1,721,164 research outputs found
Nuovi meccanismi infiammatori nella patogenesi della psoriasi: effetti dell'IL-17A nel rilascio e cargo delle vescicole extracellulari in cheratinociti umani - New pathogenetic inflammatory mechanisms in psoriasis: Interleukin-17A affects extracellular vesicles release and cargo in human keratinocytes
Full text linkLa psoriasi è riconosciuta come uno dei più comuni disordini immuno-mediati, dove sia l'immunità acquisita che quella innata giocano un ruolo fondamentale nello sviluppo e nel mantenimento della patologia. Per tale ragione la psoriasi viene considerata un vero e proprio modello di studio dei meccanismi di infiammazione cronica
Nella psoriasi si assiste alla disregolazione dell'asse citochinico IL-23/IL-17 da cui ne consegue da una parte l'attivazione del subset linfocitario Th-17 e dall'altra una risposta proliferative cheratinocitaria.
Questo induce la secrezione di differenti citochine, chemochine e peptidi antimicrobici da parte dei cheratinociti stessi. L'induzione di specifici fattori chemiotattici richiama, nel sito dell'infiammazione, cellule dendritiche mieloidi, linfociti Th17 e neutrofili.
Il processo infiammatorio psoriasico, oltre alle interazioni cellulari, coinvolge anche le strutture vascolari con il rilascio di citochine, ormoni e secondi messaggeri. È stato, inoltre, dimostrato che le cellule comunicano anche attraverso il rilascio di vescicole contenenti DNA, RNA, microRNA e proteine. Sebbene siano state riportate alterazioni del traffico micro-vescicolare in disturbi ematologici ed infettivi, vi sono poche evidenze di tali alterazioni nella patogenesi della psoriasi.
I risultati preliminari ottenuti nei nostri laboratori indicano come l'IL-17 sia in grado di modificare, sia qualitativamente che quantitativamente, il carico e il rilascio extracellulare di vescicole. L'obiettivo del nostro studio, basato su un gruppo di ricerca multidisciplinare, è identificare nuovi biomarkers della psoriasi
Hydronephrosis in pregnancy
No full textIn this chapter we provide a critical and practical overview of the clinical management of hydronephrosis during pregnancy, which represents a very common and sometimes problematic scenario for the practising urologist
Conservative treatment of upper urinary tract urothelial carcinoma (UTUC) in patients with imperative indications: Not only an option
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Current state of laparoscopic and robotic surgery
Full text linkMinimally invasive surgical innovation has exploded in recent times. Currently, conventional laparoscopy is most widely adopted as the costs are relatively low. However, robotics and single port surgery are leading a revolution in surgery for wealthy health-care systems. We explore the historical and contemporary areas of this evolution
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