825 research outputs found
Disability
No full textThis essay examines the intersections of disability, enslavement, and writing in the Roman Mediterranean and beyond. In particular, it develops the work of Nicholas Horsfall on visual impairments and asks, more broadly, about the variety of forms of impairment that served as barriers to participation in literate affairs. It explores both the exploitation of enslaved people as prosthetic literary devices or accommodative tools and the ways that the structures of enslavement disabled literate workers. It suggests that the experience of bodily pain may have influenced the development of literate tools and technologies, including such innovations as bookstands and the codex-format book
Notions of Orthodoxy in Early Christian Martyrdom Accounts
No full textThe study of martyrdom has always implicitly involved assumptions about orthodoxy and heterodoxy in the early Church. In traditional ecclesiastical context as well as scholarship, martyrdom is often assumed to be orthodox in practice. This is in large part due to ancient caricatures of 'heretical' groups being either suicidal or anti-martyrdom. In recent years a great deal of scholarship on identity formation in the early church has pointed to the ways ion which the concept and category of the martyr was used in the formation of the idea and language of the 'true Christian.' In these studies the concept of the 'true martyr' and the 'true Christian' in ancient literature are interlaced and overlapping. We might say that they are co-produced. What it means to be Christian then, is to die as a martyr
The evolutionary rewiring of ubiquitination targets has reprogrammed the regulation of carbon assimilation in the pathogenic yeast Candida albicans
Full text linkDate of Acceptance: 13/11/2012 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited. Correction for Sandai et al., The Evolutionary Rewiring of Ubiquitination Targets Has Reprogrammed the Regulation of Carbon Assimilation in the Pathogenic Yeast Candida albicans published 20-01-2015 DOI: 10.1128/mBio.02489-14Peer reviewe
An ecophysiological study on the moss hydrogoniuh fontanum from the Asir mountains, Saudi Arabia
Full text linkThe thesis describes a study on the ecophysiology of the moss Hydrogonium fontanum (C. Mail.) Jaeg., the dominant plant at a waterfall in Saudi Arabia. The influence of environmental variables and water stress on the growth, stress metabolite accumulation and phosphatase activities of the moss was studied in laboratory axenic culture along with observations and experiments conducted in the field. The variables chosen for growth experiments were light flux, flooding, nutrient concentrations and water stress. For phosphatase activities, the influence of temperature, pH, ions, water stress were studied. Differences were found in phosphatase activities for rhlzoids, protonema and leafy shoots of the moss and, therefore, the phosphomonoesterase (PMEase) and phosphodiesterase (PDEase) activities of these fractions were also investigated. H. fontanum was originally collected from the tufa-depositing waterfall (Water chemistry - 44 mg 1(^-1) Na, 44 mg 1(^-1) Ca). High Na and Ca had significant positive effect on yield of the protonema under the laboratory conditions. Low light intensity (10 µmol photon m(^-2) s(^-1)) decreased the yield, but high light intensity (90 µmol photon m(^-2) s(^-1)) increased the yield of the protonema. The moss showed no response to water stress in respect to praline accumulation. Protein content decreased significantly over 48 h with increase in water stress. The Influence of water stress was greater in terms of dry weight and chlorophyll content changes in protonema than in leafy shoots. The protonema was capable of using various organic P substrates as sources of phosphorus and showed both PMEase and PDEase activities. PMEase and PDEase activities were detectable in all moss fractions (rhizoids, protonema, leafy shoots). Laboratory grown material showed higher activities than field grown material. Rhizoids produced the highest PMEase and PDEase activities among the moss fractions. Some leafy shoots collected from the field had low phosphorus content with high phosphatase activities, while others had high phosphorus content with low phosphatase activities. Changes in phosphatase activities in batch culture were studied in relation to growth rate. PMEase activity was first evident when cellular P was 1.15% with low activity (0.117 µmol pNP mg d. wt(^-1) h(^-1)) and PDEase appeared 4 days later when cellular P was 0.54%. The activities increased up to day 12 after which the activities maintained this level. The optimum temperatures, measured over a period of 1 h, for PMEase and PDEase activities were 60 ºC and 65 ºC with pH optima of 5.5-6.0 and 6.4-6.8, respectively. Of the six ions tested, Ca, Zn and P had significant inhibitory effects on the activities at the highest concentration used (10 mM).Drying the moss decreases PMEase and PDEase activities by about 23% and 21% (5-d) and 3.7 and 2,8 times (3 months), respectively. Water stress (PEG treatment) also reduced significantly the activities of PMEase and PDEase with a greater effect on the activity of the latter. A brief comparison in PMEase activity using two different substrates p- nitrophenyl phosphate (pNPP) and 4-methylumbelliferyl phosphate (4-MUP) was made to investigate the pH optima and time course. PMEase activity measured using 250 µM 4-MUP was about 60% of that measured using the same concentration of pNPP
The PKC, HOG and Ca2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans
Full text linkOpen Access via PMC2649417Peer reviewe
Candida albicans repetitive elements display epigenetic diversity and plasticity
Full text linkTranscriptionally silent heterochromatin is associated with repetitive DNA. It is poorly understood whether and how heterochromatin differs between different organisms and whether its structure can be remodelled in response to environmental signals. Here, we address this question by analysing the chromatin state associated with DNA repeats in the human fungal pathogen Candida albicans. Our analyses indicate that, contrary to model systems, each type of repetitive element is assembled into a distinct chromatin state. Classical Sir2-dependent hypoacetylated and hypomethylated chromatin is associated with the rDNA locus while telomeric regions are assembled into a weak heterochromatin that is only mildly hypoacetylated and hypomethylated. Major Repeat Sequences, a class of tandem repeats, are assembled into an intermediate chromatin state bearing features of both euchromatin and heterochromatin. Marker gene silencing assays and genome-wide RNA sequencing reveals that C. albicans heterochromatin represses expression of repeat-associated coding and non-coding RNAs. We find that telomeric heterochromatin is dynamic and remodelled upon an environmental change. Weak heterochromatin is associated with telomeres at 30?°C, while robust heterochromatin is assembled over these regions at 39?°C, a temperature mimicking moderate fever in the host. Thus in C. albicans, differential chromatin states controls gene expression and epigenetic plasticity is linked to adaptation
Candida R. Moss and Joel S. Baden, Reconceiving Infertility: Biblical Perspectives on Procreation and Childlessness (Princeton University Press, 2015)
No full textBook review: Candida R. Moss and Joel S. Baden, Reconceiving Infertility: Biblical Perspectives on Procreation and Childlessness (Princeton University Press, 2015.Recenzja książki: Candida R. Moss and Joel S. Baden, Reconceiving Infertility: Biblical Perspectives on Procreation and Childlessness (Princeton University Press, 2015
Candida Moss. God’s Ghostwriters. Enslaved Christians and the Making of the Bible
Full text linkCandida Moss. God’s Ghostwriters. Enslaved Christians and the Making of the Bible. London: William Collins, 2024, 317 pp. ISBN: 978-0-00-861218-4
Eugenics and Torture at the End of Days: Resurrection, Restoration and Revenge
No full textFor many, the apocalypse is the time when everyone gets their just deserts: The good will be rewarded and the wicked will be punished, but there are hints in Christian scripture that no one quite knows what the process of being resurrected will be like. Moss’ lecture will explore how the aftermath of Judgment Day is a space where contemporary desires are projected and revenge fantasies are executed
Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence
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