85,091 research outputs found
All-electron magnetic response with pseudopotentials: NMR chemical shifts
No full textA theory for the ab initio calculation of all-electron NMR chemical shifts in insulators using pseudopotentials is presented. It is formulated for both finite and infinitely periodic systems and is based on an extension to the projector augmented-wave approach of Blochl [P. E. Blochl, Phys. Rev. B 50, 17 953 (1994)] and the method of Mauri et al. [F. Mauri, B. G. Pfrommer, and S. G. Louie, Phys. Rev. Lett. 77, 5300 (1996)]. The theory is successfully validated for molecules by comparison with a selection of quantum chemical results, and in periodic systems by comparison with plane-wave all-electron results for diamond
Función homenaje a Rosita Mauri
No full textDe cada obra s'ha digitalitzat un programa sencer. De la resta s'han digitalitzat les parts que són diferents.Empresa: José F. ArquerNota informativa que anuncia una funció extraordinària pel festiu de l'1 de maig, i una funció en homenatge a la ballarina Rosita Mauri, en commemoració del centenari del seu naixemen
Wannier and Bloch orbital computation of the nonlinear susceptibility
No full textWe present a method to compute high-order derivatives of the total energy of a periodic solid with respect to a uniform electric field. We apply the 2n + 1 theorem to a recently introduced total energy functional which uses a Wannier representation for the electronic orbitals and we find an expression for the static nonlinear susceptibility which is much simpler than the one obtained by standard perturbative expansions. We show that the zero-field expression of the nonlinear susceptibility can be rewritten in a Bloch representation. We test numerically the validity of our approach with a 1D model Hamiltonian
Oltre il ritratto: Intellettuale di Fabio Mauri
No full textIl 31 maggio 1975, in occasione dell’inaugurazione della Galleria d’Arte Moderna di Bologna, ha luogo la performance Intellettuale di Fabio Mauri (1926-2009) con Pier Paolo Pasolini come protagonista. In cima alle scale d’ingresso del museo, contro la porta, Pasolini siede su un alto sgabello e sul suo torace, vestito con una camicia bianca, è proiettato il suo film Il Vangelo secondo Matteo. Il contributo propone una lettura dell’opera in dialogo con l’intera ricerca di Mauri e, attraverso il confronti con altre opere nonché con la categoria del ritratto, mira a individuare una prospettiva di analisi, non esaurita nella centralità fisica e simbolica di Pasolini, ma aperta verso il dialogo fra forme linguistiche diverse, come la performance e il cinema, il rapporto fra autore e opera nonché fra regista e pubblico, suggerendo la considerazione di Intellettuale come esercizio dialettico che supera la specificità del soggetto coinvolto e dunque la il genere del ritratto
Synthesis of photoactivable probes for the study of glycosphingolipid-protein interactions
No full textSYNTHESIS OF PHOTOACTIVABLE PROBES FOR THE STUDY OF GLYCOSPHINGOLIPID-PROTEIN INTERACTIONS
Giuseppina Brasile,1 Federica Compostella,1 Laura Mauri,2Sandro Sonnino2 and Fiamma Ronchetti1
Dipartimento di Chimica, Biochimica e Biotecnologie per la Medicina, Università di Milano
1Via Saldini 50, 20133-Milano, Italy; 2Via Fratelli Cervi 93, 20190- Segrate (Milano), Italy
E-mail:[email protected]
It is widely accepted that glycosphingolipids (GSLs) at the level of the plasma membrane can affect the biological functions of protein molecules, such as cell surface receptors or transporters. The interactions between GSLs and proteins belonging to specific membrane microdomains, called lipid rafts, could be responsible for the modulation of the functional properties of membrane proteins participating in signal transduction. GSL-protein interactions can be investigated by cell photolabelling experiments using radioactive photoactivable GSLs, which yield, when illuminated, a very reactive intermediate that covalently binds to the molecules in the environment, i.e. proteins.1,2
In this context, we have designed a fatty acid probe with two nitrophenylazide photoactivable groups, one at position 2 and the other at the end of the acyl chain. The conjugation of the fatty acid to a radioactive sphingoglycolipid generates a species to be used for photolabelling experiments. In this way, the simultaneous identification of the proteins belonging to both the leaflets of the plasma membrane, the cytoplasmatic and the extracellular one, will be realized.
Herein we describe a general synthetic strategy to obtain not commercially available α,ω-diamino acids, the synthetic precursors of the labelled fatty acids, which we have applied to the synthesis of a C-18 derivative. Furthermore, it will be described the preparation of a photolabelled radioactive GSL as a case study.
1. Aureli M., Prioni S., Mauri L. Loberto N., Casellato R., Ciampa M.G., Chigorno V., Prinetti, A.; Sonnino S. J. Lipid Res. 2010, 51, 798-808
2. Mauri L., Prioni S., Loberto N., Chigorno V., Prinetti A., Sonnino S. Glycoconj. J. 2004, 20, 11-23
Analisi dell'applicazione del modello basso rischio ostetrico (BRO) in Italia
No full textOBJECT:
Analysis on the application of the low obstetric risk model in the hospitals of S. Maria della Misericordia in Perugia and Sant'Anna in Turin.
PROJECT:
Data was collected prospectively to analyze the Italian experience of the midwife-led birth model in the alongside midwifery units. In particular, the analysis focuses on the low obstetric risk and aims to be both qualitative and quantitative. Qualitative, in comparing the managerial/organizational hierarchy of the model, the responsables for screening women and the evaluation grids that have been used; quantitative as it draws an analogy between the outcomes of the Italian models with the English model of the Birthplace in England research program. Two environments with similar organizational models have been put in comparison: the Birth Center of Sant'Anna Hospital in Turin and the Hospital S. Maria della Misericordia in Perugia.
RESULTS:
In terms of managerial/organizational hierarchy, the two Italian show substantial differences, especially with regard to the professional profiles involved in screening. In particular, Perugia’s hospital still involves the gynecologist in the evaluation to admit women to the program, despite scientific evidence and the Professional Profile of the midwife confirm that the latter is the most suitable to recognize and diagnose the physiological pregnancy and to assist low-risk women during labor, delivery and post-partum.
Furthermore, the comparison between evaluation grids for the screening of women shows that some exclusion criteria are not shared, for this reason grids that can be shared by all the birth centers are needed to make the outcomes more comparable.
Finally, from a quantitative point of view, we can say that the outcomes of the Italian analysis exactly overlap with the English ones of the Birthplace in England research program
Ga self-interstitials in GaN investigated by ab-initio calculations of the electronic g-tensor
No full textIn GaN, an exceptionally important role is played by Ga-interstitials being mobile at room temperature: Despite rather large formation energy, they have been observed in irradiated uurtzite-GaN: at least two similar, but clearly distict ODEPR-signals L5 and L6/L6* have been identified (via exceptionally large, nearly isotropic hyperfine splittings of about 4 GHz) as interstitial Ga-i(2+) in two diffent lattice configurations. However, judging from experimental data and total energy calculations alone, the exact microscopic configuration remains unclear. In this theoretical work, the situation is elucidated by ab-initio calculating the complete set of EPR parameters, hyperfine splittings as well as g-tensors, for the stable structural configurations of the Ga-interstitial using a gauge-including projector augmented plane wave (GI-PAW) approach. (c) 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
La Corte costituzionale tra questione di genere, discrezionalità del legislatore ed esigenza di preservare l’armonia del sistema (a margine della sentenza 1/22 della Corte costituzionale)
No full textThe paper analyzes the decision 1/2022 of the Italian Constitutional Court on the
constitutionality of the gender-based selection of boarding school educators. Focusing on the Court’s reasoning, the paper investigates the relationship between the Constitutional court and the legislator concerning sensitive issues requiring an interpretation of the collective wil
Framing the Rule of Law: The Contribution of the Venice Commission to the Implementation of the Rule of Law in Europe
No full textThe Rule of law principle represents one of the most important pillars
of the Common European Heritage. As expressed in the Preamble
and in Article 2 of the Treaty on European Union, Rule of Law is one
of the founding values shared between the European Union and its
Member States. In its 2014 A new EU Framework to strengthen the
Rule of Law the European Commission recalls that “the principle of
the Rule of Law has progressively become a dominant organisational
model of modern constitutional law and international organisations
to regulate the exercise of public powers”. Similarly, both in the
Preamble of the Statute of the Council of Europe and the Preamble
of the European Convention on Human Rights, the Rule of Law is
recognised as one of the three “principles which form the basis of
all genuine democracy” and an element of common constitutional
heritage. In the European scenario, both the European Union and the Council
of Europe have acted in several respects with a view to promoting
and strengthening the Rule of Law through many of their bodies.
This paper intends to study the contribution offered by the Venice
Commission, the advisory constitutional body of the Council of
Europe, to the protection and strengthening of the Rule of Law
principle among its Member States. The added value of this research concerns the Commission’s
innovative methodological approach to the Rule of Law principle.
Until now, the Rule of Law has been approached from a theoretical
point of view, in an attempt to give it a definition that would include
all the doctrinal theories elaborated on the principle. The Venice
Commission, on the contrary, after identifying a consensus between
its Member States on the core elements of the Rule of Law, the Rechtsstaat and the État de Droit, has elaborated a checklist for
evaluating the state of the Rule of Law in single countries, following
a practical approach. This original approach aims to facilitate a
correct and consistent understanding and interpretation of the
notion of the Rule of Law and, therefore, to facilitate the practical
application of the principles of the Rule of Law at a national level.
The research will first analyse the work conducted by the
Commission in identifying and selecting the common European
values constituting the implementation of the Rule of Law principle.
In order to do so, it will concentrate on the study of the “Rule of
Law Checklist”, adopted by the Venice Commission in 2016.
After outlining the benchmarks of the Rule of Law principle in
Europe, the paper will examine its practical implementation within
the Commission’s Member States. This analysis will be carried out
by taking into account the standards defined by the Commission
on the one hand and, on the other, by evaluating their practical
application in the Commission’s opinions.
For this purpose, it will be useful to proceed to a cross-study of the
Venice Commission’s Checklist and the relevant opinions.
The rationale of the research will be to demonstrate the ever-
increasing relevance of the Venice Commission as a soft law body
not only in Europe but also in the international scenario and its
fundamental contribution to the strengthening and implementation
of the Rule of Law in Europe
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