1,721,050 research outputs found
Factura, 1936 sept. 16, Madrid, de Grabador de Moda F. Sierra
No full textFactura impresa en negro, manuscrita en tinta negra y numerada "2731". Figura rubricada, la palabra "Recogida"Alcance y contenido: Versa sobre la adquisicíón de un sello y el tampón. Se indican los precios y el coste totalEn la parte superior aparecen impresos el nombre, la dirección y el teléfono del establecimiento: "Grabador de Moda F. Sierra / Montera, 38 / Teléfono 13063"Sello en tinta azul para la fecha. La fecha de pago es "21-9-936", coincide con la indicada en la siguiente nota: "El día 21 las 7 (salvo contrariedad) puede retirarse el encargo presentando nota"Membrete en negro y a la izquierda, formado con los datos del establecimiento, sin ornamento y en diferentes líneas y tipografía variadaPapel en color crema con rayas perteneciente a un tac
Novel screening approaches for human prion diseases drug discovery
No full textIntroduction: Human prion diseases are rare fatal neurodegenerative diseases caused by the misfolding and aggregation of the prion protein in the form of infectious prions. So far, these diseases are incurable. One of the major difficulties in identifying suitable drugs is the availability of robust preclinical screening methods. All molecules identified have been screened using cell-based assays and in vivo murine models. The existence of a continuum of prion strains has hampered the identification of efficacious molecules modulating the progression of different forms of the disease. Areas covered: The advent of new in vitro screening methodologies is allowing for novel strategies to develop new compounds that could interfere with a broad range of diseases. In particular, two innovative techniques named Real Time Quaking Induced Conversion (RT-QuIC) and Protein Misfolding Cyclic Amplification (PMCA) have opened new venues for testing compounds in a rapid a reproducible way. These are discussed within. Expert opinion: For human prion diseases, one major hurdle has been a well-defined screening methodology. In other animal species, cell-based assays have been employed that could replicate animal prions indefinitely. Such a tool for human prion diseases is still missing. Therefore, the advent of RT-QuIC and PMCA has proven instrumental to overcome this limitation
EST: an exploratory model for Ecosystem Services in the Venice lagoon
No full textThe Venice lagoon is a complex socio-ecological system, where Ecosystem Services (ES) and benefits for people
result as emergent properties from the interactions between ecological processes and human activities. Such
a complex system is threatened by several drivers of change, including those connected to resource
exploitation and ecosystem fruition, along with climate related drivers. EST (Ecosystem Services Screening
Tool) is an exploratory numerical model based on dynamic system theory, aimed at investigating the
interactions among the different ES, the lagoon resources and the social dynamics, and compare possible
scenarios of evolution of the whole socio-ecological system. The conceptual model was inspired by the “Socialecological systems framework” and considers 13 Ecosystem Services, along with the biophysical component,
represented by specific macrohabitats characterizing the lagoon seascape and key faunal groups, and the main
groups of actors involved in services fruition. Increase in water temperature and relative sea level rise were
provided as external forcings in the model, which also attempted to account for the feedbacks on services
produced by the regulation of lagoon high tides through the closure of mobile gates. EST was implemented in
Simile v. 6.1 software environment, as an attempt to improve its applicability for participatory modelling
applications. Model development and parameterization is presented, and contrasting tendency scenarios are
preliminarily explored, considering a 50 year time horizon. Scenarios included both changes in climate-related
forcings and in governance choices aimed at preserving the biophysical component, ensuring ES sustainability
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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