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In Memoriam: Paolo Angelini (1941-2023)-A Pioneer and World-Leading Expert in Coronary Artery Anomalies. A Tribute From the International Coronary Artery Anomalies Collaborative (ICAAC).
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Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Perfil plasmático da ICAM-1 e da VCAM-1 no pós-operatório cardíaco de lactentes submetidos à circulação extracorpórea
Get PDFIntrodução – Grande parte da população de crianças portadoras de defeitos cardíacos congênitos torna-se criticamente doente durante o primeiro ano de vida e necessita tratamento cirúrgico. No entanto, durante cirurgias cardíacas, ocorre uma resposta inflamatória intensa desencadeada pelo período de circulação extracorpórea (CEC), o que provoca disfunção de órgãos e tecidos. Os neutrófilos assumem um papel importante e complexo neste período, envolvendo a ligação às células endoteliais, ativação e liberação de mediadores inflamatórios. Esse processo é iniciado e mantido através de moléculas de adesão específicas, como a molécula de adesão intercelular-1 (ICAM-1) e a molécula de adesão celular-vascular-1 (VCAM-1). Formas solúveis destas moléculas apresentam variações de seus níveis durante cirurgias cardíacas com uso de CEC. Há poucos dados na literatura relacionados ao comportamento destas moléculas após cirurgia cardíaca com uso de CEC em lactentes, estando seu significado no plasma ainda por ser decifrado. Objetivos – Mensurar os níveis plasmáticos das moléculas de adesão solúveis ICAM-1 e VCAM-1 em condições basais e após exposição ao circuito de CEC em lactentes submetidos à cirurgia cardíaca para correção de defeitos cardíacos congênitos. Comparar os níveis plasmáticos destas moléculas entre pacientes acianóticos e cianóticos. Métodos – Foram estudados 21 lactentes, durante o período de junho de 1998 a março de 1999, submetidos à cirurgia cardíaca com uso de CEC. Foram analisados os níveis plasmáticos da ICAM-1 e da VCAM-1 solúveis pelo método de ELISA, na indução anestésica, ao término da CEC e 8 e 26 horas após o término da CEC. Resultados – As patologias cardíacas congênitas mais comuns foram defeito do septo atrioventricular e tetralogia de Fallot. As médias de idade e de peso foram 6,6 meses e 5,8 Kg. As medianas dos tempos de CEC e de clampeamento de aorta foram, respectivamente, 87 e 53 minutos. Todos os lactentes utilizaram inotrópicos. As medianas dos tempos de intubação e de internação foram 72 horas e 21 dias. A taxa de mortalidade dos pacientes foi de 9,5%. Os níveis basais da ICAM-1 e da VCAM-1 foram significativamente mais elevados do que aqueles considerados normais (P<0,0001). Os níveis da ICAM-1 diminuíram significaticamente ao término da CEC (P<0,001), voltando a aumentar significativamente 8 horas após o término deste período (P<0,005), sem no entanto, alcançar os valores basais 26 horas depois. A VCAM-1 apresentou comportamento semelhante. No entanto, 26 horas após CEC houve diminuição significativa de seus níveis em relação ao valor identificado 8 horas após tal período (P<0,005). Não houve diferença estatisticamente significativa quanto aos valores das moléculas entre pacientes acianóticos e cianóticos (P>0,1). Não houve associação entre os valores das moléculas e as variáveis perioperatórias e os desfechos clínicos. Conclusões – Os níveis plasmáticos das moléculas de adesão solúveis ICAM-1 e VCAM-1 são aumentados em lactentes com cardiopatias congênitas acianóticas e cianóticas no seu estado basal. Os níveis plasmáticos de ICAM-1 e VCAM-1 solúveis variam após exposição ao circuito de CEC em lactentes submetidos à cirurgia cardíaca para correção de cardiopatias congênitas, apresentando um comportamento característico nestes pacientes. Não há diferenças no comportamento das moléculas entre pacientes acianóticos e cianóticos.Introduction – A large number of children presenting with congenital cardiac defects become critically ill in the first year of life and need definitive surgical treatment. Nevertheless, there is an intense inflammatory response as a result of cardiac surgery, triggered by the use of cardiopulmonary bypass (CPB), leading to organ and tissue injury. Neutrophils have an important and complex role during that period, promoting adherence to endothelial cells, release and activation of inflammatory mediators. This process is initiated and mantained by specific adhesion molecules, such as intercellular adhesion molecule-1 (ICAM-1) and vascular-cellular adhesion molecule-1 (VCAM-1). Soluble forms of these molecules present variable levels throughout cardiac surgeries with CPB. There is few information about the behaviour of these molecules after cardiac surgeries with CPB in infants, and the significance of these findings are yet to be unraveled. Objectives – To measure the soluble ICAM-1 e VCAM-1 plasmatic levels at baseline and after CPB exposure in infants undergoing cardiac surgery for repair of cardiac defects. To compare these molecules plasmatic levels in acyanotic and cyanotic patients. Methods – 21 infants undergoing cardiac surgery with CPB were studied, between June 1998 and March 1999. Soluble ICAM-1 and VCAM-1 plasmatic levels were measured using ELISA at induction of anesthesia, at the end of the CPB, and 8 hours and 26 hours after CPB. Results – Atrioventricular septal defects and tetralogy of Fallot were the most common congenital cardiac defects. The age and weight mean values were 6,6 months and 5,8 Kg. The median values of CPB time and aortic cross-clamping time were 87 minutes and 53 minutes. All infants used inotropic drugs. The median values of intubation time and hospitalization time were 72 hours and 21 days. The patients mortality rate was 9,5%. The baseline levels of ICAM-1 and VCAM-1 were higher than normal values (P<0,0001). The ICAM-1 levels significantly decreased at the end of CPB (P<0,001), significantly increasing 8 hours after that period (P<0,005), without reaching baseline values 26 hours after that. VCAM-1 presented a similar behaviour. Nevertheless, its levels decreased significantly 26 hours after CPB, compared with levels measured 8 hours after that period (P<0,005). There was no statistically significant difference in molecules levels in acyanotic and cyanotic patients (P>0,1). There was no significant association between molecules levels and perioperative variables or clinical endpoints. Conclusions – The soluble ICAM-1 and VCAM-1 baseline plasmatic levels are higher than normal in infants presenting acyanotic and cyanotic congenital cardiopathies. The soluble ICAM-1 and VCAM-1 plasmatic levels vary after CPB exposure in infants undergoing reparative congenital cardiac surgeries, presenting a characteristic behaviour in these patients. There are no differences in these molecules behaviour in acyanotic and cyanotic patients
Perfil dos níveis plasmáticos das interleucinas 6 e 8 em lactentes submetidos à cirurgia cardíaca com circulação extracorpórea
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Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Perfil dos níveis plasmáticos de endotelina-1 em lactentes submetidos à cirurgia cardíaca com circulação extracorpórea
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Late gadolinium enhancement and anomalous coronary aortic origin in a large paediatric cohort
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Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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