3,085 research outputs found
sj-docx-1-tam-10.1177_17588359231192400 – Supplemental material for Impact of the coronavirus disease 2019 pandemic on sarcoma management in France: a 2019 and 2020 comparison
No full textSupplemental material, sj-docx-1-tam-10.1177_17588359231192400 for Impact of the coronavirus disease 2019 pandemic on sarcoma management in France: a 2019 and 2020 comparison by Nicolas Penel, Coralie Cantarel, Claire Chemin-Airiau, Françoise Ducimetiere, François Gouin, François Le Loarer, Maud Toulmonde, Sophie Piperno-Neumann, Carine Bellera, Charles Honore, Jean-Yves Blay and Simone Mathoulin-Pelissier in Therapeutic Advances in Medical Oncology</p
Chapitre 9 : Risques sanitaires
No full textCoordination : Isabelle Baldi Rédacteurs : Isabelle Baldi, Gaëlle Coureau, Gaëlle Gault, Pierre-Yves Guernion, Denis Malvy, Simone Mathoulin-Pelissier, Chantal Raherison, Patrick Rolland, Roger Salamon Si les questions sur le changement climatique sont encore souvent centrées sur ses conséquences en matière d’environnement et d’économie, l’attention se tourne progressivement vers les enjeux de santé publique. Ceux-ci recouvrent à la fois les effets sanitaires directs liés aux catastrophes occ..
Rozpor ako východisko, láska ako smer u Simone Weilovej (Contradiction as base, Love as direction in writings of Simone Weil)
No full textArticle is explaining contradiction and love, Simone Weil‘s essential terms of hermeneutics of human Being. It introduces close relation of these terms with her understanding of God as well as with her overall concept of religion. Author also mentions Simone Weil‘s inspirations with philosophical and spiritual concepts of the East
Cervical cancer and HIV infection in West Africa : Epidemiology, determinants and screening
No full textLe cancer du col de l’utérus est la première cause de cancer chez la femme en Afrique de l’Ouest, une région du monde où le virus de l’immunodéficience humaine (VIH) sévit de manière endémique. Ce travail s’inscrit dans le cadre de l’étude du lien entre ces deux pathologies ainsi que des spécificités du dépistage du cancer du col dans le contexte de l’infection à VIH.Notre travail de recherche a été conduit en plusieurs étapes. Une enquête hospitalière a tout d’abord comparée la fréquence du VIH chez des femmes atteintes de cancer du col et chez des femmes atteintes d’autres cancers. Nous avons ensuite mis en place un programme de dépistage des cancers du col par inspection visuelle au sein de trois cliniques VIH à Abidjan offrant cette intervention pendant une période de plusieurs mois. Un échantillon de ces femmes dépistées a enfin été prélevé pour la recherche de papillomavirus humains (PVH). Sur les 152 cas de cancer du col inclus dans la première enquête, 25% étaient VIH-positifs contre 4,7% chez les 257 patientes du groupe de comparaison, donnant un Rapport de Côte (RC) ajusté de 7,6 (3,6 – 16,2) pour l’association entre ces deux morbidités sévères. Un total de 4 046 femmes a été dépisté par inspection visuelle. La fréquence d’un test positif était de 9,0% (8,0 – 10,0) chez les 2 998 femmes VIH-positives et 3,9% (2,7 – 5,1) chez les 1 048 femmes VIH-négatives. La prévalence de l’infection à PVH oncogène était de 33,0% chez les 191 femmes VIH-négatives et de 52,8% chez les 254 femmes VIH-positives ayant pu être testé par PCR. Un taux de CD4<200 cellules/mm3 était associé à la présence d’un PVH oncogène (RC= 2,8 [1,1 – 8,3] Ref. CD4 ≥500). L’infection à VIH est fortement associée au risque de cancer du col ainsi qu’à la présence de ses précurseurs que sont les PVH. La mise en place de programmes de dépistage associé à une bonne reconstitution immunitaire semble être des mesures essentielles pour réduire le fardeau de ce cancer chez les femmes VIH-positives en Afrique de l’Ouest à l’ère de l’accès élargi aux antirétroviraux.Cervical cancer is the leading cause of cancer among women in West Africa, where infection with the Human Immunodeficiency Virus (HIV) is endemic. This work study the link between these two pathologies as well as the specificities linked to cervical cancer screening in the context of HIV infection. Our research project was conducted in several stages. A first hospital-based study compared the prevalence of HIV in women with cervical cancer and in women with other cancers. We then implement a cervical cancer screening program with visual inspection methods in three HIV clinics in Abidjan during several months. A sample of women screened was finally selected and collected for human papillomavirus (HPV) identification. Of the 152 cases of cervical cancer included during the first study, 25% were HIV-positive compared to 4.7% among the 257 patients of the comparison group, giving an adjusted odd ratio (OR) of 7.6 (3.6 - 16.2). A total of 4,046 women were screened by visual inspection. The frequency of a positive test was 9.0% (8.0 - 10.0) in the 2,998 HIV-positive women and 3.9% (2.7 - 5.1) in the 1,048 HIV-negative women. The prevalence of oncogenic HPV was 33.0% in the 191 HIV-negative women and 52.8% in the 254 HIV-positive women that underwent PCR testing. A CD4 count <200 cells/mm3 was associated with the presence of oncogenic HPV (OR = 2.8 [1.1 - 8.3] Ref. CD4≥500). HIV infection is strongly associated with cervical cancer and the presence of its precursors, oncogenic HPV. The implementation of adapted screening programs combined with good immune reconstitution seems to be key measures to reduce the burden of cervical cancer in HIV-positive women in West Africa in the era of expanded access to antiretroviral drugs
“I beg you to tell me what has become of Djamila”: The Political Mobilization of Simone de Beauvoir’s Readers During the Boupacha Affair
No full textBy Sophia Millman This is a condensed version of a Masters thesis dedicated to the political mobilization of Simone de Beauvoir’s readers. The citations from the letters were translated from French by the author. *** On June 2, 1960, the French government ordered all copies of the daily Algiers edition of Le Monde seized and destroyed to suppress the publication of Simone de Beauvoir’s article “Pour Djamila Boupacha.” Beauvoir, a self-professed “woman of letters”, not “of action[1]”, and one ..
Bull Cancer
No full textScreening (secondary prevention) is a public health action aimed at identifying diseases at their earliest stages, before the onset of signs and symptoms and, thus, avoiding or mitigating their negative consequences. The abnormality can be a genetic defect, an infection or the preclinical phase of a chronic disease such as cancer. We discuss elements common to the cancer screening debate: vocabulary about screening, overdiagnosis, and program indication criteria. Finally, we present some significant evolutions on the programs since their implementation in France
Perception de la prise en charge des patients atteints de cancer par les médecins généralistes (résultats d'une enquête auprès de 422 médecins en Aquitaine)
No full textBORDEAUX2-BU Santé (330632101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
A comparative study of form and theology in the works of Flannery O'Connor and Simone Weil
No full textIn this comparative study of the form and theology of Flannery O'Connor and Simone Weil I interrogate how Weil's philosophical writings and her theology illuminate O'Connor's use of both narrative and non-fictional forms, and her Catholicism. The Introduction analyses how Weil's concept of superposed reading provides a new method of approaching both O'Connor, her writings, and O'Connor
studies, and focuses on how such apparently different women interconnect. Chapter One explores how both Weil and O'Connor attempt to write their theologies on the
souls of their readers yet are each subject to constraints imposed by form. Weil's concept of locating equilibrium between incommensurates is discussed, and her
distinctively philosophical approach to fictions and fictionality is used to investigate O'Connor's notion of prophetic fictions and the writer's role. Chapter Two assesses how both writers revivify Christian paradoxes. Weil's monstrous concept of affiiction, and O'Connor's use of the grotesque genre to jolt secular man into an
awareness of the sacred are scrutinised. Chapter Three studies how both writers consider an encounter between God and man is possible through the action of grace. My Conclusion interrogates how Weil's work can deepen our understanding of O'Connor's writings, and examines how successful O'Connor is at realising a truly
Christian literature. I conclude that despite being a writer of powerful fictions, O'Connor can not be totally successful in her mission as writer-prophet because
ultimately fiction escapes orthodoxy
Microlinices benthovus Simone 2014
No full textbenthovus, Microlinices Simone, 2014 Microlinices benthovus Simone, 2014: 575–578 (figs 6A–J, 7A–H, 11A–C). Gastropoda, Naticidae Paratypes (22 spc): MZSP 105269. Paratypes 1 (15 spc): MZSP 105270. Paratypes 2 (16 spc): MZSP 105271. Paratypes 3 (7 spc): MZSP 105272. Localities: Brazil, Espírito Santo, off Itaúnas, Abrolhos Slope, 18°59' S, 37°50' W, MD55 sta. DC 73, 637 m depth, 27 May 1987; 1) 19°00' S, 37°48' W, MD55 sta. DC72, 950– 1050 m, 27 May 1987; 2) off Regência, 19°40' S, 37°48' W, MD55 sta. CB77, 790– 940 m depth, 27 May 1987; 3) off Itaúnas, Abrolhos Slope, 19°01' S, 37°47' W, MD55 sta. CB79, 1500–1575 m depth, 28 May 1987. Collectors: P. Bouchet, J.H. Leal and B. Métivier. Preservation: Dry. Remarks: Former MNHN, Paris. The catalogue number MZSP 105250 is mentioned twice in Simone’s (2014) paper, among the paratypes of M. ibitingus Simone, 2014 and M. benthovus. This duplicity was a mistake by the author: the latter is an erroneous designation and should be disregarded. The only valid paratype lots for M. benthovus are the ones shown above.Published as part of Cavallari, Daniel C., Dornellas, Ana Paula S. & Simone, Luiz Ricardo L., 2016, Second annotated list of type specimens of molluscs deposited in the Museu de Zoologia da Universidade de São Paulo, Brazil, pp. 1-59 in European Journal of Taxonomy 213 on page 10, DOI: 10.5852/ejt.2016.213, http://zenodo.org/record/384012
Joint modelling and prediction of several risks of cancer progression from repeated measurements of biomarkers
No full textDans les études longitudinales en cancer, une problématique majeure est la description de l’évolution de la maladie d’un patient ou la prédiction de son état futur, à partir de mesures répétées d’un marqueur biologique. La modélisation conjointe permet de répondre à ces objectifs, mais elle a principalement été développée pour l’étude simultanée d’un marqueur longitudinal Gaussien et d’un unique temps d’événement. Afin de caractériser les transitions entre événements successifs qu’un patient peut connaître, nous étendons la méthodologie classique en introduisant un modèle conjoint pour un processus longitudinal Gaussien et un processus multi-états Markovien non homogène. Le modèle suppose que les temps de transition individuels sont indépendants conditionnellement aux covariables incluses. Nous proposons aussi un score test afin de tester cette hypothèse. Ces développements sont appliqués à deux cohortes d’hommes avec un cancer de la prostate localisé traité par radiothérapie. Le modèle permet de quantifier l’impact des dynamiques de l’antigène spécifique de la prostate, et d’autres facteurs pronostiques mesurés à la fin du traitement, sur chaque intensité de transition entre états cliniques prédéfinis. Cette thèse fournit ensuite des outils statistiques et des lignes directrices pour le calcul de prédictions dynamiques individuelles d’événements cliniques, dans le cadre de risques compétitifs. Enfin, un dernier travail amène une réflexion sur la modélisation conjointe de données longitudinales ordinales et de données de survie, avec une technique d’inférence innovante. Ainsi, ce travail introduit des méthodes statistiques adaptées à divers types de données longitudinales et d’histoire d’événements, qui permettent de répondre aux besoins des cliniciens. Des recommandations méthodologiques et des outils logiciels sont associés à chaque développement, pour une utilisation pratique par les communautés clinique et statistique.In longitudinal studies in cancer, a major problem is the description of the patient’s disease evolution or the prediction of his future state, based on repeated measurements of a biological marker. Joint modelling enables to meet these objectives but it has mainlybeen developed for the simultaneous study of a Gaussian longitudinal marker and a single event time. In order to characterize the transitions between successive events that a patient may experience, we extend the classical methodology by introducing a joint model for a Gaussian longitudinal process and a non-homogeneous Markovian multi-state process. The model assumes that individual transition times are independent conditionally to included covariates. We also propose a score test to assess this assumption. These developments are applied on two cohorts of men with localized prostate cancer treated with radiotherapy. The model quantifies the impact of prostate specific antigen dynamics, and other prognostic factors measured at the end of treatment, on each transition intensity between predefined clinical states. This thesis then provides statistical tools and guidelines for the computation of individual dynamic predictions of clinical events in the context of competitive risks. Finally, a last work leads to a reflection on joint modelling of longitudinal ordinal data and survival data with an innovative inference technique. To conclude, this work introduces statistical methods adapted to various types of longitudinal data and event history data, which meet the needs of clinicians. Methodological recommendations and software tools are associated with each development, for practical use by the clinical and statistical communities
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