330,920 research outputs found
Mest en mineralen
No full textEen beschrijving van het onderzoeksprogramma mest en mineralen van Wageningen UR. Dit programma loopt van 2002 tot 2005. De thema´s zijn: alternatieven voor toediening van dierlijke mest op een ongunstig tijdstip voor de plant; optimalisatie van gras-klavermengsels; optimalisatie van composteren, handling en opslag van mest; karakterisering organische inputs; bodemkwaliteit waaronder nawerking van dierlijke mest. Dit zijn thema’s uit “Mest en Mineralen” die ook relevant zijn voor de biologische landbou
Influence of trapidil and derivatives on cholesterol synthesis and esterification in cultured cells
No full textThe effect of trapidil (Rocornal) and its derivatives AR 12456 and AR 12463 on endogenous cholesterol synthesis and on cholesterol esterification rate was studied in human skin fibroblasts (HSF), in human hepatoma cell line Hep G2 and in primary culture of peritoneal macrophages from mouse (PMM). The cholesterol esterification rate was not influenced by the drugs in the tested cell lines. The incorporation of [14C]acetate into cholesterol in HSF was inhibited by AR 12463 and AR 12456, but not by trapidil. The inhibitory potency of AR 12456 in HSF was enhanced after preincubation of the drug with Hep G2 and removal of the medium to HSF, suggesting that the formed metabolite(s) are more potent inhibitors than the parent substance. The metabolite(s) formed seem(s) to influence the first steps in the endogenous formation of cholesterol, because the incorporation of [14C]mevalonate into cholesterol was not significantly inhibited. These findings suggest that the demonstrated inhibition of the endogenous cholesterol synthesis by AR 12456, especially after transformation into a probably more active substance(s), together with the recently described enhanced expression of LDL receptors in Hep G2 cells may partially explain the hypocholesterolaemic activity of AR 12456
Influence of trapidil and derivatives on cholesterol synthesis and esterification in cultured cells
No full textThe effect of trapidil (RocornalR) and its derivatives AR 12456 and AR 12463 on endogenous cholesterol synthesis and on cholesterol esterification rate was studied in human skin fibroblasts (HSF), in human hepatoma cell line Hep G2 and in primary culture of peritoneal macrophages from mouse (PMM). The cholesterol esterification rate was not influenced by the drugs in the tested cell lines. The incorporation of [14C]acetate into cholesterol in HSF was inhibited by AR 12463 and AR 12456, but not by trapidil. The inhibitory potency of AR 12456 in HSF was enhanced after preincubation of the drug with Hep G2 and removal of the medium to HSF, suggesting that the formed metabolite(s) are more potent inhibitors than the parent substance. The metabolite(s) formed seem(s) to influence the first steps in the endogenous formation of cholesterol, because the incorporation of [14C]mevalonate into cholesterol was not significantly inhibited. These findings suggest that the demonstrated inhibition of the endogenous cholesterol synthesis by AR 12456, especially after transformation into a probably more active substance(s), together with the recently described enhanced expression of LDL receptors in Hep G2 cells may partially explain the hypocholesterolaemic activity of AR 1245
Diffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The MEST score provides earlier risk prediction in lgA nephropathy
No full textThe Oxford Classification of IgA nephropathy (IgAN) includes the following four histologic components: mesangial (M) and endocapillary (E) hypercellularity, segmental sclerosis (S) and interstitial fibrosis/tubular atrophy (T). These combine to form the MEST score and are independently associated with renal outcome. Current prediction and risk stratification in IgAN requires clinical data over 2 years of follow-up. Using modern prediction tools, we examined whether combining MEST with cross-sectional clinical data at biopsy provides earlier risk prediction in IgAN than current best methods that use 2 years of follow-up data. We used a cohort of 901 adults with IgAN from the Oxford derivation and North American validation studies and the VALIGA study followed for a median of 5.6 years to analyze the primary outcome (50% decrease in eGFR or ESRD) using Cox regression models. Covariates of clinical data at biopsy (eGFR, proteinuria, MAP) with or without MEST, and then 2-year clinical data alone (2-year average of proteinuria/MAP, eGFR at biopsy) were considered. There was significant improvement in prediction by adding MEST to clinical data at biopsy. The combination predicted the outcome as well as the 2-year clinical data alone, with comparable calibration curves. This effect did not change in subgroups treated or not with RAS blockade or immunosuppression. Thus, combining the MEST score with cross-sectional clinical data at biopsy provides earlier risk prediction in IgAN than our current best methods
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Analiza povezanosti pametnih mest s policijsko in kriminalistično dejavnostjo
No full textPurpose:
The main objective is to present the symbiosis between smart cities, policing, criminal investigation and criminal intelligence. Moreover, another purpose is to critically address the underlying privacy concerns arising from smart city designs.
Design/Methods/Approach:
The paper is theoretical in scope and utilises a literature review as the basic method. Correlations between smart cities, policing and criminal investigations are identified by analysing the applicability of core smart city technologies and services [SCTS].
Findings:
It is evident that SCTS can influence policing styles and police effectiveness. SCTS hold great potential for criminal investigations and criminal intelligence as they provide information upon which police can develop investigations or crime-control strategies. Vice-versa, criminal investigations and criminal intelligence can provide guidelines for SCTS developers and the governance of smart cities. However, privacy concerns and the slowly developing regulatory framework remain the biggest issues when it comes to SCTS adoption, thus making measures to safeguard privacy a key factor for the legitimacy of smart cities and smart policing.
Practical Implications:
The paper introduces practical knowledge about the implications of smart cities for policing and crime investigation. Some research ideas are presented as well as suggestions for legislators, developers and others whose work area falls in the scope of (smart) city governance.
Originality/Value:
A comprehensive study of the symbiosis between smart cities and policing must not only consider the potential of SCTS but the related need to develop regulation and skillsets of human resources. Only a handful of papers address the connectivity of smart cities, criminal investigations and criminal intelligence from such a multidisciplinary scope. Therefore, the paper represents a contribution to works discussing these concepts.Namen prispevka:
Namen prispevka je predstaviti simbiozo med pametnimi mesti, policijsko dejavnostjo, kriminalističnim preiskovanjem in kriminalističnoobveščevalno dejavnostjo. V tem kontekstu je podan tudi kritični razmislek o izzivih in dilemah, povezanih z varstvom zasebnosti.
Metode:
Prispevek je teoretične narave in temelji na pregledu literature. Korelacije med temeljnimi pojmi (pametna mesta, policijska in kriminalistična dejavnost) smo identificirali z analizo temeljnih tehnologij, sistemov in storitev, ki podpirajo delovanje pametnih mest.
Ugotovitve:
Tehnologije pametnih mest omogočajo razvoj novih oblik policijskega dela in imajo potencial za izboljšanje policijske učinkovitosti. Funkcionalnost tehnologij je razvidna tudi na področju kriminalistične dejavnosti, ki lahko z obdelovanjem podatkov in njihovo uporabo bolje načrtuje kriminalistične preiskave in razvija strategije preprečevanja kriminalitete. Simbioza je opazna tudi z nasprotnega vidika – s podajanjem smernic lahko kriminalistična in policijska dejavnost pomagata upravljavcem pametnih mest in razvojnikom tehnologij ter rešitev. Glavni izziv predstavlja varovanje zasebnosti in osebnih podatkov prebivalcev, zato so mehanizmi za preprečevanje zlorab ključni faktor legitimnosti pametnih mest in policijske dejavnosti.
Praktična uporabnost:
V prispevku so predstavljena uporabna znanja glede potencialov pametnih mest za izvajanje policijske in kriminalistične dejavnosti, prav tako tudi predlogi za raziskovalce in oblikovalce politik, razvojnike in druge, ki delujejo na področju upravljanja (pametnih) mest.
Izvirnost/pomembnost prispevka:
Če želimo razumeti sistem dejavnikov, ki vplivajo na simbiozo med policijsko dejavnostjo in pametnimi mesti, je treba upoštevati ne samo potenciale različnih tehnologij in rešitev, temveč tudi potrebe in dileme, ki se pojavijo sočasno s tehnološkim razvojem, primarno na področju razvoja kadrovskih kompetenc in prilagoditve normativnih okvirjev. Pregled literature pokaže, da obstajajo redke znanstvene objave, ki multidimenzionalno proučujejo simbiozo pametnih mest in policijske dejavnosti. Prispevek zato dopolnjuje obstoječa dela in znanja na tem področju
Effect of trapidil derivative AR 12456 on intracellular cholesterol homeostasis in human hepatoma cell line Hep G2
No full textThe effect of trapidil derivative AR12456 on intracellular cholesterol metabolism was investigated in human hepatoma cell line HepG2. AR12456 enhanced the uptake and degradation of 125I-LDL in a dose-dependent manner. The drug inhibited cholesterol synthesis and esterification without affecting cellular cholesterol content and bile acid synthesis; cholesterol efflux was slightly increased. These results show that the inhibition of cholesterol synthesis together with the enhanced expression of LDL receptors may partially explain the hypocholesterolemic activity of compound AR12456
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