1,212 research outputs found
Biogeochemical redox proxies in sediments from Dotternhausen during the Toarcian (Early Jurassic)
No full textAuthor contributions:
The lead author is Angela L. Coe. Measurements were performed by Stephan M. Harding, with supervision of Angela L. Coe and Anthony S. Cohen. Measurements were gathered, processed and analysed by Itzel Ruvalcaba Baroni
Biogeochemical redox proxies in sediments from Yorkshire during the Toarcian (Early Jurassic)
No full textAuthor contributions:
The lead author is Angela L. Coe. Measurements were performed by Stephan M. Harding, with supervision of Angela L. Coe and Anthony S. Cohen. Measurements were gathered, processed and analysed by Itzel Ruvalcaba Baroni
Food and eating in fiction since 1950 with particular reference to the writing of Angela Carter, Doris Lessing, Michele Roberts and Alice Thomas Ellis.
No full textPhDEating is a fundamental activity. What people eat, how and with whom, what
they feel about food, what they do or do not want to eat and why - even who
they eat - are of crucial significance in any reading of human behaviour.
In this thesis, I consider the diverse and complex uses of food and eating
in fiction since 1950, especially that written by women. I argue both that food
and eating carry much of the meaning of a novel or story and that the acts of
cooking, feeding and eating depicted are inseparable from issues of power and
control: individually, interpersonally, culturally, politically.
My discussion centres on the writing of Angela Carter, Doris Lessing,
Michele Roberts and Alice Thomas Ellis. Drawing on psychoanalytic theory,
sociology, anthropology, Foucault, Bakhtin and others, the thesis aims to
construct an interdisciplinary perspective which both resists reductive
interpretations and emphasises the centrality, complexity and diversity of food
and eating in literature in our culture.
I begin with an examination of the ambiguities of maternal feeding and
nurturing, moving on to explore the links between appetite, eating and sexuality.
I explore cannibalism and vampirism as manifestations of oppression, but also as
indicating insatiable emptiness and transgressive appetite. The body itself is
crucial, and my argument considers the paradox of not eating as
control/enslavement, also tracing self-starvation as a positive route towards
wholeness and connection. The last part of my argument focuses on social
eating, examining conventions, rituals and food itself in connection with power
relations, and finally considers how we might truly speak of food and eating in
the context of society as a whole
Regulation of store-operated calcium channel by Mitsugumin29 in skeletal muscle aging:
No full textThe study of store-operated Ca2+ channel entry (SOCE) and its role in muscle contractility in young and aged skeletal muscle necessitates a thorough knowledge of the Ca2+ signaling from the sarcoplasmic reticulum (SR) that activates SOCE. Yet, all of the molecular components involved have yet to be fully elucidated, as neither T-tubule voltage sensors, nor SR ryanodine receptor Ca2+ channels, together or independently, are necessary or sufficient for the establishment of a close association between the T-tubule and SR membranes. Therefore, other protein components must be involved for the formation of triad junctional complexes.
Mitsugumin29 (MG29), a protein localized to the triad junction, may function as a structural component involved in the coupling between the SR and T-tubule, as abnormalities in both T-tubule and SR membranes have been reported in mg29(-/-) mice. In addition, muscles from these mice share many morphological and functional characteristics with muscle from aged mice, including increased susceptibility to fatigue, defective SR Ca2+ release and defective SOC function. Either of these may be responsible for the altered Ca2+ signaling in skeletal muscle during exercise and aging.
Our data suggests that SOCE is not merely important for skeletal muscle function in aging; but, it is also required for maintenance of Ca2+ signaling during repetitive stimulation under intensive muscle activity (i.e., fatigue) in the healthy state. In addition, we propose that SOCE diminishes with age, contributing to the age-associated muscle weakness. Finally, we find that while SOCE is a functional marker of muscle performance in aging, MG29 is a molecular marker, as SOCE is compromised in aged wild type mice through the decreased expression of MG29. Therefore, mg29(-/-) mice can serve as an appropriate model for the study of skeletal muscle aging. Through this project, we have begun to understand the physiological function of SOCE and MG29 and their contribution to muscle contractility in both young and aged mice.Ph.D.Includes bibliographical references (p. 71-87)by Angela M. Thornto
Angela Carter as Fiction: Refiguring the real author as Performative Author
No full textIn a 2006 article in The Independent, Christina Patterson echoes Gore Vidal by stating ‘Death, as any biographer knows, can be an excellent career move’. Commenting on a brief revival of Angela Carter’s work in 2006 concomitant with Emma Rice’s bringing of Nights at the Circus to the stage, and Vintage’s reissuing of six of her works with new introductions, Patterson refers to Carter’s ‘whole new lease on life’ suggesting the metamorphic potential and curious temporality of the authorial figure with regard to reader reception. The Vintage editions suggest, as Stephen Benson observes, the ‘legend’ of the ‘Carter effect’, identified by The British Academy Humanities Research Board, which distributes postgraduate studentships. This ‘Carter’ effect was also fostered by the theatricality of Carter’s authorial performances. Sarah Gamble has observed the ‘screen’ of authorial identity upon which readers are led to project impressions, which functions as a ‘hall of mirrors’ in relation to penetrating to the authentic author. Such attempts at authorial effacement and control are certainly not unusual. However, Carter’s postmodern enactment of the play of surfaces in the realm of authorial identity appears to heighten the consequent shifting of boundaries between fiction and life staged in her fiction. This article will address the interaction between the games with identity inscribed in Carter’s short stories and the complex identity and temporality of the Performative Author
MARC 21 para recursos contínuos.
No full textTradução e adaptação de MARC 21 Format for Bibliographic Data e MARC 21 Format for Holdings Data, da Network Development and MARC Standards Office, da Library of Congress, USA, por Angela Salles
MARC 21 para recursos contínuos
No full textTranslation and adaptation of the MARC 21 Format for Bibliographic Data, and MARC 21 Format for Holdings Data, Network Development and MARC Standards Office, Library of Congress, USA, by Angela Salles. Rio de Janeiro, 2010. 2 v. V.1 MARC 21 format for bibliographic data (updated until October 2010). V.2 MARC 21 format for data collection (Holdings) (updated until October 2008)
Wellcome Witnesses to Twentieth Century Medicine: Volume 1
No full textAnnotated and edited transcript of four Witness Seminars. Introduction by E M Tansey First published by the Wellcome Trust, 1997. ©The Trustee of the Wellcome Trust, London, 1997.In Volume One (Occasional Publication no. 4, 1997).All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated and edited transcript of four Witness Seminars. Introduction by E M Tansey.Annotated and edited transcript of four Witness Seminars. Introduction by E M Tansey.Annotated and edited transcript of four Witness Seminars. Introduction by E M Tansey.Annotated and edited transcript of four Witness Seminars. Introduction by E M Tansey.Four Witness Seminar transcripts of meetings held between 1993 and 1996: ‘Technology Transfer in Britain: The case of Monoclonal Antibodies’ (E M Tansey and P P Catterall, eds); ‘Self and Non-Self: A History of Autoimmunity’ (E M Tansey, S V Willhoft and D A Christie, eds); ‘Endogenous Opiates’ (E M Tansey and D A Christie, eds); ‘The Committee on Safety of Drugs’ (E M Tansey and L A Reynolds, eds). Introduction by E M Tansey, ‘What is a Witness Seminar’, separate index for each meeting. Tansey E M, Catterall P P, Christie D A, Willhoft S V, Reynolds L A. (eds) (1997) Wellcome Witnesses to Twentieth Century Medicine, volume 1. London: The Wellcome Trust.The Wellcome Trust is a registered charity, no. 210183
The European community and the Belgrade CSCE
No full textThe EC Nine were effectively able to speak with a single voice and came to be recognised as a distinct and unitary actor at the Helsinki CSCE. Thanks to this successful experience, the Nine made the CSCE process a permanent task of their political cooperation efforts. This chapter offers the first assessment of the EC Nine’s action at the first CSCE follow-up conference in Belgrade, It first reports the EC Nine’s preparation for the Helsinki conference in order to provide the fundamental elements of their approach to the CSCE process. The analysis then appraises the effects of the Helsinki experience on the EC Nine and their preparation for the next meeting. It therefore focuses on the EC Nine’s action in Belgrade on the different issues on the agenda, also paying due attention to tactics and internal coordination. In this context the author acknowledges meaningful changes, viz. the attitude of the new US administration, which somehow conditioned the action of the EC Nine during the negotiations. In the concluding part, the author assesses the performance of the EC Nine in Belgrade by also taking into consideration the perspective of the West European governments and EC institutions. The analysis is based on archival sources from the European Union, the United Kingdom, France, and the United States
Increased sensitivity to ozone-induced injury and altered pulmonary mechanics in mice with chronic lung inflammation. effects of aging
No full textOzone is a ubiquitous urban air pollutant known to damage the lung. Injury is a result of both direct interaction of ozone and its oxidative products with proteins and lipids in the epithelial lining fluid of the lung and the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and inflammatory mediators by infiltrating inflammatory cells. Surfactant protein-D (SP-D) is a pulmonary collectin that down-regulates macrophage activation. In these studies we analyzed the effects of progressive pulmonary macrophage inflammation and emphysema associated with aging in mice lacking SP-D on the persistence of ozone-induced injury, macrophage activation, and altered functioning of the lung. We hypothesized that loss of SP-D results in increased sensitivity to ozone. Young (8 wk), middle age (27 wk), and elderly (80 wk) wild type (WT) and SPD-/- mice were exposed to air or ozone (0.8 ppm, 3 h). Bronchoalveolar lavage fluid (BAL) and tissue were collected 72 h later. Loss of SP-D resulted in increased sensitivity to inhaled ozone at 8 wk and 27 wk of age as observed by increased BAL protein, nitrogen oxides and chemotactic activity. Increased numbers of enlarged, vacuolated macrophages were also present. Aging was associated with increased macrophage numbers, alveolar wall rupture and increases in BAL protein, as well as Type II hyperplasia and expression of proliferating cell nuclear antigen. Heme oxygenase-1+ macrophages together with classically (iNOS+) and alternatively (mannose receptor+, YM-1+, or galectin-3+) activated macrophages also increased in aging SP-D-/- mice. In contrast, while increases in MR+, Ym1+, and galectin-3+ macrophages were observed in WT mice following ozone exposure, no changes were observed in SP-D-/- mice. In both WT and SP-D-/- mice, aging was associated with reduced lung stiffness. Ozone exposure caused alterations in tissue mechanics in WT mice, and both airway and tissue mechanics in SP-D-/- mice. Loss of SP-D led to increased sensitivity to ozone up to 27 wk of age, however at 80 wk, this was overwhelmed by the larger effects of age-related increases in baseline inflammation and lung injury. Understanding how these responses are regulated could improve disease prognosis in those exposed to air pollutants. Ph. D.Includes bibliographical referencesIncludes vitaby Angela M. Grove
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