16 research outputs found
Supplemental videos to PhD thesis Evert de Froe: Dinner's Served in the Deep Sea.
No full textThis file contains two supplemental videos to chapter 4 of the PhD thesis of Evert de Froe which is registered as follows:
ISBN/EAN: 978-90-6266-643-0
Title: Dinner's Served in the Deep Sea
Subtitle: Environmental conditions, organic matter transport, and benthic fluxes at cold-water coral and sponge
communities in the deep sea.
Author: Froe, Evert de
Uitgever: Universiteit Utrecht,Bibliotheek Geowetenschappen/TNO
Bibliografische imprint: Universiteit Utrecht,Bibliotheek Geowetenschappen/TNO
NUR-code: 930
NUR-omschrijving: Aardwetenschappen algemeen
Reeks: Utrecht Studies in Earth Sciences
Reeksnummer: 273
Druk: 1
Illustraties: Ja
Aantal pagina's: 211
Taal: Engels
Verschijningsvorm: Paperback / softback
Verschijningsdatum: 13-03-202
The etiology of esophageal cancer in high- and low- risk areas of Jiangsu province, China
No full text [Background]Esophageal cancer (EC) remains one of the most common and fatal malignancies worldwide. The geographic variation in EC occurrence is striking, and China is an area with one of the highest incidences of EC. A number of epidemiological studies have been conducted toward EC in the past decades, results suggested that tobacco smoking, alcohol drinking, unhealthy dietary factors and chronic injuries of the esophageal mucosa are important in the development of this disease. Genetic polymorphisms in enzymes involved in metabolism of carcinogens may also influence individual susceptibility. However, the effects of major lifestyle and hereditary risk factors on the development of EC remain poorly understood in China. Moreover, little attention has been paid to the etiological heterogeneity between similar areas with great risk gradient. [Methods]From 2003 to 2007, a large population-based case-control study of EC has been conducted in a selected high-risk area and a selected low-risk area of Jiangsu Province, one of the highest cancer incidence areas in China. In total, 1,520 cases and 3,879 controls were recruited. In this thesis, we evaluated the role of major lifestyle factors such as tobacco smoking, alcohol drinking and dietary factors, as well as inherited determinants including family history of cancer and genetic polymorphisms of alcohol-metabolizing related genes on the risk of EC. In addition, we investigated how much of the risk gradient between two areas could be explained by variation in the distributions of major risk factors. [Results] Tobacco smoking and alcohol drinking moderately increased the risk of EC, while the positive associations were only found among men but not among women. Dietary factors were observed to play important roles in the development of EC. Specific dietary habits i.e., fast eating speed, and hot eating and/or drinking substantially elevated EC risk and could explain more than 20% of EC cases each. High intake of salty foods and fried foods, low consumption of raw garlic were also observed to increase the risk of EC. In addition to environmental and lifestyle factors, we confirmed that a positive family history can significantly increase EC risk, and found the inheritance may modify the effect of some unhealthy lifestyles. Moreover, we further explored the relationship between EC and single nucleotide polymorphismsof ADH1B, ADH1C and ALDH2 genes. Results showed that the slow metabolizing ADH1B G allele, ADH1C G allele and ALDH2 A allele significantly increased EC risk among moderate-to-heavy alcohol drinkers, and a significant interaction was observed between ALDH2 gene and alcohol consumption. Lastly, we found that more than 60% of EC cases could be attributable to major lifestyle risk factors in the study population; furthermore, dissimilar distribution of several lifestyle factors, together with variations of hereditary factors may be largely responsible for the incidence difference between two study areas. [Conclusion]The findings in this thesis confirm that unhealthy lifestyles including smoking, alcohol drinking and some dietary factors are the predominant risk factors of EC in China, and a large proportion of incidence difference between regions at varying risk could be attributed to the different prevalence of lifestyle factors. As most of the identified risk factors are modifiable, these could be translated into risk reduction prevention programs in China, and a substantial proportion of new EC cases are expected to be prevented by eliminating or avoiding these risk factors in the population. </p
Chaotic self-pulsation and cross-modulation in a wavelength-selective external-cavity laser diode
No full textChaotic self-pulsation in a single wavelength external-cavity laser diode is observed. It is shown that the self-pulsation is caused by interdependencies between the optical output power and the compound cavity losses through the refractive index of the laser diode material. Refractive index changes result in a detuning between the externally selected wavelength and the weak internal-mode structure of the anti-reflection coated laser diode. This detuning is directly related to the compound cavity losses. On the one hand, a change in optical output power results in a change of the refractive index via the carrier density. On the other hand, it results in a change of refractive index via temperature changes. Compared to the carrier induced refractive index change, the temperature induced refractive index change is opposite in sign, a factor of about 10 squared smaller and slower. The switch-on and switch-off time of the self-pulsation is governed by the carrier life time. The repetition rate of the self-pulsation is governed by the thermal time constant and is in the megahertz region. Cross-modulation resulting from the thermal induced refractive index change is demonstrated. In a two-wavelength double external-cavity laser diode, optical power at one wavelength effects the optical power at the other wavelength. This cross-modulation is shown to be related to previous experiments on a laser neural network. A novel technique is introduced to measure the thermal impedance of a laser diode that is based on the cross-modulation
Longitudinal mode-switching dynamics in a dual external-cavity laser diode
No full textWe study the potential speed of an optical neural network that uses the longitudinal cavity modes of an external-cavity laser diode as neurons. For this purpose, we used a laser diode coupled to two external cavities, each corresponding to one longitudinal cavity mode. The process of longitudinal mode switching is investigated for the case of intracavity optical modulation. In this experiment, the feedback for the mode in one cavity is modulated, and the length of the other cavity can be controlled. Three limitations are imposed on the switching speed. A number of external-cavity round trips are needed to switch from one mode to the other. It is observed that, depending on the amount of optical feedback in both cavities, between 7 and 21 round trips are needed. When the experimental results for varying cavity length are extrapolated to zero cavity length, a residual delay of a few nanoseconds remains. It is believed that this delay is due to a change in carrier density, needed to switch from one mode to another. Modified rate equations are used to model our experiments. The results of numerical simulations are in good agreement with the experimental results and predict the residual delay. The model also predicts a turn-on delay that is related to relaxation oscillations and imposes a third limitation on the operation speed of our optical neural network. Implications of our findings on the potential operation speed of the optical neural network are discussed and suggestions are made for optimizatio
Multi-level Governance and Security: The Security Sector Reform Process in the Central African Republic
No full textAnalysing how the SSR process in CAR has been defined and then implemented, this article puts emphasis on the international interactions between institutional actors who may be geographically/territorially situated at different levels of the policy-making process in different places around the world, thus suggesting ways to grasp multi-actor and multi-sited governance. Therefore, it advocates an approach which consists of expanding the agenda of the traditional multi-level governance approach. The issue at stake here is to capture the interactive institutional dynamic at an international level, thus developing a methodological framework that is likely to seize both the topdown and the bottom-up dynamics of decision-making processes. The first objective is to capture the sets of actors and procedures which drive the process, and to map out the various levels of government at which decisions are made, either the more top-down, or the more bottom-up oriented ones, answering two sets of questions: How is security governance organised? Who decides, and on which matters? Secondly – and more fundamentally – is to capture the intermingling of domestic and international decision-making processes which increasingly overlap and interfere with each other in Southern countries.multilevel governance
Feasibility Study of Controlled-Source Electromagnetic Method for Monitoring Low-Enthalpy Geothermal Reservoirs
No full textTracking temperature changes by measuring the resulting resistivity changes inside low-enthalpy reservoirs is crucial to avoid early thermal breakthroughs and maintain sustainable energy production. The controlled-source electromagnetic method (CSEM) allows for the estimation of sub-surface resistivity. However, it has not yet been proven that the CSEM can monitor the subtle resistivity changes typical of low-enthalpy reservoirs. In this paper, we present a feasibility study considering the CSEM monitoring of 4–8 Ω·m resistivity changes in a deep low-enthalpy reservoir model, as part of the Delft University of Technology (TU Delft) campus geothermal project. We consider the use of a surface-to-borehole CSEM for the detection of resistivity changes in a simplified model of the TU Delft campus reservoir. We investigate the sensitivity of CSEM data to disk-shaped resistivity changes with a radius of 300, 600, 900, or 1200 m at return temperatures equal to 25, 30, …, 50 °C. We test the robustness of CSEM monitoring against various undesired effects, such as random noise, survey repeatability errors, and steel-cased wells. The modelled differences in the electric field suggest that they are sufficient for the successful CSEM detection of resistivity changes in the low-enthalpy reservoir. The difference in monitoring data increases when increasing the resistivity change radius from 300 to 1200 m or from 4 to 8 Ω·m. Furthermore, all considered changes lead to differences that would be detectable in CSEM data impacted by undesired effects. The obtained results indicate that the CSEM could be a promising geophysical tool for the monitoring of small resistivity changes in low-enthalpy reservoirs, which would be beneficial for geothermal energy production
Estimating reservoir permeability with borehole radar
No full textWe would like to express our gratitude to C. Warren at Northumbria University for the valuable help in gprMax modeling and W. Filinger at The University of Edinburgh and J. Liu at the Delft University of Technology for their assistance in the high-performance computing. We acknowledge the Sinopec Petroleum E&P Institute for the permission to use the oil field logging and coring data. The research was funded by the National Natural Science Foundation of China (41674138, 41811530749, 41974165), the NWO Cooperation and Exchange Fund (040.22.011/7048), and the China Scholarship Council grant (201806415048). The work has been performed under the Project HPC-EUROPA3 (INFRAIA-2016-1-730897), with the support of the EC Research Innovation Action under the H2020 program, and used the Cirrus UK National Tier-2 HPC Service at EPCC (http://www.cirrus.ac.uk) funded by the University of Edinburgh and EPSRC (EP/P020267/1). DATA AND MATERIALS AVAILABILITY Data associated with this research are available and can be obtained by contacting the corresponding author.Peer reviewe
Cholangiocarcinoma landscape in Europe: Diagnostic, prognostic and therapeutic insights from the ENSCCA Registry
No full textBackground & AimsCholangiocarcinoma (CCA) is a rare and heterogeneous biliary cancer, whose incidence and related mortality is increasing. This study investigates the clinical course of CCA and subtypes (intrahepatic [iCCA], perihilar [pCCA], and distal [dCCA]) in a pan-European cohort.MethodsThe ENSCCA Registry is a multicenter observational study. Patients were included if they had a histologically proven diagnosis of CCA between 2010-2019. Demographic, histomorphological, biochemical, and clinical studies were performed.ResultsOverall, 2,234 patients were enrolled (male/female=1.29). iCCA (n = 1,243) was associated with overweight/obesity and chronic liver diseases involving cirrhosis and/or viral hepatitis; pCCA (n = 592) with primary sclerosing cholangitis; and dCCA (n = 399) with choledocholithiasis. At diagnosis, 42.2% of patients had local disease, 29.4% locally advanced disease (LAD), and 28.4% metastatic disease (MD). Serum CEA and CA19-9 showed low diagnostic sensitivity, but their concomitant elevation was associated with increased risk of presenting with LAD (odds ratio 2.16; 95% CI 1.43-3.27) or MD (odds ratio 5.88; 95% CI 3.69-9.25). Patients undergoing resection (50.3%) had the best outcomes, particularly with negative-resection margin (R0) (median overall survival [mOS] = 45.1 months); however, margin involvement (R1) (hazard ratio 1.92; 95% CI 1.53-2.41; mOS = 24.7 months) and lymph node invasion (hazard ratio 2.13; 95% CI 1.55-2.94; mOS = 23.3 months) compromised prognosis. Among patients with unresectable disease (49.6%), the mOS was 10.6 months for those receiving active palliative therapies, mostly chemotherapy (26.2%), and 4.0 months for those receiving best supportive care (20.6%). iCCAs were associated with worse outcomes than p/dCCAs. ECOG performance status, MD and CA19-9 were independent prognostic factors.ConclusionCCA is frequently diagnosed at an advanced stage, a proportion of patients fail to receive cancer-specific therapies, and prognosis remains dismal. Identification of preventable risk factors and implementation of surveillance in high-risk populations are required to decrease cancer-related mortality.Lay summaryThis is, to date, the largest international (pan-European: 26 hospitals and 11 countries) observational study, in which the course of cholangiocarcinoma has been investigated, comparing the 3 subtypes based on the latest International Classification of Diseases 11th Edition (ICD-11) (i.e., intrahepatic [2C12], perihilar [2C18], or distal [2C15] affected bile ducts), which come into effect in 2022. General and tumor-type specific features at diagnosis, risk factors, biomarker accuracy, as well as patient management and outcomes, are presented and compared, outlining the current clinical state of cholangiocarcinoma in Europe
