2,188,117 research outputs found
Mishnayot ... : im perush ha-gaon Ovadyah mi-Bertenorah
No full textMISHNAYOT ... : IM PERUSH HA-GAON OVADYAH MI-BERTENORAH
Mishnayot ... : im perush ha-gaon Ovadyah mi-Bertenorah
Seder Neziin (Vol. II,2) (1
Deep-MI/FastSurfer: v2.1.1
No full textFastSrufer 2.1.1
What's Changed
hotfix: --no_fs_t1 lower case by @m-reuter in https://github.com/Deep-MI/FastSurfer/pull/325
Added CerebNet, removed copying empty dir and corrected ckpt downloaddir by @LeHenschel in https://github.com/Deep-MI/FastSurfer/pull/326
Full Changelog: https://github.com/Deep-MI/FastSurfer/compare/v2.1.0...v2.1.
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Límites de mi lengua, límites de mi mundo.
No full textEsta es la versión interactiva de “Límites de mi lengua, límites de mi mundo”, con la cual el lector logrará expresarse correctamente en lo oral y en lo escrito con los principios elementales del arte y conceptos de cultura como puerta de entrada a nuestra maravillosa lengua: el español. Dentro de este eBook encontrarás ejercicios interactivos que te ayudarán a reforzar lo aprendido de una forma divertida y dinámica
Park Mi-jin
No full text학위논문(석사)--아주대학교 일반대학원 :의생명학과,2011. 2ABSTRACT i
TABLE OF CONTENTS iii
LIST OF FIGURES iv
LIST OF TABLES v
I. INTRODUCTION 1
II. MATERIALS AND METHODS 3
A. Subjects 3
B. Methods 4
1. Cell preparation 4
2. Cell culture and stimulation of PBMCs 4
3. Flow cytometry 5
4. ELISA 5
5. RNA preparation and Real time PCR 5
6. Statistical analysis 6
III. RESULTS 7
IV. DISCUSSION 25
V. CONCLUSION 29
REFERENCES 30
국문요약 34MasterBackground: Behçet’s disease (BD) is a multisystem inflammatory disorder characterized by recurrent oro-genital ulcers, and cutaneous, ocular, arthritics, gastrointestinal, vascular, and neurovascular involvement. The etiology and pathogenesis of BD have remained unclear, however it has been assumed that genetic factors, infectious, and immune mechanisms are involved in the onset of this disease. In human autoimmunity, the T helper(Th) 1 immune responses have been traditionally associated with the induction and progression of disease. Recently, a number of other T cell populations were discovered, and IL(Interleukin)-17 producing Th17 cells were recognized as novel group of T cells which play a major role in autoimmunity. A recent study has shown elevated production of IL-17, IL-23, and IFN (Interferon)-γ by peripheral blood mononuclear cells (PBMCs) besides increased frequencies of IL-17 and IFN-γ producing T cells in BD patients with active uveitis. It was also reported that increased expression of IL-23 p19 mRNA in erythema nodosum-like lesions in patients with active BD.
Purpose: In this study, we aimed at investigating the expression Th17 and related cytokines during active states of BD.
Materials and Methods: From April 2010 to September 2010, a total of 22 patients with active and inactive BD were enrolled in this study. The disease control and healthy control (HC) group consisted of age- and sex-matched 10 recurrent aphthous ulcer (RAU) patients without any other evident disease and 10 healthy volunteers, respectively. PBMCs of subjects were cultured and stained with the appropriate fluorescent antibody for analysis by flow cytometry. To measure the IL-17, IL-23 and IFN-γ concentrations in serum and in culture supernatants, ELISA was performed. To investigate the mRNA expression level of IL-12p35, IL-12/23p40 and IL-23p19 in PBMCs, real time polymerase chain reaction (RT-PCR) was performed.
Results: In the active BD group, CD4+ and CD8+ T cells from patients expressed significantly higher level of IL-17 and IFN-γ, compared with the cells from the control group. High serum and supernatant concentration of IL-17 and IFN-γ was in active BD group compared with HC group and RAU group. In addition, mRNA expression of IL-23p19, IL-12p35 and IL-12/23p40 in PBMCs was up-regulated in total BD patient groups. Expression of IL-23p19 mRNA was significantly higher in the active BD group compared with HC groups.
Conclusion: Increased expression of the IL-17 and IFN-γ was observed in this study and these results suggest that Th17 cells has a important implication in immune modulation of BD. Future studies clarifying the further immunopathologic role of Th17 pathway in BD are needed.
Key Words: Behçet’s disease, Th17 cells, IL-17, IL-2
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Figure 2: BAG3 Overexpression Improves Myocyte Contractility Post-MI
No full textMyocytes were isolated from the left ventricles and septum of the 3 groups of mice (n = 3 mice each) used in Figure 1, with care being taken to excise the infarct scar in MI-GFP and -BAG3 hearts. In Sham-GFP hearts, the area corresponding to the infarct scar in MI hearts was excised before myocyte isolation. Representative contraction traces obtained in freshly isolated myocytes (2 Hz, 37°C, 1.8 mmol/l [Ca2+]o) (please see the Methods section) are shown at baseline (A) and after 1 μmol/l of isoproterenol (Iso) (B). Contraction amplitudes (C), maximal shortening (D), and re-lengthening velocities (E) are shown for Sham-GFP, MI-GFP, and MI-BAG3 myocytes, both at baseline and in the presence of isoproterenol. There are 17 Sham-GFP, 18 MI-GFP, and 25 MI-BAG3 myocytes at baseline and 21 Sham-GFP, 18 MI-GFP, and 17 MI-BAG3 myocytes after isoproterenol. Differences between groups are analyzed with 2-way analysis of variance are given in the Results section. RCL = resting call length; other abbreviations as in Figure 1
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Conociendo mi empresa
No full textLocutores: Susana Fevrier y Luis Diego Solórzano Entrevistados: Miguel García“Conociendo mi empresa”. Elementos que se deben tomar en cuenta para que una empresa sea más competitiva y exitosa
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