117 research outputs found
Emeline Renz, CSCJ Supplemental Assignments, Spring 2020
No full textCSCJ Supplemental Assignments, Spring 2020. Submitted by Emeline Renz, GIS Coordinator, Sociology and Criminal Justice Department, Clark Atlanta University
Emeline Renz, Clark Atlanta University, April 20, 2020
No full textStatement submitted by Emeline Renz, GIS Coordinator (Faculty/Staff), Sociology and Criminal Justice Department, Clark Atlanta University
Susan Glaspell’s Poetics and Politics of Rebellion, Iowa City, University of Iowa Press, 2017, 258 p
No full textInternational audience“In Susan Glaspell’s Poetics and Politics of Rebellion, Emeline Jouve has cleared away what Lawrence Langer once called Glaspell’s ‘old lace’ to reveal the ‘steel lining beneath the tender surface’—the politics and, really, outrage at injustice and belief in democratic idealism that are at the center of Glaspell’s dramaturgy—and her raison d’être as a writer.”—Drew Eisenhauer, Coventry UniversityA pioneer of American modern drama and founding member of the Provincetown Players, Susan Glaspell (1876–1948) wrote plays of a kind that Robert Brustein defines as a “drama of revolt,” an expression of the dramatists’ discontent with the prevailing social, political, and artistic order. Her works display her determination to put an end to the alienating norms that, in her eyes and those of her bohemian peers, were stifling American society. This determination both to denounce infringements on individual rights and to reform American life through the theatre shapes the political dimension of her drama of revolt.Analyzing plays from the early Trifles (1916) through Springs Eternal (1943) and the undated, incomplete Wings, author Emeline Jouve illustrates the way that Glaspell’s dramas addressed issues of sexism, the impact of World War I on American values, and the relationship between individuals and their communities, among other concerns. Jouve argues that Glaspell turns the playhouse into a courthouse, putting the hypocrisy of American democracy on trial. In staging rebels fighting for their rights in fictional worlds that reflect her audience’s extradiegetic reality, she explores the strategies available to individuals to free themselves from oppression. Her works envisage a better future for both her fictive insurgents and her spectators, whom she encourages to consider which modes of revolt are appropriate and effective for improving the society they live in. The playwright defines social reform in terms of collaboration, which she views as an alternative to the dominant, alienating social and political structures. Not simply accusing but proposing solutions in her plays, she wrote dramas that enacted a positive revolt.A must for students of Glaspell and her contemporaries, as well as scholars of American theatre and literature of the first half of the twentieth century
Evaluation of a new biodegradable and bioactive synthetic ligament for the treatment of anterior cruciate ligament ruptures with remnants-preserving reconstruction. Study through two preclinical surgical models in the rat and the sheep.
No full textLa rupture du ligament croisé antérieur (LCA) est une affection fréquemment rencontrée en chirurgie orthopédique. Les pratiques thérapeutiques actuelles, qui consistent en son remplacement par une autogreffe tendineuse après exérèse complète des reliquats ligamentaires, se heurtent à des résultats occasionnellement décevants en termes de récupération fonctionnelle, imputés à la morbidité liée au prélèvement de l'autogreffe et à la non-préservation des restes du LCA. Les nouvelles pistes de recherche se penchent ainsi sur la préservation des reliquats du ligament croisé, leur suture lorsqu'elle est possible, et l'utilisation d'un échafaudage pour guider la régénération tissulaire et maintenir la stabilité de l'articulation pendant la cicatrisation du ligament. Ce projet propose ainsi de développer et d'évaluer un nouveau ligament synthétique fabriqué en polycaprolactone résorbable, fonctionnalisée par greffage de polyNaSS, utilisable en tant qu'échafaudage lors de ruptures fraîches du LCA. Cette évaluation a été réalisée au travers de deux modèles précliniques définis chez le rat et la brebis. Ainsi, ce travail a porté dans un premier temps sur la mise au point d'un modèle préclinique pertinent de reconstruction ligamentaire avec préservation des reliquats du LCA chez le rat ; ce modèle a permis de documenter les bénéfices apportés par cette technique sur les lésions cartilagineuses, l'inflammation des membranes synoviales, le gonflement articulaire et la microarchitecture des reliquats de LCA des grassets opérés, en comparaison à une absence de reconstruction. L'évaluation du ligament synthétique fonctionnalisé, adapté au format du rat, a été effectuée dans ce modèle dans un deuxième temps. Elle visait à en apporter la preuve du concept sur les plans de sa biocompatibilité, de sa biofonctionnalité et de sa bioactivité, au travers d'études histologiques, tomodensitométriques, d'imagerie à résonance magnétique, et de biologie moléculaire, menées sur les parties intra-articulaire et intra-osseuses du ligament synthétique après 12 semaines d'implantation, en le comparant à l'autogreffe et à son équivalent non greffé. Le ligament synthétique greffé s'est avéré aussi performant que l'autogreffe sur le plan fonctionnel et a conduit à de meilleurs résultats que celle-ci sur l'inflammation des membranes synoviales, l'épaississement des capsules articulaires, ainsi que sur la néoformation osseuse au sein des tunnels osseux fémoraux. Les bénéfices du greffage par rapport à la PCL non greffée se sont révélés, au travers de cette évaluation, sur les lésions cartilagineuses et le gonflement articulaire, et ils ont été suspectés sur le taux de rupture. Le ligament synthétique, fonctionnalisé ou non, adapté au format brebis avec l'architecture de la prothèse ligamentaire LARS TM, a ensuite été implanté dans un modèle de reconstruction avec préservation des reliquats ligamentaires dans cette espèce, au sein duquel il a fait l'objet d'études similaires à celles menées chez le rat. Le ligament en PCL, qu'il soit greffé ou non, a permis d'aboutir à une régénération macroscopique du LCA natif après 12 semaines d'implantation, avec un bénéfice significatif du greffage sur la colonisation de l'échafaudage synthétique et l'architecture des reliquats de LCA, et un bénéfice suspecté sur le taux de rupture et la néoformation osseuse du tunnel tibial en partie proximale. L'impact du greffage sur les propriétés mécaniques de la reconstruction avec le ligament synthétique doit être confirmé par des études biomécaniques à 3 mois (en cours de réalisation) et à 12 mois postopératoires chez la brebis avant d'en envisager l'application en situation clinique.Anterior cruciate ligament (ACL) rupture is a frequently encountered condition in orthopedic surgery. Current therapeutic strategies, which consist in replacing the torn ACL with a tendinous autograft after complete excision of its remnants, is still facing limits in terms of functional recovery and morbidity, attributed to the autograft harvesting and to the non-preservation of the ACL remnants. New avenues of research are thus looking at the preservation of the torn ACL remnants and the use of a scaffold to guide the tissue regeneration and to maintain the stability of the joint during ligament healing. This project therefore proposed to evaluate a new synthetic ligament made of absorbable polycaprolactone, functionalized by polyNaSS grafting, which can be used as a scaffold in remnants-preserving reconstruction of acute ACL tears. This evaluation was carried out through two preclinical models defined in rats and sheep. This work initially focused on the establishment of a relevant preclinical model of remnants-preserving ACL reconstruction in rat, which enabled to document the benefits provided by this technique compared to an absence of reconstruction following ACL transection on cartilage lesions, synovitis, joint swelling and on the microarchitecture of ACL remnants of operated knees, in comparison to isolated transection without reconstruction.The evaluation of the synthetic ligament, prototyped for rat dimensions, was carried out secondly in this model. It aimed at providing the proof of concept in terms of its biocompatibility, biofunctionality and bioactivity, through histology, tomodensitometry, magnetic resonance imaging, and molecular biology studies, carried out on the intra-articular and intra-osseous parts of the synthetic ligament, after 12 weeks of implantation, by comparing it to the autograft and to non-grafted counterpart. The grafted synthetic ligament has been shown to be as efficient as the autograft on the functional plane, and has led to better results on synovitis, thickening of articular capsules, as well as on new bone formation within the femoral bone tunnels. The benefits of grafting over non-grafted PCL were revealed, through this evaluation, on cartilage damage, joint swelling, and were suspected on the rupture rate.The grafted and non-grafted synthetic ligaments, sized for a use in sheep, and reproducing the LARS TM design, were subsequently implanted in a remnants-preserving ACL reconstruction model in this species, in which studies similar to those carried out in the rat were lead. Both PCL ligaments (grafted or non-grafted), lead to a macroscopic regeneration of the native ACL, with a significant benefit of the grafting on the intra-articular colonization of the synthetic scaffold and the architecture of the ACL remnants, and a suspected benefit on the rupture rate and bone neoformation into the proximal part of the tibial tunnel. Biomechanical studies must now be performed in the same sheep model after 3 (under investigation) and 12 months implantation periods to confirm the benefits of grafting before translating the technique into clinical setting
Les caliciviroses hypervirulentes : étude épidémiologique, clinique et virologique chez le chat et le lapin
No full textThe purpose of this work is to compare two caliciviruses which provoke life-threatening systemic diseases to cats and rabbits. The virological aspects are initially explained, such as the virion structure, the genomic organization and the cycle ofthe viruses. The epidemiology is approached after, with the description of the epizooties due to the two viruses, their host specificities, their transmission and the risk factors. The clinical signs and macro- and microscopical lesions as well as the biological modifications generated by the two viruses are detailed. The pathogenicity is also exposed. The immunity induced by the infection into the host is later presented together with the diagnosis and therapeutic methods. Finally, the prevention measures to apply are described in both cases.L’objectif de ce travail est d’établir une comparaison entre deux calicivirus à l’origine d’atteintes systémiques mortelles chez le chat et le lapin. Les aspects virologiques seront traités dans un premier temps, tels que la structure des virions et l’organisation du génome ainsi que le cycle viral. Les caractéristiques épidémiologiques seront ensuite abordées, avec la description des épizooties provoquées par les deux virus, leur spécificité d’hôtes, leurs modes de transmission ainsi que les facteurs de risques d’atteinte. Les signes cliniques et les lésions macro- et microscopiques seront exposées ainsi que les modifications des paramètres biologiques engendrées par les deux calicivirus hypervirulents. Les données concernant la pathogénie propre à chaque virus seront également précisées. Seront ensuite envisagés l’immunité induite chez l’hôte suite à l’infection puis les moyens diagnostiques face à une suspicion ainsi que la démarche thérapeutique à mettre en œuvre. Enfin, les mesures de prophylaxie médicales et sanitaires à appliquer dans chacun des deux cas seront définies
In vivo characterization of ARN14140, a memantine/galantamine-based multi-target compound for Alzheimer's disease
No full textAlzheimer's disease (AD) is a chronic pathological condition that leads to neurodegeneration, loss of intellectual abilities, including cognition and memory, and ultimately to death. It is widely recognized that AD is a multifactorial disease, where different pathological cascades (mainly amyloid and tau) contribute to neural death and to the clinical outcome related to the disease. The currently available drugs for AD were developed according to the one-target, one-drug paradigm. In recent times, multi-target strategies have begun to play an increasingly central role in the discovery of more efficacious candidates for complex neurological conditions, including AD. In this study, we report on the in vivo pharmacological characterization of ARN14140, a new chemical entity, which was obtained through a multi-target structure-activity relationship campaign, and which showed a balanced inhibiting profile against the acetylcholinesterase enzyme and the NMDA receptor. Based on the initial promising biochemical data, ARN14140 is here studied in mice treated with the amyloidogenic fragment 25-35 of the amyloid-β peptide, a consolidated non-transgenic AD model. Sub-chronically treating animals with ARN14140 leads to a prevention of the cognitive impairment and of biomarker levels connected to neurodegeneration, demonstrating its neuroprotective potential as new AD agent
Atelier pédagogique Mai 68 à travers les quartiers de Paris
No full textInternational audienceUn atelier pédagogique est proposé à partir de documents d'archives (rapports administratifs et photographies) de Maurice Grimaud, préfet de Police à Paris en Mai 68, pour en analyser le contenu, situer et placer les photos sur un plan de Paris et dessiner le parcours des manifestations
D. Stuttard (ed.), Looking at Medea: Essays and a translation of Euripides’ tragedy
No full text"Euripides’ Medea is one of the most often read, studied and performed of all Greek tragedies": such an introduction of the great Greek classics by Bloomsbury, the publisher of Looking at Medea. Essays and a translation of Euripides’ tragedy raises great expectations. Is it possible, in 2014, to offer new significant insights into Euripides’ most discussed play? Founder of the theatre company Actors of Dionysus, editor or author of several books on Ancient Greek drama and translator, David St..
Integrating somatics and meditation into dance curriculum
No full textIt can feel impossible to find time to add moments of healthful relaxation to an already crowded dance schedule, but it's something that can enhance a dancer's body and mind. Many universities offer a few courses in somatic techniques, but often they are minimal. The author proposes series of daily classes be offered to dance majors, consisting of Improvisation or Gaga Technique, Stretch and Conditioning, Mindful Meditation, Yoga, and Foam Roller coupled with Self and Partner Massage
Exercise training to reduce cardiovascular risk in patients with metabolic syndrome and type 2 diabetes mellitus: How does it work?
No full textMetabolic syndrome (MetS) – a clustering of pathological conditions, including abdominal obesity, hypertension, dyslipidemia and hyperglycaemia – is closely associated with the development of type 2 diabetes mellitus (T2DM) and a high risk of cardiovascular disease.
A combination of multigenetic predisposition and lifestyle choices accounts for the varying inter-individual risk to develop MetS and T2DM, as well as for the individual amount of the increase in cardiovascular risk in those patients. A physically active lifestyle can offset about half of the genetically mediated cardiovascular risk. Yet, the extent to which standardized exercise programmes can reduce cardiovascular risk differs between patients. Exercise parameters, such as frequency, intensity, type and duration or number of repetitions, differentially target metabolic function, vascular health and physical fitness. In addition, exercise-induced molecular mechanisms are modulated by other patient-specific variables, such as age, diet and medication.
This review discusses the molecular and cellular mechanisms underlying the effects of exercise training on cardiovascular risk specifically in patients with MetS and T2DM.The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: NK, MB and MD are supported by the German Centre for Cardiovascular Research (DZHK, partner sites Berlin (NK) and Greifswald (MB, MD)). EMVC is supported by the Fund for Scientific Research Flanders
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