1,720,973 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dataset for "Characterising a novel adult erythroid cell line for red blood cell manufacture"
No full textThis dataset contains information from a study characterising the Bristol Erythroid Line-A (BEL-A) cell line for mass production, including growth and metabolic kinetics of BEL-A cells, effect of doxycycline, impact of (and tolerance to) lactate and ammonia, and impact of high density culture. Data is provided in an Excel file with individual tabs containing the dataset for each experiment, and comprises live and dead cell numbers, nutrient/metabolite concentrations, and pH measurements.For details of the data acquisition experiments, refer to the "Materials and Methods" section in the associated paper.Microsoft Excel software was used to create the data file
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
An evaluation of tailored magnetic nanoparticles in the induction of stem cell differentiation
Get PDFImproving the differentiation capacity of stem cells by defining the ideal physico-chemical and spatial parameters will enhance the efficiency of stem cell-based clinical therapies. In this thesis the hypothesis that heat shock (elevated temperatures) could positively influence osteogenic differentiation was investigated. A methodology was developed to employ magnetic nanoparticle-based local heating (magnetic hyperthermia) to spatially control temperature distribution at the cellular level. For this purpose, bacterially synthesized zinc and cobalt doped iron oxide nanoparticles with tuned physical and magnetic properties were assessed for their interaction with cells, and their magnetic response and heating properties when in a cellular milieu. Nanoparticles with moderate levels of zinc doping showed strong heating effects and minimal cytotoxicity, proving to be promising candidates for cellular applications.The effects of mild and severe heat stress were assessed by heating cells using conventional techniques such as water baths (bulk heat shock); using localised heating with extracellular nanoparticle suspensions; or by targeting different cellular regions with nanoparticles. The effect of the heat shock treatment on the osteogenic differentiation was assessed in primary bone marrow-derived human mesenchymal stem cells and a cancerous osteoblastic cell line, MG-63. With both bulk and nanoparticle-mediated extracellular mild heat shock (~420C), very little evidence for a positive effect on osteogenic differentiation was found in both cell types. On the other hand, severe heat shock treatments (>500C) showed differentiation enhancement though this also negatively impacted cell viability. Further experimentation can shed light on the optimum temperature range within which the differentiation behaviour of cells can be influenced without compromising viability. The nanoparticle-based methodology developed here to apply heat shock to different cellular components, could lead to further work investigating how intracellular pathways translate the heat stimulus into a cellular response for stem-cell based applications
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Dataset for "Assessing the immunosuppressive activity of alginate-encapsulated mesenchymal stromal cells on splenocytes"
No full textThe dataset includes all raw data for the journal article. It includes flow cytometry data (.fcs files) for figures 2 and 4 measuring the splenocyte count in each sample. This gives a measure of the immunosupression of splenocyte proliferation by mesenchymal stromal cells. It also includes PCR data for figure 3 was obtained using StepOne software (ThermoFisher). This dataset shows the effect of alginate encapsulation on MSC immunosuppressive genes. It contains the gene expression levels, as measured through qRT-PCR, on key immunosupressive genes IDO , NOS2, ARG1 and PTGS2 using β-Actin and HPRT-1 as the housekeeping genes. MSC as monolayers on tissue culture plastic or encapsulated within alginate beads were either left untreated or exposed to 10 mg/ml TNF-α, 10 ng/ml INFγ or both (10 ng/ml TNF-α + 10 ng/ml INFγ) for 24h.ETERM_Fig02_DvsTW and ETERM_Fig04_Exp01_03: To determine effect of MSCs on the suppressing the proliferation of splenocytes, the cells were co-cultured for defined periods of time. The splenocytes were stained with the CellTrace™ violet dye and their degree of proliferation measured using flow cytometry. All flow cytometry measurements were performed on a LSRFortessa (BD Biosciences) instrument and data aquisition through the FACSDiva software. Two experimental controls were defined: (1) Splenocytes without any Concanavalin A stimulation (negative control) and (2) splenocytes treated with concanavalin A without any MSCs (positive control). The results were all normalized to the proliferation index (PI) of the positive control. The MSCs were unstained and hence did not interfere with the flow cytometric measurements. During aquisition, the splenocytes were gated in the forwards versus side scatter plot and 10,000 to 100,000 events collected. The .fcs files were then processed using the FlowJo software (BD Biosciences) to gate for single events and finally the histogram for the V450 channel where the CellTracker Violet signal is recorded. The files were saved in the .fcs format and processed using custom-writted R code to calculate the proliferation index.
ETERM_Fig03_PCR: This folder contains the qPCR data for measuring gene expression. The samples were run on a qPCR machine and data aquired using the StepOne software (ThermoFisher). All information on genes analysed, housekeeping genes used are recorded within the sample dataset.Please refer to the data collection method for information on equipments and softwares used for data collection and processing.The raw data are classified into 3 folders refereing to the figure number in the manuscript. Raw data files and post processed data files (as excel files) are available
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