133 research outputs found
Effect of Ginger Against Arsenic Induced Toxicity on Hepatic Organ
No full textArsenic-induced hepatotoxicity poses a significant public health concern due to its detrimental effects on liver function, including oxidative stress, inflammation, and apoptosis. This review explores the protective role of ginger (Zingiber officinale) in mitigating arsenic-induced hepatic damage, highlighting its potent antioxidant, anti-inflammatory, and anti-apoptotic properties. The bioactive compounds of ginger, such as gingerols, shogaols, and flavonoids, have been shown to neutralize reactive oxygen species (ROS), restore antioxidant enzyme activity, and suppress pro-inflammatory cytokines like TNF-α and IL-6. These mechanisms collectively contribute to improved liver function, reduced oxidative damage, and enhanced hepatocyte regeneration. Hepatoprotective potential of ginger is further supported by its ability to modulate apoptotic pathways, reduce lipid peroxidation, and enhance cellular detoxification processes. Comparative studies indicate that the efficacy of ginger is on par with or superior to synthetic antioxidants and standard hepatoprotective agents like silymarin, with the added advantage of minimal toxicity. However, limitations in current research, such as the lack of standardized formulations, insufficient human trials, and incomplete understanding of molecular pathways, present challenges to its clinical application. Future research should prioritize large-scale clinical trials, pharmacokinetic studies, and investigations into synergistic effects with other therapeutic agents. Addressing these knowledge gaps will pave the way for the development of ginger-based interventions for liver diseases
The nucleation of self-poled electroactive β-phase in Eu3+ doped PVDF nanocomposite film for optoelectronic devices
No full textPre-heating in the framework of massive gravity
No full textAbstractIn this paper we propose a mechanism of natural pre-heating of our universe by introducing an inflaton field dependent mass term for the gravitational wave for a specific class of massive gravity theory. For any single field inflationary model, the inflaton must go through the oscillatory phase after the end of inflation. As has recently been pointed out, if the gravitational fluctuation has inflaton dependent mass term, there will be a resonant amplification of the amplitude of the gravitational wave during the oscillatory phase of inflaton. Because of this large enhancement of the amplitude of the gravitational wave due to parametric resonance, we show that universe can naturally go through the pre-reheated phase with minimally coupled matter field. Therefore, during the reheating phase, there is no need to introduce any arbitrary coupling between the matter field and the inflaton
Masterguide to Maity & Ghosh's integral calculus including differential equations
No full textPenned with utmost care for the undergraduate students of Mathematics of all major universities, this book can be treated as a remarkable combination of erudite scholarship and educational utility. Now Dr K C Pal, the author, known for his unique and student-friendly teaching methods, has come up with this invaluable text as a long-awaited extension of the original book
Colloidal silver nanoparticles prepared by UV-light induced citrate reduction technique for the quantitative detection of uric acid
No full textAssociation of Vitamin B12, Lactate Dehydrogenase, and Regulation of NF-κB in the Mitigation of Sodium Arsenite-Induced ROS Generation in Uterine Tissue by Commercially Available Probiotics
No full textThe consequence of NAC on sodium arsenite-induced uterine oxidative stress
No full textArsenic consumption through drinking water is a worldwide major health problem. Management of arsenic intoxication with invasive, painful therapy using metal chelators is usually used as a conventional treatment strategy in human. In this present study, we examined the efficacy of oral administration of N-acetyl l-cysteine (NAC) in limiting arsenic-mediated female reproductive disorders and oxidative stress in female Wistar rats. The treatment was continued for 8 days (2 estrus cycles) on rats with sodium arsenite (10 mg/Kg body weight) orally. We examined the electrozymographic imprint of three different enzymatic antioxidants in uterine tissue. Rats fed with sodium arsenite exhibited a significant lessening in the activities of superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx). Uterine DNA breakage, necrosis, ovarian and uterine tissue damage, disruption in steroidogenesis were also found in arsenic treated rats. Co-administration of NAC at different doses (50 mg/kg body weight, 100 mg/kg body weight, respectively) significantly reversed the action of uterine oxidative stress markers like malondialdehyde (MDA), conjugated dienes (CD) and non protein soluble thiol (NPSH); and noticeably improved antioxidant status of the arsenic fed rats. This ultimately resulted in the uterine tissue repairing followed by improvement of ovarian steroidogenesis. However, this effective function of NAC might be crucial for the restoration of arsenic-induced female reproductive organ damage in rats. Keywords: Arsenic, N-acetyl-l-cysteine, Oxidative stress, Uteru
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