103 research outputs found
Experimental evaluation of long term evolution-based NC OFDM secondary-to-secondary interference
No full textScarcity of spectrum resources, inefficient spectrum usage and the inflexibility of the current spectrum assignment are few of the major roadblocks in the development of new wireless communication standards. Secondary spectrum sharing has become a viable solution to alleviate this problem. Secondary users are unlicensed devices that use opportunistic spectrum access to identify vacant frequency bins and thereby utilize the spectrum. For advanced wireless communication standards like the Long Term Evolution (LTE) which primarily calls for higher data rates, evaluation of design parameters for ensuring efficient coexistence of heterogeneous secondary users and guaranteeing acceptable minimum level of performance becomes essential. Additionally, the understanding of the interference between secondary users occupying adjacent frequency bands for their transmission is imperative. This thesis focuses on the coexistence of secondary users in the same band assuming that the primary spectrum is found available. By Implementing two Non Contiguous Orthogonal Frequency Division Multiplexing ( NC-OFDM) based secondary transmitters on a real time platform, the design parameters that need to be considered to ensure efficient coexistence have been identified and investigated. The performance degradations observed at a particular secondary link due to presence of another interfering secondary link occupying adjacent frequency bands for its transmission have also been studied. This thesis also focuses on implementation of algorithms to modify the existing NC-OFDM transmission at the secondary transmitter end to reduce its Interference effects on the other secondary links operating within the same band. The focus is on an LTE-based Secondary Non Contiguous Orthogonal Frequency Division Multiplexing Transceiver on a Real Time Platform developed by National Instruments. The various blocks needed to design a real time LTE based communications links are discussed. An experimental LTE-to-LTE interference analysis based on the Real Time Platform and the designed system is presented.M.S.Includes bibliographical referencesby Ajay Ramkumar Iye
Cross-Talk Between Inflammation and Barrier Framework at Mucosal Surfaces in the Lung: Implications for Infections and Pathology
No full textThis eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contac
Transcriptional Landscape Of FOXP3+ Regulatory T Cells Under Mitochondrial Oxidative Stress: Implications For Inflammaging
No full textThis thesis explores the intricate relationship between mitochondrial oxidative stress and the function of FOXP3+ regulatory T cells (Tregs), highlighting their essential roles in the aging immune system and the development of age-related diseases. The study delves into how mitochondrial impairments within Tregs contribute to widespread inflammation leading to pathological aging. One key analysis shows that mitochondrial oxidative stress undermines Treg functionality, intensifying inflammatory responses and increasing frailty in older adults. This dysfunction is associated with elevated inflammatory markers and presents a potential target for therapeutic interventions aimed at restoring mitochondrial health to alleviate these impacts. Another significant discovery connects the dysfunction of CD4 Foxp3 Tregs in cerebrospinal fluid with the worsening of Alzheimer\u27s pathologies. The study finds that mitochondrial deterioration within Tregs is crucial in regulating neuroinflammation, thereby affecting the progression of Alzheimer\u27s disease. Enhancing mitochondrial function is identified as a possible approach to diminish inflammatory signals and the buildup of amyloid in the brain. A Foxp3-specific TFAM conditional knockout mouse model reveals that the absence of mitochondrial transcription factor A (TFAM) in Tregs leads to a shift in the CD4 T cell landscape toward more pathogenic profiles, characterized by increased cellular senescence, plasticity, and systemic inflammation. These findings highlight the potential of targeting mitochondrial function in Tregs as a novel therapeutic strategy to influence immune aging. The thesis underscores that boosting mitochondrial biogenesis or curtailing mitochondrial oxidative stress could stabilize Treg function, thus reducing inflammaging and its associated health risks. This research offers a thorough examination of the role of Tregs under mitochondrial oxidative stress, substantially enhancing our understanding of immune regulation in aging and its implications for treating age-related diseases. By outlining the links between mitochondrial dysfunction and immune regulation, this thesis enriches the field of geroscience, proposing viable interventions to improve health span and reduce the burdens faced by aging population
A Computational And Experimental Framework For Investigating Mitochondrial Dysfunction In Neuroinflammation And Neurodegeneration
No full textNeurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS) and Alzheimer’s disease (AD), are characterized by progressive neuronal loss and functional decline, driven by chronic neuroinflammation and oxidative stress. ALS primarily affects motor neurons, leading to muscle weakness and paralysis, while AD results in cognitive decline due to widespread neuronal degeneration. Microglia, the brain’s resident immune cells, maintain neuronal health but can become excessively reactive under mitochondrial dysfunction, exacerbating neuroinflammatory responses. Mitochondrial Transcription Factor A (TFAM), essential for mitochondrial DNA (mtDNA) stability and function, is critical for mitochondrial maintenance. Its dysfunction in microglia leads to impaired mitochondrial function, excessive reactive oxygen species (ROS) production, oxidative stress, and inflammatory signaling, all of which contribute to disease progression. However, the molecular mechanisms linking TFAM dysfunction to neuroinflammation remain poorly understood. This dissertation investigates these mechanisms using genetically engineered mouse models with microglial-specific TFAM deletion (Cre-loxP system) to mimic mitochondrial dysfunction. Single-cell RNA sequencing, proteomics analysis, and ontology-driven gene interaction networks were leveraged to identify transcription factors, pathways, and gene interactions involved in oxidative stress and neuroinflammation. Experimental validation using immunohistochemistry and quantitative PCR (qPCR) further assessed mitochondrial integrity and microglial activation. This study aims to uncover novel molecular interactions linking TFAM loss to mitochondrial damage and neuroinflammatory signaling, providing insights into potential therapeutic targets. By integrating computational and experimental approaches, this research advances the understanding of mitochondrial dysfunction and neuroinflammation, offering new strategies to mitigate oxidative stress and reduceinflammation
Regulation of senescence in cancer and aging
No full textCo-author Charusheila Ramkumar is a student in the Cell Biology program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.Senescence is regarded as a physiological response of cells to stress, including telomere dysfunction, aberrant oncogenic activation, DNA damage, and oxidative stress. This stress response has an antagonistically pleiotropic effect to organisms: beneficial as a tumor suppressor, but detrimental by contributing to aging. The emergence of senescence as an effective tumor suppression mechanism is highlighted by recent demonstration that senescence prevents proliferation of cells at risk of neoplastic transformation. Consequently, induction of senescence is recognized as a potential treatment of cancer. Substantial evidence also suggests that senescence plays an important role in aging, particularly in aging of stem cells. In this paper, we will discuss the molecular regulation of senescence its role in cancer and aging. The potential utility of senescence in cancer therapeutics will also be discussed
RAMKUMAR MUKHAPADHYAYER ‘DHANAPATIR SINHALYATRA’ : NABARUPE CHANDIMANGAL/ রামকুমার মুখোপাধ্যায়ের ‘ধনপতির সিংহলযাত্রা’ : নবরূপে চন্ডীমঙ্গল
No full textoai:ojs2.tirj.org.in:article/2Ramkumar Mukherjee\u27s novel \u27Dhanpati\u27s Sinhala Yatra\u27 is also medieval in terms of language. The novel has been reimagined by Chandimangal. Ramkumar Mukherjee has adopted the first part of the narrative of the merchant section in his novel. From Dhanpati\u27s Sinhala Yatra to captivity. Here, the novelist has looked back at medieval Bengal and Bengalis from a distance of several centuries, keeping Mukund\u27s poetry in front of him. He has made no attempt to drag the past into the present. Nor has he taken the present into the past and placed it there. In this book, the past cannot be seen in the present and the present in the past. A pure historical setting has been created where there is no shadow of the twenty-first century. Chapters such as the lifting of the Saptadinga, Dhanpati\u27s journey to the Dingaghata, Ajay Yatra, Muktabeni, and the journey of rivers and streams describe extinct rivers, towns, etc. The novel contains themes such as mythological consciousness, religious ideals, and a reevaluation of divine consciousness. Dhanpati traveled to the southern country in the hope of prosperity. However, his fate and destiny were determined by the hideous plots and cruelty of two goddesses. Ignoring many ominous signs and the desperate pleas of Khulna, Dhanpati has to travel helplessly towards the inevitable end. This is his destiny. Ramkumar Mukherjee has presented the novel \u27Dhanpati\u27s Singhal Yatra\u27 in a magical bond of intense fascination with the tradition of Bengali cultural heritage. The novel has a unique and modern reconstruction of the well-known Afghan poem of the medieval \u27Chandimangal\u27. The novelist has kept the basic structure of the story intact here, but has analyzed the psychological depth of the characters and the socio-economic context of the time from a modern perspective. As a result, it emerges as a picture of the conflict between man and time instead of the story of the greatness of the Goddess. In the novel, Dhanpati is a prosperous merchant of Ujjainnagar, but he has endless questions and doubts about the social system of the time. He wants to magnify the efforts and logic of man instead of the miracles of the conventional gods and goddesses. This rational mind has taken him against the conventional beliefs and conventional customs. And later it has become the main reason for the conflict in his life. On the king\u27s orders, Dhanpati has to undertake a journey to Sinhala despite his reluctance. Before the journey, the wish of his husband for his well-being did not open, so when the puja of Goddess Chandi was organized, the rational, confident, and realistic leader trampled the auspicious place of the Goddess with contempt. To him, the greatness of the Goddess is irrational and miraculous. However, the author portrays this insult not only as an insult, but as a clash between traditional beliefs and modern logic. The novel is not just a religious story, but also a story of human survival in the face of adversity. Overall, the novel has become a reinterpretation of the medieval \u27Chandimangal\u27 poem
Dialect Accent Features for Establishing Speaker Identity: A Case Study
No full textDialect Accent Features for Establishing Speaker Identity: A Case Study discusses the subject of forensic voice identification and speaker profiling. Specifically focusing on speaker profiling and using dialects of the Hindi language, widely used in India, the authors have contributed to the body of research on speaker identification by using accent feature as the discriminating factor. This case study contributes to the understanding of the speaker identification process in a situation where unknown speech samples are in different language/dialect than the recording of a suspect. The authors' data establishes that vowel quality, quantity, intonation and tone of a speaker as compared to Khariboli (standard Hindi) could be the potential features for identification of dialect accent
- …
