198,015 research outputs found
Gelsolin : a regulator of postsynaptic actin assembly and AMPA receptor expression
No full textDendritic spines are the postsynaptic contact sites for the majority of excitatory
synapses in the brain. Synaptic activity influences the number, shape and
motility of dendritic spines and these effects are likely mediated by dynamic
actin filaments, which are highly concentrated in spine heads. Drugs that inhibit
actin dynamics block spine motility and interfere with the development of longterm
potentiation (LTP), a long-lasting increase in synaptic strength considered
to be closely related to learning and memory. This suggests that actin may
serve as a link between activity-induced modulation of synaptic transmission
and long-term changes in synaptic morphology. Despite this evidence for the
importance of actin dynamics in synaptic plasticity, very little is known about its
regulation at the synapse. In particular the mechanisms linking synaptic activity
to the actin cytoskeleton in dendritic spines are not well understood.
The experiments described in this thesis were focused on gelsolin as a
promising candidate for mediating synaptic activity to actin cytoskeleton in
dendritic spines. It is shown here that exposure of cultured hippocampal
neurons to glutamate results in the accumulation of gelsolin in dendritic spines.
This effect is the consequence of activation of NMDA receptors and influx of
Ca2+. It is also shown that the F-actin binding domain of gelsolin is necessary
for its enrichment at postsynaptic sites. Further experiments showed that actin
filaments are more vulnerable to disruption by glutamate stimulation in gelsolin
over-expressing neurons. The disruption of actin filaments in these neurons is
also dependent on NMDA receptor activation and Ca2+ influx. LTD-related
electric field stimulation likewise increased the loss of filamentous actin in
gelsolin expressing cells compared with untransfected cells. The disruption of
actin filaments required the severing function of gelsolin, which is associated
with the specific filament-severing domain (domain 1) of the gelsolin molecule. Severing of F-actin by active gelsolin reduces the amount of AMPA receptors
(GluR1) associated with dendritic spines.
These results indicate that gelsolin plays an important role in linking synaptic
activity to the postsynaptic actin cytoskeleton. Our results are also consistent
with evidence that activation of NMDA receptors and influx of calcium ions play
a crucial role in regulating the actin cytoskeleton in dendritic spines and hence
are involved in the regulation of postsynaptic glutamate receptor plasticity at
excitatory synapses via a feedback mechanism. This could occur in both the
developing and mature brain under both normal and pathologic conditions.
Taken together, our data support a model in which activity-dependent targeting
of proteins into dendritic spines is a major mechanism for regulating synaptic
plasticity at excitatory synapses
Analyses of fuels, ash composition and ash melting temperatures for poultry litter with 8% aluminosilicate addition.
No full textENG:The collection contains research results produced as part of the project entitled 'Influence of aluminosilicate additives on the high-temperature corrosion process and ash characteristics of animal biomass', funded by the National Science Centre.Animal biomass is gaining popularity as an economically viable source of renewable energy. However, due to its specific composition and properties, this biomass can pose problems during thermal conversion. The aim of the project is to investigate the influence of aluminosilicate additives on the corrosion potential and properties of animal biomass ash. The project focuses on problems such as slagging propensity, high-temperature corrosion, ash grain distribution and metal content and leachability. Two types of biomass with the greatest potential are being investigated: poultry litter and from cattle dung.In the package named ‘Ash_Fuel_Analysis,’ the results of fuel and ash analyses were included for two different samples of poultry litter. The analysis results are presented in the publication: Maj, I.; Niesporek, K.; Matus, K.; Miccio, F.; Mazzocchi, M.; Łój, P. The Impact of Aluminosilicate Additives upon the Chlorine Distribution and Melting Behavior of Poultry Litter Ash. Energies 2024, 17, 1854. https://doi.org/10.3390/en17081854.. This publication also includes the results of the SEM analysis included in the dataset: Niesporek, Kamil; Matus, Krzysztof; Maj, Izabella, 2024, "Analiza SEM wpływu dodatków glinokrzemianowych na charakterystykę popiołu z biomasy pochodzenia zwierzęcego", https://doi.org/10.18150/9NS2VJ, RepOD, V1. The poultry litter samples, after pre-drying and grinding in a laboratory grinder, were combusted with an 8% fuel additive in ceramic crucibles. Aluminosilicates in the form of halloysite, bentonite, and kaolin were used as additives. The process took place at a constant temperature zone of 550°C, resulting in chemically stable ash with minimal unburned carbon.The dataset contains an XLSX file with the analysis results conducted in accredited laboratories and README text file with essential information about the provided filesPOL:Zbiór zawiera wyniki badań wytworzone w ramach projektu pt. "Wpływ dodatków glinokrzemianowych na proces korozji wysokotemperaturowej i charakterystykę popiołu z biomasy pochodzenia zwierzęcego" finansowanego przez Narodowe Centrum Nauki.Biomasa pochodzenia zwierzęcego zyskuje popularność jako opłacalne ekonomicznie źródło energii odnawialnej. Jednak ze względu na specyficzny skład i własności biomasa ta może nastręczać problemów podczas konwersji termicznej. Celem projektu jest zbadanie wpływu dodatków glinokrzemianowych na potencjał korozyjny i własności popiołu z biomasy pochodzenia zwierzęcego. Projekt skupia się na problemach takich jak skłonność do żużlowania, korozja wysokotemperaturowa, rozkład ziarnowy popiołu oraz zawartość i wymywalność metali. Badane są dwa rodzaje biomasy o największym potencjale: odpady z produkcji drobiu (poultry litter) oraz z hodowli bydła (cattle dung).W paczce o nazwie "Ash_Fuel_Analysis" zawarto wyniki analiz paliwa i popiołu dla dwóch różnych próbek ściółki drobiowej. Wyniki analiz zostały przedstawione w publikacji: Maj, I.; Niesporek, K.; Matus, K.; Miccio, F.; Mazzocchi, M.; Łój, P. The Impact of Aluminosilicate Additives upon the Chlorine Distribution and Melting Behavior of Poultry Litter Ash. Energies 2024, 17, 1854. https://doi.org/10.3390/en17081854. W publikacji tej zawarto również wyniki analizy SEM zawarte w zbiorze danych: Niesporek, Kamil; Matus, Krzysztof; Maj, Izabella, 2024, "Analiza SEM wpływu dodatków glinokrzemianowych na charakterystykę popiołu z biomasy pochodzenia zwierzęcego", https://doi.org/10.18150/9NS2VJ, RepOD, V1. Próbki ściółki drobiowej, po wstępnym wysuszeniu i zmieleniu w młynku laboratoryjnym, zostały spalone z 8% dodatkiem paliwa w tyglach ceramicznych. Jako dodatki zastosowano glinokrzemiany w postaci haloizytu, bentonitu i kaolinu. Proces odbywał się w strefie stałej temperatury 550°C, w wyniku czego uzyskano stabilny chemicznie popiół z minimalną ilością niespalonego węgla.Zbiór danych składa się z pliku XLSX z wynikami analiz przeprowadzonych w akredytowanych laboratoriach oraz pliku tekstowego README z niezbędnymi informacjami na temat dostarczonych plików.</p
Miracle icons of the Mother of God in Pukhly and Zherchitse parishes
No full textIкона займае ў Праваслаўнай Царкве надзвычай важнае месца. Мацi Божая, а таксама яе цудоўныя выявы адыгрываюць вялiкую ролю ў жыццi праваслаўных хрысцiян. У артыкуле разглядаецца гiсторыя культу цудоўных абразоў Багародзiцы: Пакравоў у праваслаўным прыходзе ў Пухлах, а таксама Цiхвiнскай i Журобiцка-Руднянскай iкон, якiя знаходзяцца ў праваслаўным прыходзе ў Жэрчыцах. Падкрэслена, што, нягледзячы на шматлiкiя выпрабаваннi, яны дасюль аточаны асаблiвай пашанай, а пiлiгрымы, якiя перад iмi моляцца, атрымлiваюць ацаленне i ласку ад Багародзiцы.The icon in Orthodox Church occupies an important place. The Mother of God and her miracle images play a crucial role in the life of Orthodox Christians. In the article the worship of miracle icons from Pukhly and Zherchitse parishes has been analyzed. The author emphasizes that the icons are still enshrined. Pilgrims who pray in front of them return to health and St. Mary the Virgin grants them mercy.Matus Justyna, magister filologii rosyjskiej, studentka Studiów Doktoranckich Uniwersytetu w Białymstoku.Uniwersytet w BiałymstokuBołtryk M., Krzyże na kurhanie, [online], http://www.przegladprawoslawny.pl/articles.php?id n=2701&id=8, [12.07.2017].Charkiewicz J., Tobą raduje się całe stworzenie, Warszawa 2007.Klimaszewski C., Legenda z Żurobic – Źródło z cudowną wodą bije wśród olszyny, [online], http://siemiatycze.com.pl/notatnik-historyczny/681-legenda-z-urobic-rodo-z-cudown-wod-bije-wrod-olszyny-.html, [13.07.2017].Matus I., Historia parafii Opieki Matki Bożej w Puchłach, [w:] Kalendarz prawosławny 2016, Białystok 2015.Matus I., Schyłek Unii i proces restytucji prawosławia w obwodzie białostockim w latach 30. XIX wieku, Białystok 2013.Matus I., W Puchłach, Stawku, Trześciance: z dziejów oświaty ludu białoruskiego na Podlasiu, Białystok 2000.Sosna G., Troc-Sosna A., Parafia w Żerczycach, Białystok 2001.Sosna G., Troc-Sosna A., Święte miejsca i cudowne ikony. Prawosławne sanktuaria na Białostocczyźnie, Białystok 2001.Szpakowski Z., Czy ślad najstarszej organizacji parafialnej?, „Więź” 1966, Nr 10 (102).Tradigo A., Ikony i święci prawosławni, Warszawa 2011.Бреннъ Я., Особенности религиозного быта крестьян Бельского уезда Гродненской губерни, “Литовския Епархальныя Ведомости за 1887 г.”,№1–2, Вильна 1888, с. 5.Archiwum Wojewódzkiego Urzędu Ochrony Zabytków w Białymstoku [karty poszczególnych zabytków].937338
Suplementary Material. Comparison of LTC needs in 6 Latin American countries
No full textOBJECTIVES: To provide comparable estimates of LTCS needs among the older populations of six Latin American countries.
METHODS: Observational transversal, cross-national study, using microdata drawn from national surveys conducted in Argentina (n = 3291), Brazil (n = 3903), Chile (n = 31667), Colombia (n = 17134), Mexico (n = 8194), and Uruguay (n = 4042). Comparable indicators of the difficulties and need for help in the performance of daily and instrumental activities of daily living were calculated.
RESULTS: Mexico (44.8%) and Brazil (39.0%) had the largest percentages of older adults with difficulties in the performance of daily activities, while Uruguay had the lowest (21.4%). in Colombia, almost one in three older adults needs help in doing these activities (31.9%). Brazil is the second highest (29.1%).
DISCUSSION: The findings are warning about the high potential demand for long-term care services in those countries. The information could be useful for research on the demand, and estudios de viabilidad técnica y económica of long-term care policies
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Buscando la adhesión de stakeholders: la responsabilidad y la eficacia como valores en las cartas de los CEO en las memorias de RSE en Chile
No full textThis paper shows part of the results of a study on the rhetorical use of values in the communication of corporate social responsibility in Chile: In particular, an analysis of the discourse applied to the letters from Chief Executive Officers (CEOs) which were included in the reports of the ten companies that led the Corporate Sustainability Ranking, prepared in 2017 by the Prohumana Foundation. To face this challenge, a model of rhetorical - communicational analysis that considers argumentation principles by values was elaborated (Perelman and Olbrechts - Tyteca, 1994, Bellenger, 1992).The results show that the letters are addressed to a particular audience (the stakeholders), that they are hybrid rhetorical expressions (of judicial and epidictic nature), and that specific values, such as responsibility and effectiveness, prevail in them. These values pretend to logically and ethically sustain the companies’ argument or story, implying a level of agreement: The reader is committed not to discuss or deny himself in the existence of the validity of values and, from that perspective, he aspires to eliminate resistance or criticism of financial, environmental and social management. In this sense, the premise that sustainability reports are representative texts of corporate identity and strategies is confirmed.Este artigo mostra parte dos resultados de um estudo sobre o uso retórico dos valores na comunicação da responsabilidade social corporativa no Chile. Em particular, uma análise do discurso aplicada às cartas dos Chief Executive Officer (CEO) incluídas nos relatórios das dez companhias que lideraram o Ranking de sustentabilidade empresarial elaborado pela fundação Prohumana em 2017. Para enfrentar esse desafio, elaborou - se um modelo de análise retórica - comunicacional que considera princípios da argumentação por valores (Perelman e Olbrechts - Tyteca, 1994; Bellenger, 1992). Os resultados mostram que as cartas estão dirigidas a um público particular (os stakeholders), que são expressões retóricas híbridas (judiciais e epidícticas) e que nelas primam os valores concretos, como a responsabilidade e a eficácia. Esses valores pretendem sustentar lógica e eticamente o argumento ou relato das empresas, implicando um nível de acordo: aposta - se que o leitor não discutirá nem porá em dúvida a existência nem a vigência daqueles valores e, a partir dessa perspectiva, aspira - se a eliminar as resistências ou críticas ao gerenciamento financeiro, ambiental e social. Nesse sentido, corrobora - se a premissa de que as memórias de sustentabilidade são textos representativos da identidade corporativa e de suas estratégias.Este artículo muestra parte de los resultados de un estudio sobre el uso retórico de los valores en la comunicación de la responsabilidad social corporativa en Chile. En particular, un análisis del discurso aplicado a las cartas de los Chief Executive Officer (CEO) incluidas en los reportes de las diez compañías que lideraron el Ranking de sustentabilidad empresarial elaborado por la fundación Prohumana en 2017. Para enfrentar este desafío se elaboró un modelo de análisis retórico - comunicacional que considera principios de la argumentación por valores (Perelman y Olbrechts - Tyteca, 1994; Bellenger, 1992). Los resultados muestran que las cartas están dirigidas a un auditorio particular (los stakeholders), que son expresiones retóricas híbridas (judiciales y epidícticas) y que en ellas priman los valores concretos, como la responsabilidad y la eficacia. Estos valores pretenden sustentar lógica y éticamente el argumento o relato de las empresas, implicando un nivel de acuerdo: se apuesta a que el lector no discutirá ni pondrá en duda la existencia ni la vigencia de aquellos valores y, desde esa perspectiva, se aspira a eliminar las resistencias o críticas a la gestión financiera, ambiental y social. En ese sentido se corrobora la premisa de que las memorias de sostenibilidad son textos representativos de la identidad corporativa y sus estrategias
Dr. Glendon Swarthout
No full textHosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness
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