64 research outputs found
Aisopou Mythoi/Fabulae Aesopicae Graecae Quae Maximo Planudi Tribuuntur
No full textThe full title reads this way: Aisopou mythoi Fabulae Aesopicae Graecae quae Maximo Planudi tribuuntur ad veterum librorum fidem emendatas Ioannis Hudsonis suisque adnotationibus illustratas atque indice verborum locupletissimo instructas edidit Io. Michael Heusinger curavit et praefatus est Christ. Adolph. Klotzius. The book is easy to find online; it seems to be the only book that comes up if one Googles Wittekindt, although this edition may be a reprint of a 1770 edition also done by Wittekindt. The book has three parts: a lengthy unpaginated introduction; 120 pages of some 149 fables and their variants; and a Greek/Latin dictionary of all the vocables that occur in Aesop's fables. This third section has a two-page addition cataloguing items explained in the notes. The whole comes, online sources say, to 288 pages. The introductory section includes a preface by Klotz; a catalogue of manuscripts by Heusinger, a preface to the reader by Hudson; and sixty-eight ancient testimonies to Aesop and the fables. For those confused by the shortened and Latinized names on the title-page, here are more complete and modern names: Christian Adolph Klotz edited this book, following on the work of editor and commentator John Hudson with Johann Michael Heusinger's index verborum. The publisher is Johann Georg Ernst Wittekindt.This is a hardbound book (hard cover)Language note: GreekJoannis Hudsonis, Io. Michael Heusinger, Christ. Adolph. Klotziu
Ludwig: The physiologist
No full textThe thought reproduced in the above epigraph is taken from an article by Thurau et al. [1], who attribute it to Arthur Schopenhauer (17881860), an outstanding philosopher and author of the far-reaching piece Die Welt als Wille und Vorstellung (The World as Will and Representation). In German, it would perhaps read as etwas denken, das niemand vorher gedacht hat, während etwas sehen, was jeder sieht. We could not assert whether Schopenhauer really said that, but it should not be at all surprising if it were, because it sounds simple, perhaps even naïve, and very deep, indeed. It fits perfectly to Carl Friedrich Wilhelm Ludwigs personality (18161895), whom we will look at as physiologist in this second note. Yes, second notebecause in the first one [2], we looked at him as bioengineer. A third and last Retrospectroscope column completing this series will deal with his wonderful and always humble and generous activities as teacher. © 2012 IEEE.Fil: Valentinuzzi, Maximo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Beneke, Klaus. Christin-Albrechts-University; AlemaniaFil: González, Germán Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentin
Book of Abstracts of the Minisymposium on Publicly Available Geometric/Topological Software
No full textDisputatio Textualis De Donis, Et Vocatione Dei, Quorum Ipsum Non Poenitet : Ad Locum Rom. XI. vers. 29
No full textQuam, Favente Deo Opt. Maximo, Sub Præsidio ... Joh. Jacobi Hottingeri ..., Publicè ventilandam sistit, Petrus Jac. Nonius ... Cernetio-Engadinâ Rhætus, Author & Respondens, Ad Diem 9. Julii, H.L.Q.S.Diss. Hohe Schule Zürich, 171
“Love is...”: An Inaesthetic Inquiry on Love and Attention in Aureus Solito’s The Blossoming of Maximo Oliveros
No full textDrawing from Alain Badiou’s concept of inaesthetics, which proposes that art conditions philosophical thought, this essay offers an inaesthetic reading of The Blossoming of Maximo Oliveros (2005) and suggests that it is a film that offers enabling possibilities in the thinking of love by providing the spectator with a different experience of cinematic attention in the visual field. The author suggests that the film raises the philosophical question “What is love?” and attempts to answer the very question it poses through punctual encounters, which are moments of cinematic interruption—described by Roland Barthes as “what I add . . . and what nonetheless is already there” (A Lover’s Discourse 55)—that may offer opportunities for philosophical speculation. This essay further argues that those punctual moments initiate a new form of attention that is not sustained by “visual pleasure,” as theorized by Laura Mulvey, but by the “movement of thought” (Badiou, Cinema 17). The film uses that mode of attention as a way to think about love while also suggesting that love itself is a form of attention
Love is … : An inaesthetic inquiry on love and attention in Aureus Solito’s The blossoming of Maximo Oliveros
No full textDrawing from Alain Badiou’s concept of inaesthetics, which proposes that art conditions philosophical thought, this essay offers an inaesthetic reading of The Blossoming of Maximo Oliveros (2005) and suggests that it is a film that offers enabling possibilities in the thinking of love by providing the spectator with a different experience of cinematic attention in the visual field. The author suggests that the film raises the philosophical question “What is love?” and attempts to answer the very question it poses through punctual encounters, which are moments of cinematic interruption—described by Roland Barthes as “what I add… and what nonetheless is already there” (A Lover’s Discourse 55)—that may offer opportunities for philosophical speculation. This essay further argues that those punctual moments initiate a new form of attention that is not sustained by “visual pleasure,” as theorized by Laura Mulvey, but by the “movement of thought” (Badiou, Cinema 17). The film uses that mode of attention as a way to think about love while also suggesting that love itself is a form of attention. © Ateneo de Manila University
“Love Is…”: An Inaesthetic Inquiry on Love and Attention in Aureus Solito’s The Blossoming of Maximo Oliveros
No full textDrawing from Alain Badiou’s concept of inaesthetics, which proposes that art conditions philosophical thought, this essay offers an inaesthetic reading of The Blossoming of Maximo Oliveros (2005) and suggests that it is a film that offers enabling possibilities in the thinking of love by providing the spectator with a different experience of cinematic attention in the visual field. The author suggests that the film raises the philosophical question “What is love?” and attempts to answer the very question it poses through punctual encounters, which are moments of cinematic interruption—described by Roland Barthes as “what I add . . . and what nonetheless is already there” (A Lover’s Discourse 55)—that may offer opportunities for philosophical speculation. This essay further argues that those punctual moments initiate a new form of attention that is not sustained by “visual pleasure,” as theorized by Laura Mulvey, but by the “movement of thought” (Badiou, Cinema 17). The film uses that mode of attention as a way to think about love while also suggesting that love itself is a form of attention
Obesity enhances nongenomic estrogen receptor crosstalk with the PI3K/Akt and MAPK pathways to promote in vitro measures of breast cancer progression
No full textLaura W Bowers1, David A Cavazos1, Ilane XF Maximo1, Andrew J Brenner12, Stephen D Hursting13 and Linda A deGraffenried14*
Author Affiliations
1 Department of Nutritional Sciences, University of Texas at Austin - DPRI, 1400 Barbara Jordan Blvd, R1800, Austin, TX 78723-3092, USA
2 Division of Hematology and Medical Oncology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
3 Department of Molecular Carcinogenesis, UT-MD Anderson Cancer Center Science Park, 1808 Park Road 1C, Smithville, TX 78957, USA
4 Department of Cellular and Structural Biology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USAIntroduction: Epidemiological and clinical studies indicate that obesity is associated with a worse postmenopausal breast cancer prognosis and an increased risk of endocrine therapy resistance. However, the mechanisms mediating these effects remain poorly understood. Here we investigate the molecular pathways by which obesity-associated circulating factors in the blood enhance estrogen receptor alpha (ERα) positive breast cancer cell viability and growth.
Methods: Blood serum was collected from postmenopausal breast cancer patients and pooled by body mass index (BMI) category (Control: 18.5 to 24.9 kg/m2; Obese: ≥30.0 kg/m2). The effects of patient sera on MCF-7 and T47D breast cancer cell viability and growth were examined by MTT and colony formation assays, respectively. Insulin-like growth factor receptor 1(IGF-1R), Akt, and ERK1/2 activation and genomic ERα activity were assessed to determine their possible contribution to obese patient sera-induced cell viability and growth. To further define the relative contribution of these signaling pathways, cells grown in patient sera were treated with various combinations of ERα, PI3K/Akt and MAPK targeted therapies. Comparisons between cells exposed to different experimental conditions were made using one-way analysis of variance (ANOVA) and Student's t test.
Results: Cells grown in media supplemented with obese patient sera displayed greater cell viability and growth as well as IGF-1R, Akt and ERK1/2 activation relative to control sera. Despite the lack of a significant difference in genomic ERα activity following growth in obese versus control patient sera, we observed a dramatic reduction in cell viability and growth after concurrent inhibition of the ERα and PI3K/Akt signaling pathways. Further, we demonstrated that ERα inhibition was sufficient to attenuate obese serum-induced Akt and ERK1/2 activation. Together, these data suggest that obesity promotes greater ERα positive breast cancer cell viability and growth through enhanced crosstalk between nongenomic ERα signaling and the PI3K/Akt and MAPK pathways.
Conclusions: Circulating factors in the serum of obese postmenopausal women stimulate ERα positive breast cancer cell viability and growth by facilitating non-genomic ERα crosstalk with the PI3K/Akt and MAPK signaling pathways. These findings provide valuable insight into one mechanism by which obesity may promote ERα positive postmenopausal breast cancer progression and endocrine therapy resistance.Nutritional [email protected]
De feudis ecclesiasticis iisque Trevirensibus oblatis
No full textQuam optimo maximo duce ex speciali, post rigorosa Examina Amplissimae, Nobilissimae Consultissimaeque Facultatis Juridicae Trevirorum Decreto Publicè propugnandam dedit ... Henricus Josephus Moehn ... Author Et Respondens ...Vorlageform des Erscheinungsvermerks: Augustae Trevirorum, Typis J. C. Reulandt, Aul. & Univ. Typogr. - Erscheinungsjahr nach einem ChronogrammText teilw. dt., teilw. lat.Trier, Jur. Diss., 16. Juli 175
Estrategias de promoción turística para el balneario Los Cerritos ubicado en el Rcto. Calabí, cantón Quinsaloma
No full textThe objective of this research work was to determine the importance of the implementation of strategies for the tourist promotion of the "Los Cerritos" Spa located in the Rcto. Calabí, Quinsaloma canton. For these reasons, in the following document an analysis was presented in order to promote tourism growth in the sector. This project was raised after the spa was recognized as a tourist attraction that attracts locals and foreigners; but at the same time it does not have advertising promotion strategies that attract more tourists. The methodology applied for the project consisted of exploratory research through the use of surveys, which allowed for a clearer approach to the subject. The results were shown through the development of cases that allowed observing the situations raised and detected; the same that allowed the author to conclude on the work investigated and recommend alternatives that promote the growth of tourism in the sector.The objective of this research work was to determine the importance of the implementation of strategies for the tourist promotion of the "Los Cerritos" Spa located in the Rcto. Calabí, Quinsaloma canton. For these reasons, in the following document an analysis was presented in order to promote tourism growth in the sector. This project was raised after the spa was recognized as a tourist attraction that attracts locals and foreigners; but at the same time it does not have advertising promotion strategies that attract more tourists. The methodology applied for the project consisted of exploratory research through the use of surveys, which allowed for a clearer approach to the subject. The results were shown through the development of cases that allowed observing the situations raised and detected; the same that allowed the author to conclude on the work investigated and recommend alternatives that promote the growth of tourism in the sector.El presente trabajo investigativo tuvo como objetivo determinar la importancia de la implementación de estrategias para la promoción turística del Balneario “Los Cerritos” ubicado en el Rcto. Calabí, cantón Quinsaloma. Por tales razones en el siguiente documento se presentó un análisis con la finalidad de fomentar el crecimiento turístico en el sector. Este proyecto se planteó a partir de que se reconoció el balneario como un atractivo turístico que atrae a propios y extraños; pero que a la vez no cuenta con estrategias de promoción publicitaria que atraigan a más turistas. La metodología aplicada para el proyecto consistió en investigación exploratoria mediante la utilización de encuestas, las mismas que permitieron tener un enfoque más claro del tema. Se mostraron los resultados mediante el desarrollo de casos que permitió observar las situaciones planteadas y detectadas; las mismas que permitieron al autor concluir sobre el trabajo investigado y recomendar alternativas que fomenten el crecimiento turístico del sector
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