84 research outputs found
Rapport evaluatie nautisch onderzoek havenmond van Hoek van Holland
No full textTen behoeve van de bouw van de nieuwe havenmond nabij Hoek van Holland, de definitieve toegang naar Europoort en de aanleg van de naderingsgeul voor diepstekende schepen, is in de periode van 1960 tot heden veel onderzoek verricht. Als onderdeel van de afsluiting van de werkzaamheden wordt een samenvattende rapportage én evaluatie gemaakt van alle "hiertoe verrichte nautische onderzoekingen. Het onderhavige rapport behandelt daartoe dat gedeelte van de uitgevoerde onderzoeken, dat verricht werd door/bij het Nederlands Scheepsbouwkundig Proefstation te Wageningen. Het onderzoek dat door het N.S.P. in de verschillende fasen van de realisatie van de nieuwe havenmonden werd uitgevoerd kan naar de aard van de toegepaste methodieken in twee groepen worden onderverdeeld. Eén groep bevat het onderzoek waarbij gekozen is voor metingen aan schaalmodellen van schepen in een fysisch model van de vaarsituatie. Een tweede groep omvat onderzoeken welke meer gericht zijn op de bestudering van het integrale gedrag van het "mens-schip-omgevings syteem", waarbij inschakeling van een scheepsmanoeuvreersimulator werd geprefereerd
Double nuclear spin switching in single quantum dots
No full textHyperfine interaction in a quantum dot produces a spin-coupled system between an injected electron and a few tens of thousands of nuclei in the electron wavefunction. We report here that the double bistable phenomenon of nuclear spin polarization (NSP) can be observed by sweeping three control parameters. All the observations indicate that the NSP has three stable branches under a longitudinal magnetic field, whereas the number of the stable branches of NSP has been believed to be two at most. The incorporation of the electron spin relaxation due to the nuclear spin fluctuation enables reproduction of the observed features of the NSP and the electron spin polarization
Vergelijkbaarheid van diverse golfverwerkingsprogramma's
No full textVergelijking van de golfverwerkingsprogramma's van het Waterloopkundig Laboratorium (WL), KNMI, de Deltadienst (Rijkswaterstaat) en het Nederlands Scheepsbouwkundig Proefstation (NSP)
Influence of nut shell powder content on the tribological properties of recycled polyolefin composites
No full textThe purpose of this study is to investigate the influence of nut shell powder (NSP) content on the tribological properties of recycled polyolefin (R-PO) composites. NSP was previously grinded the dried nut shell by crusher machine cryogenically in liquid nitrogen. NSP/R-PO composites with NSP content of 5, 10 and 20 vol.% were prepared in this study. These composites were extruded by a twin screw extruder and injection-molded. Their tribological properties were measured by a reciprocating type sliding wear tester at constant normal load and sliding speed under dry condition. It was found that NSP is effective for reducing the wear resistance of R-PO, and the influence of NSP content on the tribological properties of NSP/R-PO composites does not remarkably appear, but they are improved with the addition of low content such as 5 vol.%. This may be attributed to the change of wear mechanism according to the filling of NSP. © 2016 Author(s).MEXT, Ministry of Education, Culture, Sports, Science, and Technolog
Temporal patterns of sitting at work are associated with neck–shoulder pain in blue-collar workers: a cross-sectional analysis of accelerometer data in the DPHACTO study
No full text© 2016, The Author(s). Background: Our aim was to examine the extent to which temporal patterns of sitting during occupational work and during leisure-time, assessed using accelerometry, are associated with intense neck–shoulder pain (NSP) in blue-collar workers. Methods: The population consisted of 659 Danish blue-collar workers. Accelerometers were attached to the thigh, hip, trunk and upper dominant arm to measure sitting time and physical activity across four consecutive days. Temporal sitting patterns were expressed separately for work and leisure by the proportion of total time spent sitting in brief bursts (0–5 min), moderate ( > 5–20 min) and prolonged ( > 20 min) periods. The peak NSP intensity during the previous 3 months was assessed using a numerical rating scale (range 0–10) and dichotomized into a lower (=4) and higher ( > 4) NSP score. Logistic regression analyses with multiple adjustments for individual and occupational factors were performed to determine the association between brief, moderate and prolonged sitting periods, and NSP intensity. Results: Time in brief bursts of occupational sitting was negatively associated with NSP intensity (adjusted OR 0.68, 95 % CI 0.48–0.98), while time in moderate periods of occupational sitting showed a positive association with NSP (adjusted OR 1.32, 95 % CI 1.04–1.69). Time in prolonged periods of occupational sitting was not associated with NSP (adjusted OR 0.78, 95 % CI 0.78–1.09). We found no significant association between brief, moderate or prolonged sitting periods during leisure, and NSP. Conclusion: Our findings indicate that the association between occupational sitting time and intense NSP among blue-collar workers is sensitive to the temporal pattern of sitting
Atrophy and structural covariance of the cholinergic basal forebrain in primary progressive aphasia
No full textAbstractPrimary progressive aphasia (PPA) is characterized by profound destruction of cortical language areas. Anatomical studies suggest an involvement of cholinergic basal forebrain (BF) in PPA syndromes, particularly in the area of the nucleus subputaminalis (NSP). Here we aimed to determine the pattern of atrophy and structural covariance as a proxy of structural connectivity of BF nuclei in PPA variants. We studied 62 prospectively recruited cases with the clinical diagnosis of PPA and 31 healthy older control participants from the cohort study of the German consortium for frontotemporal lobar degeneration (FTLD). We determined cortical and BF atrophy based on high-resolution magnetic resonance imaging (MRI) scans. Patterns of structural covariance of BF with cortical regions were determined using voxel-based partial least square analysis. We found significant atrophy of total BF and BF subregions in PPA patients compared with controls [F(1, 82) = 20.2, p < .001]. Atrophy was most pronounced in the NSP and the posterior BF, and most severe in the semantic variant and the nonfluent variant of PPA. Structural covariance analysis in healthy controls revealed associations of the BF nuclei, particularly the NSP, with left hemispheric predominant prefrontal, lateral temporal, and parietal cortical areas, including Broca's speech area (p < .001, permutation test). In contrast, the PPA patients showed preserved structural covariance of the BF nuclei mostly with right but not with left hemispheric cortical areas (p < .001, permutation test). Our findings agree with the neuroanatomically proposed involvement of the cholinergic BF, particularly the NSP, in PPA syndromes. We found a shift from a structural covariance of the BF with left hemispheric cortical areas in healthy aging towards right hemispheric cortical areas in PPA, possibly reflecting a consequence of the profound and early destruction of cortical language areas in PPA
Network pharmacology, molecular simulation, and binding free energy calculation-based investigation of Neosetophomone B revealed key targets for the treatment of cancer
No full textIn the current study, Neosetophomone B (NSP-B) was investigated for its anti-cancerous potential using network pharmacology, quantum polarized ligand docking, molecular simulation, and binding free energy calculation. Using SwissTarget prediction, and Superpred, the molecular targets for NSP-B were predicted while cancer-associated genes were obtained from DisGeNet. Among the total predicted proteins, only 25 were reported to overlap with the disease-associated genes. A protein-protein interaction network was constructed by using Cytoscape and STRING databases. MCODE was used to detect the densely connected subnetworks which revealed three sub-clusters. Cytohubba predicted four targets, i.e., fibroblast growth factor, FGF20, FGF22, and FGF23 as hub genes. Molecular docking of NSP-B based on a quantum-polarized docking approach with FGF6, FGF20, FGF22, and FGF23 revealed stronger interactions with the key hotspot residues. Moreover, molecular simulation revealed a stable dynamic behavior, good structural packing, and residues' flexibility of each complex. Hydrogen bonding in each complex was also observed to be above the minimum. In addition, the binding free energy was calculated using the MM/GBSA (Molecular Mechanics/Generalized Born Surface Area) and MM/PBSA (Molecular Mechanics/Poisson-Boltzmann Surface Area) approaches. The total binding free energy calculated using the MM/GBSA approach revealed values of -36.85 kcal/mol for the FGF6-NSP-B complex, -43.87 kcal/mol for the FGF20-NSP-B complex, and -37.42 kcal/mol for the FGF22-NSP-B complex, and -41.91 kcal/mol for the FGF23-NSP-B complex. The total binding free energy calculated using the MM/PBSA approach showed values of -30.05 kcal/mol for the FGF6-NSP-B complex, -39.62 kcal/mol for the FGF20-NSP-B complex, -34.89 kcal/mol for the FGF22-NSP-B complex, and -37.18 kcal/mol for the FGF23-NSP-B complex. These findings underscore the promising potential of NSP-B against FGF6, FGF20, FGF22, and FGF23, which are reported to be essential for cancer signaling. These results significantly bolster the potential of NSP-B as a promising candidate for cancer therapy.The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by Qatar University grant No. QUPD-CPH-23/24-592. The statements made herein are solely the responsibility of the authors. Open Access funding provided by the Qatar National Library.Scopu
Closed-Form Pricing in Multiuser Access Networks With Incomplete Information
No full textPricing has been widely used to solve network optimization problems. In this paper, we study the case where the network service provider (NSP) has incomplete information about the users, such as the specific user type. Formulating the pricing of the monopolistic NSP and the flow control of the users as a two-level hierarchical game, we first obtain closed-form equilibrium solutions that jointly maximize the benefits of the monopolistic NSP and the users with heterogeneous quality-of-service (QoS) requirements. Then, based on the closed-form solutions, we consider a more general and practical multi-NSP and multiuser model. We further propose a novel one-sided job-hopping matching game to obtain stable NSP-user matching that can optimize network performance in a multi-NSP and multiuser scenario. Simulations demonstrate the effectiveness of the proposed game-theoretic approaches in both the monopolistic and multi-NSP cases.National Science Foundation [CNS-1343189, ECCS-1232305]; National Natural Science Foundation of China [61101079, 61471177]; Science Foundation for the Youth Scholar of Ministry of Education of China [20110001120129]SCI(E)[email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]
Analysis of patient- and procedure-related risk factors for nasal septal perforations following septoplasty
No full text© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.Objectives: To assess the possible relationship between various predictive factors (patient or surgery related) and the development of nasal septal perforations (NSP) with the help of a large study group. Methods: One hundred and forty-three patients were included in the study. The presence of the following factors was evaluated and compared between the NSP and healthy group: types of surgeries, presence of unilateral or bilateral mucosal tears, concomitant inferior turbinate interventions, smoking, accompanying diabetes mellitus (DM) or allergic rhinitis (AR), types of nasal packings, duration of the surgery (minutes), and the experience of the surgeon (senior/junior). Nasal septal deviations were grouped into two: simple cartilage crests at the septum base and other—more complicated—deviations. Results: NSP was detected in six (4.2%) patients after a mean follow-up of 9.3 ± 3.7 (min: 6 max: 14) months. None of these patients suffered from (AR) or DM. Four of these patients had unilateral and one patient had bilateral mucosal tears during the surgeries. None of the above-mentioned factors—including mucosal tears, type of the deviation or experience of the surgeon—had a significant effect on NSP. Conclusion: Untreated bilateral corresponding mucosal tears are the main cause of NSP. When immediately repaired, unilateral or bilateral tears do not affect the development of NSP significantly. Patient-related factors such as age, DM, smoking, AR, and procedure-related factors such as duration, the complexity of the septal deviation, type of the nasal packing, and experience of the surgeon also do not have a significant effect on NSP
Intravenous versus inhalation anaesthesia for one-lung ventilation
No full textBackground the technique called one-lung ventilation can confine bleeding or infection to one lung, prevent rupture of a lung cyst or, more commonly, facilitate surgical exposure of the unventilated lung. During one- lung ventilation, anaesthesia is maintained either by delivering a volatile anaesthetic to the ventilated lung or by infusing an intravenous anaesthetic. It is possible that the method chosen to maintain anaesthesia may affect patient outcomes.Objectives the objective of this review was to evaluate the effectiveness and safety of intravenous versus inhalation anaesthesia for one- lung ventilation.Search strategy We searched the Cochrane Central Register of Controlled Trials (CENTRAL) ( the Cochrane Library 2006, Issue 3), MEDLINE, LILACS, EMBASE ( from inception to June 2006), ISI web of Science ( 1945 to June 2006), reference lists of identified trials, and bibliographies of published reviews. We also contacted researchers in the field. There were no language restrictions.Selection criteria We included randomized controlled trials and quasi- randomized controlled trials of intravenous versus inhalation anaesthesia for one-lung ventilation.Data collection and analysis Two authors independently assessed trial quality and extracted data. We contacted study authors for additional information.Main results We included nine studies that enrolled 291 participants. We could not perform meta-analyses as the included studies did not report the outcomes listed in the protocol for this review.Authors' conclusions There is no evidence from randomized controlled trials of differences in patient outcomes for anaesthesia maintained by intravenous versus inhalational anaesthesia during one- lung ventilation. This review highlights the need for continued research into the use of intravenous versus inhalation anaesthesia for one- lung ventilation. Future trials should have standardized outcome measures such as death, adverse postoperative outcomes and intraoperative awareness. Dropouts and losses to follow up should be reported.Hosp Sirio Libanes, Dept Anesthesiol, BR-05011040 São Paulo, BrazilMcMaster Univ, Toronto, ON, CanadaUniversidade Federal de São Paulo, Brazilian Cochrane Ctr, São Paulo, BrazilUniversidade Federal de São Paulo, Brazilian Cochrane Ctr, São Paulo, BrazilWeb of Scienc
- …
