1,508 research outputs found
Programmed death-1 blockade with pembrolizumab in patients with classical hodgkin lymphoma after brentuximab vedotin failure
No full textPurpos Classical Hodgkin lymphoma (HL) frequently exhibits genetic alterations leading to overexpressio of the programmed death-1 (PD-1) ligands, suggesting a possible vulnerability to PD-1 blockade. Th phase Ib study KEYNOTE-013 (NCT01953692) tested the safety and efficacy of the anti-PD-antibody pembrolizumab in patients with hematologic malignancies. Based on its genetics, HL wa included as an independent cohort Method We enrolled patients with relapsed or refractory HL whose disease progressed on or after treatmen with brentuximab vedotin. Patients received pembrolizumab, 10 mg/kg every 2 weeks, until diseas progression occurred. Response to treatment was assessed at week 12 and every 8 week thereafter. Principal end points were safety and complete remission (CR) rate Result Thirty-one patients were enrolled; 55% had more than four lines of prior therapy, and 71% ha relapsed after autologous stem cell transplantation. Five patients (16%) experienced grade 3 drugrelate adverse events (AEs); there were no grade 4 AEs or deaths related to treatment. The CR rat was 16% (90% CI, 7% to 31%). In addition, 48% of patients achieved a partial remission, for a overall response rate of 65% (90% CI, 48% to 79%). Most of the responses (70%) lasted longer tha 24 weeks (range, 0.14+ to 74+ weeks), with a median follow-up of 17 months. The progression-fre survival rate was 69% at 24 weeks and 46% at 52 weeks. Biomarker analyses demonstrated a hig prevalence of PD-L1 and PD-L2 expression, treatment-induced expansion of T cells and natural kille cells, and activation of interferon-g, T-cell receptor, and expanded immune-related signaling pathways Conclusion Pembrolizumab was associated with a favorable safety profile. Pembrolizumab treatment induce favorable responses in a heavily pretreated patient cohort, justifying further studies
Les Pommes en Pleine air de Gustave Courbet: Emblematizing the Massacred Communards of the 1871 Semaine Sanglante
No full textStony Brook University Libraries.
SBU Graduate School in Art.
Lawrence Martin (Dean of Graduate School), Michele H. Bogart – Thesis Advisor
Professor Department of Art, Anita Moskowitz – Chairperson of Defense
Professor Department of Art, Megan Craig
Assistant Professor Department of Philosophy
Art Department Affiliate
At limits of life: multidisciplinary insights reveal environmental constraints on biotic diversity in continental Antarctica
No full textData source: Supporting information, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044578#s5Multitrophic communities that maintain the functionality of the extreme Antarctic terrestrial ecosystems, while the simplest of any natural community, are still challenging our knowledge about the limits to life on earth. In this study, we describe and interpret the linkage between the diversity of different trophic level communities to the geological morphology and soil geochemistry in the remote Transantarctic Mountains (Darwin Mountains, 80uS). We examined the distribution and diversity of biota (bacteria, cyanobacteria, lichens, algae, invertebrates) with respect to elevation, age of glacial drift sheets, and soil physicochemistry. Results showed an abiotic spatial gradient with respect to the diversity of the organisms across different trophic levels. More complex communities, in terms of trophic level diversity, were related to the weakly developed younger drifts (Hatherton and Britannia) with higher soil C/N ratio and lower total soluble salts content (thus lower conductivity). Our results indicate that an increase of ion concentration from younger to older drift regions drives a succession of complex to more simple communities, in terms of number of trophic levels and diversity within each group of organisms analysed. This study revealed that integrating diversity across multi-trophic levels of biotic communities with abiotic spatial heterogeneity and geological history is fundamental to understand environmental constraints influencing biological distribution in Antarctic soil ecosystems.Catarina Magalhães, Mark I. Stevens, S. Craig Cary, Becky A. Ball, Bryan C. Storey, Diana H. Wall, Roman Tűrk and Ulrike Ruprech
Safety & tolerability of pembrolizumab in patients with relapsed/refractory primary mediastinal large B-cell lymphoma
No full textTreatment options for relapsed/refractory primary mediastinal large B-cell lymphoma (rrPMBCL) are limited and prognosis is generally poor (overall response rate [ORR] 0-25%; 2-year overall survival 15%). PMBCL frequently involves PD-1 ligand overexpression, potentially making PMBCL particularly susceptible to PD-1 blockade. We evaluated safety and antitumor activity of pembrolizumab, an anti-PD-1 antibody, in rrPMBCL as part of the KEYNOTE-013 multicohort Phase 1b trial. At time of data cutoff, 18 patients (median age 30; median 3 prior lines of therapy) had been enrolled and treated, of whom 17 were included in the efficacy analyses. Eleven patients (61%) experienced drug-related adverse events, mostly grade 1-2; none discontinued treatment due to adverse events. ORR was 41% (7/17); 6 additional patients (35%) had stable disease. Of patients evaluable by imaging, 13/16 (81%) had decreases in target lesions. With a median follow-up of 11.3 months, median duration of response was not reached. Two patients reached the maximum 2-year treatment duration and remain in remission. Median overall survival was not reached for treated patients overall; all responders were still alive at data cutoff. These results in heavily pretreated rrPMBCL patients demonstrate that PD-1 blockade with pembrolizumab has a manageable safety profile and promising antitumor activity. (Registered to www.clinicaltrials.gov as NCT01953692)
Alice Craig Edgerton
No full textAlice Craig Edgerton, Class of 1910
Alice Marie Craig was born in Wisconsin in 1874, where she graduated from Carroll College and began her teaching career. She moved to Chicago after her marriage to Charles H. Edgerton, who passed away several years later. Edgerton secured a job as a stenographer in a law office, having no previous training. She soon became a private secretary to the Judge and Clerk of the Probate Court of Cook County, and during this time attended Chicago-Kent College of Law, graduating in 1910 and earning her LL.M. in 1911. During her first year, Edgerton won a prize of $100 for having the highest grade in a class of 150. She also co-founded both Kappa Beta Pi, the nation’s first legal sorority, with eight female classmates, and the Women’s Bar Association of Illinois. She was admitted to the Illinois bar in 1910, and to the Wisconsin bar in 1926, where, in Mukwonago, she opened a law office and engaged in general practice. Edgerton became an author of children’s books, including Queen Nature’s Fairy Helpers, wrote two books of original speeches, and co-authored a book of debates with her father, Both Sides of 30 Public Questions Completely Debated. She also contributed to books, magazines, and newspapers, and wrote speeches for businessmen and masters of ceremonies. In 1941, she was awarded for professional achievement and public service by the Wisconsin Federation of Women’s Clubs. She practiced law from her Mukwonago office until her death in 1946.https://scholarship.kentlaw.iit.edu/womeninlaw/1009/thumbnail.jp
Should all patients with HL who relapse after ASCT be considered for allogeneic SCT? A consult, yes; a transplant, not necessarily
No full textAbstract
This article has a companion Point by Peggs.</jats:p
Blog fingerprinting identifying anonymous posts written by an author of interest using word and character frequency analysis
No full textInternet blogs are an easily accessible means of global communications. Monitoring blogs for criminal and terrorist activity is a serious challenge, due to blogs' anonymous nature and the sheer volume of data. The intelligence community is often faced with more information than it can process. The need exists to develop methods for processing the massive amounts of data this media presents, without a significant increase in manpower. An automated tool capable of indentifying posts written by an individual, given a sample of his writing, would allow law enforcement and intelligence agencies to gather evidence that would otherwise be overlooked due to manpower and time constraints. This research focuses on identifying blog posts written by a particular author, when we do not have a model of every potential author. Previous research either builds a distinct model for every possible author, or limits itself to large documents. Neither approach is appropriate for processing blog posts. Blog posts tend to be short documents, and building a distinct model of each author is unreasonable if you are looking for one author among millions. We address this problem by combining sample posts by other authors to create a model of an "average author."Approved for public release; distribution is unlimited.Outstanding ThesisUS Marine Corps (USMC) author.http://archive.org/details/blogfingerprinti10945452
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