2,133 research outputs found
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No full textA multilingual book on Seed Spices in Hindi, English, Urdu and Telgu Ed.by Lal,G. Mehta,R.S and Khan,M.A..Pp19-23Not AvailableNot Availabl
A comparison of farming practices and performance for wheat production in Haryana, India
No full textAvailable online: 15 May 2015Abstract not availableD.R. Coventry, R.S. Poswal, Ashok Yadav, Amritbir Singh Riar, Yi Zhou, Anuj Kumar, Ramesh Chand, R.S. Chhokar, R.K. Sharma, V.K. Yadav, R.K. Gupta, Anil Mehta, J.A. Cummin
R.S. Peters' Comprehensive Theory of Moral Education
No full textThis article presents R.S. Peters’ theory of moral education embedded in his broad conception of morality. The author examines Peters’ views against the background of Kohlberg’s stage theory of moral development; hence, the positions of both thinkers are interwoven throughout the discussion. It addresses some central issues relevant to moral education such as, for example: cognitive and affective aspects of morality, and the acquisition of virtues. In the article the author argues that Peters’ account of moral development and moral education provides supplementation for the somewhat narrow theory developed by Kohlberg, thus establishing a broader framework relevant to moral education.status: Publishe
Combining Fault Analysis Technologies for ISO26262 Functional Safety Verification
No full textThe development of Integrated Circuits for the Automotive sector imposes on complex challenges. ISO26262 Functional Safety requirements entail extensive Fault Injection campaigns and complex analysis for the evaluation of deployed Software Tools. This paper proposes a methodology to improve Fault Analysis Tools Confidence Level (TCL) by detecting errors in the classification of faults. By combining the strengths of Automatic Test Pattern Generators (ATPG), Formal Methods and Fault Injection Simulators we are able to automatically generate a Test Environment that enables the validation of the tools and provides supplementary information about the design behavior. Our results showed fault detection rates above 99% including information to improve ISO26262 metrics calculationAccepted author manuscriptComputer EngineeringQuantum & Computer Engineerin
Transition and wavy walls: an experimental study: An experimental study
No full textA wide body of research exists which explores the effects of surface roughness or patterned wall shapes on instability growth and transition. Building on those works as well as recent experiments demonstrating passive laminar flow control using arrays of discrete roughness [3, 8], a set of spanwise-wavy walls is designed with the goal of suppressing instability growth in two-dimensional boundary layers. In a numerical investigation of Tollmien-Schlichting (TS) wave growth in the presence of streamwise boundary-layer streaks, Cossu and Brandt [1] found that stabilization of TS waves results from spanwise shear in the mean flow, which forms a negative contribution to production in the perturbation kinetic energy equation. Whereas previous efforts have employed streamwise vorticity developing in roughness wakes to provide the requisite mean-flow deformation, in this work stabilization is achieved through modulation of the no-slip surface. Miniature vortex generators (MVGs) have proven an effective means of producing streamwise streaks for transition delay [8], though relatively large streak amplitudes are necessary to counter their eventual decay through viscous dissipation. The notion motivating this work is that spanwise-wavy walls extended in the streamwise direction can produce a similar effect while avoiding bypass transition resulting from large-amplitude streamwise streaks. Toward that end, six wavy walls are used in a modular test model. When TS waves are excited upstream of the wavy walls, substantial delays in the onset of transition are observed for certain spanwise wavelengths compared with the flat-plate reference case
Milczące życie liter. O związku języka i przyrody w poezji R.S. Thomasa
No full textJoanna SoćkoSilent Life of Letters. On Interconnections between Language and Nature in the Poetry of R.S. Thomas.The essay sets out to explore R.S. Thomas’ (1913–2000) vision of the problematic relations between the man, the nature and their Creator. In the context of contemporary critique as well as the 20th century, post-husserlian philosophy, the author analyses Thomas’ cosmological poems and represents, on the one hand, the place that both man and God take in the creation and, on the other, the sacramental relationship between the human and the nature. What is important from this perspective is the material existence of both man and nature, which enables mutual infiltration that leads to discovery of imperceptible dimension of materiality, which, in turn, influences both human consciousness and language. This is why the author asks about the role of science in Thomas’ poetry and about the influence that “the machine” has on language and consciousness.Joanna SoćkoSilent Life of Letters. On Interconnections between Language and Nature in the Poetry of R.S. Thomas.The essay sets out to explore R.S. Thomas’ (1913–2000) vision of the problematic relations between the man, the nature and their Creator. In the context of contemporary critique as well as the 20th century, post-husserlian philosophy, the author analyses Thomas’ cosmological poems and represents, on the one hand, the place that both man and God take in the creation and, on the other, the sacramental relationship between the human and the nature. What is important from this perspective is the material existence of both man and nature, which enables mutual infiltration that leads to discovery of imperceptible dimension of materiality, which, in turn, influences both human consciousness and language. This is why the author asks about the role of science in Thomas’ poetry and about the influence that “the machine” has on language and consciousness
Phylogeny of Sampled Mustelidae.
No full textPhylogeny trimmed from Law, C.J., Slater, G.J., & Mehta, R.S. 2018. Lineage diversity and size disparity in
Musteloidea: testing patterns of adaptive radiation using molecular and fossil-based methods. Syst. Biol. 67: 127-144
Czwarty wymiar. Poezja R.S. Thomasa wobec pytania o (nie)obecność
No full textThe Fourth Dimension. R.S. Thomas’s Poetry and the Question of God’s AbsenceThe text deals with the poetry of R.S. Thomas (1913−2000) – a British author and an Anglican priest in the Church of Wales – whose works are full of controversial (given his priesthood) statements concerning the absence of God. As a lot of Thomas’s poems convey thoughts intersecting with post-secular reflection on the death of God, rooted in Derrida’s questioning of the “metaphysics of presence,” the article aims at tracing the inspirations behind Thomas’s quasi-religious poetry. The point of departure for this reflection is the poet’s recollection of being left by his parents alone for the first time. The impression of an empty house turns out to be an experience which shaped the poet’s attitude towards the disenchanted space he lives in. Although most critics claim that the apparent absence of God in Thomas’s poetry results directly from the tradition of theological via negativa, the author of the article pays attention to those characteristics which differentiate Thomas’s spirituality from the theological tradition and the most important difference between the poet’s attitude and the traditional model of Christian contemplation turns out to be time, or, more precisely, the temporal discrepancy between the possible accessibility of the transcendent being and the man’s ability to “catch it at work.
Czwarty wymiar. Poezja R.S. Thomasa wobec pytania o (nie)obecność
No full textThe Fourth Dimension. R.S. Thomas’s Poetry and the Question of God’s AbsenceThe text deals with the poetry of R.S. Thomas (1913−2000) – a British author and an Anglican priest in the Church of Wales – whose works are full of controversial (given his priesthood) statements concerning the absence of God. As a lot of Thomas’s poems convey thoughts intersecting with post-secular reflection on the death of God, rooted in Derrida’s questioning of the “metaphysics of presence,” the article aims at tracing the inspirations behind Thomas’s quasi-religious poetry. The point of departure for this reflection is the poet’s recollection of being left by his parents alone for the first time. The impression of an empty house turns out to be an experience which shaped the poet’s attitude towards the disenchanted space he lives in. Although most critics claim that the apparent absence of God in Thomas’s poetry results directly from the tradition of theological via negativa, the author of the article pays attention to those characteristics which differentiate Thomas’s spirituality from the theological tradition and the most important difference between the poet’s attitude and the traditional model of Christian contemplation turns out to be time, or, more precisely, the temporal discrepancy between the possible accessibility of the transcendent being and the man’s ability to “catch it at work.
Genetic and Biochemical Studies with Chinese Hamster Ovary Cell Mutants Resistant to the Purine Nucleoside Analogs: Toyocamyin, Formycin A and Formycin B
No full textThe aim of this study was to investigate the mechanism of cellular resistance and toxicity to the purine nucleoside analogs toyocamycin, formycin A and formycin B by using genetic, biochemical and immunological approaches. To investigate the similarity or differences in the mechanism of action of various pyrrolopyrimidine nucleosides, second-step toyocamycin resistant mutants (Toyʳᴵᴵ mutants) of Chinese hamster ovary cells were isolated from a cell line which exhibited similar degree of resistance to toyocamycin and tubercidin. These second-step mutants exhibited a further 8- to 9-fold increase in resistance to toypcamycin but no concurrent increase in their resistance towards tubercidin. The Toyʳᴵᴵ mutants were found to be very similar to the first-step mutants in their levels of adenosine kinase activity ( The genetic and biochemical approach was also used to investigate the mechanism of resistance and metabolism to another group of nucleoside analogs in which the base is linked to ribose moiety by a C-C linkage. Studies presented showed that stable mutants which are approximately 3- and 8-fold resistant to the C-nucleoside, formycin A (Fomᴿ mutants) could be obtained in a single step in CHO cells. In cell extracts, the Fomᴿ mutants contained no measurable activity of the enzyme adenosine kinase. In cell hybrids formed between formycin A resistant and sensitive cells (Fomˢ) as well as formycin A resistant and toyocamycin resistant cells (Toyʳ), the drug resistant phenotype of Fomᴿ mutants behaved codominantly as indicated by the degree of resistance of the hybrid cells to formycin B. However, extracts from these hybrid cells contained either≈50% (Fomᴿ x Fomˢ) or Since formycin A under the normal cell culture condition is rapidly deaminated to the inosine analog, formycin B, cellular toxicity and resistance of formycin B was also investigated. Mutants of CHO cells selected for resistance to formycin B (Fomʳ mutants) were found to be 5- to 8-fold resistant to this drug. Cross-resistance studies with these mutants revealed that they exhibit increased resistance to all adenosine analogs (N- and C-nucleosides); as well as reduced cellular uptake and phosphorylation. However, unlike the Fomᴿ and Toyʳ mutants, which contained no AK activity in their cell extracts, the Fomʳ mutants were found to contain between 60 - 110% of WT activity in their cell extracts. The AK activity present in both Fomʳ mutant cell extracts differed from the WT AK activity in terms of its specific activity as well as in its ability to phosphorylate adenosine analogs. The AK activity from the Fomʳ mutants was found to have less affinity for phosphorylation of the formycin A derivative, Bbb-85. Like Toyʳ mutants, Fomʳ mutants were found to show recessive-behaviour in cell hybrids. Biochemical studies on the metabolism of formycin B indicated that upon incubation with CHO cells, [³H]formycin B is metabolized into formycin B-5'-monophosphate, formycin A-5'-monophosphate and higher phosphorylated derivatives of formycin A which are incorporated into RNA. All three different classes of mutants affected In AK exhibit appreciable cross-resistance as well as reduced cellular uptake and phosphorylation of formycin B. These observations strongly indicate that in CHO cells, formycin B is phosphorylated via AK and like other nucleoside analogs, its phosphorylation is essential for the cellular toxicity. Formycin B-5'-monophosphate and formycin A-5'-monophosphate have been found to inhibit the purine nucleotide biosynthetic enzyme adenylosuccinate synthetase. To gain further insight into the nature of genetic and biochemical alterations in different types of mutants affected in adenosine kinase, this enzyme from CHO cells was purified to homogeneity. Antibodies which specifically cross-react with adenosine kinase have been raised. Immunoblot analyses using these antibodies showed that all three classes of mutants i.e., Toyʳ, Fomᴿ and Fomʳ contained nearly similar amounts of cross-reacting material that had a similar electrophoretic mobility to the enzyme in the WT cells. These results indicate that the lesion in these mutants does not involve a deletion or regulatory type of genetic alteration in the AK gene nor a nonsense type of mutation which may cause premature chain termination. Instead, these mutants may contain a missense type of alteration in the structural gene of AK. Using these antibodies, regions (or spots) on two-dimensional gels that correspond to the AK protein have been identified. Comparison of the 2-D gel electrophoretic patterns of total cellular proteins from different-mutant lines indicates that some of the mutants show a specific alteration in this region. This supports the inference that these mutants may contain a missense type of mutation in the structural gene of AK. The results presented in this thesis have been presented or submitted in the following publications. 1. Mehta, K.D. and Gupta, R.S. (1983) Formycin B-Resistant Mutants of Chinese Hamster Ovary Cells: Novel Genetic and Biochemical Phenotype Affecting Adenosine Kinase. Mol. Cell. Biol. 3, 1468. 2. Gupta, R.S. and Mehta, K.D. (1984) Genetic and Biochemical Studies on Mutants of CHO Cells Resistant to 7-Deazapurine Nucleosides: Differences in the Mechanisms of Action of Toyocamycin and Tubercidin. Biochem. Biophys. Res. Commun. 120, 88. 3. Mehta, K.D. and Gupta, R.S. Novel Mutants of Adenosine Kinase Specifically Affected in the Phosphorylation of C-Nucleosides. Manuscript submitted to FEBS Lett. 4. Mehta, K.D. and Gupta, R.S. Metabolism and the Mechanism of Action of Formycin B in Chinese Hamster Ovary Cells: Involvement of Adenosine Kinase in Drug Phosphorylation. Manuscript submitted to J. BioI. Chem.Doctor of Philosophy (PhD
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