832 research outputs found
Influence of sidewalls on the centerline small-scale turbulence of a turbulent high-aspect-ratio rectangular jet
No full textAbstract not availableY. Liu, J. Zhang, R. Deo, J. Mi, G.J. Nathan, R. Zh
Nathan Filer and Agata Vitale
No full textWhat can writers and teachers of Creative Writing learn from psychiatry, neuroscience, and other medical disciplines about the links between creativity and mental illness?
Nathan Filer, author of 'The Shock of the Fall', and Agata Vitale, Senior Lecturer in Abnormal/Clinical Psychology at Bath Spa University, will be in conversation with Richard Hamblyn of Birkbeck College
Androgen receptor-binding sites are highly mutated in prostate cancer
No full textAndrogen receptor (AR) signalling is essential in nearly all prostate cancers. Any alterations to AR-mediated transcription can have a profound effect on carcinogenesis and tumor growth. While mutations of the AR protein have been extensively studied, little is known about those somatic mutations that occur at the non-coding regions where AR binds DNA. Using clinical whole genome sequencing, we show that AR binding sites have a dramatically increased rate of mutations that is greater than any other transcription factor and specific to only prostate cancer. Demonstrating this may be common to lineage-specific transcription factors, estrogen receptor binding sites were also found to have elevated rate of mutations in breast cancer. We provide evidence that these mutations at AR binding sites, and likely other related transcription factors, are caused by faulty repair of abasic sites. Overall, this work demonstrates that non-coding AR binding sites are frequently mutated in prostate cancer and can impact enhancer activity.We thank Dogancan Ozturan, Firat Uyulur, and Kenan Sevinc for their helpful scientific discussions. Mehmet Gonen is supported by the Turkish Academy of Sciences (GEBIP; The Young Scientist Award Program) and the Science Academy of Turkey (BAGEP; The Young Scientist Award Program). Nathan Lack is supported by the Turkish Academy of Sciences (GEBIP; The Young Scientist Award Program).Lack, NA (reprint author), Koc Univ, Sch Med, TR-34450 Istanbul, Turkey, Univ British Columbia, Vancouver Prostate Ctr, Vancouver, BC V6H 3Z6, Canada, Koc Univ, Koc Univ Res Ctr Translat Med KUTTAM, TR-34450 Istanbul, Turkey.
[email protected]
Big Data, Big Libraries, Big Problems?: the 2014 LibTech Anti-talk?
No full textThe desire to create automatons is a familiar theme in human history, and during the age of the Enlightenment mechanical automatons became not only an “emblem of the cosmos”, but a symbol of man’s confidence that he would unlock nature’s greatest mysteries and fully harness her power. And yet only a century later, automatons had begun to represent human repression and servitude, a theme later picked up by writers of science fiction. Man’s confidence undeterred, the endgame of the modern scientific and technological mindset, or MSTM, seems to be increasingly coming into view with the rise of “information technology” in general and “Big data” in particular. Along with those who wield them, these can be seen as functioning together as a “mechanical muse” of sorts – surprisingly alluring – and, like a physical automaton can serve as a symbol – a microcosm – of what the MSTM sees (at the very least in practice) as the cosmic machine, our “final frontier”. And yet, individuals who unreflectively participate in these things – giving themselves over to them and seeking the powers afforded by the technology apart from technology’s rightful purposes – in fact yield to the same pragmatism and reductionism those wielding them are captive to. Thus, they ultimately nullify themselves philosophically, politically, and economically – their value increasingly being only the data concerning their persons, and its perceived usefulness. Likewise libraries, the time-honored place of, and symbol for, the intellectual flowering of the individual, will, insofar as they spurn the classical liberal arts (with the idea that things are intrinsically good, and in the case of humans, special as well) in favor of the alluring embrace of MSTM-driven “information technology” and Big data - unwittingly contribute to their irrelevance and demise as they find themselves increasingly less needed, valued, wanted. Likewise for the liberal arts as a whole, and in fact history itself, if the acid of a “science” untethered from what is, in fact, good (intrinsically), continues to gain strengt
Functional and phylogenetic ecology in R
No full textFunctional and Phylogenetic Ecology in R is designed to teach readers to use R for phylogenetic and functional trait analyses. Over the past decade, a dizzying array of tools and methods were generated to incorporate phylogenetic and functional information into traditional ecological analyses. Increasingly these tools are implemented in R, thus greatly expanding their impact. Researchers getting started in R can use this volume as a step-by-step entryway into phylogenetic and functional analyses for ecology in R. More advanced users will be able to use this volume as a quick reference to understand particular analyses. The volume begins with an introduction to the R environment and handling relevant data in R. Chapters then cover phylogenetic and functional metrics of biodiversity; null modeling and randomizations for phylogenetic and functional trait analyses; integrating phylogenetic and functional trait information; and interfacing the R environment with a popular C-based program. This book presents a unique approach through its focus on ecological analyses and not macroevolutionary analyses. The author provides his own code, so that the reader is guided through the computational steps to calculate the desired metrics. This guided approach simplifies the work of determining which package to use for any given analysis. Example datasets are shared to help readers practice, and readers can then quickly turn to their own datasets
The intergenerational ethics of climate change : the failure of cost-benefit analysis as a normative framework
No full textThesis: S.M. in Technology and Policy, Massachusetts Institute of Technology, Engineering Systems Division, 2014.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 50-52).Climate change generates a conflict between generations: while it is in the interest of the current generation to continue to exploit inexpensive carbon-based fuel to drive economic growth, it is in the interest of future generations that we reduce our carbon emissions by making these fuels more expensive. This raises the following question: what moral framework should we use to adjudicate between the interests of different generations? In this work, I argue that the commonly used framework of "cost-benefit analysis"-the analytic framework for public policy that developed out of the field of welfare economics-fails as a normative framework for intergenerational policy. For one, by aggregating costs and benefits across all generations, it ignores that what matters is each generation. For another, by reducing all value into a unitary objective function, it ignores important distinctions between different categories of moral claims. Third, by attempting to optimize a function across all time, it reflects a false sense of knowledge about the distant future. For all these reasons-and more-I conclude that this approach cannot offer a reasonable normative framework for intergenerational public policy. In its stead, I propose an "intergenerational threshold" principle which avoids aggregating generations together, gives space for different categories of value, and, I will argue, is more robust to the epistemic limitations of intergenerational policy analysis.by Nathan R. Lee.S.M. in Technology and Polic
GSA lease procurement : opportunities and challenges
No full textThesis (S.M.)--Massachusetts Institute of Technology, Program in Real Estate Development in Conjunction with the Center for Real Estate , 2009.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections."September 2009." Cataloged from student submitted PDF version of thesis.Includes bibliographical references (p. 64-65).In 2009's fragile real estate market, many developers are looking for safe investments for their invested capital. Developers are looking to the federal government, specifically the General Services Administration, for growth and safety. The General Services Administration (GSA) is the contracting body of the U.S. federal government. It is the nation's largest public real estate organization. It leases space from private developers in over 7,100 facilities across the United States comprising office buildings, border patrol stations, courthouses, warehouses, clinics, post offices and many other uses. The GSA pays over $4.6 billion in rent to landlords annually on nearly 181 million square feet of space. GSA is authorized by law to acquire, manage, utilize, and dispose of real property for most federal agencies. The thesis is primarily based on interviews conducted with industry professionals: developers, financiers, brokers, and GSA contracting officials. It looks at the opportunities and challenges of working with the General Services Administration on new lease construction build-to-suits. It focuses on four areas; 1) the lease procurement process; 2) opportunities for new procurements in 2009's market; 3) developer financed new lease construction build-to-suit projects; and 4) opportunities and challenges of financing projects in 2009's credit crunch.by Nathan R. Boyer.S.M
Publisher’s Erratum to: Metamaterial-based graphene thermal emitter
No full textThis is the final version. Available from Springer Verlag via the DOI in this record.The article to which this is the erratum is in ORE: http://hdl.handle.net/10871/30747The article Metamaterial-based graphene thermal emitter, written by Cheng Shi, Nathan H. Mahlmeister, Isaac J. Luxmoore, and Geoffrey R. Nash, was originally published electronically on the publisher’s internet portal (currently SpringerLink) on December 6th 2017 without open access. With the author(s)’ decision to opt for Open Choice the copyright of the article changed in February 2018 to © The Author(s) 2018 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. The original article has been corrected
Parallel R&D Paths Revisited
No full textThis paper revisits the logic of pursuing parallel R&D paths when there is uncertainty as to which approaches will succeed technically and/or economically. Previous findings by Richard Nelson and the present author are reviewed. A further analysis then seeks to determine how sensitive optimal strategies are to parameter variations and the extent to which parallel and series strategies are integrated. It pays to support more approaches, the deeper the stream of benefits is and the lower is the probability of success with a single approach. Higher profits are obtained with combinations of parallel and series strategies, but the differences are small when the number of series trial periods is extended from two to larger numbers. A "dartboard experiment" shows that when uncertainty pertains mainly to outcome values and the distribution of values is skew-distributed, the optimal number of trials is inversely related to the cost per trial.
The impact of attachment anxiety on susceptibility to false memories
No full textPrevious research shows that people's attachment styles predict memory functioning. For example, people with relatively insecure attachment styles tend to forget relationship-relevant information, as well as negatively bias their emotional evaluations of interpersonal experiences over time. An emerging body of research has also begun to suggest that attachment anxiety in particular relates to people's propensity to experience false memories. The present dissertation describes two randomized experiments which attempted to examine a causal link between attachment anxiety and false memories. Furthermore, the present studies attempted to isolate whether attachment anxiety causes false memories during memory maintenance or retrieval processes.
Participants were primed with either (1) high attachment anxiety, (2) low attachment anxiety, or (3) were not primed prior to retrieval (Study 1) or during maintenance (Study 2). The experimental primes had no main effects on false memories in either study. This may indicate that attachment anxiety does not cause false memories during maintenance or reconstruction. However, future research should explore whether attachment anxiety might cause false memories during encoding processes. Alternatively, it may be the case that the priming paradigms used failed to appropriately manipulate participants' attachment security, which would render the present findings ambiguous. Current procedures for priming attachment security and future directions for studying links between attachment anxiety and false memories are discussed.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2018-05-01The student, Nathan Hudson, accepted the attached license on 2016-02-01 at 08:56.The student, Nathan Hudson, submitted this Dissertation for approval on 2016-02-01 at 09:04.This Dissertation was approved for publication on 2016-02-02 at 10:58.DSpace SAF Submission Ingestion Package generated from Vireo submission #9057 on 2016-07-07 at 14:16:01Made available in DSpace on 2016-07-07T21:04:21Z (GMT). No. of bitstreams: 2
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