104 research outputs found
Temperature-Confining Pressure Coupling Effects on the Permeability of Three Rock types under Triaxial Compression
No full textTriaxial compression tests were carried out at 295K and 353K under confining pressure of 1–15MPa for Shikotsuwelded tuff, Kimachi sandstone and Inada granite.The sampleswere kept for 24 hr consolidation and then axial compression was applied measuring permeability. Permeability decreased monotonously for Shikotsu welded tuff. The permeability decreased first, began to increase before peak load and showed almost constant value in the residual strength state for Kimachi sandstone and Inada granite. Permeability decreased by failure for Shikotsu welded tuff. It increased due to failure under low confining pressures but decreased under high confining pressures for Kimachi sandstone. It increased due to failure for Inada granite. The permeability at 353K was lower than that at 295K for all of the three types of rock. The mechanisms of the permeability decrease are also shown.2014 ISRM European Rock Mechanics Symposium (EUROCK 2014), May 27-29, 2014, Vigo, Spain
Fractured Rock Permeability as a Function of Temperature and Confining Pressure
No full textTriaxial compression tests were carried out on Shikotsu welded tuff, Kimachi sandstone, and Inada granite under confining pressures of 1–15 MPa at 295 and 353 K. The permeability of the tuff declined monotonically with axial compression. The post-compression permeability became smaller than that before axial compression. The permeability of Kimachi sandstone and Inada granite declined at first, then began to increase before the peak load, and showed values that were almost constant in the residual strength state. The post-compression permeability of Kimachi sandstone was higher than that before axial compression under low confining pressures, but lower under higher confining pressures. On the other hand, the permeability of Inada granite was higher than that before axial compression regardless of the confining pressure values. For the all rock types, the post-compression permeability at 353 K was lower than at 295 K and the influence of the confining pressure was less at 353 K than at 295 K. The above temperature effects were observed apparently for Inada granite, only the latter effect was apparent for Shikotsu welded tuff, and they were not so obvious for Kimachi sandstone. The mechanisms causing the variation in rock permeability and sealability of underground openings were discussed
Sealability Recovery of Fractured Rocks by Post-failure Consolidation
No full textPost-failure consolidation was carried out on Kimachi sandstone, Toyotomi siliceous mudstone and Inada granite to clarify whether the increased hydraulic conductivity due to failure decreased by post-failure consolidation or not. The hydraulic conductivity of post-failure consolidated rocks were 0.3-0.6 times that before post-failure consolidation and 0.9-1.5 times that before failure for Kimachi sandstone and the ratios were 0.4 times and 0.6 times for Toyotomi siliceous mudstone. On the other hand, the ratio was 0.2 times and 16 times for Inada granite. Namely, the phenomenon in which the increased hydraulic conductivity decreases by post-failure consolidation was obviously confirmed for the clastic rocks and was confirmed at some degree for the crystalline rock. The dominating mechanisms of decrease in hydraulic conductivity due to the post-failure consolidations were considered to be closure of rupture plane by crushing of mineral particles and irrecoverable closure of microcracks and elliptic pores in intact rock matrix due to plastic deformation for Kimachi sandstone, time-dependent closure of rupture plane due to visco-plastic deformation and visco-plastic pore collapse in intact rock matrix for Toyotomi siliceous mudstone, and a little visco-plastic deformation and a few pressure solution at the rupture plane for Inada granite. The different mechanisms were mainly induced by the differences in strength and deformation characteristics of mineral particles and rock matrixes.ARMS8(2014 ISRM International Symposium): 8th Asian Rock Mechanics Symposium. The theme of the symposium is ‘Rock Mechanics for Global Issues - Natural Disasters, Environment and Energy - ’. 14–16 October 2014, Sapporo, JAPA
A Method of Pelvic Phlebography ; Pelvic PhlebographY Via Femoral Veins
No full textA method established by Dalali to visualize the pelvic veins by injecting opaque media directly into the femoral veins has been reported. It is capable of clearly visualizing the ramifications of the internal and external iliac veins and vesical plexus etc. No reaction by this method has ever experienced. The author thanks Prof. Inada for his invaluable assistance in guiding this work
Perempuan dalam Masyarakat Papua: Suku Kamoro dan Muyu
No full textAbstrak: Tulisan ini menilik dua jenis komunitas suku, Kamoro dan Muyu, atau dua ‘warna’ perempuan yang penulis anggap dapat mewakili keseluruhan perempuan Papua. Penulis beberapa kali mengunjungi Papua dalam satu dekade terakhir, pada kesempatan tersebut penulis tinggal dan beraktivitas bersama masyarakat Kamoro dan Muyu. Kedua komunitas tersebut tinggal di tanah Papua, yang secara administratif ada di Provinsi Papua Barat dan Provinsi Papua. Dengan melihat kepada kondisi dan konteks sosial-budaya yang melatari posisi perempuan Papua di tengah masyarakatnya, penulis ingin memberikan penggambaran yang jelas bagaimana sesungguhnya kesulitan yang dialami perempuan Papua sebagai warga negara.Kata Kunci: Perempuan, Papua, Kamoro, MuyuAbstract: This article looks at two ethnic communities, Kamoro and Muyu, or two ‘colours’ of women whom the writer considers as representative of all Papuan women. The author has several times visited Papua in the past decade, on that occasion the author lived and did activities together with the Kamoro and Muyu people. Both communities live in the land of Papua, which administratively are in the West Papua and Papua Provinces. By looking at the condition and socio-cultural context which underlie the position of women in the midst of their society, the author wants to give a clear description on how difficult it is the real situation faced by Papuan women as citizens.Key Words: Papua, Women, Kamoro, Muy
Availability of Circulating MicroRNAs as a Biomarker for Early Diagnosis of Diffuse Large B-Cell Lymphoma
No full textAbstract Background: MicroRNA (miRNA) regulates post-transcriptional gene expression through binding to complementary sites of target messenger RNA, including that from oncogenes or tumor suppressor genes. This study planned to pursue the possibility that circulating miRNA could be used for the early diagnosis of diffuse large B-cell lymphoma (DLBCL). Materials and Methods: Expression levels of miRNA obtained from serum, exosome-enriched serum, and formalin-fixed paraffinembedded (FFPE) tissue were evaluated. Samples were collected from patients with newly diagnosed DLBCL (n = 33) or healthy volunteers (n = 22). Based on the results of previous reports, ten miRNAs were selected and expression levels were analyzed by the quantitative real-time PCR. Results: The expression levels of hsa-miR-15a-3p, hsa-miR-21-5p, hsa-miR-181a-5p, and hsa-miR-210-5p differed significantly between DLBCL patients and controls in serum and/or exosomeenriched serum, but not in FFPE tissue. In contrast, expression levels of hsa-miR-155-5p in FFPE tissue were significantly higher in DLBCL patients, as previously reported. Conclusion: We confirmed that some miRNAs were differentially expressed in serum from DLBCL patients as previously reported. Measurement of these miRNA in exosome-enriched serum did not improve the accuracy in the differential diagnosis of DLBCL. In addition, these miRNAs seem to be produced outside of lymphoma tissue. * Corresponding author. K. Inada et al. 4
Clinical outcome after two-stage bicruciate reconstruction
No full textOrientador: Sérgio Rocha PiedadeDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências MédicasResumo: Introdução: A lesão bicruzado do joelho é rara e está frequentemente associada a traumas de alta energia, sendo o procedimento cirúrgico o tratamento instituído devido a sua complexidade. Objetivo: Avaliar os resultados clínicos e funcionais de pacientes submetidos a reconstrução bicruzado do joelho, realizada em dois tempos cirúrgicos, utilizando os Escores de Lysholm, Tegner, KOOS e SF-36. Materiais e Métodos: 25 pacientes (20 homens e 5 mulheres) foram avaliados, idade média de 32,3 anos (17 a 53 anos), IMC médio de 26,2(18,9 a 34,9 Kg/m²), tempo de lesão de 18,3 meses (lesões crônicas). Quanto ao mecanismo de lesão, os acidentes auto-moto-ciclístico responsáveis por 72% dos casos, a prática esportiva por 16% e queda ou entorse por 12%. Inicialmente, foi utilizada a técnica Inlay para a reconstrução do LCP, utilizando o terço central do tendão patelar. Após um intervalo mínimo de 3 meses realizou-se a reconstrução do ligamento cruzado anterior via artroscópica, utilizando tendões flexores. Foram observadas as seguintes lesões associadas: condral em 7 pacientes (28%), meniscal em 16 pacientes (64%), lesões ligamentares associadas em 12 pacientes (48%). Procedimento cirúrgico adicional foram necessários em 4 pacientes (tendão patelar em 2 casos e ligamento colateral medial em 2 pacientes). Resultados: Com seguimento pós-operatório médio de 24,8 meses, em 60% dos casos a gaveta posterior foi classificada como zero e + (0,5 cm), enquanto 40% foram classificados como ++ (até 1cm). 60% dos pacientes obtiveram Escore de Lysholm bom/excelente. O Escore de atividade Tegner apresentou queda no nível de atividade física pós-reconstrução bicruzado, em comparação com o nível de atividade física pré-lesão, com relevância estatística. Entretanto, apenas 1 paciente retornou ao mesmo nível de atividade pré-lesão. A análise estatística revelou que o tempo de lesão influenciou negativamente os resultados clínicos pós-operatórios, em particular os parâmetros atividades esportivas/recreativas, do questionário KOOS, além dos domínios capacidade funcional, limitação dos aspectos físicos, vitalidade e saúde mental, do questionário SF-36. Por outro lado, variáveis como idade, IMC, presença de lesões condrais, meniscais e ligamentares associadas, assim como gaveta posterior residual não afetaram o resultado final. Conclusão: neste estudo o tempo de lesão teve um impacto negativo no prognóstico pós-operatório da reconstrução bicruzado, realizado em dois tempos cirúrgicos. Entretanto, é importante ressaltar que outras variáveis estudadas devem ser consideradas. Palavras-chave: ligamento cruzado posterior, ligamento cruzado anterior, joelho, traumatismos do joelhoAbstract: Introduction: Bicruciate lesions of the knee are rare and often related to high-energy traumas. A surgical procedure is used because of their complexity. Objective: to assess the clinical and the functional outcomes after two-stages bicruciate knee reconstruction using the Lysholm, Tegner, KOOS and SF-36 scores. Materials and methods: 25 patients (20 males and 5 females) were evaluated, mean age 32,3 years (17-53 years), mean BMI 26,2 (18,9-34,9), mean duration of lesion 18,3 months (chronic lesions). Regarding the mechanism of injury, car, motorcycle and bicycle accidents were responsible for 72%, while sports practices 16% and falls or sprains 12%. The Inlay technique was applied in PCL reconstruction using the central 1/3 of the patellar tendon. After 3 months minimum interval, ACL reconstruction was arthroscopically performed using flexor tendons. The following intraoperative lesions were detected: chondral ¿ 07 patients (28%); meniscal ¿ 16 patients (64%); associated ligament lesions ¿ 12 (48%). An additional surgical procedure was required for 4 patients (patellar tendon ¿ 2 cases, CML ¿ 2 cases). Results: With a 24,8 month mean postoperative follow-up of the cases, the posterior drawer test rated zero or + (0,5 cm) were observed in 60% of the patients, while 40% as ++ ( 1cm) and 60% of patients rated good/excellent condition (Lysholm). The Tegner activity score revealed that postoperative physical activity was less than physical activity level before the lesion and and the reduction was statistically significant. Moreover, only one patient achieved the pre-lesion activity level. The statistical analysis revealed that duration of lesion negatively influenced postoperative clinical results, especially regarding parameters such as sports/recreative activities (KOOS) and physical functioning, limitation of physical aspects, vitality and mental health (SF-36). However, in this study, the variables such as age, BMI, presence of chondral, meniscal, ligament lesions and residual posterior drawer did not affect the final result. Conclusion: The results obtained by this study concluded that duration of lesion had a negative impact on postoperative prognosis. However, it is important that other analyzed variables should also be considered. Keywords: posterior cruciate ligament, anterior cruciate ligament, knee, knee injuryMestradoFisiopatologia CirúrgicaMestre em Ciência
Investment Opportunities and Barriers in Japan: The Regulation of Direct Investment
No full textForeign investors are often interested in direct investment in Japan by establishing a subsidiary in Japan or in investing in already-existing Japanese companies. However, investors\u27 plans are often thwarted by unexpected legal problems and cultural differences. The author explores the many formal and informal barriers to direct investment in Japan, including regulatory and legal impediments
Investment Opportunities and Barriers in Japan: The Regulation of Direct Investment
No full textForeign investors are often interested in direct investment in Japan by establishing a subsidiary in Japan or in investing in already-existing Japanese companies. However, investors\u27 plans are often thwarted by unexpected legal problems and cultural differences. The author explores the many formal and informal barriers to direct investment in Japan, including regulatory and legal impediments
Giant Earthquakes are Occurring at Lunar Phases Specific to Each Subduction Zone
No full textHere, we statistically proved that giant earthquakes occur at lunar phases specific to each subduction zone. Enough attention during the lunar period, especially when seismicity is occurring, will significantly reduce damage from giant earthquakes. Two case studies in which giant earthquakes occurred after seismicity in dangerous lunar phases were discussed, and the mechanisms underlying why giant earthquakes occur around neap tide at some subduction zones were explained by prohibition of giant earthquake occurrences due to high strain rates at spring tides at N–S subduction zones. The prohibition was statistically proven for uniaxial creep tests on Inada granite with slight stress disturbances.ISRM Congress 2015(13th ISRM International Congress on Rock Mechanics). 10-13 May 2015. Montréal, Canada
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