1,722,738 research outputs found
Manipolazione di tessuti. Progetto Vincitore Europan 9 per il sito di Carbonia
No full textL’autore con Adriano Dessì e Silvia Mocci nel 2008 si è aggiudicato il primo premio al concorso internazionale di architettura Europan9 per il sito di Carbonia‐Sardegna‐Italia. Young Blood annual 2007 è un catalogo che si occupa della promozione dei giovani telenti italiani che si sono distinti nel mondo conseguendo premi internazionali nel campo delle arti, dell’architettura e del mondo della creatività. Il saggio costituisce una sintesi del progetto vincitore per il concorso Europan9 nel sito di Carbonia
Section Introduction : Molecular Dynamics Simulations and Reaction Rates
No full textThis collection about “Molecular Dynamics simulations and reaction rates” in the “Comprehensive Computational Chemistry” series has attracted excellent scholars from the entire field. Among them are many pioneers and developers of novel methods and tools. The volume features the latest developments of widely used packages to perform MD simulations, methodological advances and many ingenious applications of the state-of-the-art MD methodology, with very different types of materials in varying conditions and for systems of high complexity that could not have been simulated in the past. The contributions in this collection demonstrate the vast potential and promise of utilizing MD, the primary particle-based computer simulation method, to investigate the structural, thermodynamic, and dynamic properties of molecular matter, modeled on multiple scales from including the electronic degrees-of-freedom to meso-scale soft particles, both at equilibrium and non-equilibrium conditions. Many new ideas are given to detect rare events and to improve the poor sampling as well as to connect spatial and temporal scales in multi-scale modeling. Readers can find many ideas on where MD is going in the future, aided by the many flavors of artificial intelligence, combined with knowledge-based modeling and new sophisticated schemes allowing chemical reactions to enter into simulations having classical mechanics as foundation. With such a rapid development it would really be interesting to see in the crystal ball what we will be simulating ten years from now. In this introduction to the volume and research field, we start by looking at the rear-view mirror and discuss some selected single developments that have made the entire Computational Chemistry possible. The present and future is well covered by the contributions of excellent authors to this volume.</p
Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity
Full text linkMito-SEPs are small open reading frame-encoded peptides that localize to the mitochondria to regulate metabolism. Motivated by an intriguing negative association between mito-SEPs and inflammation, here we screen for mito-SEPs that modify inflammatory outcomes and report a mito-SEP named "Modulator of cytochrome C oxidase during Inflammation" (MOCCI) that is upregulated during inflammation and infection to promote host-protective resolution. MOCCI, a paralog of the NDUFA4 subunit of cytochrome C oxidase (Complex IV), replaces NDUFA4 in Complex IV during inflammation to lower mitochondrial membrane potential and reduce ROS production, leading to cyto-protection and dampened immune response. The MOCCI transcript also generates miR-147b, which targets the NDUFA4 mRNA with similar immune dampening effects as MOCCI, but simultaneously enhances RIG-I/MDA-5-mediated viral immunity. Our work uncovers a dual-component pleiotropic regulation of host inflammation and immunity by MOCCI (C15ORF48) for safeguarding the host during infection and inflammation
Premio del paesaggio Regione Sardegna per il progetto di recupero della ex-tonnara di Calasetta da adibire a casa per vacanze,
No full textCoding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity
No full textMito-SEPs are small open reading frame-encoded peptides that localize to the mitochondria to regulate metabolism. Motivated by an intriguing negative association between mito-SEPs and inflammation, here we screen for mito-SEPs that modify inflammatory outcomes and report a mito-SEP named “Modulator of cytochrome C oxidase during Inflammation” (MOCCI) that is upregulated during inflammation and infection to promote host-protective resolution. MOCCI, a paralog of the NDUFA4 subunit of cytochrome C oxidase (Complex IV), replaces NDUFA4 in Complex IV during inflammation to lower mitochondrial membrane potential and reduce ROS production, leading to cyto-protection and dampened immune response. The MOCCI transcript also generates miR-147b, which targets the NDUFA4 mRNA with similar immune dampening effects as MOCCI, but simultaneously enhances RIG-I/MDA-5-mediated viral immunity. Our work uncovers a dual-component pleiotropic regulation of host inflammation and immunity by MOCCI (C15ORF48) for safeguarding the host during infection and inflammation
Margaret Fuller, repubblicanesimo e femminismo in Woman in the Nineteenth Century
No full textMargaret Fuller is mainly known as the first American feminist manifesto’s author, Woman in the Nineteenth Century, published in1845. The article tries to analyze Fuller’s work from different perspectives, discussing her claim to women’s rights as a part of the antebellum debate on American democracy. Using the republican theory of freedom as independence from arbitrary power, Fuller demonstrated that, where domination was primarily social rather than political, the legal recognition of women’s rights would never bring freedom unless there was also a change in the cultural patterns and the defeat of the patriarchal ideology. The paper examines how Fuller challenged nineteenth-century rules and tried, with the publication of her book, to fight women’s social domination, which prevented them from becoming independent, in the republican sense, in order to establish more equal relations between the sexes
Republicanism and Feminism: A Plausible Alliance. The Case of Margaret Fuller’s Woman in the Nineteenth Century
No full textMargaret Fuller is chiefly known as the author of the first American feminist manifesto, Woman in the Nineteenth Century, published in 1845. This article undertakes to read Full- er’s work through a republican lens by viewing her discussion on women’s rights as a part of the antebellum debate on American democracy. It also aims to put together two ap- proaches, republicanism and feminism, whose relationship some scholars consider to be an- tithetical, i.e. Phillips (2000), Friedman (2008) and Hirschmann (2003) but which, in general, has been scarcely analysed. Although republicanism called for freedom and equality among men, it never seriously considered, especially in ancient and early-modern times, the status of women and the recognition of their civil and political rights. However, recent studies, such as Vega (2002), Coffee (2012), Costa (2013) and Halldenius (2015), have tried to reinterpret the possible dialectical connections between women and republicanism, opening up new lines of research on this topic. The purpose of this paper is therefore to provide new food for thought to this contemporary academic debate by adopting a historical approach. This paper argues that Fuller’s use of the concept of ‘liberty’ in her defence of wom- en’s civil and political rights corresponds to Philip Pettit’s (1997) definition of liberty as ‘nondomination’. Taking freedom to mean independence from arbitrary power, Fuller demonstrated that due to their submission to the arbitrary power of men, women totally lacked any measure of independence, and could thus be defined as ‘slaves’. In addition, Fuller bolstered these affirmations by considering a further form of interference resulting from what Alan Coffee (2012) has called ‘social domination’, which was based on cultural values and traditions that condoned women’s exclusion from social, political and working life on the basis of their supposed physical and intellectual inferiority. This did not allow them to exercise their right to freedom as independent agents. The paper demonstrates that thanks to the use of republican paradigms to develop her feminist critique, Margaret Fuller took republicanism a step further and developed a more
inclusive and egalitarian model of republican liberty that embraced women. Indeed, her feminist internal critique of republicanism can offer new food for thought to the contemporary academic debate on the compatibility between republicanism and feminism. The research brings to light how Fuller criticized women’s legal status and the institution of marriage, how she compared the condition of women to that of slaves, and how she supported higher levels of education for women as a right and an emancipatory instrument in a free republic
Addressing Racial Conflict in Antebellum America: Women and Native Americans in Lydia Maria Child’s and Margaret Fuller’s Literary Works
Full text linkThrough an analysis of two lesser-known works, Summer on the Lakes (1844) and The First Settlers of New-England: or, Conquest of the Pequods, Narragansets and Pokanokets (1829),the essay aims to investigate the ways in which two American thinkers, Margaret Fuller and Lydia Maria Child, used literature as a means of resistance against American expansionist policies and as an instrument for portraying, addressing and resolving racial conflict at U.S. borders during two crucial moments in antebellum American history
Torsion angle relationship of the (17)O NMR chemical shift in alpha,beta-unsaturated carbonyl compounds
No full texttorsion angle effect on the isotropic shielding of (17)O nucleus in alpha,beta-unsaturated carbonyl groups is studied by means of density functional theory (DFT) calculations using a polarizable continuum model (PCM) for the solvent, employing the PBEO functional together with the 6-311 G(cl,p) basis set for geometry optimization, and the 6-311+G(2d,p) basis set for calculating the NMR shielding with the gauge-including atomic orbitals (GIAO) method. This study adds new information on the sensitivity of the (17)O nucleus to conformational changes, revealing a strong dependence of the (17)O NMR chemical shift on the dihedral angle between the carbonyl and the vinyl moiety in all studied compounds; remarkable differences are observed with the data reported for alpha-diketones. Copyright (C) 2009 John Wiley & Sons, Ltd
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