1,723,764 research outputs found
Orange juice and cardiovascular disease
No full textThis Symposium aims to provide an open forum with various speakers from around the globe to present latest research and discussion in understanding how Citrus, especially oranges, and its bioactive compounds, positively improved human health. International speakers, Dr Tomás-Barberán, Dr. Paul Kroon, Dr. David Vauzour, Dr. Dragan Milenkovic and Brazilian researchers, will show their most current work in clinical, basic and applied research. This Symposium aims to provide an open forum with various speakers from around the globe to present latest research and discussion in understanding how Citrus, especially oranges, and its bioactive compounds, positively improved human health. International speakers, Dr Tomás-Barberán, Dr. Paul Kroon, Dr. David Vauzour, Dr. Dragan Milenkovic and Brazilian researchers, will show their most current work in clinical, basic and applied research.This Symposium aims to provide an open forum with various speakers from around the globe to present latest research and discussion in understanding how Citrus, especially oranges, and its bioactive compounds, positively improved human health.International speakers, Dr Tomás-Barberán, Dr. Paul Kroon, Dr. David Vauzour, Dr. Dragan Milenkovic and Brazilian researchers, will show their most current work in clinical, basic and applied research.Orange juice and cardiovascular disease. 1. International Symposium on Citrus Bioactive Compounds and Health Benefit
Estimating poverty lines for West Beirut - by Goran Milenkovic
No full textThesis (M.A.)--American University of Beirut. Department of Economics, 1987.;"Advisor: Nadim Khalaf, Professor, Economics -- Members of Committee: Nahla Hwalla (Baba) , Associate Professor, Nutrition Toufic Gaspard, Lecturer, Economics."Bibliography: leaves 185-192.It is the objective of this thesis to partially fill this void and attempt to estimate poverty lines for the city of Beirut which are differentiated with regard to household size and household composition
Motions of the SecA protein motor bound to signal peptide: Insights from molecular dynamics simulations
No full textSecA is an essential part of the Sec pathway for protein secretion in bacteria. In this pathway, SecA interacts with the N-terminal fragment of the secretory protein the signal peptide, and couples binding and hydrolysis of adenosine triphosphate with movement of the secretory protein across the SecY protein translocon. How interactions with the signal peptide alter the conformational dynamics and long-distance conformational couplings of SecA is a key open question that we address here with molecular dynamics techniques. Analyses of protein motions indicate that the signal peptide alters SecA dynamics not only at the site where this peptide binds, but also at a nucleotide-binding domain. Hydrogen bond clusters contribute to the long-distance propagation of changes in SecA dynamics
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Mechanism of conformational coupling in SecA: Key role of hydrogen-bonding networks and water interactions
No full textSecA uses the energy yielded by the binding and hydrolysis of adenosine triphosphate (ATP) to push secretory pre-proteins across the plasma membrane in bacteria. Hydrolysis of ATP occurs at the nucleotide-binding site, which contains the conserved carboxylate groups of the DEAD-box helicases. Although crystal structures provide valuable snapshots of Seth along its reaction cycle, the mechanism that ensures conformational coupling between the nucleotide-binding site and the other domains of Seth remains unclear. The observation that Seth contains numerous hydrogen-bonding groups raises important questions about the role of hydrogen-bonding networks and hydrogen-bond dynamics in long-distance conformational couplings. To address these questions, we explored the molecular dynamics of Seth from three different organisms, with and without bound nucleotide, in water. By computing two-dimensional hydrogen-bonding maps we identify networks of hydrogen bonds that connect the nucleotide-binding site to remote regions of the protein, and sites in the protein that respond to specific perturbations. We find that the nucleotide-binding site of ADP-bound Seth has a preferred geometry whereby the first two carboxylates of the DEAD motif bridge via hydrogen-bonding water. Simulations of a mutant with perturbed ATP hydrolysis highlight the water-bridged geometry as a key structural element of the reaction path. (C) 2015 Published by Elsevier B.V
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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