210 research outputs found
Ancora sul giordanismo meridionale: aggiunte a Matteo Simonelli
No full textIl saggio traccia un primo catalogo delle opere di Matteo Simonelli, un pittore nell’ambito di Luca Giordano, in precedenza noto solamente per due dipinti in Basi-licata. Vengono proposte opere inedite, alcune firmate altre qui attribuite, rico-struendo per la prima volta la sua diramata attività, che si estese anche a Napoli, Mercogliano, Montoro, Sassari e Spezzano della Sila.The essay traces a first catalog of the works of Matteo Simonelli, a painter in the context of Luca Giordano, previously known only for two paintings in Basilicata. Un-published works are proposed, some signed, others attributed here, reconstructing for the first time its branched activity, which also extended to Naples, Mercogliano, Mon-toro, Sassari and Spezzano della Sila
La vendita dei lotti boschivi: un analisi dei costi di transazione in quattro realtà amministrative italiane
No full textHarmonization of market entry regulation for the operation of air services in the European Union: A comparative survey of the implementation of Regulation (EC) no. 1008/2008 by Member States’ authorities
No full textLa filiera del Legno in Umbria. Potenzialità dell'offerta e prospettive di svilupppo della domanda
No full text
Tivantinib : a new promising mesenchymal–epithelial transition factor inhibitor in the treatment of hepatocellular carcinoma
No full textTivantinib (ARQ 197) is an orally administered, selective small molecule that inhibits mesenchymal-epithelial transition factor (MET) via a novel, ATP-independent binding mechanism. Preclinical studies demonstrated that tivantinib has a broad-spectrum anti-tumor activity, especially in cells expressing high levels of MET. A randomized Phase II study in second-line hepatocellular carcinoma showed statistically significant improvement in time to progression with tivantinib compared to a placebo. Noteworthy, a significant pronounced benefit in time to progression and overall survival was observed in MET-high patients. In addition, MET expression was defined as a negative prognostic factor. The most frequent adverse events were hematologic events. A Phase III study in the MET-high hepatocellular carcinoma is actively recruiting patients. Phase II and III studies in non-small-cell lung cancer and colorectal cancer are ongoing
Driven dissipative dynamics in an open many-body quantum system
No full textIn a large variety of systems in nature, a small change of an external parameter around a critical value could affect the microscopic dynamics in such a deep way that the entire system changes sharply its macroscopic state and properties, experiencing what is known as a phase transition. Non equilibrium phase transitions are a particular class of phase transitions which occur in systems far from the thermal equilibrium. An example is that of absorbing state phase transitions, in which the behaviour of the system is determined by the competition of two processes, where one increases the order parameter of the transition, while the other lowers it. The system thus ends in one of two different states, either an oscillating state, or an absorbing state in which the order parameter equals zero and from which the system cannot escape. An example is represented by the infectious spreading of a disease, in which the two processes are the infection and the spontaneous healing, while the two final states are a partially infected or a completely healed population
Analysis of Refractive Errors in a Large Italian Cohort of Pediatric Subjects Post the COVID-19 Pandemic
No full textBackground: The prevalence of refractive errors has sharply risen over recent decades. Despite the established role of genetics in the onset and progression of such conditions, the environment was also shown to play a pivotal role. Indeed, the COVID-19 pandemic has majorly impacted people's lifestyles and healthy habits, especially among the youth, which might have led to a significant increase in this trend. Therefore, the aim of this study was to investigate the actual prevalence of refractive errors in a large cohort of pediatric patients. Methods: A large cohort of 496 participants was screened through anamnesis, a non-cycloplegic autorefractometry, a corrected and uncorrected visual acuity assessment, and a questionnaire and was retrospectively evaluated. Results: Overall, refractive errors were present in 25.1% of eyes, of which 14.6% were diagnosed with myopia/myopic astigmatism and 10.5% with hyperopia/hyperopic astigmatism. Among the patients enrolled, 298 (60%) had their eyes checked one year earlier or before and 122 (25%) had never had ophthalmological consultations; a total of 105 (21%) needed glasses and 34 (7%) required a change in their previous prescription. A substantial increase in daily electronic device screen exposure was declared by 426 patients (87.6%). Conclusions: Pediatric patients appear to have a higher prevalence of refractive errors than before
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