1,721,284 research outputs found
Stato costituzionale democratico e governo dell'emergenza . Rilievi su una condizione eccezionale
Full text linkLa gestione politica della crisi sanitaria ha posto con forza alla teoria giuridica e alla filosofia politica la questione classica del
rapporto tra normalità istituzionale ed emergenzialità dell’intervento politico. Quanto è accaduto ha spinto parte della dottrina
a utilizzare il concetto di stato d’eccezione e in alcuni casi a denunciare l’uso disinvolto di poteri extra-ordinem che hanno messo
sotto sforzo il tessuto democratico delle nostre collettività. A un esame attento dei profili giuridico-costituzionali implicati, la tesi
della illegittimità di alcuni provvedimenti adottati dalle autorità govern
Percezione e narrazione dei luoghi. La poetica di Guccini fra prospettive geografiche e applicazioni didattiche
No full textIl presente contributo intende collocarsi in seno al dibattito, propriamente geografico, che indaga il ruolo della percezione nella lettura delle complessità del paesaggio, specie in ambito letterario. Si vuole infatti porre in risalto la sensibilità geografica dei testi delle canzoni di Francesco Guccini e si vuole altresì enfatizzare, attraverso una riflessione metodologica, il ruolo che il discorso musicale e letterario possa avere nella didattica dell’insegnamento della Geografia nelle scuole secondarie di I e II grado
When chromatin organization floats astray: the Srcap gene and the Floating Harbor syndrome.
No full textFloating–Harbor syndrome (FHS) is a rare human disease
characterised by delayed bone mineralisation and growth
deficiency, often associated with mental retardation and
skeletal and craniofacial abnormalities. FHS was first
described at Boston’s Floating Hospital 42 years ago, but
the causative gene, called Srcap, was identified only
recently. Truncated SRCAP protein variants have been
implicated in the mechanism of FHS, but the molecular
bases underlying the disease must still be elucidated and
investigating the molecular defects leading to the onset
of FHS remains a challenge. Here we comprehensively
review recent work and provide alterative hypotheses to
explain how the Srcap truncating mutations lead to the
onset of FHS
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Unconventional roles of chromatin remodelers and long non-coding RNAs in cell division
Full text linkThe aim of this review article is to focus on the unconventional roles of epigenetic players (chromatin remodelers and long non-coding RNAs) in cell division, beyond their well-characterized functions in chromatin regulation during cell differentiation and development. In the last two decades, diverse experimental evidence has shown that subunits of SRCAP and p400/TIP60 chromatin remodeling complexes in humans relocate from interphase nuclei to centrosomes, spindle or midbody, with their depletion yielding an array of aberrant outcomes of mitosis and cytokinesis. Remarkably, this behavior is shared by orthologous subunits of the Drosophila melanogaster DOM/TIP60 complex, despite fruit flies and humans diverged over 700 million years ago. In short, the available data support the view that subunits of these complexes are a new class of moonlighting proteins, in that they lead a "double life": during the interphase, they function in chromatin regulation within the nucleus, but as the cell progresses through mitosis, they interact with established mitotic factors, thus becoming integral components of the cell division apparatus. By doing so, they contribute to ensuring the correct distribution of chromosomes in the two daughter cells and, when dysfunctional, can cause genomic instability, a condition that can trigger tumorigenesis and developmental diseases. Research over the past few years has unveiled a major contribution of long non-coding RNAs (lncRNAs) in the epigenetics regulation of gene expression which also impacts on cell division control. Here, we focus on possible structural roles of lncRNAs in the execution of cytokinesis: in particular, we suggest that specific classes of lncRNAs relocate to the midbody to form an architectural scaffold ensuring its proper assembly and function during abscission. Drawing attention to experimental evidence for non-canonical extranuclear roles of chromatin factors and lncRNAs has direct implications on important and novel aspects concerning both the epigenetic regulation and the evolutionary dynamics of cell division with a significant impact on differentiation, development, and diseases
The Bucentaur (BCNT) family: a long neglected class of essential proteins required for chromatin/chromosome organization and function
No full textThe evolutionarily conserved Bucentaur
(BCNT) protein superfamily was identified about two
decades ago in bovines, but its biological role has long
remained largely unknown. Sparse studies in the literature
suggest that BCNT proteins perform important
functions during development. Only recently, a functional
analysis of the Drosophila BCNT ortholog, called
YETI, has provided evidence that it is essential for
proper fly development and plays roles in chromatin
organization. Here, we introduce the BCNT proteins
and comprehensively review data that contribute to clarify
their function and mechanistic clues on how they
may control development in multicellular organisms
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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