6,866 research outputs found
Interview with Nicholas Christopher, author of Somewhere in the Night: Film Noir and the American City
No full textInterview with Nicholas Christopher, author of Somewhere in the Night: Film Noir and the American Cit
Resurrecting the Author
No full textPresentation of Nicholas Wolterstorff\u27s Paper Resurrecting the Author with time after for questions beginning at 18:00
Replicated effects of sex and genotype on gene expression in human lymphoblastoid cell lines
No full textCopyright © The Author 2006. Published by Oxford University Press. All rights reserved.The expression level for 15 887 transcripts in lymphoblastoid cell lines from 19 monozygotic twin pairs (10 male, 9 female) were analysed for the effects of genotype and sex. On an average, the effect of twin pairs explained 31% of the variance in normalized gene expression levels, consistent with previous broad sense heritability estimates. The effect of sex on gene expression levels was most noticeable on the X chromosome, which contained 15 of the 20 significantly differentially expressed genes. A high concordance was observed between the sex difference test statistics and surveys of genes escaping X chromosome inactivation. Notably, several autosomal genes showed significant differences in gene expression between the sexes despite much of the cellular environment differences being effectively removed in the cell lines. A publicly available gene expression data set from the CEPH families was used to validate the results. The heritability of gene expression levels as estimated from the two data sets showed a highly significant positive correlation, particularly when both estimates were close to one and thus had the smallest standard error. There was a large concordance between the genes significantly differentially expressed between the sexes in the two data sets. Analysis of the variability of probe binding intensities within a probe set indicated that results are robust to the possible presence of polymorphisms in the target sequences.Allan F. McRae, Nicholas A. Matigian, Lata Vadlamudi, John C. Mulley, Bryan Mowry, Nicholas G. Martin, Sam F. Berkovic, Nicholas K. Hayward and Peter M. Vissche
Heritability and Linkage Analysis of Appendicitis Utilizing Age at Onset
No full textAppendicitis usually afflicts the young, but there is a large tail in the distribution of onset age. The genetics of this disease are still not well understood. A heritability analysis and genome wide linkage analysis of a large twin dataset was undertaken. Treating age of onset of appendicitis as a censored survival trait revealed a heritability of 0.21, and found evidence of linkage to Chromosome 1p37.3. Author(s): Christopher Oldmeadow 1 * | Kerrie Mengersen 2 | Nicholas Martin 3 | David L. Duffy
Nicholas de Monchaux: Local Code / Real Estates
No full textNicholas de Monchaux is an architect and urbanist whose work explores the intersections between nature, technology, and the city. He is the author of Spacesuit: Fashioning Apollo (MIT Press, 2011), an architectural history of the Apollo 11 spacesuit. He is Assistant Professor of Architecture and Urban Design at UC Berkeley. The work of his design studio has been exhibited widely and is currently being featured in the US Pavillion of the 13th Venice Biennale
Nicholas Meyer: 10-31-1979
No full textNicholas Meyer is a screenwriter, producer, director, and author, and a graduate of the University of Iowa. He is the author of the screenplay the Seven Per Cent Solution and co-author of The Black Orchid. He begins the interview by discussing his professional career as both a film writer/director and a novelist. He then talks about how he began writing novels, and discusses the research that goes into his novels. Meyer continues by discussing his movie Time After Time and concludes the interview by listing prominent teachers and writing influences.Archived web contentSUNY BrockportWriters Forum Video
Nicholas Meyer: 10-31-1979
No full textNicholas Meyer is a screenwriter, producer, director, and author, and a graduate of the University of Iowa. He is the author of the screenplay the Seven Per Cent Solution and co-author of The Black Orchid. He begins the interview by discussing his professional career as both a film writer/director and a novelist. He then talks about how he began writing novels, and discusses the research that goes into his novels. Meyer continues by discussing his movie Time After Time and concludes the interview by listing prominent teachers and writing influences.https://digitalcommons.brockport.edu/writers_videos/1022/thumbnail.jp
Interview with Nicholas Wade by Marni Siegel, November 8, 2007
No full textThe interview was a project of the Center for Public Genomics (http://www.genome.duke.edu/centers/cpg/).Nicholas Wade is a science writer for the New York Times and author of several books, including LifeScripts, about genetics and genomics. He also covered the Asilomar Conference for Science magazine.Funded by a grant from the National Human Genome Research Institute and the US Department of Energy (P50 HG003391)
LSE festival Beveridge 2.0 preview: the five giants by Nicholas Timmins
No full textOn Monday 19 February, LSE Festival opened with ‘The Five Giants and the Ministers Who Made a Difference’. Chaired by LSE Director Minouche Shafik, Nicholas Timmins, author of The Five Giants: A Biography of the Welfare State, and Professor Sir Julian Le Grand debated the key UK politicians who really made a difference when it came to Beveridge’s ‘Five Giants’: listen to the podcast here. Ahead of the event, Nicholas Timmins gives insight into the reception and impact of Beveridge’s 1942 report, as well as its enduring significance in today’s global, 21st-century context
01-06-2020 Author Nicholas Sparks Speaking at SWOSU on February 5
No full textAuthor Nicholas Sparks speaks at Southwestern Oklahoma State University in Weatherford on Wednesday, February 5, and the public is invited
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