277 research outputs found
A periferia contra-ataca: entrevista com Auritro Majumder
No full textInterview with Auritro Majumder, author of Insurgent Imaginations: World Literature and the Periphery (2021).Entrevista a Aurito Majumder, autor de Insurgent Imaginations: World Literature and the Periphery (2021).Entrevista com Aurito Majumder, autor de Insurgent Imaginations: World Literature and the Periphery (2021)
Coordinated Regulation of the Neutral Amino Acid Transporter SNAT2 and the Protein Phosphatase Subunit GADD34 Promotes Adaptation to Increased Extracellular Osmolarity
No full textCells respond to shrinkage induced by increased extracellular osmolarity via programmed changes in gene transcription and mRNA translation. The immediate response to this stress includes the induction of expression of the neutral amino acid transporter SNAT2. Increased SNAT2-mediated uptake of neutral amino acids is an essential adaptive mechanism for restoring cell volume. In contrast, stress-induced phosphorylation of the α subunit of the translation initiation factor eIF2 (eIF2α) can promote apoptosis. Here we show that the response to mild hyperosmotic stress involves regulation of the phosphorylation of eIF2α by increased levels of GADD34, a regulatory subunit of protein phosphatase 1 (PP1). The induction of GADD34 was dependent on transcriptional control by the c-Jun-binding cAMP response element in the GADD34 gene promoter and posttranscriptional stabilization of its mRNA. This mechanism differs from the regulation of GADD34 expression by other stresses that involve activating transcription factor 4 (ATF4). ATF4 was not translated during hyperosmotic stress despite an increase in eIF2α phosphorylation. The SNAT2-mediated increase in amino acid uptake was enhanced by increased GADD34 levels in a manner involving decreased eIF2α phosphorylation. It is proposed that the induction of the SNAT2/GADD34 axis enhances cell survival by promoting the immediate adaptive response to stress
Protein Kinase R Mediates the Inflammatory Response Induced by Hyperosmotic Stress
No full textHigh extracellular osmolarity results in a switch from an adaptive to an inflammatory gene expression program. We show that hyperosmotic stress activates the protein kinase R (PKR) independently of its RNA-binding domain. In turn, PKR stimulates nuclear accumulation of nuclear factor kappa B (NF-kappa B) p65 species phosphorylated at serine-536, which is paralleled by the induction of a subset of inflammatory NF-kappa B p65-responsive genes, including inducible nitric oxide synthase (iNOS), interleukin-6 (IL-6), and IL-1 beta. The PKR-mediated hyperinduction of iNOS decreases cell survival in mouse embryonic fibroblasts via mechanisms involving nitric oxide (NO) synthesis and posttranslational modification of proteins. Moreover, we demonstrate that the PKR inhibitor C16 ameliorates both iNOS amplification and disease-induced phenotypic breakdown of the intestinal epithelial barrier caused by an increase in extracellular osmolarity induced by dextran sodium sulfate (DSS) in vivo. Collectively, these findings indicate that PKR activation is an essential part of the molecular switch from adaptation to inflammation in response to hyperosmotic stress
Rajalaksmi-adarsana
No full textBengali fiction. The author is unknown. This monograph is from the private collection of Indranath Majumder, Kolkata, W.B., India
Sunitira prema
No full textA Bengali novel. The author is unknown. This monograph is from the private collection of Indranath Majumder, Kolkata, W.B., India
A Modified Minibatch Sampling Method for Parameter Estimation in Hidden Markov Models using Stochastic Variational Bayes
No full textParameter estimation using stochastic variatonal Bayes (SVB) under a mean field assumption can be carried out by sampling a single data point at each iteration of the optimization algorithm. However, when latent variables are dependent like in hidden Markov models (HMM), a larger sample is required at each iteration to capture that dependence. We describe a minibatch sampling procedure for HMMs where the emission process can be segmented into independent and identically distributed blocks. Instead of sampling a block and using all elements within it, we divide the block into subgroups and sample subgroups from different blocks using simple random sampling with replacement. Simulation results are provided for an HMM for precipitation data, where each block of 90 days represents 3 months of wet season data. SVB based on the proposed sampling method is shown to provide parameter estimates comparable with existing methods.This work is supported in part by the U.S. National Science Foundation under the CyberTraining (OAC–1730250)
and MRI (OAC–1726023) programs. The hardware used in the computational studies is part of the UMBC High Performance Computing
Facility (HPCF). Co-author Reetam Majumder was supported as an HPCF RA.https://onlinelibrary.wiley.com/doi/abs/10.1002/pamm.20210020
Tarabati
No full textA Bengali novel. According to the title page not for public circulation [prakasarthe mudrita nahe]. The author is unkown This monograph is from the private collection of Indranath Majumder, Kolkata, W.B., India
Kamini o mrnmayi
No full textA Bengali novel. Published approximately in 1878. The author is described as being "a Bengali Lady". This monograph is from the private collection of Indranath Majumder, Kolkata, W.B., India
Brae Formation Grain Size data
No full textThis folder contains files for 3D modelling of micro CT images for the article "Microstructural Analysis from X-ray CT Images of the Brae Formation Sandstone, North Sea" by Thomson, Ellis, Chiarella and Hier-Majumder.
To create the figures in the article run the python script Grain_length_stats.py
Description of data:
The folder ‘Grain_data_csv_files’ contains a series of datasheets obtained from the 3D grain size analysis using PerGeos. Files with the name including ‘grain_morphology’ were used to obtain the average grain length measurements. Open the .csv files to see the grain length and grain width data for each sample.
Three other files are found in this folder containing grain size and permeability data that belong to work by other authors. The name of the author and publication date of the data is shown in each the file names. This data was used as a comparison against our own results.
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Structural and electronic properties of Sn substituted Cun (n=10, 13) clusters: A first principles study
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