1,315 research outputs found
HASTE DE LÍRIOS, DE KENJI MIYAZAWA
No full textThe present work is a translation from Japanese to Brazilian Portuguese of the Yomata no Yuri (Stem of Lillies) tale written by the Japanese author Kenji Miyazawa (1893-1933). Miyazawa was an essayist, poet and writer of Japanese children's tales. Even though his work is not so popular in Brazil, in Japan it has achieved much notoriety. He is considered one of the most relevant writers in both prose and poetry. Miyazawa was born in Iwate and graduated in Agricultural Sciences. He was also a professor and dedicated himself fundamentally to the writing career. His work is notably influenced by Nichiren Buddhism, which can be seen in the following work. This translation aims at presenting to the Brazilian public an example of the Kenji’s literature, considering the cultural relevance of his work and the importance for understanding the Japanese way of thinking.O presente trabalho é uma tradução para o português do Brasil do conto Yomata no Yuri (Haste de Lírios) do autor japonês Kenji Miyazawa (1893 – 1933). Miyazawa foi ensaísta, poeta e escritor de contos japoneses infantis. Embora a obra dele não seja tão conhecida no Brasil, no Japão ela alcançou bastante notoriedade, podendo ser considerado um dos escritores mais relevantes tanto na prosa, quanto na poesia. Miyazawa nasceu na prefeitura de Iwate, graduou-se em Ciências da Agricultura, foi professor universitário e dedicou-se fundamentalmente à carreira de escritor. Sua obra apresenta forte influência do Budismo Nichiren, como pode ser visto pela leitura do conto a seguir. Esta tradução visa a apresentar ao público brasileiro um exemplo da literatura de Kenji, tendo em vista a riqueza cultural de seu trabalho, bem como relevância para o entendimento do pensamento japonês
Biological age prediction using a DNN model based on pathways of steroidogenesis
No full textWang Qiuyi, Wang Zi, Mizuguchi Kenji, et al. Biological age prediction using a DNN model based on pathways of steroidogenesis. Science Advances 11, 2468 (2025); https://doi.org/10.1126/sciadv.adt2624.Aging involves the progressive accumulation of cellular damage, leading to systemic decline and age-related diseases. Despite advances in medicine, accurately predicting biological age (BA) remains challenging due to the complexity of aging processes and the limitations of current models. This study introduces a method for predicting BA using a deep neural network (DNN) based on pathways of steroidogenesis. We analyzed 22 steroids from 148 serum samples of individuals aged 20 to 73, using 98 samples for model training and 50 for validation. Our model reflects the often-overlooked fact that aging heterogeneity expands over time and uncovers sex-specific variations in steroidogenesis. This study leveraged key markers, including cortisol (COL), which underscore the role of stress-related and sex-specific steroids in aging. The resulting model establishes a biologically meaningful and robust framework for predicting BA across diverse datasets, offering fresh insights and supporting more targeted strategies in aging research and disease management
Miyazawa Kenji and a Tale of “Kanji”
No full textMiyazawa Kenji (1896-1933), a poet and author of children’s stories, spent much of his life laboring to improve the material and spiritual lives peasants in the impoverished farming communities of Iwate Prefecture. He received little notice during his lifetime, but since the Second World War the sincerity of his work, reflecting a life of spiritual struggle, has attracted growing attention. In this paper we examine relationship between kanji and Miyazawa Kenji and the meaning of kanji for him referring some works including Otsuberu to Zou (1926, literally Otsuberu and the Elephant) and Kaze no Matasaburō (1934, literally Matasaburō of the Wind)
A Will from Miyazawa Kenji : Journey to the West, the Monkey King, and Dayu
No full textMiyazawa Kenji (1896-1933) is a well-known author of children\u27s literature from and poet. He created many children\u27s literature and poet applying with his inexhaustible imagination. At the same time he often applied his rich culture for Chinese classics including not only the Four Books and Five Classics of Confucianism but also popular novel like Journey to the West to his works. In this paper we examined Miyazawa Kenji\u27s works and discussed meanings of Chinese classics for Miyazawa Kenji
Systems biology approaches to a rational drug discovery paradigm
No full textThe published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1568026615666150826114524.Prathipati P., Mizuguchi K.. Systems biology approaches to a rational drug discovery paradigm. Current Topics in Medicinal Chemistry, 16, 9, 1009. https://doi.org/10.2174/1568026615666150826114524.Ligand- and structure-based drug design approaches complement phenotypic and target screens, respectively, and are the two major frameworks for guiding early-stage drug discovery efforts. Since the beginning of this century, the advent of the genomic era has presented researchers with a myriad of high throughput biological data (parts lists and their interaction networks) to address efficacy and toxicity, augmenting the traditional ligand- and structure-based approaches. This data rich era has also presented us with challenges related to integrating and analyzing these multi-platform and multi-dimensional datasets and translating them into viable hypotheses. Hence in the present paper, we review these existing approaches to drug discovery research and argue the case for a new systems biology based approach. We present the basic principles and the foundational arguments/underlying assumptions of the systems biology based approaches to drug design. Also discussed are systems biology data types (key entities, their attributes and their relationships with each other, and data models/representations), software and tools used for both retrospective and prospective analysis, and the hypotheses that can be inferred. In addition, we summarize some of the existing resources for a systems biology based drug discovery paradigm (open TG-GATEs, DrugMatrix, CMap and LINCs) in terms of their strengths and limitations
Identification of the differences in molecular networks between idiopathic pulmonary fibrosis and lung squamous cell carcinoma using machine learning
No full textNojima Y., Mizuguchi K.. Identification of the differences in molecular networks between idiopathic pulmonary fibrosis and lung squamous cell carcinoma using machine learning. Computational Biology and Chemistry 119, 108560 (2025); https://doi.org/10.1016/j.compbiolchem.2025.108560.Idiopathic pulmonary fibrosis (IPF) is an independent risk factor for lung cancer, especially squamous cell carcinoma (SCC). The prognosis of patients with both IPF and SCC is poorer than that of patients with only IPF, and preventive measures against SCC in patients with IPF remain elusive. Understanding the distinct mechanisms that induce both diseases is crucial for mitigating SCC onset in patients with IPF. We developed highly accurate machine learning (ML) models to classify patients with IPF or SCC using public RNA sequencing data. To construct the ML models, a random restart technique was applied to the five algorithms. To identify the differentially expressed genes (DEGs) between IPF and SCC, feature importance was calculated in the classification models. Furthermore, we detected somatic mutations affecting gene expression using SCC data. The ML models identified VCX2, TMPRSS11B, PRUNE2, PRG4, PZP, SCARA5, DES, HPSE2, HOXD11, S100A7A, and PLA2G2A as DEGs. Somatic mutations were detected in four transcription factors, BHLHE40, MYC, STAT1, and E2F4, which regulate the expression of these 11 genes. Furthermore, a molecular network comprising four transcription factors and 11 downstream genes was discovered. This newly identified molecular network enhances our understanding of the distinct mechanisms underlying IPF and SCC onset, and provides new insights into preventing SCC complications in patients with IPF
Posuton Shuyojo ポストン収容所
No full textA a travel journal written by Kenji Kawabe of his time away from the Poston camp, Arizona from May 9 through June 2, 1944. He visited the Granada camp in Colorado and Salt Lake and the Topaz camp in Utah, meeting his friends and going sightseeing and shopping.The Kuwahara Family Papers contains documentation of the Kuwahara family depicting the daily life and people incarcerated in the Poston camp in Arizona during World War II. Materials include: junior high school, high school, and camp community newsletters in both Japanese and English, a short travel journal written by Kenji Kaware of his time away from the Psoton camp, visiting the Granada camp in Colorado and Salt Lake and the Topaz camp in Utah, photographs of class groups, farm workers, and desert landscape, watercolor paintings of the camp facilities, and programs and booklets of the family and community reunions of the Poston incarceration camp
Does Trust Work in the Era of Distrust? Kenji Miyazawa and William James Give the Same Answer
No full textThis essay discusses ideas of Kenji Miyazawa that could help people of today rebuild confidence in themselves. Kenji held numerous ideas in common with great thinkers such as Fyodor Dostoevsky and William James. Kenji knew a great deal about the latest theories of natural science and psychology of his time. These were key sources of spiritual energy that enabled him to reexamine the relation between individual happiness and the happiness of the entire world. As the issue remains a major concern in our society, the author outlines Kenji's conclusion as to it
Does Trust Work in the Era of Distrust? Kenji Miyazawa and William James Give the Same Answer
No full textThis essay discusses ideas of Kenji Miyazawa that could help people of today rebuild confidence in themselves. Kenji held numerous ideas in common with great thinkers such as Fyodor Dostoevsky and William James. Kenji knew a great deal about the latest theories of natural science and psychology of his time. These were key sources of spiritual energy that enabled him to reexamine the relation between individual happiness and the happiness of the entire world. As the issue remains a major concern in our society, the author outlines Kenji's conclusion as to it
Unveiling unique expression patterns of D20S16 satellite DNA in human embryonic development
No full textHu Y., Mizuguchi K., Hashimoto K.. Unveiling unique expression patterns of D20S16 satellite DNA in human embryonic development. Scientific Reports 15, 26770 (2025); https://doi.org/10.1038/s41598-025-11753-w.Satellite DNA is essential for chromosome stability and gene regulation, yet its specific roles in early human embryogenesis remain poorly defined. Here, we integrated the complete human genome reference (T2T-CHM13) with RNA-seq data to investigate the expression and regulation of the satellite DNA element D20S16 across key stages of human embryonic development. We identified 20 distinct D20S16 tandem repeat clusters, but found that only two, both located on chromosome 20, were actively transcribed during early embryogenesis. Expression of D20S16 was high in early developmental stages, significantly declining thereafter. Comparative analysis revealed minimal expression of D20S16 in macaque embryos, correlating with fewer and shorter repeat units. Beyond embryogenesis, D20S16 also exhibited notably high expression levels in breast cancer and testicular tissues, suggesting additional biological roles. Furthermore, we investigated the evolutionary distribution of D20S16 across primates and other mammals. Our findings highlight the potential regulatory functions of satellite DNA in human development, pointing to the importance of specific chromosomal contexts for transcriptional activation. This study enhances our understanding of satellite DNA’s functional and evolutionary significance, laying the groundwork for future research into its roles in development and disease
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