2,123 research outputs found
Comparison of Serum Dkk1 (Dickkopf-1) and bone mineral density in patients on bisphosphonate treatment versus no treatment
No full textComplex pathways affect bone metabolism at the cellular level, and a balance between osteoblast and osteoclast activity is critical to bone remodeling. One of the major pathways affecting bone metabolism is Wnt/?-catenin signaling, and its disturbances lead to a wide range of bone abnormalities. An important antagonist of this pathway is Dickkopf-1 (Dkk1). Higher Dkk1 levels have been associated with increased bone loss due to inhibition of Wnt pathway. Currently, bisphosphonates are the most commonly used agents to treat primary osteoporotic patients. This study demonstrates the effect of bisphosphonates on Dkk1 levels and its correlation with bone mineral density (BMD). Eighty patients with low BMD were recruited and divided into 2 groups of 40 each (bisphosphonate treatment group and control group). The mean Dkk1 level in the treatment group was significantly reduced to 2358.18 vs 3749.80pg/mL in the control group (p<0.001). Pearson correlation coefficient showed negative correlation between Dkk1 and BMD at lumbar spine (r=?0.55) and femoral neck in the control group; however, no such correlation was found in the treatment group (r=?0.05). Hence, bisphosphonate therapy leads to reduction in Dkk1 levels, but it does not correlate with BMD in such patients.<br/
Easter Morning: A.R. Ammons and His Poem Video Recording
No full textAudio recording of a poem entitled, "Easter Morning", recited by the poem's author, A.R. Ammons
A.R Baswedan dan PAl: Potret Nasionalisme Warga Keturunan perspektif sosiopolitik historis
No full textIn this article, the authors review about A.R. Baswedan
and his movement through the Arab Party of Indonesia (PAl).
A.R Baswedan is an Arab descendant known as the pioneer
of independence of the Republic of Indonesia. The author
through historical socio-political studies found that A.R
Baswedan is an example of Arabic descent who counter
Arabism and views between the Arab descendants and the
descendants of indigenous Indonesians are the same or
equal and the same fate. They both have one nationality,
Indonesia. This fusion attitude in the Indonesian citizenship
and nationality equation is evident in its movement within
the PAl.
Keywords: A.R. Baswedan, Biography, and Thought
(PAl
A.R. Luria: Ideas and Prospects of Their Development in Pedagogical Psychology of the Twenty-first Century
No full textA.R. Luria’s ideas are well-known and recognized both in Russia and abroad. Scientists from different countries are actively working in neuropsychology, a part of the psychological science developed by A.R. Luria. The author has shown the relevance and importance of the neuropsychological approach to the pedagogical psychology problems and the availability to choose an adequate educational and nurturing strategy from these standpoints. The study seeks to rethink and assess the importance of A.R. Luria’s main ideas from the modern pedagogical psychology’s standpoints. The characteristic of the main theoretical provisions has been set forth based on the analysis of A.R. Luria’s academic papers and the main directions and prospects for the development of A.R. Luria’s ideas in the modern psychological pedagogical science have been determined. A.R. Luria’s academic papers most sought by the modern researchers have been noted. The study is based on the materials of the thesis researches on the pedagogical psychology problems conducted in the beginning of the twenty-first century, A.R. Luria’s papers, the publications of other researchers who have studied his contribution to the psychological science. The study results show that A.R. Luria has significantly contributed to the development of the pedagogical psychology problems. A.R. Luria’s ideas on the interaction of the humanitarian and science knowledge in the human comprehensive study, the cultural and historical understanding of the psychical functions development, and the language evolution in the music language study for the musical education development seem most promising for the pedagogical psychology development. Note has been taken of the importance of A.R. Luria’s ideas for the elaboration of the relevant problems of the training and development of a person at any age; the study of individual and typical features in mastering a foreign language; the study of the semantics of speech and means of coding meanings in the context of professional training of psychologists and teachers, specialists in the field of artistic creativity. The analysis of A.R. Luria’s main ideas facilitates the deeper understanding of the modern problems of the pedagogical psychology theory and practice
Incorporation of acceleration effects into the one-dimensional-turbulence model, with application to turbulent combustion and shock-turbulence interactions
No full textOne-dimensional turbulence (ODT) is a stochastic simulation in which 3D turbulence effects are captured on a notional 1D line of sight by introducing instantaneous spatial re-arrangements (maps) that represent advection by notional turbulent eddies. These eddy events incorporate the possibility of kinetic-energy changes that are equal and opposite to changes of other forms of energy such as the gravitational potential energy change due to a re-arrangement of a vertical density profile. This illustrates that motion aligned with an applied force, in this case gravitation , can be associated with energy change. Using this principle, we 1) present a model of turbulence interaction with the dilatational acceleration caused by thermal expansion in flames and show results for a turbulent counterflow flame with comparison to DNS and 2) present a model for shock-induced turbulence and show results for mixing width growth in a shock tube with comparison to experiments
ODTLES: A multi-scale ansatz for highly turbulent flows
No full textWe use ODTLES, a multi-dimensional extension of the One-Dimensional-Turbulence model (ODT). ODT describes turbulent advection on a 1D sub-domain using a stochastic process for turbulent advection. These 1D sub-domains are coupled to obtain a 3D approach. ODTLES is applied to channel flow. Preliminary results for the pdf of the wall shear stress are compared to DNS
Author Correction: Imaging-based representation and stratification of intra-tumor heterogeneity via tree-edit distance
No full textMartina Sollini and Paola Anna Erba were omitted from the author list in the original version of this Article. The Author Contributions section now reads: “L.C. conceived the pipeline, set up the case study, analysed the results, prepared the figures, and wrote the manuscript. M.P. formulated and tuned the pruned tree edit distance, provided the mathematical proofs and the simulation study, and wrote the manuscript. A.R. contributed to implement the patient representation pipeline. M.S. segmented the Prostate Cancer lesions and extracted the radiomic features for all patients in the case study. P.A.E collected the data and enrolled the patients in the clinical study. F.I. supervised the analyses and the conception of the pipeline. L.C., M.P., A.R. and F.I. reviewed and approved the manuscript.” The original Article and accompanying Supplementary Information file have been corrected.</p
The IPHAS catalogue of H alpha emission-line sources in the northern Galactic plane
No full textWe present a catalogue of point-source H alpha emission-line objects selected from the INT/WFC Photometric Ha Survey (IPHAS) of the northern Galactic plane. The catalogue covers the magnitude range 13 <= r' <= 19.5 and includes Northern hemisphere sources in the Galactic latitude range -5 degrees < b < 5 degrees. It is derived from similar to 1500 deg(2) worth of imaging data, which represents 80 per cent of the final IPHAS survey area. The electronic version of the catalogue will be updated once the full survey data become available. In total, the present catalogue contains 4853 point sources that exhibit strong photometric evidence for Ha emission. We have so far analysed spectra for similar to 300 of these sources, confirming more than 95 per cent of them as genuine emission-line stars. A wide range of stellar populations are represented in the catalogue, including early-type emission-line stars, active late-type stars, interacting binaries, young stellar objects and compact nebulae.
The spatial distribution of catalogue objects shows overdensities near sites of recent or current star formation, as well as possible evidence for the warp of the Galactic plane. Photometrically, the incidence of Ha emission is bimodally distributed in (r' - i'). The blue peak is made up mostly of early-type emission-line stars, whereas the red peak may signal an increasing contribution from other objects, such as young/active low-mass stars. We have cross-matched our H alpha-excess catalogue against the emission-line star catalogue of Kohoutek & Wehmeyer, as well as against sources in SIMBAD. We find that fewer than 10 per cent of our sources can be matched to known objects of any type. Thus IPHAS is uncovering an order of magnitude more faint (r' > 13) emission-line objects than were previously known in the Milky Way
Hybrid simulation for health and social care: the way forward, or more trouble than it’s worth?
No full textBook Review: Anthony Fontenot, Non-Design: Architecture, Liberalism, and the Market. Chicago: University of Chicago Press, 2021 and Matthew Soules, Icebergs, Zombies, and the Ultra Thin: Architecture and Capitalism in the Twenty-First Century. New York: Princeton Architectural Press, 2021.
No full textGreen Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care. Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Situated Architectur
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