe
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