127 research outputs found
Concerning the Discussion around the Circumstances of Creating the Law Code of the Ouchi Clan
No full textThe article examines the «Ouchi-shi okitegaki», law code of Ouchi clan, created in the end of XVth century. The author argues that this collection of laws was drawn up in order to ensure the smooth transfer of power from daimyo Ouchi Masahiro to his son Yoshioki. The appearance of this code of laws reflected the maturation of the Ouchi clan power structure. According to the author, the Ouchi law code could be used in judicial practice. It could also be used as a model for drafting new ordinances and regulations in the Ouchi house
Organic Anion Transporter 5 (Oat5) Urinary Excretion Is a Specific Biomarker of Kidney Injury: Evaluation of Urinary Excretion of Exosomal Oat5 after N-Acetylcysteine Prevention of Cisplatin Induced Nephrotoxicity
No full textCisplatin is a commonly used chemotherapeutic agent. Its main side-effect is nephrotoxicity. It was reported that the organic anion transporter 5 (Oat5) urinary excretion is elevated, implying renal perturbation, when no modifications of traditional markers of renal damage are still observed in cisplatin-induced acute kidney injury (AKI). It was also demonstrated that Oat5 is excreted in urine by the exosomal pathway. This study was designated to demonstrate the specific response of the urinary excretion of exosomal Oat5 to kidney injury independently of other cisplatin toxic effects, in order to strengthen Oat5 urinary levels as a specific biomarker of AKI. To accomplish that aim, we evaluated if urinary excretion of exosomal Oat5 returns to its basal levels when cisplatin renal damage is prevented by the coadministration of the renoprotective compound N-acetylcysteine. Four days after cisplatin administration, AKI was induced in cisplatin-treated male Wistar rats (Cis group), as it was corroborated by increased urea and creatinine plasma levels. Tubular damage was also observed. In cotreated animals (Cis + NAC group), plasma urea and creatinine concentrations tended to return to their basal values, and tubular damage was improved. Urinary excretion of exosomal Oat5 was notably increased in the Cis group, but when renal injury was ameliorated by N-acetylcysteine coadministration, that increase was undetected. So, in this work we observed that urinary excretion of exosomal Oat5 was only increased if renal insult is produced, demonstrating its specificity as a renal injury biomarker.Fil: Bulacio, Romina Paula. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Anzai, Naohiko. Dokkyo Medical University; JapónFil: Ouchi, Motoshi. Dokkyo Medical University; JapónFil: Torres, Adriana Monica. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
What You Can Do to Improve Your School
No full textThis issue of Policy Perspectives presents seven "rules of change" that were developed by noted author and UCLA professor William G. Ouchi in his new book, Making Schools Work: A Revolutionary Plan to Get Your Children the Education They Need (Simon & Schuster)
Piezo1-pannexin-1-P2X3 axis in odontoblasts and neurons mediates sensory transduction in dentinal sensitivity
No full text©2022 Ohyama, Ouchi, Kimura, Kurashima, Yasumatsu, Nishida, Hitomi, Ubaidus, Kuroda, Ito, Takano, Ono, Mizoguchi, Katakura and Shibukawa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
IDEOLOGY OF DISASTER EDUCATION TRAUMA HANDLING POST-EARTHQUAKE IN PICTURE STORIES BOOK: CRITICAL DISCOURSE ANALYSIS
No full textThis research analyzes the ideology that the author intends to instill in picture storybooks for children in Japan. The study aims to explore how the author conveys the ideology of handling trauma in children after earthquake disasters. The objects of the study are two picture storybooks titled Yuzuchan and Yappari Ouchi Ga Ii Na. The research was conducted qualitatively using the documentary data search method. The analysis was carried out with van Dijk\u27s CDA theory and Peirce\u27s Semiotics Theory. The results of the analysis reveal that Yuzuchan and Yappari Ouchi Ga Ii Na are picture storybooks produced to help children cope with post-earthquake trauma. Disaster education handling the trauma is distributed in Macro Structure, Superstructure, and Microstructure. Although both of them deliver disaster education to overcome the same trauma, because the two authors have different backgrounds, the goals of the post-disaster ideology to be conveyed are different, the themes raised, and the topics raised are different. To convey the ideology of dealing with the trauma of death in Yuzuchan\u27s story, the author raised the theme of loss due to catastrophic death. While at Yappari Ouchi Ga Ii Na , from the ideology of disaster education facing trauma healing the ideology of earthquake trauma. The ideology of earthquake trauma handling is reflected in the macro and micro structures in both picture story discourses. The author uses diction and atmosphere to depict the post-earthquake trauma experienced by the characters. Meanwhile, disaster education in the form of trauma handling is conveyed through schematic elements, settings, presuppositions, diction, sentence patterns, and rhetoric in the stories. This research is not only beneficial for learners of the Japanese language and literature implementing CDA theory in discourse but also valuable for authors seeking to create stories about post-disaster trauma handling
A literature review on the use of expert opinion in probabilistic risk analysis
No full textRisk assessment is part of the decision making process in many fields of discipline, such as engineering, public health, environment, program management, regulatory policy, and finance. There has been considerable debate over the philosophical and methodological treatment of risk in the past few decades, ranging from its definition and classification to methods of its assessment. Probabilistic risk analysis (PRA) specifically deals with events represented by low probabilities of occurring with high levels of unfavorable consequences. Expert judgment is often a critical source of information in PRA, since empirical data on the variables of interest are rarely available. The author reviews the literature on the use of expert opinion in PRA, in particular on the approaches to eliciting and aggregating experts'assessments. The literature suggests that the methods by which expert opinions are collected and combined have a significant effect on the resulting estimates. The author discusses two types of approaches to eliciting and aggregating expert judgments-behavioral and mathematical approaches, with the emphasis on the latter. It is generally agreed that mathematical approaches tend to yield more accurate estimates than behavioral approaches. After a short description of behavioral approaches, the author discusses mathematical approaches in detail, presenting three aggregation models: non-Bayesian axiomatic models, Bayesian models, andpsychological scaling models. She also discusses issues of stochastic dependence.Health Monitoring&Evaluation,ICT Policy and Strategies,Public Health Promotion,Enterprise Development&Reform,Statistical&Mathematical Sciences,ICT Policy and Strategies,Health Monitoring&Evaluation,Statistical&Mathematical Sciences,Science Education,Scientific Research&Science Parks
A Literature Review on the Use of Expert Opinion in Probabilistic Risk Analysis
No full textRisk assessment is part of the decision
making process in many fields of discipline, such as
engineering, public health, environment, program management,
regulatory policy, and finance. There has been considerable
debate over the philosophical and methodological treatment
of risk in the past few decades, ranging from its definition
and classification to methods of its assessment.
Probabilistic risk analysis (PRA) specifically deals with
events represented by low probabilities of occurring with
high levels of unfavorable consequences. Expert judgment is
often a critical source of information in PRA, since
empirical data on the variables of interest are rarely
available. The author reviews the literature on the use of
expert opinion in PRA, in particular on the approaches to
eliciting and aggregating experts' assessments. The
literature suggests that the methods by which expert
opinions are collected and combined have a significant
effect on the resulting estimates. The author discusses two
types of approaches to eliciting and aggregating expert
judgments-behavioral and mathematical approaches, with the
emphasis on the latter. It is generally agreed that
mathematical approaches tend to yield more accurate
estimates than behavioral approaches. After a short
description of behavioral approaches, the author discusses
mathematical approaches in detail, presenting three
aggregation models: non-Bayesian axiomatic models, Bayesian
models, and psychological scaling models. She also discusses
issues of stochastic dependence
HOXB9 acts as a negative regulator of activated human T cells in response to amino acid deficiency
No full textMARCKS phosphorylation and amylase release in GLP-1-stimulated acini isolated from rat pancreas
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