743 research outputs found
How to manage early-stage follicular lymphoma
No full textearly-stage follicular lymphoma (FL) is characterized by good prognosis and can be cured with involved-field radiotherapy (IF-RT) in most cases. PET scan is a milestone of diagnostic work-up, with the aim of identifying a truly-localized disease; however, staging in most of the studies was without PET
Bianca Garavelli studiosa e scrittrice
No full textBianca Garavelli (Vigevano, 1958-2021) was a highly regarded figure in the literary world, both on the critical and creative side. Author of important critical studies on Dante and of a successful commentary on the Commediam (begun under the supervision of Maria Corti but then continued independently), as well as critic and reviewer for newspapers and periodicals, Garavelli also wrote and published poems, novels and short stories. This article offers an exhaustive bio-bibliographical profile of Bianca Garavelli, whose literary work in various fields is reconstructed and critically examined
Let´s (watch me) play : which factors relate to Let´s Play addiction?
No full textAuthor Bianca Haun, BScZusammenfassungen in englischer SpracheMasterarbeit Universität Linz 201
Prognostic impact of tumor-associated macrophages, lymphocyte-to-monocyte and neutrophil-to-lymphocyte ratio in diffuse large B-cell lymphoma
No full textIntroduction: Microenvironment has a prognostic influence in diffuse large B-cell lymphoma (DLBCL); among its components, tumor-associated macrophages (TAM) play a leading role. TAM can be classified into M1 (anti-tumor) and M2 (pro-tumor). Another prognostic factor could be represented by lymphocyte-to-monocyte and neutrophil-to-lymphocyte ratio (LMR and NLR). Objective: The aim of the study is to evaluate the prognostic impact of M1 and M2 TAM subtypes, LMR and NLR in DLBCL. Methods: We analyzed 37 consecutive patients between 2009 and 2013. Out of 37 patients, 28/37 (75.6%) received R-CHOP/CHOP-like regimens, 9/37 (24.4%) less intensive therapies. Immunohistochemistry was performed with antibodies against CD68 and CD163. We divided our cohort into 2 categories according to the Steidl score. TAM who coexpressed CD68 and CD163 were considered as M2. For LMR and NLR we used previously published cut-offs of 2.71 and 2.81. Results: CR rate was 70.3%; we did not record a significant correlation between CD68+ TAM, CD163+ TAM, CD68+/CD163+ TAM, LMR, NLR and CR. We observed a reduced PFS in patients with IPI >= 2 and high M2 TAM expression and a trend between higher expression of CD68+ TAM and improved PFS. Conclusion: M2 TAM could have a prognostic role for IPI >= 2 DLBCL patients receiving R-CHOP, which thus warrants further investigation
A combined intervention for executive deficits and anxiety in Parkinson's patients: a case study
No full textParkinson’s disease (PD) is a neurodegenerative disorder most commonly associated with motor symptomatology, yet often presenting with deficits in attention, executive functioning (EF; e.g., planning, mental flexibility, complex attention), anxiety, and depression, with debilitating effects on patients’ quality of life. Current interventions, including pharmacological and surgical methods show efficacy in motor symptom management, yet produce equivocal results in addressing non-motor dysfunction. The goal of this paper was to describe and investigate the efficacy and patient acceptance of a nonpharmacological intervention for treatment of executive dysfunction (ED) and anxiety in PD, in the context of a case study (the case of Mr. K). Brain and Mind Fitness Program (BMFP) is a short-term intervention, consisting of a combination of cognitive remediation and cognitive behavioral therapy (CBT). BMFP was demonstrated to be fully acceptable to Mr. K, based on ratings of 4 feasibility dimensions (fatigue, effort, progress, and enjoyment). The program also proved to be efficacious in alleviating Mr. K’s anxiety and depression symptoms, with benefits extending over the treatment period. BMFP, elsewhere shown to be an effective cognitive re-training of EF in PD patients, exhibited limited gains in the case of Mr. K., possibly due to his relatively intact cognitive abilities at baseline. Despite its limitations, the case of Mr. K presents a novel approach to treatment of PD non-motor symptoms and a learning opportunity for researchers and clinicians interested in expanding their knowledge across disciplines.Psy. D.Includes bibliographical referencesby Bianca R. Georgesc
BIANCA (Brain Intensity AbNormality Classification Algorithm): a new tool for automated segmentation of white matter hyperintensities
No full textReliable quantification of white matter hyperintensities of presumed vascular origin (WMHs) is increasingly needed, given the presence of these MRI findings in patients with several neurological and vascular disorders, as well as in elderly healthy subjects. We present BIANCA (Brain Intensity AbNormality Classification Algorithm), a fully automated, supervised method for WMH detection, based on the k-nearest neighbour (k-NN) algorithm. Relative to previous k-NN based segmentation methods, BIANCA offers different options for weighting the spatial information, local spatial intensity averaging, and different options for the choice of the number and location of the training points. BIANCA is multimodal and highly flexible so that the user can adapt the tool to their protocol and specific needs. We optimised and validated BIANCA on two datasets with different MRI protocols and patient populations (a “predominantly neurodegenerative” and a “predominantly vascular” cohort). BIANCA was first optimised on a subset of images for each dataset in terms of overlap and volumetric agreement with a manually segmented WMH mask. The correlation between the volumes extracted with BIANCA (using the optimised set of options), the volumes extracted from the manual masks and visual ratings showed that BIANCA is a valid alternative to manual segmentation. The optimised set of options was then applied to the whole cohorts and the resulting WMH volume estimates showed good correlations with visual ratings and with age. Finally, we performed a reproducibility test, to evaluate the robustness of BIANCA, and compared BIANCA performance against existing methods. Our findings suggest that BIANCA, which will be freely available as part of the FSL package, is a reliable method for automated WMH segmentation in large cross-sectional cohort studies. © 2016 The Author
Dataset: Culturally Responsive Supervision
No full textThesis title: A Study Exploring the Supervisory Relationship in the Context of Culturally Responsive Supervision: A Supervisee’s Perspective
Quantitative and qualitative survey data on supervisee perspectives of culturally responsive supervision and their supervisory relationship. The data was collected by the primary author and can be viewed in SPSS.
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Long-Term Safety of Rapid Daratumumab Infusions in Multiple Myeloma Patients
No full textMultiple myeloma survival has significantly improved in recent years, due to novel agents that are available for treatment. The anti-CD38 monoclonal antibody Daratumumab is particularly efficient for patients with relapse/refractory disease, and many studies have shown its unprecedented efficacy also as a first treatment. However, to avoid the incidence of infusion reactions, long infusion schedules of 8 h at first dose and 4 h in the following doses are required, which can reduce the compliance of patients and health care professionals. A reduced infusion time of 90 min has been reported previously, but data are missing on the prolonged safety of this over time as well as the efficacy of this approach. In this work, we investigate the safety of 484 rapid Daratumumab infusions given early after the second dose over a 22 months period in 39 myeloma patients
Il chiostro dell'abbazia benedettina di Monreale: documenti d'archivio inediti per ricostruire la storia degli interventi di restauro tra 1867 e 1907.
No full textThe Cloister of the Monreale Benedictine Abbey: New Archival Documents to Reconstruct the History of Restoration Work Between 1867 and 1907
Soon after the unification of Italy, the cloister of the Monreale benedictine Abbey underwent restoration work supervised by the architect Giuseppe Patricolo which transformed the cloister image, determining largely his current configuration. The history of these restoration interventions occurred between 1867 and 1907 has been reconstructed by the author through the examina- tion of unpublished archival documents and pictures, equally relevant to summarize in detail the most important works which changed the aspect of the cloister courtyard
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