430 research outputs found
Why the way we consider the body matters – Reflections on four bioethical perspectives on the human body
No full textAbstract Background Within the context of applied bioethical reasoning, various conceptions of the human body are focused upon by the author in relation to normative notions of autonomy. Results The author begins by descriptively exploring some main positions in bioethics from which the "body" is conceptualized. Such positions conflict: the body is that which is constitutive of the individual's experience and perception, or it is conceived of materially or mechanistically; or as a constructed locus, always historically and culturally transformed. The author goes on to suggest a methodological approach that dialectically considers embodiment from four different perspectives: as bodily self-determination, as respect for the bodily unavailability of the other, as care for bodily individuality; and lastly, as acknowledgement of bodily-constituted communities. These four perspectives encompass autonomy in two of its main interpretations: as the capability of a person to act independent of external forces, and as the moral ideal of pursuing individual wishes by means of role distance, self-limitation and universalization. Various bioethical cases are utilized to show how the four perspectives on the body can complement one another. Conclusion The way we consider the body matters. The author's dialectical method allows a premise-critical identification and exploration of bioethical problems concerning the body. The method is potentially applicable to other bioethical problems.</p
Silke Forlag : Building Brand Equtiy for a Publisher
No full textThe purpose of this master thesis is to contribute to the knowledge about increasing
the brand equity for a publisher. More specifically the thesis emphases on the
communication the publisher sends out to consumers, in order to get the consumer to
be aware of the publisher when buying books. Making the consumer notice the
publisher and their values and not only the author or the book itself. Silke Forlag has
been chosen as the publisher to be analyzed for this case.
The theoretical framework for this study mainly focus on brands, brand equity and
brand knowledge. The first part defines and elaborates about brands, brand equity and
brand knowledge. The elements of brand awareness and brand image are also
explained. The second part focuses on how to manage and build brand equity through
different strategies and Keller´s (2008) guidelines for manage consumer based brand
equity and his pyramid is applied.
In order to map out todays situation, a qualitative research has been executed, where
both Silke Forlag and the end consumers have been interviewed. The collected data
have then been analyzed and systemized and viewed in the light of the theory. The
focus has been on what associations the consumers have towards the publisher.
From the findings in this thesis, Silke Forlag have done many things right in terms of
associations and having a unique focus, but the focus have not been strong enough on
the end users. It seems that consumer do not consider what publisher is behind the
book. It is more important for the consumers who have written the book and how it
looks. The research shows that Silke Forlag needs to be more active in marketing
themselves as a brand, in order to create resonance towards the consumers
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Mindfulness Based Stress Reduction Program
No full textThe Founder and President of Ivy Child International, Rose Pavlov and author, Autumn Silke developed and implemented a customized 8-week Mindfulness Based Stress Reduction (MBSR) curriculum to provide techniques and strategies for an inner-city adolescent population to cope with stress. Students and teachers were given pre, mid, and post assessments to evaluate the effectiveness of the program. The results indicate a significant reduction in disciplinary action taken as well as a reduction in stress reported by both students and teachers
Adult and Continuing Education in France
No full text"The English language volume offers a current stock-take of central areas in adult and vocational further education in France. The author Silke Schreiber-Barsch bases her work on various types of data and information. Beginning with historical developments, Schreiber-Barsch covers the topics of political, financial and institutional framework conditions, as well as offer, participation and teaching personnel. In closing, she outlines the current research status in terms of adult education and its role in the third level education system.
The regional portrait offers well founded starting point and good orientation for getting to know the French system for adult and vocational further education.
Adult and continuing education in France
No full textDer englischsprachige Text liefert eine aktuelle Bestandsaufnahme zu den zentralen Bereichen der Erwachsenen- und Weiterbildung in Frankreich. Die Autorin Silke Schreiber-Barsch stützt sich auf vielfältige Daten und Informationen. Beginnend mit der historischen Entwicklung spannt Schreiber-Barsch den Bogen über die politischen, finanziellen und institutionellen Rahmenbedingungen bis zu Angebot, Teilnahme und Lehrpersonal. Abschließend umreißt sie den Forschungsstand zur Erwachsenenbildung und deren Rolle im Hochschulsystem.
Das Länderporträt bietet fundiertes Einstiegswissen und eine gute Orientierung über das System der Erwachsenen- bzw. Weiterbildung in Frankreich.The English language volume offers a current stock-take of central areas in adult and vocational further education in France. The author Silke Schreiber-Barsch bases her work on various types of data and information. Beginning with historical developments, Schreiber-Barsch covers the topics of political, financial and institutional framework conditions, as well as offer, participation and teaching personnel. In closing, she outlines the current research status in terms of adult education and its role in the third level education system.
The regional portrait offers well founded starting point and good orientation for getting to know the French system for adult and vocational further education
Inhibitoren des Ubiquitin-Proteasom Systems als potentielle Therapeutika bei kardiovaskulären Erkrankungen
No full textThe therapeutic potential of proteasome inhibitors as cytostatic drugs was
early realized. However, it is the cytotoxic potential of proteasome
inhibitors that has long hampered their therapeutic application as nontoxic
remedies. Here, we provide evidence that proteasome inhibitors are potential
remedies for the therapy of various cardiovascular diseases. While local and
pronounced inhibition of the proteasome with high doses of proteasome
inhibitors have anti-proliferative, anti-inflammatory and pro-apoptotic
effects on vascular smooth muscle cells and suppress development of restenosis
in rat carotid arteries, nontoxic and partial inhibition of the proteasome
with low inhibitor doses induces a variety of beneficial effects in several
different cardiovascular cell types: • reduced expression of collagen isoforms
and matrixmetalloproteinases in cardiac fibroblasts, which is associated with
suppression of cardiac fibrosis in spontaneous hypertensive rats; • suppressed
hypertrophic growth of cardiomyocytes; • enhanced expression of eNOS versus
downregulation of ET-1 in endothelial cells leading to improved endothelial
function of rat aortic rings; • induction of a conserved stress response with
upregulation of hsp70 and several anti-oxidative enzymes in cardiomyocytes and
endothelial cells which is associated with protection from thermal and
oxidative stress. Our data confirm the concept that proteasome inhibitors are
able to act as poisons which induce cell death but also as remedies which
modulate cellular function and protect from cell death. To reconcile these
divergent effects of proteasome inhibitors we would like to extend the old
observation of Paracelsus that “the right dose differentiates a poison and a
remedy”, and postulate that for proteasome inhibitors the right dose and cell
type differentiate a poison and a remedy: For a given cell type, the degree of
proteasome inhibition determines whether the cell dies or is protected from
death. While sustained inhibition of multiple sites strongly restricts overall
protein turnover and ultimately results in cell death, partial inhibition of
only the chymotrypsin-like site may affect degradation of specific sets of
substrates and induces a protective stress response. This hypothesis might
provide a conceptual framework to pave the way for the clinical application of
proteasome inhibitors in other diseases beyond cancer, and in cardiovascular
diseases in particular. However, application of proteasome inhibitors is
clearly limited for diseases that require chronic treatment, since there is
increasing evidence that long-term proteasome impairment may contribute to
neurodegenerative disease, cardiac and aortic dysfunction, and aging. For this
reason, short-term and/or local treatment with proteasome inhibitors may
represent a more feasible approach. In particular, treatment of ischemia-
reperfusion injuries and restenosis offer promising clinical applications, as
proteasome inhibitors combine acute and local anti-proliferative and anti-
inflammatory actions with beneficial systemic effects on endothelial function.Das therapeutische Potential von Proteasominhibitoren als Zytostatika wurde
bereits früh erkannt, und verhinderte lange den Einsatz von
Proteasominhibitoren als nicht-toxische „Heilmittel“. Die hier dargestellten
Daten belegen durch eine Reihe von proof of concept Experimenten, dass
Inhibitoren des Proteasoms neue und viel versprechende „Heilmittel“ für die
Therapie unterschiedlicher kardiovaskulärer Erkrankungen darstellen. Während
die ausgeprägte Hemmung des Proteasoms durch hoch-dosierte Protesominhibitoren
deutlich anti-proliferative, anti-inflammatorische und pro-apoptotische
Effekte auf glatte Muskelzellen zeigt, die zu einer verminderten Restenose-
Ausbildung in Rattenkarotiden beitragen, vermittelt die nicht-toxische und
partielle Hemmung des Proteasoms durch niedrig-dosierte Proteasominhibitoren
eine Reihe benefizieller Effekte in unterschiedlichen kardiovakulären
Zelltypen: • Die reduzierte Expression mehrerer Kollagen Isoformen und
Matrixmetalloproteinasen in kardialen Fibroblasten ist assoziiert mit einem
deutlich verminderten Grad der kardialen Fibrose in spontan hypertensiven
Ratten; • das hypertrophe Wachstum von Kardiomyozyten wird supprimiert; • eine
erhöhte Expression von eNOS zusammen mit einer verminderten Expression von
ET-1 in Endothelzellen korreliert mit einer verbesserten Endothelfunktion in
Rattenaortenringen; • das Auslösen einer konservierten Stress-Antwort mit
Hochregulation von hsp70 und der konzertierten Induktion mehrerer anti-
oxidativer Enzyme schützt sowohl Endothelzellen wie auch Kardiomyozyten vor
thermalen und oxidativem Stress. Unsere Daten sind somit in vollem
Einvernehmen mit dem Konzept, dass Proteasominhibitoren als „Gift“ – also als
zytotoxische Substanzen - oder „Heilmittel“, welche unterschiedlichste
zelluläre Funktionen benefiziell beeinflussen, wirken können. Um diese
offensichtlich divergenten zellulären Effekte von Proteasominhibitoren in
Einklang zu bringen, lässt sich die Beobachtung von Paracelsus (1493 - 1541)
„Alle Dinge sind Gift und nichts ohn Gift, allein die Dosis macht, dass ein
Ding kein Gift ist!“ erweitern als nicht nur Dosis- sondern auch Zelltyp-
abhängige Wirkung von Proteasominhibitoren: Für einen definierten Zelltyp
bestimmt der Grad der Proteasomenhemmung, ob die Zelle stirbt oder vor dem
drohenden Zelltod geschützt wird. So führt die gleichzeitige und effektive
Hemmung mehrere katalytischer Aktivitäten des Proteasoms zu einem massiv
verminderten Proteinumsatz in der Zelle, der - weil nicht mehr kompensierbar -
in Apoptose mündet. Demgegenüber könnte eine nur partielle Hemmung der
katalytischen Zentren möglicherweise gezielt den Abbau spezifischer
Substratgruppen beeinflussen und eine protektive Stress-Antwort auslösen.
Diese Hypothese kann als konzeptueller Rahmen für die therapeutische Anwendung
von Proteasominhibitoren jenseits der Tumortherapie und insbesondere bei
kardiovaskulären Erkrankungen dienen. Der therapeutische Einsatz von
Proteasominhibitoren ist dabei jedoch eingeschränkt bei der Behandlung
chronischer Erkrankungen. So gibt es eine Reihe von Befunden, die zeigen, dass
eine lang anhaltende Einschränkung der proteasomalen Aktivität zur Entwicklung
neurodegenerativer und kardiovaskulärer Erkrankungen sowie zu
Alterungsprozessen beiträgt. Aus diesem Grund erscheint besonders die
kurzzeitige und/oder lokale Anwendung von Proteasominhibitoren Erfolg
versprechend, insbesondere die Behandlung von Ischämie/Reperfusionschäden und
Restenose. Hier wirken Proteasominhibitoren nicht nur lokal anti-proliferativ
und anti-inflammatorisch, sondern auch protektiv und verbessern die
endotheliale Funktion im systemischen Kontext
Music made visible in time and space : concepts of simultaneity in tone-eurythmy choreography
No full textIncludes bibliographical references (leaves 105-113).Eurythmy is an art of movement that expresses music and speech. This dissertation explores eurythmy's musical field, called tone-eurythmy, in its multifaceted appearances, background and within its philosophical context. Tone-eurythmy, carried out by performers moving in space and time, makes music visible. It transforms music into a new movement-art form, that of audible-visible music, by expressing musical components as well as the artistic intentions within a composition and those held by the performing artists. The dissertation examines how musical concepts are seen by eurythmists to integrate ideas of wholeness and to understand music as both audible and inaudible. It draws on studies and findings from music psychology to show distinct effects of musical elements on the human being, and to indicate the similarities between those and the qualitative expressions of music through tone-eurythmy
Gender Differences in Political Participation: Comparing Street Demonstrators in Sweden and the United Kingdom
No full textThis is the author accepted manuscript. The final version is available from SAGE Publications via the DOI in this record.Research on gender and politics has primarily focused on women’s participation in women’s movements and institutional politics separately. Our paper is innovative in multiple respects: First, employing a comparative perspective we analyse what impact gender regimes have on participation in street protests. Second, we study the relationship between participation in electoral and protest politics and how this relationship is gendered. Third, we compare the participation of men and women in social movements. We are able to do this by drawing on nuanced survey data of five street demonstrations in the UK and Sweden which we benchmark against the more widely used European Social Survey. Our comparative research demonstrates that involvement in protest and institutional politics varies by gender, country and context. Our findings have important implications for gender equality in terms of social inclusion and political representation and contribute to political sociology, sociology of gender, and social movement research.Economic and Social Research Council (ESRC)British Academ
Bringing the Mass Media in. The Contribution of the Mass Media for Understanding Citizens’ Attitudes towards the European Union
No full textEconomic considerations, identity related considerations and cueing theory are used for explaining citizens’ attitudes towards the European Union. Yet, all of this research has failed to show how elite cues on interests and identities actually reach the citizens. As a consequence, the author argues that domestic mass media as the most widely used source for citizens’ information about the European Union has the potential to fill this missing link. Mass media actively construct reality by promoting ideas (agenda-setting and framing) and thereby shaping processes of socialization and persuasion. In this article the author discusses theoretical concepts of how mass media might affect citizens’ attitudes, summarizes what we know about the role of domestic mass media in the course of EU integration, derives research desiderates and finally shows why knowledge on the link between mass media and citizens is paramount to understand the future of EU integration
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