5,603 research outputs found
sj-pdf-1-smm-10.1177_09622802211048030 - Supplemental material for A class of two-sample nonparametric statistics for binary and time-to-event outcomes
No full textSupplemental material, sj-pdf-1-smm-10.1177_09622802211048030 for A class of two-sample nonparametric statistics for binary and time-to-event outcomes by Marta Bofill Roig and Guadalupe Gómez Melis in Statistical Methods in Medical Research</p
6-n-propylthiouracil taste disruption and TAS2R38 nontasting form in Parkinson's disease
No full textBackground: The few studies that evaluated taste function in Parkinson's disease (PD) showed inconsistent results. The inherited ability to taste the bitter compound of 6-n-propylthiouracil has been considered to be a paradigm of general taste perception. 6-n-propylthiouracil taste perception is mediated by the TAS2R38 receptor, and reduced 6-n-propylthiouracil sensitivity has been associated with several diseases not typically related to taste function. Objectives: We evaluated the 6-n-propylthiouracil taste perception and the TAS2R38 gene as genetic risk factors for the development of idiopathic PD in PD patients and healthy controls (HC). Methods: The 6-n-propylthiouracil taste perception was assessed by testing the responsiveness, and the ability to recognize, 6-n-propylthiouracil and sodium chloride. The participants were classified for 6-n-propylthiouracil taster status and genotyped for the TAS2R38 gene. Results: A significant increase in the frequency of participants classified as 6-n-propylthiouracil nontasters and a reduced ability to recognize bitter taste quality of 6-n-propylthiouracil were found in PD patients when compared with healthy controls. The results also showed that only 5% of PD patients had the homozygous genotype for the dominant tasting variant of TAS2R38, whereas most of them carried the recessive nontaster form and a high number had a rare variant. Conclusions: Our results show that 6-n-propylthiouracil taster status and TAS2R38 locus are associated with PD. The 6-n-propylthiouracil test may therefore represent a novel, simple way to identify increased vulnerability to PD. Moreover, the presence of the nontasting form of TAS2R38 in PD may further substantiate that disease-associated taste disruption may represent a risk factor associated with the disease. © 2018 International Parkinson and Movement Disorder Society
The genetic structure of populations of Isthmiophora melis (Schrank, 1788) (Digenea: Echinostomatidae). Does the host’s diet matter?
No full textAbstract Background Here we provide a comparative analysis of the genetic structure of populations (based on nad1 mtDNA) of Isthmiophora melis isolated from the American mink (Neogale vison), an introduced invasive species, commonly occurring in the territory of Poland, and from the striped field mouse (Apodemus agrarius). Methods A total of 133 specimens of I. melis were obtained from naturally infected N. vison collected from six localities in Poland (108 samples) and 25 individuals of I. melis from A. agrarius. All sequences of the nad1 gene obtained during the present study were assembled and aligned. The standard statistics for haplotype composition, i.e., the number of haplotypes, haplotype diversity, nucleotide diversity, and average number of nucleotide differences, were calculated. Haplotype analysis and visualization of haplotype frequency among populations were performed using a median-joining network. Results Based on the samples collected from different localities in Poland, our study revealed that the overall genetic diversity of I. melis isolated from the American mink and of the striped field mouse do not differ significantly. The median-joining network showed that the three main haplotypes are in the centre of a star-like structure, with the remaining haplotypes as the satellites, reflecting the recent expansion of the populations. Conclusions The overall genetic diversity of I. melis isolated from the American mink and striped field mouse reveals a high level of homogeneity. Moreover, regional differences in the food composition of the definitive hosts play an important role in shaping the genetic structure of the trematode populations. Graphical Abstrac
Stages for the More Sustainable Farm
No full textCurrently, agricultural farm units are faced with a double and most times contradictory challenge, in order to be successful: on the one hand the invested capital has to be profitable and the economic performance has to be maximised. On the other hand, given the socio-environmental situation, it is necessary to preserve and to protect the environment and natural resources. Given the potential conflict of the two aims, since the satisfaction of one implies the underperformance of the other (and vice versa), the question then is: which is the solution to choose? We intend, in this work, to formulate a farm plan with the purpose of reconciling the criteria of environmental sustainability with that of economic competitiveness. For this achievement we proceed to the comparative study of sustainability of different groups of farms identified in the study area (first evaluation cycle) through MESMIS (“Marco para la Evaluación de Sistemas de Manejo de Recursos Naturales Mediante Indicadores de Sustentabilidad” - Framework for Evaluation of Natural-Resource Systems Handling through Sustainability Indicators) methodology, that allowed to select the more sustainable group of farms. Based on the found potentialities and weakness on these production systems, we stepped to the planning of a production unit of bovine meat, which obeys simultaneously to economic and environmental objectives, using Multicriteria Decision. We finished the work with the sustainability evaluation between groups of farms identified previously and the planned farms (second evaluation cycle), based, again, in the MESMIS methodology, to confirm (or not) the greatest sustainability of the last ones. Analyses of the results allow us to confirm the greatest relative sustainability of the planned farm, for the diverse traced scenarios.Decision taking, planning, sustainability, Environmental Economics and Policy, Farm Management,
Static and thermal FE analysis of a Flexible Electronic BOard (FEBO) prototype and the characterization of its innovative materials
No full textAn FE model of an experimental flexible electronic board was built to determine its performance in terms of mechanical and thermal distortions, heat and transient thermal flow, thereby detecting critical issues and identifying opportunities for improvement. Commercial sensors were connected to the flexible board (100x40x2mm), which was based on a commercial thermoplastic polyurethane (TPU), with a PEDOT-based conductive resin trapped in a PEGDA network, a biocompatible polymer. Three thermal loads (ΔT=175°C, ΔT=100°C, ΔT=50°C) were applied which revealed critical stresses for high ΔTs but at ΔT=50°C only the connectors had a critical σvm, while for ΔT=50°C + 1mm displacement a critical strain value occurred in one area of the substrate. Heat transient analysis and overheating simulations were performed to determine the heat flow behavior for the photodiode and accelerometer. FE analyses allow more studies to be undertaken to improve material properties and suggest redesign activities for similar concept demonstrators. The funds of the European Union and the Piedmont Region, and agreements with the most important players in SBE (Simulation Based Engineering) software sales and services, allowed the authors (ITACAe srl, Proplast, and Politecnico di Torino) to conduct industrial research and experimental development together with manufacturers and users of innovative technologies to identify, study and optimize the design parameters of the board while simultaneously contributing to its technological development
Parole d'artiste : Marta Cuscunà
No full textInternational audienceModeration of the interview with Marta Cuscunà, an Italian performer, director, puppeteer and author. In 2009, she was awarded the Premio Scenario per Ustica for E bello vivere liberi!, first show of a trilogy on female resistance, followed by La semplicità ingannata (2012) and Sorry, boys (2015). These three texts are published in Resistenze femminili (Udine: Forum, 2019). In 2018 she created Il canto della caduta. Earthbound (2021) is her last devised show, which brings in the themes of ecofeminism, taking cues from the theories of Donna Haraway and Bruno Latour. In 2021 she became associate artist at the Piccolo Teatro in Milan. In 2023, she is guest of honor at the 11th Biennale internationale des arts de la marionette in Paris. She was awarded the prizes Rete Critica (2017), Premio della Critica – ANCT (2018) and Premio Hystrio - Altre Muse (2019).Animation de la discussion avec Marta Cuscunà, performeuse, metteuse en scène, marionnettiste et autrice italienne. En 2009, elle a remporté le prix Premio Scenario per Ustica pour È bello vivere liberi !, premier spectacle d’une trilogie sur les résistances féminines, suivi par La semplicità ingannata (2012) et Sorry, boys (2015). Ces trois textes ont été réunis dans Resistenze femminili (Udine : Forum, 2019). En 2018, elle a créé Il canto della caduta. Son dernier spectacle, Earthbound (2021), traite de l’écoféminisme en s’inspirant des théories de Donna Haraway et de Bruno Latour. En 2021, elle devient artiste associée au Piccolo Teatro de Milan. En 2023, elle est invitée d’honneur à la Biennale Internationale des Arts de la Marionnette à Paris. Elle a obtenu les prix Premio Rete Critica (2017), Premio della Critica – ANCT (2018) et Premio Hystrio - Altre Muse (2019)
Proposal for the optional subject Business Protocol in the career Bachelor in Education Economy.
No full textLa presente investigación educativa está encaminada al mejoramiento cualitativo en las normas de cortesía y protocolo en las distintas actividades sociales de los estudiantes y profesores de la Facultad de Ciencias Económicas de la Universidad Central “Marta Abreu” de Las Villas y de la eficiencia en aspectos particulares, para afianzar la buena imagen constituye, para el autor del estudio, el punto de partida para crear la línea de investigación en la carrera de Licenciatura en Educación Economía y el Grupo de Trabajo Científico Estudiantil Protocolo Empresarial, con la participación de los estudiantes del tercer año y profesores de la carrera de Licenciatura en Educación Economía; las temáticas a desarrollar responden a las investigaciones del profesor líder Ms.C. José Miguel Garcia Aguiar; que se integra al Proyecto Asociado a Programa; Sistema de Educación Cubano Perspectiva en Desarrollo, que dirige desde CITMA el DrC. Poul Torres; siendo miembro activo en el proyecto “La Educación Ciudadana y la Educación Cívica en la Escuela Cubana Actual que dirige DrC. J. Gardenia Ruiz Rodríguez. Profesora Titular que imparte la docencia en la carrera de Marxismo –Leninismo e Historia en la Sede Pedagógica “Félix Varela”. La novedad científica de la investigación radica en la concepción pedagógica del programa de la asignatura optativa Protocolo Empresarial, el cual incluye de forma holística diferentes momentos de reflexión individual y colectiva, para la investigación, aplicación y creación, al modelar las normas de cortesía y protocolo, en el área laboral y el personal en el contexto de la esfera empresarial.The present educational research is aimed at qualitative improvement in the rules of courtesy and protocol in the different social activities of the students and professors of the Faculty of Economics of the Central University "Marta Abreu" of Las Villas and the efficiency in particular aspects , To consolidate the good image constitutes, for the author of the study, the starting point to create the line of research in the career of Bachelor of Education Economics and the Working Group Scientific Student Business Protocol, with the participation of students of the third Year and professors of the Bachelor of Education in Economics; The topics to be developed respond to the research of the leading teacher Ms.C. José Miguel Garcia Aguiar; Which is part of the Program Associated Project; Cuban Education System Perspective in Development, directed by CITMA DrC. Poul Torres; Being an active member in the project "Citizen Education and Civic Education in the Current Cuban School directed by DrC. J. Gardenia Ruiz Rodríguez. Full Professor who teaches in the career of Marxism - Leninism and History in the Pedagogical Headquarters "Felix Varela". The scientific novelty of the research lies in the pedagogical conception of the program of the optional Business Protocol, which holistically includes different moments of individual and collective reflection for research, application and creation, in modeling the rules of courtesy and protocol, In the area of labor and personnel in the context of the business sphere.
Palabras claves: Etiqueta; Protocolo; Diplomacia; Protocolo empresarial;
Protocolo como individuo; Protocolo con el cliente
Recursos tic para la promoción de salud mental positiva a estudiantes universitarios en tiempos de coronavirus
No full textEl presente proyecto tuvo como objetivo generar recursos audiovisuales basados en TIC para promover bienestar y salud mental positiva en estudiantes universitarios en tiempos de pandemia. Se creó una Estrategia de comunicación del conocimiento que consistió en generar recursos audiovisuales basados en TIC para promover bienestar y salud mental positiva en estudiantes universitarios en tiempos de pandemia, vinculada al proyecto INV 2371 ESTUDIO DE LAS PROPIEDADES PSICOMÉTRICAS DE LAS ESCALAS DE BIENESTAR DE DIENER EN POBLACIÓN COLOMBIANA cuya autora principal es la Dra. Marta Martín. Los tipos de recursos audiovisuales generados fueron infografías, podCaps, videos, y poster, en total fueron 10 recursos, con un resultado en general de 423 vistas, 240 like y 10 opiniones. Por los resultados de la encuesta de opinión se concluyó que las tic juegan un papel fundamental en la promoción de salud mental, puesto que la mayoría de los estudiantes encuestados les pareció bueno el material expuesto.The objective of this project was to generate audiovisual resources based on ICT to promote well-being and positive mental health in university students in times of pandemic. A Knowledge Communication Strategy was created that consisted of generating ICT-based audiovisual resources to promote well-being and positive mental health in university students in times of pandemic, linked to the INV 2371 project STUDY OF THE PSYCHOMETRIC PROPERTIES OF THE WELL-BEING SCALES OF DIENER IN COLOMBIAN POPULATION whose main author is Dr. Marta Martín. The types of audiovisual resources generated were infographics, podCaps, videos, and posters, in total there were 10 resources, with an overall result of 423 views, 240 likes and 10 opinions. Based on the results of the opinion survey, it was concluded that ict plays a fundamental role in promoting mental health, since most of the students surveyed found the exposed material to be good.Resumen. -- Abstrac. -- 1 Justificación. -- 2 Objetivo general. -- 3 Marco conceptual. -- 4 Estado del arte. -- 5 Metodología. -- 6 Resultados. -- 7 Análisis. -- 8 Resultados de la encuesta de opinión. -- 9 Conclusión. -- 10 Recomendaciones. -- 11 [email protected]
Parkinsonism and dementia are negative prognostic factors for the outcome of subdural hematoma
No full textTo determine, among a population with subdural hematoma (SH), whether patients affected by neurodegenerative disorders (parkinsonism and dementia) have a worse clinical outcome. We reviewed the data of patients diagnosed with fall-related SH discharged from the Departments of Neurology/Stroke unit, Neurosurgery, Intensive Care Unit at Brotzu General Hospital (Cagliari, Italy) between January 2010 and December 2013. Patients with severe traumatisms, evidence of spontaneous intracerebral bleeding or aged less than 50 were excluded. 332 patients were selected: 69 with a neurodegenerative parkinsonism or dementia (N-group), 217 with history of chronic non-neurological medical conditions with significant disability, previous falls and/or balance problems (NND-group) and 46 with a history of "minor" chronic non-neurological disorder. (NN-group). The clinical status at admission and discharge was assessed by modified Rankin Scale (mRS). The time-span between trauma and hospital admission was also calculated. At hospital admission we found a significantly longer delay in SH's diagnosis (χ (2) test p < 0.001) and a worse mRS score (Kruskal Wallis p < 0.001) in the N-group compared to both NN and NND-groups. During hospital stay we observed the lack of significant variation in mRS score in N-group (Wilcoxon test p = 0.86), in contrast with NN and NND-groups who significantly improved (Wilcoxon test p < 0.001). Our results demonstrate that the consequences of SH are more severe in the N-group compared to NN and NND-groups. The longer interval between trauma and hospital admittance plays a critical role in worsening the outcome of patients with parkinsonism and dementia compared to subjects without neurodegenerative disorder
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