63 research outputs found
The total synthesis of mycothiol and new inhibitors of carbohydrate processing enzymes
No full textThe work described in this dissertation covers a wide range of disciplines within organic chemistry, with the common goal of obtaining more information about various carbohydrate-processing enzymes. Carbohydrate-processing enzymes are garnering an increasing amount of attention relative to their more well-studied protein-processing counterparts, as they are ubiquitous and implicated in various regulatory, signaling and metabolic processes in eukaryotic cells. Chapter 1 involves the synthesis of anomeric phosphothioates as possible O-GlcNAc transferase inhibitors, and a mechanistic study on the anomeric Pudovik rearrangement of thiophosphites to thiophosphonates is described. Chapter 2 is an account of the development of a facile method for functionalizing 2-methyl thiazoline rings, and several selective GlcNAc-thiazoline-based O-GlcNAcase inhibitors were synthesized by this method. Chapter 3 details the 16-step total synthesis of the M. tuberculosis antioxidant carbohydrate mycothiol by a new intramolecular glycosylation method. The method is amenable to glycosylations of 2-deoxy-2-aminoglyosides, a unique aspect among such reactions. The efficiency of the synthetic route to mycothiol makes it attractive as a template from which to design analogs as potential inhibitors of enzymes involved in the biosynthesis of mycothiol. An apparently unprecedented 1,9-hydride shift is also described in the third chapter. Chapter 4 describes a tripartate prolonged-release drug delivery system, in which the drug of interest (ethynyl estradiol in this study) is coupled, through a variable linker, to another carrier drug with a long half-life and a relatively high inhibitory concentration. The effect of steric bulk on the in vitro release of ethynyl estradiol was evaluated, showing a direct relationship between steric bulk around the ester linkage and ethynyl estradiol release time. In vivo data from pigs also seemed to point to an increase in drug bioavailability with the 3-part system. Finally, chapter 5 describes early efforts to synthesize boronic acid analogs of folic acid and antifolates.Ph.D.Includes abstractVitaIncludes bibliographical referencesby Kehinde Ajay
Primary Health Care in South West Nigeria: Evaluating service quality and patients' satisfaction
No full textAdaptive capabilities of the cardiovascular system in children with systemic lupus erythematosus
No full textAdaptive capabilities of the cardiovascular system in children with systemic lupus erythematosus
No full textRelative Effects of Parents’ Occupation, Qualification and Academic Motivation of Wards on Students’ Achievement in Senior Secondary School Mathematics in Ogun State
No full textThe importance of mathematics to an individual and the society is clearly beyond debate thus, every individual needs some knowledge of mathematics in order to live a useful life and be an effective member of the society. Despite this impo9rtance role accorded mathematics in the school curriculum, many academically capable students prematurely restrict their educational and career options by discontinuing their mathematical learning early in the high school. The poor results in this subject have continued to be stumbling-blocks in the realization of the educational and employment desire of many candidates because it is a gatekeeper for many careers. This study investigated the relative effects of parents’ occupation, education and academic motivation of wards on students’ achievements in senior secondary school Mathematics in Ogun State, Nigeria. The study employed ex-post facto type of research and the sample was selected using the multistage sampling technique. Two thousand four hundred students from 60 selected schools in nine local government areas within Ogun State, Nigeria were involved and two research instruments namely; Students’ Questionnaire; (r = 0.81) and Mathematics Achievement Test; (r = 0.84) were used. Data were analyzed using multiple regression at .05 level of significance. The result reveals that parents’ education has the highest significant influence on the academic achievement of students in Mathematics while the effect of academic motivation had the least effect among the variables which exerted significant effects on students’ academic achievement in Mathematics. Keywords: Parents’ education; Occupation; Academic Motivation; Achievement
Effects of a 12-Week Structured Fitness Exercise on the Red Blood Cells of College Students in Ikere-Ekiti, Ekiti State, Nigeria.
No full textThis study investigated and determined the effects of a 12-week structured fitness training programme on the Red Blood cells of College Students. The structured exercise/ training programme consisted of graded physical activities lasting for about fifty (50) minutes and administered three times a week, The pre-test, post-test control group - design was used for the study. Sixty (60) College Students were used comprising thirty (30) subjects each for both the experimental and the control groups. Statistical procedure employed included the descriptive statistics of mean, range and standard deviation, inferential statistics of Analysis of Covariance (ANCOVA) was used to determine significance of adaptation. A post-hoc analysis of Multiple Classification Analysis (MCA) was also applied to find out the magnitude of the adaptation. Graphical illustration was also used to pictorially display the pattern of changes in the variable. The result of the findings showed a rejection of the hypothesis which stated that there will be no significant effect of a 12-week fitness training programme on the Red blood cells of College Students in Ekiti State. Based on the findings of this study, it was therefore concluded that a structured exercise training programme of 12 weeks duration is capable of reducing the red blood cells of college students in Ikere Ekiti. It was recommended that such fitness training programme be encouraged among the youths. Keywords: Resistance exercise, hematological variables, college students
Antibiotic Residues in Food Samples Sold In Abeokuta Metropolis: A Cause for Concern
No full textThe use of antibiotic plays a major role in the emerging public health crisis of antibiotic resistance. Although, the majority of antibiotics usage occurs in animal husbandry and relatively little attention has been paid to how these antibiotics in farm animals contribute to the overall problems of antibiotics resistance in human. This research focuses on antibiotics residues in seven different most commonly consumed food samples in Abeokuta, Ogun State, Nigeria as a case study. These food samples are: Chicken, Eggs, Cow-meat, Cheese, Goat-meat, Pork-meat and Turkey-meat. The antibiotics tested were: tetracycline, penicillin and streptomycin. The result, however, gave an inhibition zone of 8mm, 5mm, 6mm in frozen Turkey; Nill, 5mm, 4mm in Cow-meat; Nill, Nill, 5mm in boiled Cheese; Nill, 4mm, 5mm in frozen Pork; 6mm, 7mm , 4mm in Eggs; 5mm, 4mm, 6mm in frozen Chicken and 4mm, Nill , 5mm in Goat-meat for Tetracycline, Penicillin and Streptomycin respectively. Most of the results obtained showed relatively high amount of antibiotics residues above the permissible limit of 2mm
Nigerian Journal of Banking and Financial Issues: EFFECT OF MONETARY POLICY ON DEPOSIT LIABILITIES OF COMMERCIAL BANKS IN NIGERIA
No full text© Department of Finance
Ekiti State University, Ado Ekiti, Nigeria.
The Nigerian Journal of Banking and Financial Issues (NJBFI) provides a unique forum for the articulation and dissemination of applied research by academics and professionals in the field of Banking and Finance or tested disciplines. It is biannual journal published by the Department of Finance, Ekiti State University, Ado Ekiti, Nigeria.
The Journal contains analysis of banking and finance issues relevant to the Nigeria economic experience and financial policies. Opinions expressed herein are these of the authors and her necessarily those of the Department of Finance.
All right reserved. No part of this publication may be reproduced or transmitted in any form or by any means. electronic, mechanical, photocopying, recording or otherwise of series in any retrieval system of any nature, without the prior written permission of the copyright holder.
Subscription Rate: Nigeria
Students: N2,000
Others: N2,500
Foreign US $25
Volume 9 No. 1, March 2023
ISSN: 1119 - 8494
Printed in Nigeria by: Department of Finance Ekiti State University Ado Ekiti,
Nigeria.
Tel: 08035023117,
080283887163.
EDITOR –IN – CHIEF: PROF. J. A. OLOYEDE MANAGING EDITOR: DR.(MRS) B. A. AZEEZ ASSOCIATE EDITOR: DR. F. T. KOLAPO
ADVISORY BOARD PROF. WOLE ADEWUNMI PROF. W. I. IYIEGBUNIWE PROF. S. I. OWUALAH
PROF. (MRS) E. O. ADEGBITE PROF. FAMOUS IZEDOME PROF. A. A. AWE
PROF. T. M. OBAMUYI PROF. S. O. AKINMULEGUN PROF. F. M. EPETIMEHIN PROF. S. A. TELLA
PROF. R. O. SOMOYE
EDITORS
PROF. S. O. ADEUSI PROF. A. O. ADARAMOLA DR. L. B. AJAYI
M. O. OKE
L. A. SULAIMAN DR. J. O. MOKUOLU DR. DAPO FAPETU DR. J. A. AJAYI
BUSINESS MANAGERS
S. O. DADA
DR.MRS. O. G. OBISESAN DR. MRS. A. O. ADEJAYAN DR. I. E. AJAYI
CALL FOR PAPERS
The Nigerian Journal of Banking and Financial Issues (NJBFI) provides a unique forum for the articulation and dissemination of applied research by academics and professionals in the field of Banking and Finance or tested disciplines. It is biannual journal published by the Department of Finance, Ekiti State University, Ado Ekiti, Nigeria.
Interested contributors are invited to submit well researched papers which have not been provide published either in whole or part in any journal.
i Three copies of the manuscript should be submitted, each copy of which must be typed on one side of A4 sized paper only and double spaced.
Manuscript should not exceed twenty pages, including notes, reference, table and chart
The cover page of each manuscript should contain title of papers, names(s) and additional of author(s)
An abstract of not more than 120 words typed single spaced on a separate sheet book precede the main text. The short abstract should summarize the main argument of the article
Bibliographical references should be indicated in the text using the author data style with page numbers where necessary. All reference must adopt America psychological Associate (APA) current style and reference pattern.
Table and charts should be placed as close as possible to relevant discussion. End noted should be numbered consequently, and should not solely comprise references.
Manuscript which do not conform to these guidelines may be returned
All manuscript and other correspondences should be sent to:
The Managing Editor:
Journal of Banking and Financial Issues C/o Department of Finance
Ekiti State University, Ado -Ekiti, Nigeria.
OR
The Business Editor: Department of Finance,
E-mail: [email protected]
Nigerian Journal of Banking and Financial Issues: EFFECT OF MONETARY POLICY ON DEPOSIT LIABILITIES OF COMMERCIAL BANKS IN NIGERIA
No full text© Department of Finance
Ekiti State University, Ado Ekiti, Nigeria.
The Nigerian Journal of Banking and Financial Issues (NJBFI) provides a unique forum for the articulation and dissemination of applied research by academics and professionals in the field of Banking and Finance or tested disciplines. It is biannual journal published by the Department of Finance, Ekiti State University, Ado Ekiti, Nigeria.
The Journal contains analysis of banking and finance issues relevant to the Nigeria economic experience and financial policies. Opinions expressed herein are these of the authors and her necessarily those of the Department of Finance.
All right reserved. No part of this publication may be reproduced or transmitted in any form or by any means. electronic, mechanical, photocopying, recording or otherwise of series in any retrieval system of any nature, without the prior written permission of the copyright holder.
Subscription Rate: Nigeria
Students: N2,000
Others: N2,500
Foreign US $25
Volume 9 No. 1, March 2023
ISSN: 1119 - 8494
Printed in Nigeria by: Department of Finance Ekiti State University Ado Ekiti,
Nigeria.
Tel: 08035023117,
080283887163.
EDITOR –IN – CHIEF: PROF. J. A. OLOYEDE MANAGING EDITOR: DR.(MRS) B. A. AZEEZ ASSOCIATE EDITOR: DR. F. T. KOLAPO
ADVISORY BOARD PROF. WOLE ADEWUNMI PROF. W. I. IYIEGBUNIWE PROF. S. I. OWUALAH
PROF. (MRS) E. O. ADEGBITE PROF. FAMOUS IZEDOME PROF. A. A. AWE
PROF. T. M. OBAMUYI PROF. S. O. AKINMULEGUN PROF. F. M. EPETIMEHIN PROF. S. A. TELLA
PROF. R. O. SOMOYE
EDITORS
PROF. S. O. ADEUSI PROF. A. O. ADARAMOLA DR. L. B. AJAYI
M. O. OKE
L. A. SULAIMAN DR. J. O. MOKUOLU DR. DAPO FAPETU DR. J. A. AJAYI
BUSINESS MANAGERS
S. O. DADA
DR.MRS. O. G. OBISESAN DR. MRS. A. O. ADEJAYAN DR. I. E. AJAYI
CALL FOR PAPERS
The Nigerian Journal of Banking and Financial Issues (NJBFI) provides a unique forum for the articulation and dissemination of applied research by academics and professionals in the field of Banking and Finance or tested disciplines. It is biannual journal published by the Department of Finance, Ekiti State University, Ado Ekiti, Nigeria.
Interested contributors are invited to submit well researched papers which have not been provide published either in whole or part in any journal.
i Three copies of the manuscript should be submitted, each copy of which must be typed on one side of A4 sized paper only and double spaced.
Manuscript should not exceed twenty pages, including notes, reference, table and chart
The cover page of each manuscript should contain title of papers, names(s) and additional of author(s)
An abstract of not more than 120 words typed single spaced on a separate sheet book precede the main text. The short abstract should summarize the main argument of the article
Bibliographical references should be indicated in the text using the author data style with page numbers where necessary. All reference must adopt America psychological Associate (APA) current style and reference pattern.
Table and charts should be placed as close as possible to relevant discussion. End noted should be numbered consequently, and should not solely comprise references.
Manuscript which do not conform to these guidelines may be returned
All manuscript and other correspondences should be sent to:
The Managing Editor:
Journal of Banking and Financial Issues C/o Department of Finance
Ekiti State University, Ado -Ekiti, Nigeria.
OR
The Business Editor: Department of Finance,
E-mail: [email protected]
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