103,013 research outputs found
Mufti Muhammad Ibrahim Qadri (2021) in response to queries on ‘forced conversion’ raised Muhammad Ziauddin Siyalwi
No full textMufti Muhammad Ibrahim Qadri (2021) in response to queries on ‘forced conversion’ raised Muhammad Ziauddin Siyalwi, p.14 . available at Hussain, Ghulam (2021), “Mufti Muhammad Ibrahim Qadri (2021) in response to queries on ‘forced conversion’ raised Muhammad Ziauddin Siyalwi”, Mendeley Data, V1, doi: 10.17632/4mtfdxvp4n.1THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV
The Case for Upfront HLA-Matched Unrelated Donor Hematopoietic Stem Cell Transplantation as a Curative Option for Adult Acquired Severe Aplastic Anemia
No full textThe improved success of HLA-matched unrelated donor (MUD) hematopoietic stem cell transplantation (HSCT) for severe aplastic anemia (SAA) in recent decades has had an impact on the indications for and timing of this treatment modality. In the absence of a matched sibling donor (MSD), historically MUD HSCT was reserved as an option after failure to respond to at least 2 courses of immunosuppressive therapy (IST) in adults with SAA, but with improved outcomes over time, it is now considered following failure to respond to 1 course of IST. Recent national and international studies and guidelines now recommend upfront MUD HSCT as an option for children for whom an MUD is readily available, because outcomes are similar to those for MSD HSCT. Fludarabine-based conditioning and the use of in vivo T cell depletion with antithymocyte globulin or alemtuzumab has been associated with a reported overall survival (OS) of >85% in adult patients undergoing MUD HSCT. However, the recent introduction of eltrombopag for patients with SAA has transformed the treatment landscape, and there is currently much interest in its use with IST as upfront treatment, which showed a high response rate in an early-phase study. The risks of HSCT, especially graft-versus-host disease (GVHD), need to be carefully balanced against the concerns of IST, namely relapse and later clonal evolution to myelodysplastic syndrome (MDS)/acute myelogenous leukemia (AML). In the absence of a current prospective randomized trial comparing these 2 approaches, in this review we examine the evidence supporting consideration of early MUD HSCT in adults with SAA who would have been considered for MSD HSCT but who lack a MSD and for whom an MUD is readily available, especially using an irradiation-free conditioning regimen, with a low risk of GVHD, as another treatment option. This option may be offered to patients to provide them with an informed choice, with the aim of curing disease rather than achieving freedom from disease, relapse-free survival, or OS. Furthermore, understanding the immune signature for the response to IST and the immunologic responses to somatic mutations and clonal progression to MDS/AML may help define the future indications for upfront HSCT and a more precise medical approach to therapy
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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Icon of evil ::Hitler's mufti and the rise of radical Islam /
No full textIn 1921, the beneficiary of an appointment the British would live to regret, Haj Amin al-Husseini became the mufti of Jerusalem, the most eminent and influential Islamic leader in the Middle East. For years, al-Husseini fomented violence in the region against the Jews he loathed and wished to destroy. Forced out in 1937, he eventually found his way to the country whose legions he desperately wished to join: Nazi Germany. Here, with new and disturbing details, David G. Dalin and John F. Rothmann show how al-Husseini ingratiated himself with his hero, Adolf Hitler, becoming, with his blonde hair and blue eyes, an "honorary Aryan," while dreaming of being installed Nazi leader of the Middle East. Al-Husseini would later recruit more than 100,000 Muslims in Europe to fight in divisions of the Waffen-SS, and obstruct negotiations with the Allies that might have allowed four thousand Jewish children to escape to Palestine. --from publisher description
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3346: Samuel G. Freedman, author, 2013
No full textPhotograph of author Samuel G. Freedman, at NT Daily Slash meeting in the Mayborn School of Journalism at UNT
Prognostic and predictive impact of small PNH clones in a large cohort of patients with myelodysplastic syndrome and aplastic anemia: a single-center experience
No full textThe use of high sensitive FLAER improved the detection of very small PNH clones (<1%) in aplastic anemia (AA)/myelodysplastic syndromes (MDS). Here we aimed to evaluate the prevalence of PNH clones >0.01% in AA/MDS patients tested at a single tertiary center,and to assess their impact on disease prognosis, occurrence of thrombosis, and response to current therapies. We retrospectively collected clinical and laboratory features of 869 MDS and 531 AA patients tested from March 1998 till October 2017. Table 1 shows characteristics of MDS and AA patients, divided according to PNH positivity, which was less frequent in MDS versus AA (20.3% vs 61%). Focusing on MDS, PNH+ cases were significantly more hypoplastic,and showed deeper cytopenias and higher LDH levels. Considering clone size (negative, 0.01-1%, 1.01-10%,10.01-50%, and >50% on granulocytes), we observed a significant worsening of cytopenia and raise of LDH along with clone size increase. As regards therapy, PNH+MDS showed significantly higher response rates to immunosuppressive therapies (ATG and CyA, 84% vs 44.7%, p=0.01) and to HSCT (71% vs 56.6%, p=0.09) compared to PNH-, and the cumulative probability of response to any treatment significantly improved along with clone size increase (from 52 to 100%, p=0.03). PNH+MDS
showed lower rate of evolution, and longer OS [mean 11.9+0.7 years (10.5-13.3) vs 7.3+0.3 (6.6-7.9), p<0.0001], confirmed in multivariable analysis. However, PNH+MDS had a higher incidence of thrombotic events (from 5% in PNH- to 50% in PNH+ with clone size >50%, p<0.0001). Similarly to MDS, PNH+AA showed deeper thrombocytopenia and higher LDH, and showed higher response rates to any therapy (97 vs 77% for HSCT, p=0.01; 78 vs 50% for IST, p<0.0001; and88% vs 65% considering any treatment, p<0.0001). They also showed lower rate of MDS progression and death (p=0.01 and p<0.0001), and longer OS [mean 15.8+0.43 years (14.9-16.7) vs 6.5+0.35 (5.8-7.21), p<0.0001], confirmed in multivariable analysis. Prevalence of PNH clones of any size is high in patients with MDS and AA. We firstly
show a positive impact of PNH clone positivity on response to IST and HSCT in a large MDS series and confirmed this data in AA. The presence of a PNH clone also correlated with lower disease progression and better OS. Clone size analysis suggests that even small clones (0.01- 1%) have a clinical and prognostic significance
The Right to Strike under the United States Constitution: Theory, Practice, and Possible Implications for Canada
No full textAnswering critics of the Canadian Supreme Court's judgment in B.C. Health, the author argues that the Court laid the foundation for a principled and durable doctrine protecting constitutional labour rights, one that goes directly to the heart of the matter — the inequality of workers’ power in the employment relation. In the author’s view, two paths could lead from B.C. Health to the recognition of Charter protec- tion for a right to strike: one that treats the right as an accessory to col- lective bargaining, and one that upholds the right directly on the basis of the Charter values of equality and participation. The author supports the latter approach, contending that constitutional rights should be defined in relation to fundamental values, in a way that is not contingent on time-bound or fact-sensitive assessments about the role of strikes within a particular collective bargaining regime. Although a Charter right to strike may involve the courts in difficult choices about when to defer to legislative policy decisions, and courts may lack the institutional capac- ity to deal effectively with labour law issues, the author points out that judges can look to ILO standards for expert guidance. Noting that the U.S. experience in this area might be of considerable use to Canadians, the author concludes by providing an overview of American case law concerning a constitutional right to strike.Peer reviewe
Stenus mufti Puthz 2008, nov.sp.
No full text<i>Stenus</i> (s.str.) <i>mufti</i> nov.sp. <p>T y p e n m a t e r i a l - Holotypus: Türkei: Adiyaman province: Nemrut, Daği Mountains env. Karadut, 14.-19.VII.2000, R. Průdek: cP im MHNG.</p> <p>Ich danke Herrn Zb. Kejval für die liebenswürdige Überlassung des Holotypus für meine Spezialsammlung.</p> <p>B e s c h r e i b u n g:Schwarz,schwachschimmernd,Kopfund Pronotum wenig grob und sehr dicht punktiert, Elytren ziemlich grob und sehr dicht punktiert, Abdomen fein und dicht punktiert; Beborstung kurz, anliegend.</p> <p>Länge: 2,2 mm (RPL 1,0- 2,2 mm) (Vorderkörperlänge: 1,2 mm).</p> <p>PM des HT: HW: 20,2; FW: 12; PW: 17; PL: 19; EW: 25; WE: 25; SL: 20,5.</p> <p>M ä n n c h e n: 8. Sternit mit flacher, breiter Apikalausrandung. 9. Sternit apikal gesägt. 10. Tergit breit abgerundet. A e d o e a g u s (Abb. 34), Medianlobus vorn breit, leicht konkav ausgerandet, apikoventral jederseits mit mehreren kurzen Borsten. Ausstülpsklerit breit und stark, vorn etwa halbkreisförmig abgerundet; Parameren wenig länger als der Medianlobus, an ihren Spitzen mit 9 Borsten.</p> <p>W e i b c h e n: unbekannt.</p> <p> D i s k u s s i o n: Diese neue Art gehört in die Gruppe des <i>Stenus pusillus</i> STEPHENS (PUTHZ, 1970l) und steht hier dem <i>S. viti</i> PUTHZ nahe. Das Pronotum ist gleichmässig gewölbt, wodurch sie sich von <i>S. pusillus</i> und den ihm ähnlichsten Arten unterscheidet. Von den Spezies um <i>S. nanus</i> STEPHENS, deren Pronotum keine besonderen Eindrücke aufweist, unterscheidet sie sich so: von <i>S. nanus</i> STEPHENS, <i>S. lenkoranus</i> PUTHZ, <i>S. indifferens</i> PUTHZ, <i>S. machulkai</i> HROMÁDKA, <i>S. contumax</i> ASSING, <i>S. assequens</i> REY, <i>S. invidiosus</i> PUTHZ und <i>S. micros</i> SOLSKY durch längeres Pronotum und dunklere Beine, von <i>S. trapezipennis</i> PUTHZ durch längere Elytren, von <i>S. libanicus</i> PUTHZ durch dunklere Beine, von <i>S. viti</i> PUTHZ durch grössere, etwas weniger grob punktierte Elytren (von diesen beiden äusserlich also nur schwer), von allen, auch von <i>S. svanus</i> RYVKIN (den ich nicht kenne) durch den Aedoeagus.</p> <p>E t y m o l o g i e: Um ihre Herkunft zu signalisieren, wähle ich für diese neue Art den Namen "mufti" = Bezeichung für türkischen Rechtsgelehrten.</p>Published as part of <i>Puthz, V., 2008, Stenus LATREILLE und die segenreiche Himmelstochter (Coleoptera, Staphylinidae), pp. 137-230 in Linzer biologische Beiträge 40 (1)</i> on pages 157-158, DOI: <a href="http://zenodo.org/record/5426801">10.5281/zenodo.5426801</a>
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