183,894 research outputs found
Ancestral polymorphisms in Drosophila pseudoobscura and Drosophila miranda
No full textAncestral polymorphisms are defined as variants that arose by mutation prior to the speciation event that generated the species in which they segregate. Their presence may complicate the interpretation of molecular data and lead to incorrect phylogenetic inferences. They may also be used to identify regions of the genome that are under balancing selection. It is thus important to take into account the contribution of ancestral polymorphisms to variability within species and divergence between species. Here, we extend and improve a method for estimation of the proportion of ancestral polymorphisms within a species, and apply it to a dataset of 33 X-linked and 34 autosomal protein-coding genes for which sequence polymorphism data are available in both Drosophila pseudoobscura and Drosophila miranda, using Drosophila affinis as an outgroup. We show that a substantial proportion of both X-linked and autosomal synonymous variants in these two species are ancestral, and that a small number of additional genes with unusually high sequence diversity seem to have an excess of ancestral polymorphisms, suggestive of balancing selection
Viajantes ex-cêntricas nas histórias de Ana Miranda
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-Graduação em Literatura.No conjunto das narrativas ficcionais da escritora brasileira Ana Miranda, a temática da viagem # considerada uma das mais férteis da literatura ocidental de todos os tempos # ocupa um espaço de centralidade, podendo até mesmo ser vista como o mais importante eixo de estruturação de suas obras. O estudo realizado pela presente tese tem por objetivo analisar o tratamento dado ao tema da viagem nos romances Desmundo, O retrato do rei, Dias & Dias e Amrik, evidenciando que por intermédio das narradora-viajantes # Oribela, Mariana, Feliciana e Amina # a autora promove um diálogo entre diferentes culturas, gêneros, etnias e gerações, ao mesmo tempo em que estabelece um profícuo diálogo com o passado em sua invariante problematização concernente aos limites e cruzamentos entre o discurso ficcional e os discursos narrativos extraliterários que o cercam, sobretudo o histórico e o biográfico. In the whole of Brazilian writer Ana Miranda#s fictional narrative, the travel thematic # considered one of the most fertile themes of the western literature of all times # occupies a central space, and can even been seen as the most important structuring axis of Miranda#s works. The aim of the present thesis is to analyze the treatment given to the travel subject in the novels Desmundo, O retrato do rei, Dias & Dias and Amrik, emphasizing that, through the traveling narrators, Oribela, Mariana, Feliciana and Amina, the author promotes a connection between different cultures, genders, ethnics and generations, at the same time that establishes a profitable dialogue with the past in her invariant problematization concerning the limits and crossings between the fictional and the extra-literary narrative discourses that surrounds it, mainly the historical and the biographic ones
Farm to Fork Quantitative Microbial Risk Assessment for Norovirus on Frozen Strawberries
No full textFoodborne illness outbreaks have been increasingly linked to the consumption of fresh and frozen berries that were contaminated with pathogenic viruses, such as human norovirus (NoV). Contamination of berries is assumed to take place at harvest by the use of contaminated water for pesticide dilution, irrigation water source or by shedding berry pickers in the field. A quantitative microbial risk assessment simulation model was built to replicate the largest known NoV outbreak which sickened about 11,000 people over a 3-week period. The outbreak occurred in Germany in 2012 when contaminated frozen strawberries were served at nearly 400 schools and daycare centers. The risk model explicitly assumed that all contamination would arise from NoV contamination of surface water used for pesticide dilution. Input data was collected from the published literature, observational studies and assumptions. The model starts with contamination of the berries in the field, and proceeds through transportation to processing facility, washing, sanitizing, freezing, frozen transport to cargo ship, transport view of cargo ship, transport to distribution center, frozen storage at the distribution center, transport to the catering facility, food service preparation and consumption, dose response, and predicted illnesses. A total of 21 scenarios were chosen to evaluate the impact of model parameters on the number of illness associated with NoV contamination of berries. Scenarios evaluated include the initial level of NoV in surface water, the effect of seasonality on the prevalence of NoV in surface water, the strength of the pesticide used, the volume of water used to dilute the pesticide, temperature during transportation to processing facility, washing and sanitizing conditions at processing facility and preparation (heat-treatment) of berries prior to consumption. Scenarios were compared via the Factor Sensitivity technique where the logarithm of the ratio of mean illnesses was used to compare different assumptions. The input that had the greatest effect on increasing in the number of illnesses was a high NoV concentration in the water (8 log Genome Copies/L) when compared to the baseline scenario with resulting mean illnesses of 7,964 illnesses and ~2 illnesses, respectively. This assumption about the concentration of virus in the pesticide makeup water was the only variable capable of producing an outbreak similar to that observed in Germany in 2012. Heat-treatment of the berries, use of a pesticide with strong antiviral effect, and assumption about the virus concentration in the pesticide make-up water had the largest impact on decreasing illnesses.Peer reviewe
Oral History Interview with Oscar Miranda Jr.
No full textOscar Miranda shares stories from his life growing up as a Mexican-American in the U.S
Oral History Interview with Oscar Miranda Jr.
No full textOscar Miranda shares stories from his life growing up as a Mexican-American in the U.S
Oral history interview with Claudia Miranda
No full textSomos NC: Voices from North Carolina's Latino was the perfect opportunity for my cousin Claudia Miranda to be recognized. Her Salvadoran customs and values exemplify the life of a hard working first generational hispanic college graduat
Oral history interview with Claudia Miranda
No full textSomos NC: Voices from North Carolina's Latino was the perfect opportunity for my cousin Claudia Miranda to be recognized. Her Salvadoran customs and values exemplify the life of a hard working first generational hispanic college graduat
Magnifying Miranda
No full text"Magnifying Miranda" examines how modern criminal justice realities have eroded the protections originally envisioned in "Miranda v. Arizona". Berry argues that pervasive plea bargaining, combined with aggressive interrogation tactics, has diminished the practical value of Miranda warnings for most defendants. The article critiques the Supreme Court’s subsequent narrowing of "Miranda" and highlights structural pressures that undermine suspects’ ability to make informed, voluntary choices. Berry proposes a “magnification” of Miranda—strengthening warnings, enhancing procedural safeguards, and aligning doctrine with contemporary interrogation dynamics. Ultimately, he calls for reforms that restore Miranda’s core purpose of safeguarding the Fifth Amendment right against compelled self-incrimination
Prof. Th. W. Adorno and the author Hans Erich Nossack.
No full textProf. Th. W. Adorno and the author Hans Erich Nossack at a reception of Insel Verlag, Buchmesse Frankfurt 1966LB
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A Comparison of Miranda Procedures: The Effects of Oral and Written Administrations on Miranda Comprehension
No full textMillions of custodial suspects waive their rights each year without the benefit of legal counsel. The question posed to psychologists in disputed Miranda waivers is whether this waiver decision was, knowing, intelligent, and voluntary. Mental health professionals must be aware of potential barriers to Miranda comprehension to provide expert opinions regarding a defendant's competency to waive rights. The current study examined how Miranda warning reading level, length, and method of administration affects Miranda comprehension. Recently arrested detainees at Grayson County Jail were administered oral and written Miranda warnings from the Miranda Statements Scale (MSS; Rogers, 2005) to measure their comprehension of the warnings. Surprisingly low levels of Miranda comprehension were found for most warnings. For all warnings at or above 8th grade, a substantial minority (27.1% - 39.6%) of defendants exhibited failed (i.e., < 50% understanding) Miranda comprehension. Regardless of other variables, oral administrations resulted in a substantially larger number of defendants with failed Miranda comprehension. Implications for public policy and clinical practice are discussed
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