217 research outputs found
Bibliographics for the 983 eprints in the live archives of E-LIS : trends and status report up to 7th July 2004, based on author-self-archiving metadata
Get PDFThe priority for ideas and philosophy related to "Network Theory" have been traced back and documented by Braun(2004),and credit goes to Karinthy(1929).The IT has empowered to realise it, as the most practical phenomena and it is no more a humour. The OAI (Open Archives Initiatives)and ACIS (Academic Contributor Information System)are progressive in the direction ,which may lead to realise the "Collective Genius" at global level. Focus of present study is on Author-Self-Archiving (A-S-A)Metadata of the 983 Eprints in the Live Archives of the E-LIS (EPrints of Library and Information Science),which were approved till 7th July 2004.The A-S-A Metadata was used for librametric analysis. Self-explanatory bibliographics are illustrated.The highlights include: Conference papers (34%); highest approval, June 2004 (28%); published archives (76%);not refereed (52%); not in public domain (60%); highest self-archiving-author (De Robbio, Antonella).The Nos. of EPrints having single JITA domain specifications were: Theoretical and general aspects of libraries and information(27); Information use and sociology of information(80);Users,literacy and reading(13);Libraries as physical collections(30);Publishing and legal issues(57);Management(13);Industry, profession and education(36);Information sources, supports, channels(113) ; Information treatment for information services, Information functions and techniques (101); Technical services libraries, archives and museums(25); Housing technologies(1); Information technology and library technology(92); and Inter-domainery (395) i.e. having specifications of two or more than two JITA classes
Acute Ethanol Administration Rapidly Increases Phosphorylation of Conventional Protein Kinase C in Specific Mammalian Brain Regions in Vivo
Get PDFBackground
Protein kinase C (PKC) is a family of isoenzymes that regulate a variety of functions in the central nervous system including neurotransmitter release, ion channel activity, and cell differentiation. Growing evidence suggests that specific isoforms of PKC influence a variety of behavioral, biochemical, and physiological effects of ethanol in mammals. The purpose of this study was to determine whether acute ethanol exposure alters phosphorylation of conventional PKC isoforms at a threonine 674 (p-cPKC) site in the hydrophobic domain of the kinase, which is required for its catalytic activity.
Methods
Male rats were administered a dose range of ethanol (0, 0.5, 1, or 2 g/kg, intragastric) and brain tissue was removed 10 minutes later for evaluation of changes in p-cPKC expression using immunohistochemistry and Western blot methods.
Results
Immunohistochemical data show that the highest dose of ethanol (2 g/kg) rapidly increases p-cPKC immunoreactivity specifically in the nucleus accumbens (core and shell), lateral septum, and hippocampus (CA3 and dentate gyrus). Western blot analysis further showed that ethanol (2 g/kg) increased p-cPKC expression in the P2 membrane fraction of tissue from the nucleus accumbens and hippocampus. Although p-cPKC was expressed in numerous other brain regions, including the caudate nucleus, amygdala, and cortex, no changes were observed in response to acute ethanol. Total PKC? immunoreactivity was surveyed throughout the brain and showed no change following acute ethanol injection
Anomaly-Based DNN Model for Intrusion Detection in IoT and Model Explanation: Explainable Artificial Intelligence
No full textIoT has gained immense popularity recently with advancements in technologies and big data. IoT network is dynamically increasing with the addition of devices, and the big data is generated within the network, making the network vulnerable to attacks. Thus, network security is essential, and an intrusion detection system is needed. In this paper, we proposed a deep learning-based model for detecting intrusions or attacks in IoT networks. We constructed a DNN model, applied a filter method for feature reduction, and tuned the model with different parameters. We also compared the performance of DNN with other machine learning techniques in terms of accuracy, and the proposed DNN model with weight decay of 0.0001 and dropout rate of 0.01 achieved an accuracy of 0.993, and the reduced loss on the NSL-KDD dataset having five classes. DL models are a black box and hard to understand, so we explained the model predictions using LIME.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Cyber Securit
Erratum: The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition (Proceedings of the National Academy of Sciences of the United States of America (2020) 117 (4180-4187) DOI: 10.1073/pnas.1913481117)
No full textCorrection for “The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition,” by Simone F. Glaser, Andreas W. Heumüller, Lukas Tombor, Patrick Hofmann, Marion Muhly-Reinholz, Ariane Fischer, Stefan Günther, Karoline E. Kokot, David Hassel, Sandeep Kumar, Hanjoong Jo, Reinier A. Boon, Wesley Abplanalp, David John, Jes-Niels Boeckel, and Stefanie Dimmeler, which was first published February 7, 2020; 10.1073/pnas.1913481117 (Proc. Natl. Acad. Sci. U.S.A. 117, 4180-4187). The authors note that Hitoshi Okada should be added to the author list between Karoline E. Kokot and David Hassel. Hitoshi Okada should be credited with providing mice. The corrected author line, affiliation line, and author contributions appear below. The online version has been corrected
Analytical study of contents of LANL physics and cross-listed e-print archives, 1994-2002
No full textThe frontiers of physics and cross-listed e-print archives posted during the years 1994-2002 at http://www.arxiv.org/archives/physics web service of Los Alamos National Laboratory (LANL) are explored from 7770 submissions. E-print archives posted to top most six physics-cross-listed research categories besides physics (5390) are: Condensed matter (754), Quantum physics (279), Astrophysics (222), Chemical physics (129), High energy physics - Phenomenology (118), and High energy physics-Theory (100). Prominent contributors are B.G. Sidharth (India), V.V. Flambaum (Australia), Antonina N. Fedorova (Russia), and Michael G. Zeitlin (Russia). Most preferred journals for rechannelising e-print archives are Physical Review Letters, Physical Review A, Physical Review E, Nuclear Instruments and Methods A, and Journal of Chemical Physics
Minimum impact and immediacy of citations to physics open archives of arXiv.org: Science Citation Index based reports
No full textThe present work has calculated the minimum Open Archive Impact Factors and Open Archive Immediacy Index for the Physics Classes of arXiv.org as calculated for traditional journals in Journal Citation Reports of Institute of Scientific Information using Science Citation Index without the citation by the classes itself. The calculated Impact Factors reveal that High-Energy Physics classes of arXiv.org (‘hep-th’, ‘hep-lat’, ‘hep-ex’, and ‘hep-ph’) have made more impact on scientific community than any other classes except for the class ‘nucl-ex’. The Impact Factors for the year 2003 are: ‘hep-th’ (0.999), ‘nucl-ex’ (0.806), ‘hep-lat’ (0.766), ‘hep-ex’ (0.73), ‘hep-ph’ (0.719), ‘nucl-th’ (0.338), ‘quant-ph’ (0.334), ‘cond-mat’ (0.313), ‘astro-ph’ (0.195), ‘math-ph’ (0.162), ‘physics’ (0.061), and ‘gr-qc’ (0.002). It has been found that if the period for getting the citations to the open archive classes is considered one year as against two years for journal articles the rank of the classes are same. The immediacy of citing the Open Archives is also high for the High-Energy Physics classes. The Immediacy Indexes for the year 2003 are: ‘hep-ex’ (0.619), ‘hep-th’ (0.454), ‘hep-ph’ (0.44), ‘hep-lat’ (0.263), ‘nucl-ex’ (0.238), ‘quant-ph’ (0.202), ‘nucl-th’ (0.185), ‘cond-mat’ (0.168), ‘astro-ph’ (0.094), ‘math-ph’ (0.075), ‘physics’ (0.03), and ‘gr-qc’ (0.002). Definitely, the impact is much more than what is concluded from the calculated factors as the self-citations are not taken into the study. The above arguments may be strengthened if the study could use the web-tools like ‘Citebase’, ‘Citeseer’ etc
Transcriptomic analysis of visceral adipose from healthy and diabetic obese subjects
No full textUnderstanding the role of visceral fat accumulation in the occurrence and progression of metabolic syndrome is of considerable interest. In order to understand the difference between visceral tissue biology of healthy and unhealthy obese individuals, we have used microarray profiling to compare genome-wide expression differences between visceral adipose tissue biopsies obtained from obese diabetics, and those from age and body mass index (BMI) matched normal glucose tolerance subjects. Whereas genes upregulated in diabetics showed enrichment of natural killer cell mediated cytotoxicity, the downregulated genes showed enrichment of biosynthesis of unsaturated fatty acids. Given the known inhibitory effect of unsaturated fatty acids on inflammation and natural killer cell number or activity, our results suggest that visceral inflammation resulting from decreased levels of unsaturated fatty acids may underlie progression of diabetes in obese individuals
DOES GREATER AUTONOMY IMPROVE PERFORMANCE? EVIDENCE FROM WATER SERVICE PROVIDERS IN INDIAN CITIES
Get PDFWe assess the efficiency of urban water supply in 27 Indian cities using data envelopment analysis (DEA). We also group cities by the management structure of their water utilities. Utilities with greater degree of functional autonomy perform better, supporting the hypothesis that more autonomy in management leads to better performance among water utilites. Our results also have implications for urban domestic water pricing--most of the utilities operate under decreasing returns to scale (DRS) implying water should be priced at marginal cost of supply.
Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications
Get PDFClustering of insulin resistance and dysmetabolism with obesity is attributed to pathologic adipose tissue. The morphologic hallmarks of this pathology are adipocye hypertrophy and heightened inflammation. However, it's underlying molecular mechanisms remains unknown. Study of gene function in metabolically active tissues like adipose tissue, skeletal muscle and liver is a promising strategy. Microarray is a powerful technique of assessment of gene function by measuring transcription of large number of genes in an array. This technique has several potential applications in understanding pathologic adipose tissue. They are: (1) transcriptomic differences between various depots of adipose tissue, adipose tissue from obese versus lean individuals, high insulin resistant versus low insulin resistance, brown versus white adipose tissue, (2) transcriptomic profiles of various stages of adipogenesis, (3) effect of diet, cytokines, adipokines, hormones, environmental toxins and drugs on transcriptomic profiles, (4) influence of adipokines on transcriptomic profiles in skeletal muscle, hepatocyte, adipose tissue etc., and (5) genetics of gene expression. The microarray evidences of molecular basis of obesity and insulin resistance are presented here. Despite the limitations, microarray has potential clinical applications in finding new molecular targets for treatment of insulin resistance and classification of adipose tissue based on future risk of insulin resistance syndrome
Some exact solitons to the (2+1)-dimensional broer-kaup-kupershmidt system with two different methods
No full textThe author, Sandeep Malik, thankfully acknowledges CSIR SRF Grant: 09/1051(0028)/2018-EMR-I.
09/1051(0028)/2018-EMR-ICSIR SRF GrantThe exact solutions of the (2 + 1) dimensional Broer-Kaup-Kupershmidt (BKK) system which has been recommended to model the nonlinear and dispersive long gravity waves traveling along with the two horizontal directions in the shallow water of uniform depth were obtained. Firstly, the given system was reduced to an ordinary differential equation (ODE) with the help of the wave transformations. Then, the reduced ODE was solved with the help of two methods which are called the modified (G'/G)-expansion method and new extended generalized Kudryashov method. We checked the results with the Maple software and plotted 3D, contour and 2D plots of some obtained solutions. As a result, we obtained exact solutions that are different from each other and have not been obtained before. Results can enhance the nonlinear dynamical behavior of a given system and demonstrate the effectiveness of the employed methodology. Results will be beneficial to a large number of engineering model specialists and useful for understanding the wave motions
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