513 research outputs found
Twee kapiteins op één schip - Directeuren en voorzitters van non-profitorganisaties
No full textHet boek gaat in op de relatie tussen voorzitter en directeur in non-profitorganisaties. Zij vormen samen een belangrijk duo in de leiding van verenigingen, stichtingen en vergelijkbare instellingen op tal van gebieden. denk aan onderwijs, gezondheidszorg, goede doelen, sport, branches en beroepen, goede doelen en wat niet meer.Het boek is resultaat van onderzoek en praktijkervaring van Theo Jonkergouw, helaas overleden voordat het boek kon worden gepubliceerd. Peter Tack en Mirjam Sprangers hebben als redacteuren het boek voor publicatie gereedgemaakt
Ein Klassiker der Pädagogik in evolutionärer Perspektive: Eduard Sprangers "Lebensformen" im Lichte der modernen Biologie
Get PDFIn diesem Beitrag werden Eduard Sprangers "Lebensformen" vor dem Hintergrund von Erkenntnissen der modernen Biologie interpretiert. Der Verfasser zeigt, inwieweit Sprangers Diagnose unterschiedlicher Menschentypen, die durch äußere Einflüsse in ihren Eigenschaftsmerkmalen kaum zu beeinflussen sind, mit Forschungshypothesen heutiger biowissenschaftlicher Forschung übereinstimmt. (DIPF/Orig.)Eduard Spranger’s “Forms of Life” is interpreted against the background of findings of modern biology. The author shows in how far Spranger’s diagnosis of different human types hardly to be affected in their characteristics by external influences conforms with research hypotheses of modern bio-sciences. (DIPF/Orig.
The implausibility of response shifts in dementia patients
No full textDementia patients may express wishes that do not conform to or contradict earlier expressed preferences. Our understanding of the difference between their prior preferences and current wishes has important consequences for the way we deal with advance directives. Some bioethicists and gerontologists have argued that dementia patients change because they undergo a 'response shift'. In this paper we question this assumption. We will show that proponents of the response shift use the term imprecisely and that response shift is not the right model to explain what happens to dementia patients. We propose a different explanation for the changed wishes of dementia patients and conclude that advance directives of dementia patients cannot be simply put asid
Revision_Online_supplement_FatigueCOPD_Ther_Adv_Resp_Dis_YMJGoertz_3April2019 – Supplemental material for Fatigue is highly prevalent in patients with COPD and correlates poorly with the degree of airflow limitation
No full textSupplemental material, Revision_Online_supplement_FatigueCOPD_Ther_Adv_Resp_Dis_YMJGoertz_3April2019 for Fatigue is highly prevalent in patients with COPD and correlates poorly with the degree of airflow limitation by Yvonne M. J. Goërtz, Martijn A. Spruit, Alex J. Van ‘t Hul, Jeannette B. Peters, Maarten Van Herck, Nienke Nakken, Remco S. Djamin, Chris Burtin, Melissa S. Y. Thong, Arnold Coors, Yvonne Meertens-Kerris, Emiel F. M. Wouters, Judith B. Prins, Frits M. E. Franssen, Jean W. M. Muris, Lowie E. G. W. Vanfleteren, Mirjam A. G. Sprangers, Daisy J. A. Janssen and Jan H. Vercoulen in Therapeutic Advances in Respiratory Disease</p
Systematic review of the side effects associated with tyrosine kinase inhibitors used in the treatment of gastrointestinal stromal tumours on behalf of the EORTC Quality of Life Group
No full textTyrosine kinase inhibitors (TKIs) have revolutionised the treatment of advanced gastrointestinal stromal tumours (GISTs). Imatinib is approved as first line therapy and sunitinib is used in cases of imatinib resistance or intolerance. Compared with conventional treatments, TKIs are delivered over longer periods of time and are more specific in their targets (i.e., molecularly targeted), thus presenting different side effect profiles. We review the safety profiles of imatinib and sunitinib, documenting a total of 95 side effects including patient based as well as medically defined outcomes. Gastrointestinal complaints, particularly diarrhoea and nausea, oedema, fatigue and haematological disorders, notably anaemia, are amongst the most prevalent side effects. While there is overlap between the side effect profiles of imatinib and sunitinib, important differences emerge in the frequencies of oedema, hypertension, thyroid functioning, muscle and joint pains, as well as skin and oral conditions. Awareness of potential side effects is informative to both clinician and patient in terms of treatment decision making and can have important implications for treatment adherence and clinical outcome
Systematic review of the side effects associated with Anti-HER2-targeted therapies used in the treatment of breast cancer, on behalf of the EORTC Quality of Life Group
No full textTargeted therapies (TTs), notably trastuzumab, have improved outcomes for breast cancer characterised by overexpression of human epidermal growth factor receptors including HER2. Compared with chemotherapy treatments, TTs are more specific in their targets and are delivered over longer periods of time, thus presenting different side-effect profiles. The objective of this paper is to systematically review and describe the side effects associated with TTs used in the adjuvant and metastatic settings for HER2+ breast cancer. The MEDLINE, EMBASE, CINAHL, Web of Science and Cochrane Library databases were searched from January 2007 to March 2015 to identify clinical trials and prospective studies reporting toxicities associated with TTs (mainly trastuzumab and lapatinib) used without other therapies in the treatment of HER2-positive breast cancer. Two independent reviewers selected papers based on their titles and abstracts. All papers selected by either reviewer were included. A third reviewer extracted and tabulated the relevant data using a data extraction form. We identified 5478 papers, of which 299 were reviewed and 18 trials identified involving 6980 patients. A total of 66 side effects were identified, including 46 "patient-based" symptoms and 20 "medically defined" outcomes. Side effects were more common for patients treated with therapies other than trastuzumab or with dual-HER2 regimens and for patients with metastatic disease. Diarrhoea and skin rash were the most prevalent symptoms, experienced by 29 % and 22 % of patients overall, respectively. There were 119 (2 %) cardiac events reported, and these were not exclusive to trastuzumab-treated patients. The majority of side effects (n = 52) were experienced by 1 % or less of patients and were predominantly of grade 1/2 toxicity. This systematic review provides a detailed analysis of side effects of HER2+ therapies in a large number of patients included in trials, enabling an accurate estimate of prevalence and a complete understanding of the patients' experience. This will help clinicians and patients in treatment plannin
The relationship between overall quality of life and its subdimensions was influenced by culture:analysis of an interational database
No full textUsing structural equation modeling to investigate change in health-related quality of life
Get PDFStructural equation modeling (SEM) can be used to investigate different types of change in health-related quality of life (HRQL) outcomes, among which so-called ‘response shift’. Response shift refers to a change in the meaning of one’s self-evaluation, caused by a change in internal standards of measurement (i.e., recalibration), values regarding the relative importance of subdomains (i.e., reprioritization), or definition of the target construct (i.e., reconceptualization). Response shift effects may cause changes in observed scores that are not directly caused by changes in the construct of interest (e.g., HRQL). Therefore, taking into account possible response shift is important for a valid assessment of change. This thesis focused on several methodological issues with regard to the SEM approach for the detection of response shift and the assessment of change in HRQL outcomes. We compared the SEM approach to the ‘then-test’ approach, which is one of the most commonly applied methods for the detection of response shift (Chapter 2). We extended the SEM approach for detection of response shift to the situation in which there are many measurement occasions (Chapters 3, 4 and 5), and for the analysis of discrete data (Chapters 6 and 7). Finally, we explained how to calculate and interpret effect-size indices of change to enable interpretation of the clinical significance of response shift (Chapter 8). The overall aim of this thesis is to facilitate applications of response shift detection, and thereby contribute to a better understanding of response shift phenomena and thus change in HRQL
Highly active antiretroviral therapy for HIV-1 infection : patients' quality of life and treatment adherence
Get PDF- …
