16,746 research outputs found
Keeping focus: a study of Attention Problems in the GWAS era
No full textBoomsma, D.I. [Promotor]Middeldorp, C.M. [Copromotor
Risk Factors for Childhood Problem Behavior: Studies in Twins and Triplets
No full textBoomsma, D.I. [Promotor]Middeldorp, C.M. [Copromotor]Vink, J.M. [Copromotor
Risk factors for the development and outcome of childhood psychopathology
No full textBoomsma, D.I. [Promotor]Middeldorp, C.M. [Copromotor]Bartels, M. [Copromotor
The politics and economics of regulatory impact assessment
No full textThis is the author accepted manuscript. The final version is available from the publisher via the link in this record
Phase Distribution Efficiency of cm-Scale Ultrasonically Powered Receivers
No full textIn the domain of ultrasonically powered biomedical implants, there is an increasing interest in cm-scale ultrasonic receivers (RX). However, when a single-element transducer is used as the RX transducer, an uneven phase distribution across the RX area can significantly reduce the harvestable power. In this paper, we investigate the impact of lateral and angular misalignment on the acoustic field phase distribution across the RX surface. We show that, for a single-element RX transducer, lateral misalignment has minimal effect on the harvestable power, whereas even small angular misalignments can cause a considerable reduction, especially for larger RX sizes. We present a potential solution that consists of subdividing a large RX transducer (e.g. 20 × 20mm2) into smaller elements, which significantly improves power transfer efficiency by taking advantage of the smaller phase variation across the surface of each element. The trade-offs between achieving a minimum acceptable power transfer efficiency and managing the increased complexity in packaging and matching circuitry are also discussed.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic Components, Technology and MaterialsBio-Electronic
Highly efficient laser-driven Compton gamma-ray source
No full textThe recent advancement of high-intensity lasers has made all-optical Compton scattering become a promising way to produce ultrashort brilliant gamma-rays in an ultra-compact system. However, so far achieved Compton gamma-ray sources are limited by low conversion efficiency and spectral intensity. Here we present a highly efficient gamma photon emitter obtained by irradiating a high-intensity laser pulse on a miniature plasma device consisting of a plasma lens and a plasma mirror. This concept exploits strong spatiotemporal laser-shaping process and high-charge electron acceleration process in the plasma lens, as well as an efficient nonlinear Compton scattering process enabled by the plasma mirror. Our full three-dimensional particle-in-cell simulations demonstrate that in this novel scheme, brilliant gamma-rays with very high conversion efficiency (higher than 10(-2)) and spectral intensity (similar to 10(9) photons/0.1%BW) can be achieved by employing currently available petawatt-class lasers with intensity of 10(21) W cm(-2). Such efficient and intense gamma-ray sources would find applications in wide-ranging areas. ©2019 The Author(s)
Childhood psychiatric symptoms: genetic architecture and intergenerational contributions
No full textThe goals of this research were to investigate the genetic architecture of childhood psychiatric symptoms and disentangle the genetic and environmental pathways of transmission that link parental factors to psychiatric outcomes in children and adolescents. This thesis summarises and contextualises results from a series of molecular genetic studies, including data from up to 22 population-based cohorts with information on childhood psychiatric traits from parents, teachers, and self-report. A genome-wide association study of childhood internalising symptoms revealed substantial genetic correlations with adult internalising disorders (such as depression and anxiety) and other childhood-onset psychiatric traits (such as aggression, attention-deficit hyperactivity disorder (ADHD) and autism), indicating that genetic effects could partially explain the persistence of internalising symptoms over the lifespan and the co-occurrence of psychiatric traits in childhood. To synthesise current knowledge about the impact of parental characteristics on children’s mental health, a systematic review of genetically informed studies was conducted, which showed that parental factors were linked to children’s psychiatric outcomes through both genetic and environmental pathways. However, the size and direction of environmental effects was often unclear. Using novel family-based genetic designs, we investigated the impact of parental contributions by estimating the extent to which individual differences in children’s psychiatric outcomes were explained by genetic nurture; an effect of parental genotype that is mediated through the environment via genetically-influenced parental traits. While no strong evidence of genetic nurture was found, our results provide the first indication that genetically-indexed parental effects could explain a small proportion of variance in childhood depressive and ADHD symptoms. This calls for more studies in larger samples to make robust estimations and identify mediating factors that account for potential genetic nurture effects. One potential mediating factor is parental wellbeing, which has been linked to offspring mental health in previous research. Using polygenic scores to index genetic liability to wellbeing, we observed that associations between parental wellbeing and children’s internalising, externalising and ADHD-related symptoms were at least partly explained by overlapping genetic factors, while no clear evidence of genetic nurture effects was found. The results highlight the importance of genetically informative designs, as not accounting for the role of genes could lead to spurious or inflated associations between parental factors and children’s psychiatric outcomes. The thesis is concluded with a general discussion which highlights its clinical and research implications and provides directions for future research
CM Periods, CM Regulators, and Hypergeometric Functions, I
No full textWe prove the Gross-Deligne conjecture on CM periods for motives associated with H-2 of certain surfaces fibered over the projective line. Then we prove for the same motives a formula which expresses the K-1-regulators in terms of hypergeometric functions F-3(2), and obtain a new example of non-trivial regulators
Mapping SNOMED CT to ICD-10-CM
No full textA SNOMED CT-encoded problem list is required to satisfy the Certification Criteria for Stage 2 “Meaningful Use”. ICD-10-CM has replaced ICD-9-CM as the reimbursement code set in 2015. Having a cross-map from SNOMED CT to ICD-10-CM would promote the use of SNOMED CT as the primary problem list terminology, while easing the transition to ICD-10-CM. There is no established principle and methodology on systematically and semantically linking SNOMED CT to ICD-10-CM. This research project describes the development of mapping principle, mapping guidelines, mapping tools and mapping methodology for a rule-based crosswalk to support semi-automatic generation of ICD-10-CM codes from SNOMED CT-encoded data. A series of mapping guidelines were developed based on the clinical use case, SNOMED CT modeling convention, and ICD-10-CM classification guidelines. One of the important methodology in developing the map set is using triangulation in generating legacy maps. Using the SNOMED CT to ICD-9-CM map and General Equivalence Mappings sequentially, Indirect Map was generated from SNOMED CT to ICD-10-CM for 96.2% of the SNOMED CT concepts within the scope of the study. Another innovation in this crossmapping research is implementation of a principle to handle age specification. The age rule was one type of rule to handle cases in which one SNOMED CT concept can map to different ICD-10-CM codes depending on the age of the patient. The age rule quality assurance (QA) was a mechanism to capture the age specification that can be easily missed by manual mapping. The results showed that the mapping guidelines ensured the mapping consistency, which potentially would reduce the mapping discrepancy between the two independent parallel mapping efforts. It also made it possible that the map set can be used in a meaningful way when data is exchanged. On this triangulation method in generating legacy map, an Indirect Map generated from SNOMED CT to ICD-10-CM covered a very high percentage of SNOMED CT concepts. Overall, this Indirect Map had a moderate degree of agreement with the Direct SNOMED CT to ICD-10-CM map. However, the indirect synonymy maps have much higher precision and can be used for quality assurance (QA) of the three maps. The age rule QA identified 342 out of 7,277 concepts which potentially required age rules, among these 50.3% turned out to be true positives. Without this QA, a large proportion of age rules in the published Map would have been missed. The outcomes of this research project include a set of mapping principle, mapping guidelines, mapping tools and mapping methodology for a rule-based crosswalk from SNOMED CT to ICD-10-CM. All these could be used as a prototype in other cross standard mappings. For example, in the US, ICD-10-PCS officially replaced ICD-9-CM from October 2015 onwards. A project was formulating earlier this year (2015) for the purpose of creating the map from SNOMED CT procedure to ICD-10-PCS. It is a pleasant finding that tooling, principles and guidelines established in SNOMED CT to ICD-10-CM mapping can be re-used, with modifications, for the PCS mapping process.Ph.D.Includes bibliographical referencesby Junchuan X
- …
