114 research outputs found
Untersuchung der biologischen Aktivität von Nanopartikeln in Tumorschnittkulturen
No full textDie Entdeckung der RNA‐Interferenz (RNA‐i) als ein natürlicher Prozess der Genregulation sorgte auf Grund des möglichen Einsatzes für therapeutische Zwecke für großes Interesse. Probleme beim Transport der RNA‐i‐induzierenden kleinen RNA‐Moleküle (siRNAs) traten vor allem hinsichtlich Ladungsverhältnissen, Instabilität und Molekulargewicht auf. Um diese Probleme zu lösen, wurden zunehmend Transportsysteme aus Nanopartikeln untersucht. Die verwendeten Polyethylenimine (PEIs) sind positiv geladene, verzweigt oder linear aufgebaute Polymere, welche mit RNAs (siRNA, miRNA) Komplexe bilden. Modifikationen der PEI‐Kom‐ plexe können zu einem effektiveren Transport der RNA, zu veränderten pharmakokinetischen Eigenschaften und zu einer verbesserten Biokompatibilität führen. Der Erfolg dieser therapeu‐ tischen Nanopartikel ist insbesondere von der effizienten zellulären Aufnahme, der Fähigkeit der Gewebepenetration und vom Erreichen der Zielzellen abhängig. Der Großteil der bisheri‐ gen Untersuchungen von PEIs wurde an Zellkulturen durchgeführt. Die hier erzielten Ergeb‐ nisse lassen sich jedoch nur schwer auf komplexe in‐vivo‐Systeme übertragen.
Aus diesem Grund wurde in der vorliegenden Arbeit die Anwendung der PEIs an Tumorschnitt‐ kulturen untersucht. Dafür wurde zuerst die Kultivierung von 350 μm durchmessenden Dünn‐ schicht‐Präparaten von Xenotransplantat‐Tumoren aus PC3 und U87 Zelllinien etabliert. Eine erfolgreiche Kultivierung konnte über 14 Tage durchgeführt werden. An bestimmten Zeit‐ punkten nach Kultivierungsbeginn (Tag 1, 3, 5, 7 und 14) wurden die Morphologie und die Vitalität (Apoptose, Proliferation) durch eine HE‐ oder immunhistochemische Färbung be‐ stimmt. Es konnte gezeigt werden, dass die Morphologie der Tumorzellen sowie die Prolifera‐ tion und Apoptose über den gesamten Kultivierungszeitraum erhalten blieben.
Im nächsten Schritt wurde sowohl der Transport der siRNA von nicht‐modifizierten und modi‐ fizierten PEIs als auch der Transport durch deren Lipopolyplex‐Derivate (PEI‐siRNA‐Komplexe mit Liposomenhülle) analysiert. Für die Visualisierung der Komplexe wurde fluoreszenzmar‐ kierte siRNA verwendet. Die PEI‐siRNA‐Komplexe wurden auf die Schnittkulturen gegeben und über 24 Stunden kultiviert. In der mikroskopischen Analyse und ihrer Quantifizierung erfolgte die erste Einschätzung der Gewebepenetration. Es zeigten sich Unterschiede in der Gewebe‐ penetration der verschiedenen Nanopartikel, abhängig von deren Oberflächenladung.
Um die biologische Aktivität der Nanopartikel in lebenden Zellen besser evaluieren zu können, wurde im dritten Schritt der Knockdown eines endogenen Genproduktes untersucht. Zielgen war hier das Onkogen Survivin, welches ein wichtiger endogener Überlebensfaktor der Tu‐ morzellen darstellt. Es gelang der Nachweis eines durch PEI‐siRNA‐Komplexe vermittelten Knockdowns des Survivin‐Gens.
Insgesamt konnten somit Gewebeschnittkulturen als Grundlage für die ex‐vivo Untersuchung von Nanopartikeln etabliert werden. Es konnten nicht nur Aussagen über die Gewebepenet‐ ration der Nanopartikel, sondern auch über ihre biologischen Aktivitäten in einer intakten Ge‐ webestruktur getroffen werden.:Bibliographische Beschreibung 3
1 Einleitung 5
1.1 Der Einsatz der RNA-Interferenz (RNA-i) und von Nanopartikeln in der Medizin 5
1.2 Die RNA-Interferenz 6
1.2.1 Der Prozess der RNA-Interferenz 6
1.2.2 Vor- und Nachteile der RNA-Interferenz 9
1.3 Nanopartikel als Transportsysteme der siRNA: Polyethylenimine 10
1.4 Die Transportfähigkeit von Polyethyleniminen und ihre Optimierung 12
1.5 Anwendung der Polyethylenimine in in-vivo-Systemen 14
1.6 Präklinische Tumormodelle 15
1.6.1 Zellkulturen 15
1.6.2 Xenograft-Modelle und Gewebeschnittkulturen 16
2 Fragestellung 18
3 Literatur 19
4 Publikationen 24
5 Anlagen 32
6 Zusammenfassung und Ausblick 33
7 Erklärung über die eigenständige Abfassung der Arbeit 36
8 Lebenslauf 37
9 Danksagung 40
10 Erklärung über den wissenschaftlichen Beitrag 41
11 Teilnahmebestätigung: Vorlesung zur „Guten Wissenschaftlichen Praxis“ 4
Henry Charles lea y su red de colaboradores latinoamericanos: razones para estudiar el santo oficio en la segunda mitad del siglo XIX
No full textSe aborda en este artículo la vida y pensamiento de Henry Charles Lea en relación a sus estudios sobre la historia de la Inquisición española. Se esboza brevemente la red de colaboradores que Lea estableció en toda Latinoamérica así como su perfil político e intelectual, subrayando su importancia para la escritura de la obra The Inquisition in the Spanish Dependencies (1908). Finalmente, se plantean los motivos que llevaron a estos intelectuales a colaborar intensamente con el historiador norteamericano en el marco de los procesos de construcción de identidades sociales y políticas en Latinoamérica en la segunda mitad del siglo XIX. Se toma como eje conductor de este planteamiento la correspondencia de Juan María Gutiérrez con Henry Charles Lea.In this article the author discusses how Henry Charles Lea's life and thinking relates to his studies of the history of the Spanish Inquisition. It briefly outlines the network of collaborators that Lea had established throughout Latin America, as well as their political and intellectual profile, highlighting its importance for the writing of the work The Inquisition in the Spanish Dependencies (1908). Finally, it presents the reasons that led these intellectuals to work closely with the American historian in the context of the process of construction of social and political identities in Latin America in the second half of the Nineteenth Century. The correspondence of Juan Maria Gutierrez to Henry Charles Lea is taken as the guiding line of this approach
Planning and Potential Benefits of Changing the Planning Principles in Santa Maria AS
No full textKäesolevas lõputöös käsitletakse Santa Maria AS tootmisprotsessi kitsaskohti ning analüüsitakse planeerimispõhimõtete muutmise võimalusi lähtudes timmitud tootmise põhimõtetest. Töö käigus hinnatakse nende rakendamise mõju protsessi efektiivsuse kasvule. Santa Maria AS on toiduaineid töötlev ettevõte, mis pakendab erinevaid maitseaineid, maitseainesegusid ja puhtaid ürte. Lähtudes töö eesmärgist tehti ettepanekuid tootmisprotsessi efektiivsuse parendamiseks ning selgitati välja planeerimispõhimõtete muutmise kasu protsessi tõhusamaks toimimiseks.
Lähtudes timmitud tootmisfilosoofia põhimõtetest on protsessi efektiivsuse tõstmiseks oluline vähendada protsessis teostavaid raiskamisi. Mõistmaks protsessi kitsaskohti, viidi lõputöö käigus läbi analüüs, mille valimis oli 2020. aasta segamisprotsessi andmed. Uuringu eesmärk oli saada ülevaade eelmise aasta segumasinate kasutusastme ja planeerimispõhimõtete hetkeseisust. Analüüsist selgus, et planeeritud toodete vahelistele puhastusele kulus aasta jooksul 67,4% rohkem aega, mille põhjal esines planeeritavate aegade ebatäpsused.
Lõputöö käigus vaadati läbi hetkel olevad tootmisplaani koostamise põhimõtted ning mõeldi välja võimalikud muudatused puhastuste optimeerimiseks. Analüüsist selgus, et lõputöö käigus loodud uute planeerimispõhimõtete rakendamisel ja allergeenide koondamisel vähenes kümne nädalases tootmisplaanis tootevahetustest tingitud puhastuste arv ligikaudu 20%. Sellele lisaks koostas autor puhastuste likvideerimiseks ühtivate segude tabeli, mille tulemusel ei pea tootevahtuse puhul teostama regulaarset puhastust vaid saab koheselt alustada järgmise operatsiooniga. Eelmise aasta tootmisplaani alusel oleks antud tabeli rakendamisel kokku hoitud 25 kuivpuhastust.
Lean põhimõtted peavad tähtsaks protsesside katkematut voogu. Selleks viidi lõputöö käigus läbi kaardistusuuring, et selgitada välja protsessis teostavad tööülesanded ja analüüsida nendele kuluva aja vähendamise võimalusi. Protsessi aja analüüsist selgus, et töömahud on seadme ja töötaja vahel jaotunud ebavõrdselt, mis omakorda mõjutab masina kasutusastet. Samuti teostatakse tööpäeva jooksul korduvad tegevused, mis pärsivad sujuva tootmisprotsessi läbiviimist ja efektiivset tööaja kasutust. Võimaliku lahendusena pakkus töö autor välja paralleelsete operatsioonide teostamise läbi uue tööjaotus süsteemi, mille tulemusena kiireneb tsükliaeg, suureneb masina tööaeg ja tootmise maht ühe vahetuse jooksul.The following thesis deals with the bottlenecks of the production process of Santa Maria AS and analyzes the possibilities of changing the planning principles based on lean principles. The work evaluates the impact of their implementation on the increase of process efficiency. Santa Maria AS is a food processing company that packages various spices, spice mixtures, and pure herbs. Based on the aim of the work, proposals were made to improve the efficiency of the production process and the benefits of changing the planning principles for more efficient operation of the process were identified.
Based on the principles of a streamlined production philosophy, it is important to reduce wastage in the process to increase the efficiency of the process. To understand the bottlenecks of the process, an analysis was performed during the dissertation, the sample of which included data from the 2020 mixing process. The study aimed to get an overview of the current state of utilization and planning principles of the previous year mixing machines. The analysis showed that cleaning between planned products took 67.4% more time during the year, which led to inaccuracies in the planned times.
In the course of the dissertation, the current principles of preparation of the production plan were reviewed and possible changes were optimized to optimize the treatment. The analysis showed that the implementation of the new planning principles created during the dissertation and the concentration of allergens in the ten-week production plan reduced the number of cleanings due to product changes by approximately 20%. In addition, the author compiled a table of matching mixtures for the elimination of cleaning, as a result of which it is not necessary to perform regular cleaning during product foaming, but the next operation can be started immediately. Based on last year's production plan, the implementation of this table would have saved 25 dry cleanings.
Lean principles attach importance to the uninterrupted flow of processes. To this end, a mapping study was conducted during the dissertation in order to identify the tasks performed in the process and to analyze the possibilities of reducing the time required for them. The analysis of the time of the process revealed that the workloads are unequally distributed between the device and the employee, which in turn affects the utilization rate of the machine. There are also repetitive activities during the working day that hinder the smooth production process and the efficient use of working time. As a possible solution, the author proposed to perform parallel operations through a new division of labor system, which results in faster cycle time, increased machine operating time, and production volume in one shift
A INTERCOMPREENSÃO ENTRE LÍNGUAS ROMÂNICAS: UMA FERRAMENTA PARAS AS TROCAS INTERCULTURAIS NO CURSO DE LEA-NI/UFPB
No full textConsidering the current globalized and intercultural scenario, and also the significant migration
flow in the world (IOM, 2022), intercultural exchanges derived from contact with foreign
languages are important tools for social development, enabling connections between people
from different countries and cultures. Based on this principle, Miranda-Paulo (2018) points out
that the close relationships between different languages and cultures represent an excellent
source of sociocultural and linguistic knowledge, and this is precisely the aim of plural teaching
approaches. In this research we highlight the approach of romance language
intercomprehension, which is present in various contexts, providing its practitioners with
linguistic and intercultural improvement through contact with foreign languages. From this
perspective, the aim of this paper is to identify the benefits of using the approach of
intercomprehension between romance languages as a tool to facilitate intercultural exchanges,
with an emphasis on its dissemination in the LEA-NI course at UFPB, given that this is a
multidisciplinary course that aims to train plurilingual and pluricultural professionals. This
exploratory and autoethnographic (Santos, 2017) study reviews the literature of prominent
researchers in this field — including Dautzenberg (2016), Escudé and Calvo del Olmo (2019)
and Meissner (2016). The discussions developed in this paper converge in a three-dimensional
analysis of extracts from the interaction of the participant, a student on the LEA-NI course at
UFPB, who is also the author of this research, in the Romanofonia and Cinema 6 project. It is
therefore believed that the use of this approach between the students and teachers of the
bachelor's degree in question strongly contributes to improving the communicative and social
skills necessary for the LEA-NI professional.Considerando el actual escenario globalizado e intercultural, así como el importante flujo
migratorio en el mundo (OIM, 2022), los intercambios interculturales derivados del contacto
con lenguas extranjeras constituyen importantes herramientas para el desarrollo social,
permitiendo establecer conexiones entre personas de diferentes países y culturas. Partiendo de
este princípio, Miranda-Paulo (2018) señala que las estrechas relaciones entre diferentes
lenguas y culturas representan una excelente fuente de conocimiento sociocultural y lingüístico,
y este es precisamente el objetivo de los enfoques didácticos plurales. En este trabajo,
destacamos el enfoque de intercomprensión de las lenguas románicas, presente en diversos
contextos, que proporciona a sus practicantes un perfeccionamiento lingüístico e intercultural a
través del contacto con lenguas extranjeras. Es desde esta perspectiva que este trabajo tiene
como objetivo identificar los beneficios del uso del enfoque de la intercomprensión entre
lenguas románicas como herramienta facilitadora de los intercambios interculturales, con
énfasis en su difusión en el curso LEA-NI de la UFPB, puesto que se trata de una carrera
multidisciplinar dirigida a la formación de profesionales plurilingües y pluriculturales. De
carácter exploratorio y autoetnográfico (Santos, 2017), esta investigación revisa la literatura de
trabajos de investigadores destacados en este campo — entre ellos Dautzenberg (2016), Escudé
y Calvo del Olmo (2019) y Meissner (2016). Las discusiones desarrolladas convergen en un
análisis tridimensional de extractos de interacción de la participante, una estudiante del curso
LEA-NI de la UFPB, que también es autora de esta investigación, en el proyecto Romanofonia
y Cinema 6. Por lo tanto, se evidencia que el uso de este enfoque entre los estudiantes y
profesores de la carrera en cuestión puede contribuir en gran medida a mejorar las competencias
comunicativas y sociales necesarias para el profesional LEA-NI.Face au scénario mondialisé et interculturel, ainsi qu'au flux migratoire significatif dans le
monde (OIM, 2022), les échanges interculturels dérivés du contact avec les langues étrangères
constituent des outils importants pour le développement social, en permettant d'établir des liens
entre des personnes de pays et de cultures différentes. D’après cet avis, Miranda-Paulo (2018)
souligne que les relations étroites entre les différentes langues et cultures représentent une
excellente source de connaissances socioculturelles et linguistiques et c'est précisément
l'objectif des approches pédagogiques plurielles. Dans ce travail, nous mettons l'accent sur
l'approche de l'intercompréhension des langues romanes, qui est présente dans une variété de
contextes, fournissant à ses praticiens une amélioration linguistique et interculturelle à travers
le contact avec les langues étrangères. C'est dans cette perspective que cet article vise à
identifier les avantages de l'utilisation de l'approche de l'intercompréhension entre langues
romanes comme outil pour faciliter les échanges interculturels, en mettant l'accent sur sa
diffusion dans le cours LEA-NI à l'UFPB, puisqu'il s'agit d'un cours multidisciplinaire visant à
former des professionnels plurilingues et pluriculturels. De caractère exploratoire et auto
ethnographique (Santos, 2017), cette recherche fait une revue de la littérature des travaux des
éminents chercheurs dans ce domaine - comprenant Dautzenberg (2016), Escudé et Calvo del
Olmo (2019) et Meissner (2016). Les discussions développées convergent vers une analyse
tridimensionnelle d'extraits de l'interaction de la participante, une étudiante du cours LEA-NI à
l'UFPB, qui est également l'auteure de cette recherche, dans le projet Roumanophone et Cinéma
6. Nous considérons donc que l'utilisation de cette approche par les étudiants et les enseignants
de la licence en question, contribue grandement à l'amélioration des compétences
communicatives et sociales dont a besoin le professionnel LEA-NI.Considerando o atual cenário globalizado e intercultural e, ainda, o significativo fluxo
migratório no mundo (OIM, 2022), as trocas interculturais derivadas do contato com línguas
estrangeiras configuram-se como importantes ferramentas de desenvolvimento social, que
possibilitam o estabelecimento de conexões entre pessoas de diferentes países e culturas.
Partindo desse princípio, Miranda-Paulo (2018) aponta que as estreitas relações entre diferentes
línguas e culturas representam uma excelente fonte de obtenção de conhecimentos
socioculturais e linguísticos, e é justamente esse o objetivo das abordagens plurais de ensino.
Neste trabalho damos destaque à abordagem da Intercompreensão de línguas românicas, que
está presente em variados contextos, proporcionando aos seus praticantes o aprimoramento
linguístico e intercultural, por meio do contato com línguas estrangeiras. É nesta perspectiva
que o presente trabalho tem como objetivo identificar os benefícios da utilização da abordagem
de intercompreensão entre línguas românicas como uma ferramenta facilitadora de trocas
interculturais, com ênfase em sua difusão no curso LEA-NI, na UFPB, tendo em vista que este
se configura como um curso multidisciplinar, que se destina à formação de profissionais
plurilíngues e pluriculturais. De caráter exploratório e autoetnográfico (Santos, 2017), esta
pesquisa faz uma revisão de literatura de obras de pesquisadores de destaque nessa área — entre
eles Dautzenberg (2016), Escudé e Calvo del Olmo (2019) e Meissner (2016). As discussões
desenvolvidas convergem em uma análise tridimensional acerca de extratos de interação da
participante, uma aluna do curso LEA-NI da UFPB, que também é autora desta pesquisa, no
projeto Romanofonia e Cinema 6. Acredita-se, portanto, que a utilização desta abordagem entre
os discentes e docentes do bacharelado em questão contribui fortemente para o aprimoramento
de competências comunicativas e sociais necessárias para o profissional LEA-NI
“Leo from the Lea Street”. Leon Płoszewski – the editor of Wyspiański and Mickiewicz
No full textThe article is a reminiscence on Professor Leon Płoszewski (1890–1970) – the editor of the National Edition of Works of Adam Mickiewicz and the editor of Collected Works of Stanisław Wyspiański – written by his daughter, Maria Płoszewska-Paulsson. The author portrays her father as a man of a Benedictine diligence (in “Spartan” conditions of a one-room editorial office!) and she brings up the less-known side of Professor Płoszewski’s outstanding professional work and the so far untold events in the Płoszewski family’s life, depicting him as:the husband of the ever busy “working woman” who tried in vain to slow down his professional overzealousness; • a parodist who privately mocked the realities of the then Polish People’s Republic; • a collector of the stylistic incongruities and blatant lies printed in the Polish press of the time; • an author of occasional witty poetry, hilarious commentaries, pastiches and dedications; • a gregarious man, a brilliant conversationalist, etc. The Tatra Mountains played a very important role in Leon Ploszewski’s life. Despite closing the Polish-Czechoslovak border after WWII, the Tatras were his refuge for freedom and a regenerating retreat. Leon Płoszewski was a person enamoured of the Western culture (particularly the French one). He felt acutely the isolation of Poland behind the Iron Curtain. It was as late as 1960 when, for the first time after WWII, he was allowed to travel to Paris. In a way it was thanks to Stanisław Wyspiański whose tracks he followed. This journey was for him an enormous emotional experience
Eplerenone versus Observation in the Treatment of Acute Central Serous Chorioretinopathy: A Retrospective Controlled Study
No full textArticle full textThe full text of this article can
be found here. https://link.springer.com/article/10.1007/s40123-018-0121-2Provide enhanced content for this
articleIf you are an author of this
publication and would like to provide additional enhanced content for your
article then please contact [email protected]. The journal offers a range of
additional features designed to increase visibility and readership. All
features will be thoroughly peer reviewed to ensure the content is of the
highest scientific standard and all features are marked as ‘peer reviewed’ to
ensure readers are aware that the content has been reviewed to the same level
as the articles they are being presented alongside. Moreover, all sponsorship
and disclosure information is included to provide complete transparency and
adherence to good publication practices. This ensures that however the content
is reached the reader has a full understanding of its origin. No fees are
charged for hosting additional open access content.Other enhanced features include,
but are not limited to:• Slide decks• Videos and animations• Audio abstracts
• Audio slides</p
A atuação do profissional LEA-NI como mediador Intercultural : relato de experiência do caso dos indígenas Warao na Paraíba
No full textThis study reflects on the contributions of intercultural mediation to the reception of the
Warao indigenous people in Paraíba, based on the author's academic and outreach
experiences. The research starts from the question of how professionals in Foreign Languages
Applied to International Negotiations (LEA-NI) contribute to intercultural mediation and the
defense of the rights of these peoples. The motivation for the study stems from academic and
extension experiences lived by the author with indigenous immigrants, through projects such
as CONTEMP, the Yaotasaba Warao solidarity economy course, and I COMIGRAR PB, all
carried out at the Federal University of Paraíba. The methodology used is qualitative in
nature, exploratory and descriptive, using the textual genre of experience reports, based on
bibliographic references. In addition, the work is guided by the principles of human rights,
based, among other documents, on the United Nations Declaration on the Rights of
Indigenous Peoples (2007). Finally, the study seeks to offer theoretical and practical
contributions to the formulation of fairer and more intercultural reception strategies,
highlighting that care and mediation with indigenous migrants must take into account
linguistic, cultural, and institutional aspects in an integrated manner.Este trabalho reflete sobre as contribuições da mediação intercultural para o acolhimento
dos indígenas Warao na Paraíba, a partir do relato de experiências acadêmicas e
extensionistas vivenciadas pelo autor do presente estudo. A pesquisa parte do
questionamento de como o profissional em Línguas Estrangeiras Aplicadas às
Negociações Internacionais (LEA-NI) contribui para a mediação intercultural e a defesa
dos direitos desses povos. A motivação do estudo nasce de experiências acadêmicas e
extensionistas vivenciadas pelo autor junto a imigrantes indígenas, por meio de projetos
como CONTEMP, o curso de economia solidária Yaotasaba Warao e a I COMIGRAR PB,
todos realizados no âmbito da Universidade Federal da Paraíba. A metodologia utilizada é
de natureza qualitativa, com caráter exploratório e descritivo com a utilização do gênero
textual relato de experiência, embasado em referenciais bibliográficos. Além disso, o
trabalho é orientado pelos princípios dos Direitos Humanos, amparando-se, entre outros
documentos, na Declaração das Nações Unidas sobre os Direitos dos Povos Indígenas
(2007). Por fim, o trabalho busca oferecer contribuições teóricas e práticas para a
formulação de estratégias de acolhimento mais justas e interculturais, evidenciando que o
cuidado e a mediação com migrantes indígenas devem considerar, de forma integrada, os
eixos linguístico, cultural e institucional
Portfolio of recorded performances and exegesis: Messiaen’s musical language for the jazz pianist - an exploration through performance.
No full textMoving beyond Gunther Schuller’s Third Stream amalgamation of classical and jazz, this study explores whether the musical language of Olivier Messiaen can make a valid contribution to jazz piano performance. Initially, my project sought to answer such questions as: What elements of the musical language of Messiaen already exist in the jazz vocabulary? Am I able to extend this further? What are the timbral structures and pianistic effects within Messiaen’s musical language? What will be the most effective application of Messiaen’s musical language to jazz piano performance? Endeavouring to answer the final question led me to consider such aspects as whether the project should be limited to quoting Messiaen motifs, arranging Messiaen melodies, replacing jazz harmonic structures on standards with examples from Messiaen’s musical language or whether it would be better to approach the research conceptually. The work of Hubert Nuss provided encouraging reassurance that this was not an impossible task. In order to articulate this conception, the initial challenge was to decide how the classical and jazz worlds might meet in a ‘Messiaen’ technique. The approach adopted was similar to that used for undergraduate jazz study, namely, immersion in the piano scores and recordings of Messiaen’s music as well as by live performances. This was followed by the development and assessment of a contrived approach when specific techniques, such as tonal colourings or harmonic structures, were developed through prepared exercises and consciously included in my performance. It was then compared with an intuitive approach when no such precise parameters were established. This submission consists of CD recordings of two public recitals and an exegesis. It documents the development of this Messiaen technique and discusses its application in my performances. It also demonstrates the ways that Messiaen’s musical language can be used within jazz piano performance to provide a colour that distinguishes jazz piano performance in a competitive field.Thesis (M.Mus.) -- University of Adelaide, Elder Conservatorium of Music, 201
Building activity pressure ob valuable landscapes in Otepää Nature Park and Otepää parish
No full textMagistritöö Loodusturismi õppekavalTöö eesmärgiks on hinnata Otepää vallas ja põhiliselt Otepää looduspargis ehitustegevuse
survet väärtuslikele maastikele, selgitada asjaolud ja aspektid, mis on määranud inimeste
kodukohavaliku motiivid Otepää vallas ja Otepää looduspargis ning kui suur roll on selles
kaitsealal. Selleks koostas autor andmebaasi ehituslubade, detailplaneeringute ja muude
taotluste kooskõlastamisest Keskkonnaametiga Otepää looduspargis ning Otepää
Vallavalitsusega väljaspool loodusparki Otepää vallas, kasutades andmeid aastate 2002 –
2015 kohta, kaardistas inimeste poolt nendel aastatel esitatud taotlused ning viis läbi
küsitlust, et selgitada inimeste kodukohavaliku motiive Otepää vallas ja Otepää
looduspargis ning nende suhtumist keskkonnakaitsesse ja kaitsealasse.
Töö teoreetilises osas antakse ülevaade varasemalt läbi viidud ehitustegevuse surve
reguleerimisega ja inimeste suhtumise keskkonnakaitsesse ja kaitsealadesse selgitamisega
seotud uuringutest.
Käesoleva uuringu tulemusi saab rakendada ehitustegevuse surve paremaks
reguleerimiseks ja selle negatiivse mõju vähendamiseks väärtuslikele maastikele.
Tulemustest selgus, et ehitustegevuse surve uuritud alale on märkimisväärne.
Ehitustegevusele piirangute kehtestamisel kaitsealal arvestatakse Otepää looduspargi
maastikulise ilmega, kuid need ei ole väga ranged ja suurem osa taotlusi saab positiivsed otsused.
Küsitlusest selgus, et kodukoha asukoha valikul inimesed peavad oluliseks looduskaunist
keskkonda. Inimeste loodusteadlikkust tuleks suurendada, tehes nendega rohkem
loodushariduslikke töid, mis aitaks vältida Keskkonnaameti ja elanike vahelisi probleeme
ja arusaamatusi. Selline tegevus aitaks kaasa säästvale arengule Otepää looduspargis.
Selleks, et osata paremini planeerida Otepää looduspargi edasist kaitsetegevust on oluline
läbi viia uuring, et täpsustada, kuidas püstitatud ehitised mõjuvad maastike esteetilisele
väärtusele ning teha ka prognoose tulevikuks, ennustamaks milline olukord seoses
ehitustegevusega võib tekkida aastate pärast. Oleks kasulik ka edaspidi täiendada töös
koostatud andmebaasi, selleks et näha toimuvaid muutusi edaspidigi.The purpose of this thesis is to evaluate the pressure of building activity on the valuable
landscapes in the parish of Otepää and mainly in Otepää Nature Park; to find out the
circumstances and aspects that have determined people's choice to move to the parish of
Otepää and Otepää Nature Park and if those choices have been affected by the nature
preservation area.
In order to do that, the author compiled a database and made mapping of the building
permits, part plans and other applications accorded with the Environmental Board in
Otepää Nature Park and the parish of Otepää outside the nature park, using data from 2002
- 2015. Author carried out a questionnaire to find out the circumstances and aspects that
have determined people's choice to move to the parish of Otepää and Otepää Nature Park
and their attitude towards the nature preservation area and nature preservation in general.
The results of this study can be applied for better regulation of the pressure of building
activity and to minimize its effects on the valuable landscapes.
The results showed that the pressure of building activity in the studied area is remarkable.
Applying building restrictions in Otepää Nature Park landscape look is taken into account.
However, those restrictions are not very strict, and most of the applications get a green light.
The results of the questionnaire showed that the most important aspect for people choosing
to move to Otepää is the naturally beautiful environment. However, people need to be
better educated in terms of nature. That would help to avoid the problems between
parishioners and the Environmental Board and grant further sustainable development in the
Otepää Nature Park.
In order to plan further protection activity in a better way, it is important to carry out a
study that would help to specify how new buildings affect the esthetic value of the
landscapes, and to forecast the changes that the building activity may cause to the
environment. It would be useful to further compliment the database that was assembled in
this study, so it would be possible to see the changes taking place
Entosphenus tridentatus
No full textEntosphenus tridentatus (Richardson, 1837). Pacific Lamprey. To 85 cm (33.5 in) TL (Orlov et al. 2008b). Honshu (Orlov et al. 2008b), and Hokkaido, Japan (Nakabo in Nakabo 2002); eastern Chukchi Sea (Mecklenburg et al. 2002), and Bering Sea to Punta Canoas, northern Baja California (Miller and Lea 1972), and likely to Isla Clarión, and Islas Revillagigedo, Mexico (Renaud 2008). Southernmost freshwater occurrence is currently in the Big Sur River, central California (Reid and Goodman 2016). Depth: at sea, near surface to 1,508 m (4,946 ft) (min.: Eschmeyer and Herald 1983; max.: Hoff and Britt 2003). Anadromous, may be found at sea, often far offshore, any time of the year. Previously as Lampetra tridentata (Richardson, 1836). The author of the species description is sometimes given as Gairdner, or Gairdner in Richardson, but authorship evidently is correct as Richardson, or Richardson (ex Gairdner) (Eschmeyer 1998 and online edition 8 November 2004).Published as part of Love, Milton S., Bizzarro, Joseph J., Cornthwaite, Maria, Frable, Benjamin W. & Maslenikov, Katherine P., 2021, Checklist of marine and estuarine fishes from the Alaska-Yukon Border, Beaufort Sea, to Cabo San Lucas, Mexico, pp. 1-285 in Zootaxa 5053 (1) on page 12, DOI: 10.11646/zootaxa.5053.1.1, http://zenodo.org/record/557800
- …
