12 research outputs found
Penerapan Data Mining untuk Memprediksi Jumlah Produk Terlaris Menggunakan Algoritma Naive Bayes Studi Kasus (Toko Prapti)
No full textToko Prapti is a small privately owned company that sells basic necessities,. So far, the prapti shop produces sales data every day, but the results obtained show that the prapti shop has not maximized the data so that it becomes a data accumulation. Therefore, the researcher conducted a study on product sales data by utilizing and applying data mining using the nave Bayes classifier algorithm to determine the interest in purchasing goods at the prapti shop. data. In this study, the author uses the waterfall system development method. The author implements this research using a web programming language, namely PHP, using the CodeIgniter framework with MySQl database. The system built with the nave Bayes algorithm includes product sales data, nave calculations of each attribute and reporting. This system produces 4 attributes that greatly affect the results of the classification. The attributes used in this research are the attributes are quarter 1, quarter 2, quarter 3 and quarter 4. Prediction results obtained using the nave Bayes algorithm produce information that can be used by stores to identify the best-selling products purchased by consumers so that it can help prapti shops to find and determine the target market more accurately. Sources of data taken from the previous 1 year with system accuracy using a confusion matrix resulted in 83.3% accuracy, 84.2% precision and 88.9% recall. Â Â Â Keywords : Data mining, Nave bayes Classifier, Code Igniter, Confusion Matri
Woman
No full textI was reflecting upon how a woman's actions are misinterpreted and misunderstood and more often than not, underestimated. Our resilience and innate strength comes out in full force when there is a platform and freedom of expression
Mechanisms of cytomegalovirus regulation of neurodegenerative markers
No full textAlzheimer’s disease (AD) manifests with loss of neurons associated with intercellular amyloid plaques made up of amyloid beta peptides (Aβ) and intracellular neurofibrillary tangles of hyperphosphorylated tau proteins. Normally, Aβ peptides function as cell signaling molecules and can mediate antimicrobial activity. Tau is one of the microtubule stabilizing proteins in cells and its expression and post-translational modifications depend upon cell type and cell age.
Despite testing many therapeutics designed to target abnormal amyloid or tau, there is no sustained treatment. Current research is therefore focused on early steps in production of dysfunctional amyloid and tau11, however, there are relatively few strong established models for these studies.
Previous researchers have shown that some herpesvirus infections can alter amyloid and tau in ways similar to that seen in AD. There is clinical correlation between herpesvirus infection and higher risk of AD. Herpes simplex virus 1 can interact with amyloid precursor protein (APP) and affect tau
v hyperphosphorylation. Based on these findings, we hypothesized that MCMV infection could be a useful model if it similarly impacted AD markers.
We found that APP was upregulated in MCMV-infected fibroblasts and viral late gene products were required. Levels of processing enzymes (secretases) and one cleavage product (Aβ42) were unchanged. The activity of β-secretase was not increased. There was no similar APP induction in RCN. Thus, CMV may have cell-type or species-based differences for effects on the amyloid pathway.
Levels of total tau and tau phosphorylated at S396 were increased in MCMV-infected fibroblasts and neurons. This also required viral late gene products. There was no change in tau phosphorylation at S202 or GSK3β levels. We used lithium chloride (LiCl) to inhibit activity of GSK3. Although MCMV infection was inhibited, the banding patterns for tau and phospho-tau (S396) exhibited minor alterations when LiCl was added at the time that changes started. Thus, other kinases are more likely important.
We have confirmed that MCMV can induce AD markers. This is useful for using MCMV infection in AD animal models for elucidation of early steps, promising for testing novel preventives for these changes, and for developing novel antivirals
Functional organic thin films under extreme confinement
No full text"Confining materials can produce dramatic changes in their fundamental properties. As evident from graphene and other 2D materials, reducing film thickness of materials to a few layers of even monolayers can alter their optical, electronic and magnetic properties compared to bulk counterparts. One of the tenets of current materials research is to harvest these unique properties of thin film materials at ""extreme confinement"", i.e., at condition when the film thickness reduces below a critical value where one or more structural aspects such as molecular packing, orientation, conformation, as well as properties begin to deviate from bulk. So far, significant advancements have been made in extremely confined materials where individual entities are held together by strong covalent bonds, such as most inorganic materials. However, such studies on organic molecules are lacking. This is partly because of fabrication challenges that arise as the bonds that hold entities in the supramolecular structure of organic molecules are significantly weaker. My thesis aims to crystallize extremely confined thin films of two functional materials, active pharmaceutical ingredients (APIs) and conjugated polymers, and then to explore and elucidate the resulting variations in structure and properties compared to thicker films.
Low aqueous solubility of APIs is one of the most significant impediments in pharmaceutical industry. Nanosizing has been recognized as an effective to address this challenge. My approach to nanosize poorly soluble APIs is to solidify them in to nanothin films by utilizing meniscus-guided solution-coating (MGC) technique. In my first study (Chapter 2), we demonstrated a control in film thickness of APIs in nanometer scale range (1.5 μm to 30 nm) as well as their morphology and molecular packing by varying simple processing parameters. Moreover, we also performed sequential deposition of multiple components in a layer-by-layer manner by utilizing the same approach. Interestingly, we also observed trapping and stabilization of metastable polymorphs of API when coated under highly non-equilibrium conditions. In my following study (Chapter 3), I aimed to elucidate the role of nanoconfinement in the observed phenomenon as well as to investigate its role on dissolution properties of APIs. Here, I observed abrupt order-to-disorder transition and stabilization of semi-crystalline and amorphous forms of three different APIs when the film thickness was decreased below a critical value of ~25-30 nm in all three APIs. I also developed a dissolution model that predicted an enhancement in solubility and intrinsic dissolution rate (IDR) upon decrease in film thickness. The experimental results closely matched this model and we demonstrated a drastic increase in IDR upon decreasing the thickness and increasing disorder in the films.
Next, I explored into two-dimensionalization of conjugated polymers- a novel class of semiconducting materials that have enabled fabrication of inexpensive, transparent, flexible electronics. Monolayer films of conjugated polymers are gaining an increasing attention because of their potential in tuning optoelectronic properties compared to bulk films, application in fabrication of ultrasensitive sensors, and as a near-ideal platform for studying fundamental charge transport mechanisms. However, fabrication of 2D films with high coverage and high degree of order remains challenging, and fundamental questions on how multiscale morphology and electronic properties of these films change when confined to monolayer films remain unanswered. In my work (Chapter 4), I first utilized dynamic-template-directed MGC technique to fabricate highly ordered and aligned 2D monolayer films of conjugated polymers of ~3.5 nm thickness with 100% coverage, which contrasted with disordered monolayers produced on solid substrates. Furthermore, I observed that the polymer chains in monolayers on dynamic template were highly twisted and their backbone planarity increased monotonically until the film thickness was increased to a critical value of ~20-30 nm. This led to a decrease in interfacial trap state density and an increase in hole mobility of the polymer films by almost 3 orders of magnitude when film thickness was increased from monolayer to the critical thickness. In addition, I fabricated OFET-based sensors incorporating ultrathin films of polymers which showed sensitivity of ~83% to ammonia vapors of ~1ppb concentration. Next, I explored into graphene surfaces as a template for monolayer films of polymers (Chapter 5) and observed significant enhancement in multiscale morphology with higher fiber density, coverage, degree of crystallinity, alignment and polymer backbone planarity compared to those on control silicon substrates. This accompanied with p-doping of the polymer by the graphene substrates. OFET devices incorporating graphene nanoflakes in ultrathin films of polymer blends showed enhancement in hole mobility by ~2 orders of magnitude compared to pristine polymer films. We attributed this to a decrease in interfacial trap state density and change in morphology, resulting due to the interaction between graphene and the polymer.
Overall, my thesis has demonstrated strategies to overcome the challenges associated with fabricating extremely confined thin films of organic materials and reported deviations in structure and properties of such films with respect to the bulk. The insights gained from these studies will be helpful in harvesting enhanced properties of extremely confined thin films of pharmaceuticals and organic electronics, and will hopefully inspire exploration into confinement effects of other organic materials."Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-08-01The student, Prapti Kafle, accepted the attached license on 2021-06-23 at 16:14.The student, Prapti Kafle, submitted this Dissertation for approval on 2021-06-23 at 16:43.This Dissertation was approved for publication on 2021-06-25 at 15:41.DSpace SAF Submission Ingestion Package generated from Vireo submission #16710 on 2022-01-12 at 13:03:33Made available in DSpace on 2022-01-12T22:51:40Z (GMT). No. of bitstreams: 7
KAFLE-DISSERTATION-2021.pdf: 44210101 bytes, checksum: 8ae40efb48688535e7203ae005a8b49e (MD5)
LICENSE.txt: 4209 bytes, checksum: be6779fe4f2112d72cc78c0c242acddf (MD5)
RightsLink_PK_Thesis_Chapter 2.pdf: 105522 bytes, checksum: e92eea262e1db646eb7f7dfe7c33d23b (MD5)
RightsLink_PK_Thesis_Chapter 4.pdf: 231095 bytes, checksum: 6add246c8c01ef1b39145cdcd96089df (MD5)
RightsLink_PK_Thesis_Figure1.2.pdf: 108970 bytes, checksum: f2bdeb1ab1ae737a1d20014875499dd3 (MD5)
RightsLink_PK_Thesis_Figure1.3.pdf: 109059 bytes, checksum: 1ab560582811186c1c512deb6ddee0a2 (MD5)
RightsLink_PK_Thesis_Figure1.4.pdf: 191092 bytes, checksum: 95ff0ca77e9358f1856fc120944d27e3 (MD5)
Previous issue date: 2021-06-25Embargo set by: Seth Robbins for item 121183
Lift date: 2024-01-12T22:51:46Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 121183
Lift date: 2024-01-12T22:53:32Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 121183
Lift date: 2024-01-12T22:54:14Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 121183
Lift date: 2024-01-12T22:55:09Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 121183
Lift date: 2024-01-12T22:56:20Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemAuthor requested closed access (OA after 2yrs) in Vireo ETD systemLimite
Problematika Opsi Pembayaran Kembali Pinjaman Extended Fund Facilities-IMF: Suatu Analisis Ekono-Politik tentang Sebab Akibat dan Skenario Solusinya
No full textThe author of article below declares that the main problem in Indonesia economy is not only exit strategy of IMF, but also because of EFF-IMF will end on December 31, 2003., and MPR decided to stop it based on Tap MPR No.VI year 2002. In this respect; it needs to think way how to repay debt from EFF-IMF. The following criteria that Indonesia still needs the trust of international market, Indonesia should grow self confident, and Indonesia can be an expectation in national and integrity of Indonesia. According to writer that Indonesia should consider to choose option cash payment be tween 5,4-8,4 billion US. Dollars to propose toward reforming IMF
Herpes simplex virus: A versatile tool for insights into evolution, gene delivery, and tumor immunotherapy
No full textHerpesviruses are prevalent throughout the animal kingdom, and they have coexisted and coevolved along with their host species for millions of years. Herpesviruses carry a large (120-230 kb) double-stranded DNA genome surrounded by a protein capsid, a tegument layer consisting of viral and host proteins, and a lipid bilayer envelope with surface glycoproteins. A key characteristic of these viruses is their ability to enter a latent state following primary infection, allowing them to evade the host’s immune system and persist permanently. Herpesviruses can reactivate from their dormant state, usually during times of stress or when the host’s immune responses are impaired. While herpesviruses can cause complications with severe disease in immune-compromised people, most of the population experiences few ill effects from herpesvirus infections. Indeed, herpes simplex virus 1 (HSV-1) in particular has several features that make it an attractive tool for therapeutic gene delivery. Herpes simplex virus 1 targets and infects specific cell types, such as epithelial cells and neurons. The HSV-1 genome can also accommodate large insertions of up to 14 kb. The HSV-1-based vectors have already achieved success for the oncolytic treatment of melanoma. In addition to serving as a vehicle for therapeutic gene delivery and targeted cell lysis, comparative genomics of herpesviruses HSV-1 and 2 has revealed valuable information about the evolutionary history of both viruses and their hosts. This review focuses on the adaptability of HSV-1 as an instrument for gene delivery and an evolutionary marker. Overall, HSV-1 shows great promise as a tool for treating human disease and studying human migration patterns, disease outbreaks, and evolution
Praanggapan pada dialog mengenai kejujuran: kajian Pragmatik dalam novel Asal Kau Bahagia karya Bernard Batubara
No full textThe aims of this analysis is to examine presuppositions on dialogue about honesty through pragmatic studies. This is a qualitative study with content analysis method because this research prioritizes the content approach of dialogue in the novel. The data source of this analysis is a dialogues that contain presuppositions and imply honesty in the novel Asal Kau Bahagia by Bernard Batubara. Data provision of this analysis is done by using simak method that is applied through note-taking techniques. The results of this study indicate that 26 data containing presuppositions consisting of 9 data included in factive presuppositions, 3 lexical presuppositions data, 7 data as existantial presuppositions, 5 data as non-factual presuppositions, and 2 data are counterfactual presuppositions. In addition, the research also revealed that through several presupposition there was a message in each speech, the action would always be related to the value of honesty, but sometime it is really to be said. If it happens there is only prejudice and revenge exists. In addition, through this pragmatic, presupposition, and about honesty, the author also hopes that the results of this paper will be able to contribute ideas to the reading community about the importance of the value of honesty in friendship, romance, and in a society that has recently faded
PENGARUH DISIPLIN KERJA, LINGKUNGAN KERJA, DAN STRES KERJA TERHADAP KINERJA KARYAWAN
No full textThe source of human labor in an industry is a driving factor based on the number of activities that must be carried out, which explains that without labor an industrial activity cannot run well and according to the goals that have been made. Human resources are also the main key in the process of industrial activities and crucial in achieving the continuity of industrial activities. PT Artha Kayu Indonesia is one industry that struggles with low employee performance. Based on the attendance rate data obtained from HRD, Artha Kayu Indonesia showed a significant decrease in fluctuations. So the author needs to do research on what efforts are made to improve employee performance at Artha Kayu Indonesia so that employees come more often with a predetermined time.
The purpose of this study is to determine the effect of Work Discipline, Work Environment and Work Stress on employee performance at Artha Kayu Indonesia. The population in this study is employees of Artha Kayu Indonesia. Based on the sample criteria set, a sample was obtained in this study as many as 100 respondents. The analytical methods used in this study are instrument tests (validity tests and reliability tests), classical assumption tests include (normality tests, heterokedasticity tests, multicollinearity tests), multiple linear regression tests, partial tests (t tests), F test model accuracy, coefficient of determination (R2) tests used to analyze primary data in this study conducted with the help of SPSS version 25.
Based on the results of the study shows that there is an influence of work discipline, Work Environment on employee performance, while work stress has no influence on employee performance at Artha Kayu Indonesia. The more positive work discipline, the more employees will comply with the regulations in the Company and will improve employee performance, vice versa if there are many positive Work Environments in the employee work environment, employee performance will increase as a result, also meet predetermined targets. The lower the employee's work stress rate, the higher the employee's performance results
