3,498 research outputs found
Mitral Valve Pathoanatomy: Strategic Assessment
No full textMarc R. Moon of the Washington University School of Medicine in St. Louis, Missouri, presents a discussion on mitral valve pathoanatomy. He discusses mitral valve anatomy, foundation and science of mitral valve repair, and etiology.This presentation was originally given during the SCTS Ionescu University program at the 2019 Annual Meeting of the Society for Cardiothoracic Surgery in Great Britain and Ireland. This content is published with the permission of SCTS. Please click here for more information on SCTS educational programs.</div
Low-thrust trajectories design for the European Student Moon Orbiter mission
No full textThe following paper presents the mission analysis studies performed for the phase A of the solar electric propulsion option of the European Student Moon Orbiter (ESMO) mission. ESMO is scheduled to be launched in 2011, as an auxiliary payload on board of Ariane 5. Hence the launch date will be imposed by the primary payload. A method to efficiently assess wide launch windows for the Earth-Moon transfer is presented here. Sets of spirals starting from the GTO were propagated forward with a continuous tangential thrust until reaching an apogee of 280,000 km. Concurrently, sets of potential Moon spirals were propagated backwards from the lunar orbit injection. The method consists of ranking all the admissible lunar spiral-down orbits that arrive to the target orbit with a simple tangential thrust profile after a capture through the L1 Lagrange point. The 'best' lunar spiral is selected for each Earth spiral. Finally,comparing the value of the ranking function for each launch date, the favourable and unfavourable launch windows are identified
Aortic Regurgitation: Surgical Repair Options
No full textMarc R. Moon of the Washington University School of Medicine in St Louis, Missouri, USA, presents a discussion on the surgical repair options for aortic regurgitation. He discusses the anatomy of the aortic valve and the current guidelines for surgery.This presentation was originally given during the SCTS Ionescu University program at the 2019 Annual Meeting of the Society for Cardiothoracic Surgery in Great Britain and Ireland. This content is published with the permission of SCTS. Please click here for more information on SCTS educational programs.</div
MARC 21 para recursos contínuos
No full textTranslation and adaptation of the MARC 21 Format for Bibliographic Data, and MARC 21 Format for Holdings Data, Network Development and MARC Standards Office, Library of Congress, USA, by Angela Salles. Rio de Janeiro, 2010. 2 v. V.1 MARC 21 format for bibliographic data (updated until October 2010). V.2 MARC 21 format for data collection (Holdings) (updated until October 2008)
MARC 21 para recursos contínuos.
No full textTradução e adaptação de MARC 21 Format for Bibliographic Data e MARC 21 Format for Holdings Data, da Network Development and MARC Standards Office, da Library of Congress, USA, por Angela Salles
Marc Jacobs Unseen
No full textMarc Jacobs Unseen is ‘the first publication dedicated to Marc Jacobs’s highly influential creations’*, described by The Observer as ‘a rare insight’ and Vogue as ‘a real revelation’. The particular focus of this critical appraisal is the personal archive (a recurring feature in Webb’s practice), notably those of the subject (Marc Jacobs), the photographer (Robert Fairer), and the author (Webb). The genesis of the text for this sole-authored book that accompanies new primary material in the form of Fairer’s previously unseen backstage images, is research from Webb’s own archive, amassed over four decades during his career at the forefront of the fashion industry, and represents a culmination of the author’s commitment to the promotion of the importance of the archive as material culture, as methodology and as providing an individual insight into creative thinking. The text takes the form of painstakingly assembled commentaries, each presenting a study of specific collections, highlighting particular garments and ensembles along with an analysis of environment and staging. ‘Working with Iain R. Webb…was illuminating,’ says Fairer. Jacobs Unseen is a valuable and illuminating analysis for both colleagues and students, especially those working in areas of fashion design, journalism and visual communication
Professor Alan R. Bromberg\u27s Rule 10b-5
No full textProfessor Alan Bromberg was the foremost authority in the law of Rule 10b-5. In this article, the author Professor Marc Steinberg, Professor Bromberg\u27s colleague for 25 years, highlights Professor Bromberg\u27s scholarship in this area. Focusing on key U.S. Supreme Court decisions and congressional legislation, Professor Steinberg reflects on the dialogue that he had with Professor Bromberg through the years on these developments. As this article illustrates, Professor Bromberg enjoyed a truly impressive academic career
The discovery of SycO reveals a new function for type three secretion effector chaperones
No full textThe Type Three Secretion (T3S) system is a device used by many Gram-negative pathogens that allows bacteria to deliver effector proteins straight into the eukaryotic cell cytosol. These effectors interfere with various signaling pathways to subvert the host cell functions. The secretion machinery of the T3S system consist of a basal body spanning the bacterial inner and outer membrane followed by a stiff hollow needle outside the bacterium. The fully assembled secretion apparatus constitute a continuous hollow conduit that connects the bacteria to the eukaryotic target cell. After cell contact, virulence proteins -called effectors- are injected directly into the cytosol of the host cell via the T3S apparatus. Several effectors of the T3S system require the assistance of specific cytosolic chaperones to be efficiently exported. There are three classes of T3S chaperones. Effector proteins are assisted by Class I chaperones. Although Class I chaperones are well characterized, their main function is still a matter of controversy. In this thesis, we demonstrate that orf155 encodes a specific chaperone for the effector YopO that we called SycO. We showed that SycO enhances YopO secretion in vitro and is required for translocation of YopO into infected cells. By pulldown assay we demonstrated that residues 20 to 77 of YopO are required and sufficient for SycO binding. Using crosslinking experiments and size exclusion chromatography analysis, we determined the stoichiometry of purified SycO and YopO-SycO complexes. SycO alone forms dimers in solution and the YopO-SycO complex has a 1:2 stoichiometry. These results suggested that SycO is a typical chaperone of the Class I. YopO is a serine/theronine kinase that interacts with Rho and Rac and disrupts the cytoskeleton of the target cells. YopO has been shown to localize at the cell plasma-membrane. By transfection of YopO-EGFP hybrid proteins into HEK293T cells, we demonstrated that the chaperone-binding domain (CBD) coincides with the membrane localization domain of YopO. Nevertheless, the CBD was not needed for the kinase activity of YopO. By ultracentrifugation, we also showed that the CBD causes YopO aggregation in the bacteria, when SycO does not cover it. Further, we show that the CBD of YopE and YopT also caused aggregation in the bacteria in the absence of SycE and SycT respectively. YopE, YopT and T3S effectors in other systems also act at the membrane of the eukaryotic host cell. We propose a new hypothesis concerning the role of T3S chaperones. The sub-cellular localization domain of effectors is aggregation-prone and creates the need for a chaperone inside bacteria. We propose that masking such aggregation-prone localization domains may be a general function for type III effector chaperones
Equilibrium transition study for a hybrid MAV
No full textWind tunnel testing was performed on a VTOL aircraft in order to characterize longitudinal flight behavior during an equilibrium transition between vertical and horizontal flight modes. Trim values for airspeed, pitch, motor speed and elevator position were determined. Data was collected by independently varying the trim parameters, and stability and control derivatives were identified as functions of the trim pitch angle. A linear fractional representation model was then proposed, along with several methods to improve longitudinal control of the aircraft
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