188,279 research outputs found
Estudo das reações do acido de meldrum a bases de Schiff aromaticas
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciencias Fisicas e MatematicasOs compostos imínicos possuem reatividade semelhante a dos compostos carbonílicos, ambos apresentam ligações heteropolares insaturadas. No entanto, comparando-se os sistemas carbonílicos com os iminicos, observa-se que existem poucos estudos sobre a reatividade dos compostos iminicos. Investigou-se no presente trabalho reações de adição de um composto apresentando um grupo metilênico ativo a Bases de Schiff. O composto com metilênico ativo utilizado foi o ácido de Meldrum, que se destaca pela sua versatilidade em síntese orgânica. Foram preparadas Bases de Schiff aromáticas substituídas nas partes benzal e anilínica da molécula, sendo estes compostos utilizados nas reações de adição envolvendo o ácido de Meldrum. O produto obtido da reação de adição do ácido de Meldrum a N-benzilidenanilina foi submetido a reação de metanólise descarboxilativa. Todos os compostos obtidos foram caracterizados por técnicas espectroscópicas de IV, RMN de l H e quando necessário por análise elementar (CHN)
Síntese de potenciais antagonistas do receptor B1 da bradicinina contendo o heterociclo piridazinona
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2013.Uma série de 4,5-di-hidro-3(2H)-piridazinonas dissubstituídas nas posições 4 e 6 do heterociclo foi preparada com bons rendimentos. A metodologia utilizada na síntese do anel di-hidropiridazinônico foi a de Tóth, na qual empregou-se derivados do ácido de Meldrum e numa sequência de quatro etapas reacionais obteve-se o sistema heterocíclico com sucesso. Os derivados monoalquilados do ácido de Meldrum foram obtidos exclusivamente com bons rendimentos, assim como os derivados dialquilados. Uma modificação na metodologia de síntese dos potenciais antagonistas do receptor B1 foi feita, partindo-se do fenol 9a para introdução de sistemas como fenilacético e p-toluenossulfonila. Diferentes grupos ácidos foram incorporados na posição 4 da estrutura do heterociclo culminando em di-hidropiridazinonas contendo a porção fenoxifenilacético e fenoxifenilmetiltetrazol. A obtenção das piridazinonas dissubstituídas foi alcançada a partir da oxidação dos derivados da 4,5-di-hidro-3(2H)-piridazinona. Os intermediários bem como os produtos finais foram devidamente caracterizados por espectrometria de IV, RMN de 1H e 13C.Abstract : A series of 4,6-dissubstituted-4,5-dihydro-3(2H)-pyridazinones was prepared in good yields. The methodology employed on the synthesis of dihydropyridazinone ring was Tòth´s methodology, which made use of Meldrum´s acid derivates and in a four-step reaction sequence the heterocyclic system was sucessfully obtained. The monoalkylated derivates of Meldrum´s acid were obtained exclusively in good yields as well as the dialkylated derivates. A modification of the method of potencial receptor B1 antagonists synthesis was made, starting from phenol 9a to introduction of systems such as phenylacetic and p-toluenesulphonyl. Different acids groups were incorporated at position 4 of the heterocycle structure culminating in dihydropyridazinones containing the phenoxylphenylacetic group and the phenoxylphenyl group containing tetrazole. The obtation of dissubstituted pyridazinones derivates was achieved by oxidation reaction of 4,5-dihydro-3(2H)-pyridazinones derivates. The intermediates compounds as well as the final products were characterized by IR, 1H and 13C NMR spectroscometry
Thespis. Little maid of Arcadee. Vocal score
No full textExcerpt from the opera Thespis; orchestral accompaniment arranged for piano.Caption title.Cover illustration: head shot of a woman with a scarf encircling her head and neck.Advertisements on p. [4] from Adam, Meldrum & Anderson.Archived web conten
Blair Meldrum honored with emeritus status
No full textDr. Blair Meldrum, professor of biomedical sciences and pathobiology in the Virginia-Maryland Regional College of Veterinary Medicine at Virginia Tech, has been conferred the "professor emeritus" title by the Virginia Tech Board of Visitors.</p
On group d.g. near-rings
No full textMeldrum has generalized the idea of a group ring and has defined a group d.g. near-ring for a faithful d.g. near-ring
(
R
,
S
)
(R,S)
on a multiplicative group
G
G
. In this paper we generalize this idea even further and define a group d.g. near-ring for an arbitrary d.g. near-ring. We also prove some results about the additive group of this d.g. near-ring similar to those proved by Meldrum for a group d.g. near-ring of a faithful d.g. near-ring.</p
"I name this place - um - hmm - er - AHA!!!" [picture] /
No full textPart of the collection: Matilda collection.; Inscriptions: "Whats in a Name" "80% p.64"--In pencil lower right; signed by artist lower right.; Published in: "What's in a name?", Bill McKeown. Matilda. Canberra : Dynwest, no. 9, Dec./Jan. 1985/1986, p. 64.; Condition: Creases, tears and sticky tape upper edge.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn3766562.Matilda (Canberra, A.C.T.
New faces, "Your eyes and face are very visual ... but the rest of you doesn't quite make it for T.V." [picture] /
No full textPart of the collection: Matilda collection.; Inscriptions: "'Molly mouth', Your eyes and face are very visual"--In pencil lower right; signed by artist middle right.; Published in: Molly mouth. Matilda. Canberra : Dynwest, no. 9, Dec./Jan. 1985/1986, p. 6.; Condition: Good.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn3766585.Matilda (Canberra, A.C.T.
Know thine enemy [The show pony, Andrew Peacock as the rear end of a horse] [picture] /
No full textPart of the collection: Matilda collection.; Signed by artist lower right.; Published in: "Aunt Mathilde's nickname quiz". Matilda. Canberra : Dynwest, no. 5, July 1985, p. 44.; Condition: Creases and tear around edges.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn3766682.Matilda (Canberra, A.C.T.
"We're sorry about this, but you shouldn't have been clowning around with it in the first place" [Man with head stuck inside the America's Cup [picture] /
No full textPart of the collection: Matilda collection.; Signed by artist lower right.; Published in: "Making a mint from the holy grail", Andrew Masterson. Matilda. Canberra : Dynwest, no. 4, June 1985, p. 48.; Condition: Creases.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn3766687.Matilda (Canberra, A.C.T.
[Black space] [picture] /
No full textPart of the collection: Matilda collection.; Title from acquisition documentation.; Inscriptions: "Geoff, you might have to think about this one for a moment"--In pencil lower right; signed by artist centre.; Published in: "When it's inevitable, relax and enjoy", John Hepworth. Matilda. Canberra : Dynwest, no. 7, Sept. 1985, p. 46.; Condition: Tears lower right edge.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn3766653.Matilda (Canberra, A.C.T.
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