4,121 research outputs found
The SSC of the Generalised Jahangir’s Graph Jm,k and its Algebraic Characterizations
No full textIn this article, we present important combinatorial and algebraicproperties of spanning simplicial complex (SSC) of the generalised Jahangir’sgraph Jm,k. We describe the relation to find f−vectors associatedto Δs(Jm,k) and determine the Hilbert series for the SR-ring KΔs(Jm,k).In the end, we present the associated primes of the facet ideal IF(Δs(Jm,k))and the Cohen-Macaulay characterization of the SR-ring of Δs(Jm,k).AMS (MOS) Subject Classification Codes: Primary 13-P10, Secondary 13-F20, 13-C14, 13-H10.Corresponding Author: Agha KashifKey Words: Simplicial Complexes, f-vectors, Spanning Trees, Face Ring, Hilbert Series, CohenMacaulay
To <i>JM</i> on Its 75th Anniversary
No full text This article discusses how Journal of Marketing ( JM) has influenced marketing science and practice by publishing articles on substantive topics relevant to customers, managers, organizations, markets, and society. The journal's 75th anniversary coincides with the 50th anniversary of the Marketing Science Institute (MSI). Frequently, JM and MSI have collaborated to address important substantive marketing issues identified in MSI's Research Priorities. The author highlights seminal articles on brand equity; business-to-business marketing (including sales force management); connecting marketing information, metrics, and strategy; consumer behavior; innovation, new product development. and product management; marketing orientation and capabilities; and market research, methodology and services. She also draws attention to articles that have won the Sheth Foundation/ JM Award and the H. Paul Root Award. The article describes how JM‘s knowledge dissemination is amplified by powerful social network effects. Ideas in JM articles diffuse through the business community, influencing the mind-set of managers worldwide. </jats:p
Estudio de las complicaciones perianulares en la endocarditis infecciosa. Análisis de aspectos clínicos, microbiológicos, ecocardiográficos, terapéuticos y pronósticos en pacientes con abscesos perianulares y fístulas aorto-cavitarias en la endocarditis complicada.
No full text[spa] La endocarditis infecciosa (EI) es una enfermedad potencialmente muy grave, que puede llegar a ser mortal sin tratamiento, cuyo pronóstico ha experimentado una gran mejoría en las ultimas décadas. Este importante cambio en la historia natural de la enfermedad se ha reflejado en una progresiva disminución de la morbi-mortalidad, sobretodo gracias al uso de potentes antibióticos y al empleo de las técnicas quirúrgicas de reparación valvular. La EI es la infección del endotelio de las válvulas cardiacas por gérmenes patógenos. La elevada morbi-mortalidad de la EI se debe a la destrucción que se produce en las válvulas y los tejidos circundantes, debido a la particular anatomía valvular que impide la correcta difusión de los antibióticos al interior de las vegetaciones valvulares. La EI tenía en la era-preantibiótica una mortalidad del 100%. El gran descenso en la mortalidad se ha producido en las últimas tres décadas, con el desarrollo de la cirugía cardiaca y la posibilidad de efectuar recambios valvulares. Con la introducción de la ecocardiografía se han podido visualizar por primera vez mediante un método incruento las vegetaciones valvulares. El desarrollo de esta técnica de imagen ha sido fundamental y en la actualidad tiene un papel clave en el diagnóstico y manejo de esta entidad ya que permite estudiar con gran detalle la anatomía cardiaca. En la actualidad, la mortalidad por EI sobre válvula nativa en fase aguda oscila entre el 20% y el 30% y la supervivencia a los 10 años de seguimiento se sitúa entre el 70% y el 80%. El pronóstico de la EI depende de un gran número de variables. Las complicaciones perianulares en la endocarditis infecciosa representan la extensión de la infección más allá de las estructuras valvulares y representan una de las complicaciones más importantes en esta enfermedad. La formación de lesiones perianulares se asocia a un pronóstico desfavorable, con elevada mortalidad. La formación de fístulas aorto-cavitarias en la endocarditis sólo se ha descrito de forma ocasional en la endocarditis y, por ello, se desconocen sus características clínicas y sus factores pronósticos de mortalidad.La hipótesis del estudio es que la presencia de complicaciones graves en la EI (desarrollo de abscesos perianulares y fístulas aorto-cavitarias) detectadas por ecocardiografía se asocia a un incremento significativo de la morbi-mortalidad. El análisis de las características clínicas y pronósticas permitiría identificar los parámetros asociados a un curso desfavorable; de esta forma podrían redefinirse las líneas de actuación (fundamentalmente quirúrgicas) encaminadas a un abordaje más temprano en pacientes seleccionados, con más posibilidades de reconstrucción completa y erradicación de la infección. Identificar estas variables permitiría, en definitiva, aumentar la supervivencia a corto y medio plazo de los casos de EI complicada.Los objetivos de este estudio son: determinar las características clínicas y el pronóstico de los pacientes con abscesos perianulares íntegros y de pacientes con fistulización aorto-cavitaria en la endocarditis y determinar el impacto sobre el pronóstico de la aparición de fistulización aorto-cavitaria en la endocarditis complicada con lesiones perianulares.Se han publicado varios estudios multicéntricos con el objetivo de reclutar una gran serie de pacientes con complicaciones perianulares y poder estudiar con detalle las características clínicas de estas complicaciones y poder analizar sus factores pronósticos de mortalidad.ARTICULOS PUBLICADOSARTICULO 1:Anguera I, Quaglio G, Miró JM, Paré C, Azqueta M, Marco F, Mestres CA, Moreno A, Pomar JL, Mezzelani JL, Sanz G. Acquired aortocardiac fistulas complicating infective endocarditis. Am J Cardiol 2001;87:652-654. Impact factor (2005) : 3.14ARTICULO 2:Anguera I, Miro JM, Vilacosta I, Almirante B, Anguita M, Muñoz P, San Roman JA, de Alarcón A, Ripoll T, Navas E, Gonzalez-Juanatey C, Cabell CH, Sarriá C, Garcia-Bolao I, Fariñas MC, Leta R, Rufi G, Miralles F, Pare C, Evangelista A, Fowler Jr VG, Mestres CA, de Lazzari E, Guma JR. Aorto-cavitary fistulous tract formation in infective endocarditis. Clinical and echocardiographic features of 76 cases and risk factors for mortality. Eur Heart J 2005;26:288-297. Impact factor (2005) : 6.25ARTICULO 3: Anguera I, Miro JM, Evangelista A, Cabell CH, San Roman JA, Vilacosta, Almirante B, Ripoll T, Fariñas MC, Anguita M, Navas E, Gonzalez-Juanatey C, Garcia-Bolao I, Muñoz P, de Alarcón A, Sarriá C, Rufi G, Miralles F, Pare C, Fowler Jr VG, Mestres CA, de Lazzari E, Guma JR, Corey GR. Prognostic factors of mortality of Periannular complications in infective endocarditis. A multicenter cohort study of 351 patients with aorto-cavitary fistulae and non-ruptured periannular abscess (1992-2003). Am J Cardiol 2005 (en revisión editorial).ARTICULO 4: Anguera I, Miro JM, Cabell CH, Abrutyn E, Fowler VG, Hoen B, Olaison L, Stafford JA, Eykyn S, Habib G, Pare C, Wang A, Corey R and the ICE-MD Investigators. Characteristics of aortic periannular abscesses studied with transesophageal echocardiography. A report from the ICE-ME database. Am J Cardiol 2005;96:976-981. Impact factor (2005) : 3.14Como resultado de este estudio, puede concluirse que la fistulización aorto-cavitaria es una complicación infrecuente de la endocarditis infecciosa, que se asocia a una extensa destrucción tisular a nivel del anillo aórtico y a la presencia de abscesos perianulares. La ecocardiografía transesofágica es la técnica de elección para la detección y el estudio de las fístulas aorto-cavitarias. La aparición de insuficiencia cardiaca grave es frecuente en estos pacientes, y a pesar del tratamiento quirúrgico agresivo la mortalidad es elevada. La infección protésica, la cirugía urgente y el desarrollo de insuficiencia cardiaca son los factores pronósticos independientes de mortalidad en los pacientes con fístulas aorto-cavitarias en la endocarditis. La formación de fístulas aorto-cavitarias se asocia a un mayor grado de destrucción anular aórtica y con mayor frecuencia de desarrollo de insuficiencia cardiaca en comparación con los abscesos no fistulizados. Ambas complicaciones requieren con mucha frecuencia tratamiento quirúrgico y tienen una elevada mortalidad, pero la fistulización no constituye un factor pronóstico independiente de mortalidad, tanto a corto como a largo plazo. La formación de abscesos perianulares es frecuente en la endocarditis de localización aórtica, se asocia frecuentemente con infección estafilocócica, y tiene una elevada morbi-mortalidad. La infección estafilocócica es un factor de riesgo independiente de mortalidad en los pacientes que desarrollan abscesos perianulares a nivel aórtico.[eng] Title: "The study of periannular complications in infective endocarditis. Analysis of clinical, microbiological, echocardiographic, therapeutic and prognostic aspects of patients with non-ruptured periannular abscesses and with aorto-cavitary fistulous tract formation in IE"Infective endocarditis (IE) is a devastating disease associated with high death rates without appropriate treatment. The prognosis of IE has changed dramatically during the last three decades due to the use of potent antibiotics and the generalization of surgical therapies of valve repair. Infective endocarditis is characterized by the infection of the endothelium of cardiac valves caused by virulent organisms, and the elevated morbidity and mortality is produced by the destruction of valvular tissue and adjacent structures. In the modern era, one-year mortality of native valve IE is in the range of 20% - 30%, and 10-year survival is in the range of 70%-80%. Spread of infection in IE from valvular structures to the surrounding perivalvular tissue results in periannular complications. Periannular complications, including periannular abscess formation and aorto-cavitary fistulous (ACF) tract formation have not been adequately studied, and may place the patient at increased risk of adverse outcomes including heart failure (HF) and death. Aorto-cavitary fistulous tract formation has only been described occasionally.The main objectives of the present investigation were to investigate the clinical characteristics and the prognosis of patients with non-ruptured periannular abscesses and with aorto-cavitary fistulous tract formation in IE and to determine the prognostic impact of fistulization in patients with periannular lesions in the setting of IE.Several manuscripts including a large number of patients with periannular lesions have been published describing the clinical characteristics and prognostic factors of mortality of patients with periannular lesions in IE.Aorto-cavitary fistula is an uncommon complication of aortic IE associated with extensive aortic root destruction and presence of periannular abscesses. Transesophageal echocardiography is the diagnostic tool of choice for the detection of aorto-cavitary fistulae in both native and prosthetic valves. Despite aggressive surgical treatment, rates of heart failure and mortality are high. Prosthetic IE, urgent surgery and the development of heart failure were associated with an increased risk of death in patients with endocarditis complicated by fistulous tract formation. ACF formation in the course of IE is associated with higher rates of aortic annulus destruction and heart failure compared to non-ruptured abscess. Surgery and mortality rates for both complications were very high; however, despite the higher complications, ACF in the current era of high rates of surgical therapy was not an independent risk factor for mortality.Periannular abscess formation occurs frequently in aortic valve IE, is associated with staphylococcal etiology, and has a high morbidity and mortality. In the current era of TEE imaging and high use of surgical treatment periannular abscess formation in aortic valve IE is not an independent risk factor for mortality. Finally, S. aureus infection constitutes an independent prognostic factor for mortality in patients who develop an abscess
Dark side of comet 67P/Churyumov-Gerasimenko in Aug.-Oct. 2014 MIRO/Rosetta continuum observations of polar night in the southern regions
No full textInternational audienceThe high obliquity (similar to 50 degrees) of comet 67P/Churyumov-Gerasimenko (67P) is responsible for a long-lasting winter polar night in the southern regions of the nucleus. We report observations made with the submillimeter and millimeter continuum channels of the Microwave Instrument onboard the Rosetta Orbiter (MIRO) of the thermal emission from these regions during the period August-October 2014. Before these observations, the southern polar regions had been in darkness for approximately five years. Subsurface temperatures in the range 25 50 K are measured. Thermal model calculations of the nucleus near-surface temperatures carried out over the orbit of 67P, coupled with radiative transfer calculations of the MIRO channels brightness temperatures, suggest that these regions have a thermal inertia within the range 10-60 Jm(-2) K-1 s(-0.5). Such low thermal inertia values are consistent with a highly porous, loose, regolith-like surface. These values are similar to those derived elsewhere on the nucleus. A large difference in the brightness temperatures measured by the two MIRO continuum channels is tentatively attributed to dielectric properties that differ significantly from the sunlit side, within the first few tens of centimeters. This is suggestive of the presence of ice(s) within the MIRO depths of investigation in the southern polar regions. These regions started to receive sunlight in May of 2015, and refinements of the shape model in these regions, as well as continuing MIRO observations of 67P, will allow refining these results and reveal the thermal properties and potential ice content of the southern regions in more detail
JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species
No full text\ua9 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.Studies showed that JM-20, a benzodiazepine-dihydropyridine hybrid molecule, protects against rotenone and 6-hydroxydopamine neurotoxicity. However, its protective effects against cytotoxicity induced by endogenous neurotoxins involved in Parkinson’s disease (PD) pathogenesis have never been investigated. In this study, we evaluated the ability of JM-20 to inhibit alpha-synuclein (aSyn) aggregation. We also evaluated the interactions of JM-20 with aSyn by molecular docking and molecular dynamics and assessed the protective effect of JM-20 against aminochrome cytotoxicity. We demonstrated that JM-20 induced the formation of heterogeneous amyloid fibrils, which were innocuous to primary cultures of mesencephalic cells. Moreover, JM-20 reduced the average size of aSyn positive inclusions in H4 cells transfected with SynT wild-type and synphilin-1-V5, but not in HEK cells transfected with synphilin-1-GFP. In silico studies showed the interaction between JM-20 and the aSyn-binding site. Additionally, we showed that JM-20 protects SH-SY5Y cells against aminochrome cytotoxicity. These results reinforce the potential of JM-20 as a neuroprotective compound for PD and suggest aSyn as a molecular target for JM-20
How is infective endocarditis diagnosed in older adults? An International Collaboration on Endocarditis prospective cohort study
No full textThe fate of active left-side infective endocarditis with operative indication in absence of valve surgery
No full textObjectives Although the benefits of surgery in infective endocarditis (IE) are clear, an unneglectable proportion of patients do not undergo surgery despite clear operative indication. Outcomes of these patients are poorly reported. With this study, we aim to analyze patient profiles, indication for surgery, decision-making, and outcomes of patients not undergoing surgery despite contemporary surgical indications. Materials and Methods Retrospective review of single institution database of patients with IE was done to identify patients that, although a clear surgical indication did not receive surgery. We aimed to review the most contemporary practice from June 2014 to December 2018. Only patients who were physically evaluated at our facility were included. Follow up was 100% complete. Kaplan-Meier methods were used to estimate survival and freedom from a composite outcome of death, stroke, and heart failure. Results Of the 174 patients with surgical indication during the review period, 46 (27%) did not undergo surgery. The reasons for not pursuing surgery were varied and usually multiple, with severe brain injury and end stage liver disease between the most common. The 30-day mortality was 63%, and the estimated survival at 6 months, 1 year, and 2 years was respectively 22%, 15%, and 10%. Conclusion The mortality of this cohort of patients is extremely high. A multidisciplinary evaluation is of paramount importance in the decision-making process with shared responsibility for denial of operative options. In a perspective of correct healthcare resources allocation an early palliative care consult may need to be considered in some of those patients
Uterine transplantation: a promising surrogate to surrogacy?
No full textUterine transplantation: a promising surrogate to surrogacy?
Grynberg M1, Ayoubi JM, Bulletti C, Frydman R, Fanchin R.
Author information
Abstract
Infertility due to the inability of the uterus to carry a pregnancy ranks among the most unresolved issues in reproductive medicine. It affects millions of women worldwide who have congenital or acquired uterine affections, often requiring hysterectomy, and potentially represents a considerable fraction of the general infertile population. Patients suffering from severe uterine infertility are currently compelled to go through gestational surrogacy or adoption; both approaches, unfortunately, deprive them of the maternal experience of pregnancy and birth. Uterine transplantation represents an outstanding, yet complex, perspective to alleviating definitive uterine infertility. In the past decades, a number of scientific experiments conducted both in animals and women, focusing on uterine transplantation, have led to promising results. Collectively, these findings undoubtedly constitute a sound basis to clinically apply uterine transplantation in the near future. This paper is, however, an overview not only of the extent and limitations of accumulated scientific knowledge on uterine transplantation, but also its ethical implications, in an effort to define the actual place of such an approach among the therapeutic arsenal for alleviating infertility.
© 2011 New York Academy of Sciences
Translation and interpretation: Translation redundancy reconsidered
No full textInterpretation is an integral part of the process of translating. This article raises the question of whether interpretation fo a literary work by a translator should be guided by extratextual factors or not. The discussion is illustrated with examples taken from David Hawkes' translation of a Chinese classic, A Dream of Red Mansions. As the work of a scholar-translator, Hawkes' version is richly supplemented with disclosures concerning the characters and explanations of the cultural environment embodied in the novel. In many cases, however, this translation procedure is redundant and explanatory, enlightening the readers but at the same time robbing them of the pleasure of literary interpretation and cultural exploration. By means of this illustration of translation redundancy, the author points out that there is difference between a scholar who helps the interpretation fo a work and a translator who presents a work close to its original version. It is particularly important to pay attention tot his difference in literary translations in a cross-cultural situation involving two enormously different cultures.Language & LinguisticsA&HCI0ARTICLE1,SI115-12
INTERNATIONAL FINANCIAL REPORTING STANDARDS (IFRS), BAIK BAGI USAHA MIKRO KECIL MENENGAH? (Studi Kasus: UMKM JM KERIPIK)
No full textABSTRAKUndang-undang nomor 20 tahun 2008 tentang Usaha Makro Kecil Menengah (UMKM), usaha kecil adalah usaha ekonomi produktif yang berdiri sendiri, yang dilakukan oleh orang perseorangan atau badan usaha yang bukan merupakan anak perusahaan atau bukan cabang perusahaan yang memiliki, dikuasai atau menjadi bagian baik langsung maupun tidak langsung dari usaha menengah atau usaha besar yang memenuhi kriteria. JM Keripik merupakan salah salah UMKM yang bergelut dibidang produksi dan penjualan. IFRS merupakan seperangkat standard yang dikeluarkan oleh Dewan Standard Akuntansi Internasional (IASB). IFRS berguna untuk menyusun laporan keuangan yang dapat diterima di dunia Global.Penulistertarik untukmengetahuipencatatankeuanganJM Keripik dan apakah perlu merekomendasikan IFRS pada UMKM JM Keripik. Metode penelitian yang digunakaan penulis adalah kualitatif yaitu observasi dan wawancara. Dari hasil penelitian banyak terdapat pencatatan-pencatatan yang kurang terperinci, UMKM JM Keripik hanya memilki empat macam pencatatan yaitu pencatatan mengenai: 1.Stock barang, 2.Supliyer, 3.Costumer dan 4.Stock toko, pencatatan ini hanya dapat dimengerti oleh pemilik JM Keripik. Sebaiknya pemilik UMKM JM Keripik mengganti laporan keuangan yang sederhana ke laporan keuangan yang semestinya dan yang berbasis IFRS karena IFRS membawa dampak positif bagi UMKM dan merupakan standar akuntansi keuangan yang digunakan dunia global. Kata Kunci : UMKM, IFRS, JM Keripik ABSTRACT Act number 20 of 2008 concerning the Macro Small and Medium Enterprises, small businesses are productive economic activities that stand alone, carried out by an individual or business entity that is not a subsidiary or not a branch of the company that owns, controlled or become part either directly or indirectly from medium or large businesses that meet the criteria. JM Keripik which deals in the field of production and sales. IFRS is a set of standards issued by the International Accounting Standards Board (IASB). IFRS is useful for preparing financial statements that is acceptable in the global world. Authors interested in knowing the financial records of JM Keripik and whether to recommend IFRS on JM Keripik. The research method is qualitative author of observation and interviews. From the research there are many registries are less detailed, JM Keripik has only four kinds of recording is recording about: 1.Stock goods, 2.Supliyer, 3.Costumer and 4.Stock shop, registration can only be understood by the owner of JM Keripik. JM Keripik owners should replace the simple financial reports to the appropriate financial statements and IFRS-based IFRS for Macro Small and Medium Enterprises had a positive impact and a financial accounting standards global world. Keywords : UMKM, IFRS, JM Keripi
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