196,301 research outputs found
ChemInform Abstract: Progress in the Development of Lysine Methyltransferase SETD8 Inhibitors
No full textProgress in the Development of Lysine Methyltransferase SETD8 Inhibitors —
[34 refs. + subrefs.]. — (MILITE, C.; FEOLI, A.; VIVIANO, M.; RESCIGNO, D.;
MAI, A.; CASTELLANO, S.; SBARDELLA*, G.;
ChemMedChem 11 (2016) 16, 1680-1685, http://dx.doi.org/10.1002/cmdc.201600272
; Dip. Farm., Univ. Studi Salerno, I-84084 Fisciano, Salerno, Italy; Eng.) —
Koehle
Dynamic simulation of virtual prototypes in immersive environment
No full textVirtual Reality (VR) became a very common mean during the development of the industrial products. One of the main applications of VR in the industrial field is the validation of Virtual Prototypes (VP). The user of the VR application can interact with the Virtual Prototype in a very natural way. A virtual prototype should be able to reproduce, as realistically as possible, the behaviour of the product from any point of view. In this paper we propose an unexploited approach to the simulation of a VP in VR. A high level software library for the inter-process communication (IPC) has been developed to let the multi-body solver communicate with the VR environment. Such approach allows the designer to use different software frameworks for the simulation and the visualisation. The test case provided regards an excavator machine. It is possible to simulate the action of the actuators to move arms and bucket, and also perform visibility analyses discovering the viewing volume of the operator
Vita Jacobi Henrici Zerneckii, Præconsulis Thoruniensis : Scriptis, Fatorumque Fama Nobilitati, Exposita A M. Joanne Benjamin Dragheim, Dantiscano ; Accedunt Duæ Amplissimi Viri Disputationes, Altera Theologica, De Statu Infantium A Gentilibus Progenitorum, Cum In Infantia Decedunt ; Altera Juridica, De Milite Desertore
No full textVITA JACOBI HENRICI ZERNECKII, PRÆCONSULIS THORUNIENSIS : SCRIPTIS, FATORUMQUE FAMA NOBILITATI, EXPOSITA A M. JOANNE BENJAMIN DRAGHEIM, DANTISCANO ; ACCEDUNT DUÆ AMPLISSIMI VIRI DISPUTATIONES, ALTERA THEOLOGICA, DE STATU INFANTIUM A GENTILIBUS PROGENITORUM, CUM IN INFANTIA DECEDUNT ; ALTERA JURIDICA, DE MILITE DESERTORE
Vita Jacobi Henrici Zerneckii, Præconsulis Thoruniensis : Scriptis, Fatorumque Fama Nobilitati, Exposita A M. Joanne Benjamin Dragheim, Dantiscano ; Accedunt Duæ Amplissimi Viri Disputationes, Altera Theologica, De Statu Infantium A Gentilibus Progenitorum, Cum In Infantia Decedunt ; Altera Juridica, De Milite Desertore (1)
Cover (1)
Title page (3)
Frontispiz (Portr.) (6)
Titelblatt (7)
Widmung (9)
Ad Lectorem (11)
Index Capitum (13)
Vitae Doctorum Virorum (14)
Vita Zerneckiana (15)
Dissertatio Theologica De Statu Infantium (79)
Dissertatio Juridica De Milite Desertore (162)
In Curriculo Vitae Sequentia sunt corrigenda (219
Short-term Arterial Blood Reperfusion of Normothermic Kidney in Renal Artery and Abdominal Aorta Reconstructive Surgery
No full textAbstractObjective to prevent kidney injury in renal artery and juxta-renal aortic surgery. After 30 min of cross-clamping ischaemia, renal arterial inflow is temporary re-established for 3 min. The aim of the study was to retrospectively analyse the results of this original technique. Methods between January 1987 and May 1999, 48 patients underwent kidney short-term arterial blood reperfusion, directly or through the Pruitt–Inahara shunt. The reperfusion was repeated every 30 min of ischaemia, whenever necessary. Fifty control patients underwent <30 min of kidney ischaemia. Patients were assessed by serum creatinine, digital angiography and radioisotope renography using technecium99. Results in the study group one patient developed an acute renal failure and died (2% (−95% CI: 0–11%)). In both study and control groups patients showed a similar and moderate but temporary decline in renal function, which returned to preoperative levels after 1 week. Conclusions the results of this study indicate that kidney short-term reperfusion may protect renal tissue from prolonged cross-clamping ischaemia (up to 100 min), also in patients considered at high risk for acute renal failure
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
Model Strategy For Redevelopment Of Closed Landfill
No full textThis paper elaborates on two-years research done under the Sufalnet project in the field of redevelopment of former and abandoned landfill. Sufalnet (Sustainable Use of Former and Abandoned Landfills Network) is an EU part financed project (INTERREG IIIC) that aims to identify and bring together expertise and best practice and promote joint development of policy programmes available in Europe on redevelopment and aftercare of landfills, so that closed landfills might finally be dealt with. This contribute gives back the progress of the cooperation experience focusing on the proposal of a model strategy that could drive public and private sectors toward a successful re-use that enhances environment and creates job opportunities for local communities. In the frame of Sufalnet objectives, model strategy has been identified as a logical approach to the complexity of redevelopment plan, a sort of common minimum denominator of the decision process that facilitates a better assessment of the re-use feasibility
Microwave-Assisted Aminoalkylation of Phenols via Mustard Carbonate Analogues
No full textA microwave-assisted chlorine-free direct phenol substitution is presented, which is indicated as a key green chemistry research area for pharmaceuticals manufacturers. The reaction of -aminocarbonates (mustard carbonates) with several substituted phenols in the presence of a polar solvent (acetonitrile or butanol) led to the related aminoalkylated products via the anchimeric assistance of the nitrogen incorporated in the organic carbonate backbone. The aminoalkylation required short reaction time (7 min) and the related products were isolated in high yields (90%) via quick liquid-liquid extraction or column chromatography depending on the solvent employed. Furthermore, microwave irradiation also promoted the one-pot aminoalkylation of phenol in excellent yield. In this approach a -aminoalcohol was reacted with phenol in the presence of diethyl carbonate, used for the in situ formation -aminocarbonate, key intermediate in the consequent anchimerically driven alkylation. The resulting product, namely N,N-dimethyl-2-phenoxyethanamine, was isolated as pure in almost quantitative yield
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Straightforward, Metal-free, and Stereoselective Synthesis of 9-Oxo- and 10-Hydroxy-2(E)-decenoic acids, Important Components of Honeybee (Apis mellifera) secretions
No full text10-Hydroxy-2E-decenoic (10-HDA) and 9-oxo-2E-decenoic (9-ODA) acids, two components identified in honeybee secretions, have both received considerable recent interest due to their involvement in caste switch and maintenance. Herein we report for the first time a metal-free, gram scale, and stereoselective synthesis of these honeybee secretion components by TEMPO catalyzed oxidation of readily available alcohols and subsequent Doebner–Knoevenagel reactions between the resulting aldehydes and malonic acid. Mechanistic investigations undertaken highlighted the crucial role of the Doebner–Knoevenagel reaction in the high yielding and selective preparation of the α,β-unsaturated acids 10-HDA and 9-ODA. The combination of inexpensive and environmentally friendly reagents with simple synthetic procedures renders this approach a valuable green strategy for the gram scale preparation of these biologically relevant natural molecules
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