197,073 research outputs found
Forgotten connections: reviving the concept of upbringing in Scottish child welfare
No full textThe concept of upbringing is a central one in social pedagogy. It is also apparent in a Scottish social welfare tradition, most evidently in the 1964 Kilbrandon Report. Kilbrandon’s broad understanding of upbringing or social education was, however, subsequently subsumed beneath increasingly compartmentalised and instrumental approaches to child care and education. These fail to adequately understand and, arguably, impede and distort adult responsibility for bringing up children. This article draws on European literature, and particularly the writing of the German social pedagogue Klaus Mollenhauer, to begin to articulate the concept of upbringing, locating it as the central task of child care and education. Bringing up children is identified as, fundamentally, a moral and cultural endeavour, brought about through caring, inter-generational relationships. The article concludes by suggesting that elements within a Scottish tradition and within current policy might be drawn on to support a broad understanding of upbringing
Klaus Mollenhauer\u27s "Forgotten Connections": A sketch of a general pedagogic
No full textMollenhauer presents his book as a rough sketch of what Allgemeine Pädagogik (General Pedagogic) could be – an outline of "a general study of Bildung and upbringing" (Mollenhauer, 2014, p. 9) – a daring project, which in my view is even more needed today than in 1983. Mollenhauer shows a way to a practically committed, historically-founded and future-oriented theory of emancipatory upbringing and education; built on reliable elements in the cultural and pedagogical tradition, which we, as responsible adults, should not forget, when we, together with the new generation, face present and future challenges. In this essay, I attempt a short interpretation of his sketch and give some brief evaluative comments in the final section.
Cerebrospinal Fluid Tau, p-Tau 181 and Amyloid-beta(38/40/42) in Frontotemporal Dementias and Primary Progressive Aphasias
No full textBackground/Aims: We determined cerebrospinal fluid (CSF) concentrations of amyloid-beta(A beta)(1-38), A beta(1-40), A beta(1-42), total tau and phospho-tau (p-tau) in order to study their differential expression in frontotemporal dementia (FTD, n = 25) and primary progressive aphasia (PPA, n = 12) as compared to Alzheimer's dementia (AD, n = 25) and nondemented controls (n = 20). Methods: Commercially available ELISA and electrochemiluminescence methods were applied. Results: High CSF p-tau and low ratios of A beta(1-42)/A beta(1-40) and A beta(1-42)/A beta(1-38), respectively, were specific for AD. CSF A beta(1-38) was reduced in FTD as compared to each of the other diagnostic groups, including PPA. CSF tau and p-tau levels were elevated in PPA as compared to FTD. Conclusion: This is the first detailed report on biomarker patterns in PPA, indicating distinct CSF biomarker patterns in FTD and PPA as major subgroups of frontotemporal lobar degeneration. The diagnostic and pathophysiological implications of our results warrant further studies on larger and neuropathologically diagnosed patient populations. Copyright (C) 2010 S. Karger AG, Base
Clinical datasets related DeNoPa olfaction, cerebrospinal fluid readouts and alpha-synuclein seeding aggregation assay
No full text<p>These dataset files are associated with the manuscript: </p>
<p>Mollenhauer B*, Li J*, Schade S, Weber S, Trenkwalder C, Concha-Marambio L, Tomlinson JJ, aSCENT-PD Investigators and Schlossmacher MG. <em>Persistent Hyposmia as Surrogate for alpha-Synuclein-Linked Brain Pathology. </em>Submitted 2023</p>
<p>3 files:</p>
<p>Data dictionary.csv</p>
<p>Baseline_cut.csv</p>
<p>Time_cut.csv</p>
<p>The file "Data dictionary.csv" contains description of the two data files and the variables within.</p>
<p>Clinical data used for this study is from the DeNoPa Cohort, led by Dr. Brit Mollenhauer, Department of Neurology, University of Goettingen, Kassel, Germany and the Paracelsus-Elena-Klinik. See references below for additional details.</p>
<p>Mollenhauer B, Trautmann E, Sixel-Döring F, Wicke T, Ebentheuer J, Schaumburg M, Lang E, Focke NK, Kumar KR, Lohmann K, Klein C, Schlossmacher MG, Kohnen R, Friede T, Trenkwalder C; DeNoPa Study Group. Nonmotor and diagnostic findings in subjects with de novo Parkinson disease of the DeNoPa cohort. Neurology. 2013 Oct 1;81(14):1226-34. doi: 10.1212/WNL.0b013e3182a6cbd5</p>
<p>Concha-Marambio L, Weber S, Farris CM, Dakna M, Lang E, Wicke T, Ma Y, Starke M, Ebentheuer J, Sixel-Döring F, Muntean ML, Schade S, Trenkwalder C, Soto C, Mollenhauer B. Accurate Detection of α-Synuclein Seeds in Cerebrospinal Fluid from Isolated Rapid Eye Movement Sleep Behavior Disorder and Patients with Parkinson's Disease in the DeNovo Parkinson (DeNoPa) Cohort. Mov Disord. 2023 Apr;38(4):567-578. doi: 10.1002/mds.29329</p>
Radiocarbon data of bulk organic matter in marine sediment core PS51/154-11 from the Laptev Sea, Arctic Ocean
No full textThis datasheet includes radiocarbon measurement results of bulk organic matter from core PS51/154-11. Sediments were freeze-dried, ground, and weighed into silver boats, with sample sizes determined by TOC content to target 1 mg of organic carbon. Samples were acidified with three drops of 6 M HCl at 60 °C three times with one hour reaction time between treatments, then oven-dried overnight at 60 °C. Afterwards, acidified samples together with silver boats were folded into tin boats and converted into graphite targets using an elemental analyzer (Elementar vario Isotope) coupled to an automated graphitization system (Ionplus AG, AGE-3). Radiocarbon measurements were conducted using the MIni CArbon Dating System (MICADAS) accelerator mass spectrometer at Alfred Wegener Institute (AWI) (Mollenhauer et al., 2021)
Radiocarbon data of bulk organic matter in marine sediment core PS51/159-10 from the Laptev Sea, Arctic Ocean
No full textThis datasheet includes radiocarbon measurement results of bulk organic matter from core PS51/159-10. Sediments were freeze-dried, ground, and weighed into silver boats, with sample sizes determined by TOC content to target 1 mg of organic carbon. Samples were acidified with three drops of 6 M HCl at 60 °C three times with one hour reaction time between treatments, then oven-dried overnight at 60 °C. Afterwards, acidified samples together with silver boats were folded into tin boats and converted into graphite targets using an elemental analyzer (Elementar vario Isotope) coupled to an automated graphitization system (Ionplus AG, AGE-3). Radiocarbon measurements were conducted using the MIni CArbon Dating System (MICADAS) accelerator mass spectrometer at Alfred Wegener Institute (AWI) (Mollenhauer et al., 2021)
Tau protein, A beta 42 and S-100B protein in cerebrospinal fluid of patients with dementia with Lewy bodies
No full textThe intra vitam diagnosis of dementia with Lewy bodies (DLB) is still based on clinical grounds. So far no technical investigations have been available to support this diagnosis. As for tau protein and beta-amyloid((1-42)) (Abeta42), promising results for the diagnosis of Alzheimer's disease ( AD) have been reported; we evaluated these markers and S-100B protein in cerebrospinal fluid (CSF), using a set of commercially available assays, of 71 patients with DLB, 67 patients with AD and 41 nondemented controls (NDC) for their differential diagnostic relevance. Patients with DLB showed significantly lower tau protein values compared to AD but with a high overlap of values. More prominent differences were observed in the comparison of DLB patients with all three clinical core features and AD patients. Abeta42 levels were decreased in the DLB and AD groups versus NDC, without significant subgroup differences. S-100B levels were not significantly different between the groups. Tau protein levels in CSF may contribute to the clinical distinction between DLB and AD, but the value of the markers is still limited especially due to mixed pathology. We conclude that more specific markers have to be established for the differentiation of these diseases. Copyright (C) 2005 S. Karger AG, Basel
Radiocarbon data of bulk organic matter in marine surface sediments from the Laptev Sea, Arctic Ocean
No full textThis datasheet includes radiocarbon measurement results of bulk organic matter from marine surface sediments from the Laptev Sea. Sediments were freeze-dried, ground, and weighed into silver boats, with sample sizes determined by TOC content to target 1 mg of organic carbon. Samples were acidified with three drops of 6 M HCl at 60 °C three times with one hour reaction time between treatments, then oven-dried overnight at 60 °C. Afterwards, acidified samples together with silver boats were folded into tin boats and converted into graphite targets using an elemental analyzer (Elementar vario Isotope) coupled to an automated graphitization system (Ionplus AG, AGE-3). Radiocarbon measurements were conducted using the MIni CArbon Dating System (MICADAS) accelerator mass spectrometer at Alfred Wegener Institute (AWI) (Mollenhauer et al., 2021)
Biogeochemical data of sediment cores of Herschel island (Yukon Coast 2022)
No full textIn July 2022 within the framework of an Alfred-Wegener-Institute-managed expedition and the Nunataryuk project, sediment cores were taken at three locations, off the coast of Herschel Island, Canada, using a hand corer:
YC22_MR_6: 69°34'23.12N, 138°54'37.76W; 3 m water depth; July 6th 2022
YC22_MR_7: 69°34'23.53N, 138°56'37.66W, 6 m water depth; July 7th 2022
YC22_MR_8: 69°30'22.75''N, 138°53'21.69''W; 45 m water depth; July 24th 2022
Data sets were obtained to investigate carbon feedback from the sediments to the water column and atmosphere, using DIC concentrations and isotopic values. The local sediments are supplied primarily by organic carbon previously stored in adjacent permafrost soils (biomarker and bulk data), which erode and redeposit quickly (age model) on the ocean floor.
The acquired data includes:
1) Sediment data: Bulk total organic carbon content (Lamping et al., 2021) and its isotopic values for 13C (Brodie et al., 2011; Werner & Brand, 2001) and 14C (Mollenhauer et al., 2021) and Biomarker data: Quantifying alkanes (CPI) , and fatty acids (TAR ratio) as described by Wei et al. (2020), Glycerol dialkyl glycerol tetraethers (GDGTs basis for BIT-Index) after Hopmans et al. (2016), Hopanes (fßß) following instructions by Meyer et al., (2019), and Sterols (Dinosterol) after Dauner et al. (2022).
2) Porewater was extracted from the cores using rhizomes and quantified as described in Oni et al., (2015). Dissolved inorganic carbon isotope signatures were determined as CO2 for 13C (Torres et al., 2005) and 14C (Mollenhauer et al., 2021).
3) Intact polar lipid fatty acids were extracted from the sediments, purified, and 14C analysis was performed as described in Ruben et al. (2023). The 13C isotopy was determined with GC-IRMS (Elvert et al., 2003). The respective precursor lipids of the polar fraction used for isotope analysis were quantified following the method described in Wörmer et al. (2013). Datasets are to be found at doi:10.1594/PANGAEA.966262 and doi:/10.1594/PANGAEA.966264.
4) Sedimentary age model of core YC22_MR_7 assuming constant rate of supply (CRS) model (Appleby, 2001), based on data obtained with a HPGe gamma detector
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