7 research outputs found

    Thoracic Spinal Anesthesia With Erector Spinae Plane Block Versus Conscious Sedation for Medical Thoracoscopy: A Comparative Pilot Study

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    Background and objective Medical thoracoscopy (MT) is associated with significant postoperative pain of varying intensity and duration, leading to significant morbidity. Our study compared the efficacy of thoracic spinal anesthesia (TSA) combined with erector spinae plane block (ESPB) with conscious sedation for MT using a patient-centered outcome measure. Methods This is a non-randomized prospective comparative pilot study wherein 36 patients undergoing MT were assigned alternately to receive TSA with ESPB or conscious sedation. Conscious sedation was administered with fentanyl and midazolam in graded doses with local instillation of lignocaine 2%. TSA was administered at the T6-T7 level with 25 mcg of fentanyl and 0.5% levobupivacaine (1.5 ml), followed by ESPB with 0.25% levobupivacaine (10 ml). The primary outcome was to compare the efficacy of ESPB with conscious sedation in terms of quality of recovery. The secondary outcome was to compare the time to administration of the first analgesic post procedure, total postoperative opioid consumption (mg) at 24 hours, and duration of the procedure. Intraoperative hemodynamic stability and block-related and post-procedure complications were also assessed. Results The total Quality of Recovery-15 (QoR-15) score was 112.83 ± 27.16 vs. 65.78 ± 22.13 (p = 0.0001), time to first analgesic was 11.69 ± 6.93 hours vs. 2.39 ± 1.69 hours (p = 0.0001), opioid consumption was 50 ± 10 vs. 75 ± 15 (p = 0.001), and the mean duration of the procedure was 64.72 vs. 93.89 minutes (p = 0.0001) in the ESPB group and the conscious sedation group, respectively. No block/anesthesia-related complications were reported in either group. Conclusion The combination of TSA with ESPB can be a novel, effective, and safe anesthetic technique for MT, offering better quality of recovery, improved postoperative analgesia, shorter procedure duration, and reduced perioperative morbidity

    Information on authors and all data mined from seminars.

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    DASL Alliance author list, surname associations for DASL and Fragile Nucleosome, search queries for DEI topics, topic mentions in talk transcripts for DASL and SQUAD seminars, annotated resources cited by DASL speakers, and DASL speaker survey responses and biographical data mined from the DASL website. (XLSX)</p

    The international WAO/EAACI guideline for the management of hereditary angioedema—The 2021 revision and update

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    © 2022 The Author(s)Hereditary Angioedema (HAE) is a rare and disabling disease for which early diagnosis and effective therapy are critical. This revision and update of the global WAO/EAACI guideline on the diagnosis and management of HAE provides up-to-date guidance for the management of HAE. For this update and revision of the guideline, an international panel of experts reviewed the existing evidence, developed 28 recommendations, and established consensus by an online DELPHI process. The goal of these recommendations and guideline is to help physicians and their patients in making rational decisions in the management of HAE with deficient C1-inhibitor (type 1) and HAE with dysfunctional C1-inhibitor (type 2), by providing guidance on common and important clinical issues, such as: 1) How should HAE be diagnosed? 2) When should HAE patients receive prophylactic on top of on-demand treatment and what treatments should be used? 3) What are the goals of treatment? 4) Should HAE management be different for special HAE patient groups such as children or pregnant/breast feeding women? 5) How should HAE patients monitor their disease activity, impact, and control? It is also the intention of this guideline to help establish global standards for the management of HAE and to encourage and facilitate the use of recommended diagnostics and therapies for all patients.N

    Proceedings of International Web Conference in Civil Engineering for a Sustainable Planet

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    This proceeding contains articles of the various research ideas of the academic community and practitioners accepted at the "International Web Conference in Civil Engineering for a Sustainable Planet (ICCESP 2021)". ICCESP 2021 is being Organized by the Habilete Learning Solutions, Kollam in Collaboration with American Society of Civil Engineers (ASCE), TKM College of Engineering, Kollam, and Baselios Mathews II College of Engineering, Kollam, Kerala, India. Conference Title: International Web Conference in Civil Engineering for a Sustainable PlanetConference Acronym: ICCESP 2021Conference Date: 05–06 March 2021Conference Location: Online (Virtual Mode)Conference Organizer: Habilete Learning Solutions, Kollam, Kerala, IndiaCollaborators: American Society of Civil Engineers (ASCE), TKM College of Engineering, Kollam, and Baselios Mathews II College of Engineering, Kollam, Kerala, India. Link to the ICCESP 2024 Proceedings: Proceedings of the Second International Conference in Civil Engineering for a Sustainable Planet: ICCESP 202

    Proceedings of the 2nd International Conference on Modern Trends in Engineering Technology and Management

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    This proceeding contains articles on the various ideas of the academic community presented at The 2nd International Conference on Modern Trends in Engineering Technology and Management (ICMEM 2023) organized by the Sree Narayana Institute of Technology Adoor-691554, Kerala, India on 4th-6th May 2023.  ICMEM 2023 aimed to provide a forum for the exchange of ideas, issues, challenges, discoveries, opportunities, and applications of Modern Trends in Engineering Technology and Management. The ever-changing scope and rapid development of science and technology generate new problems, questions, and curiosity, necessitating the exchange of brilliant ideas and raising awareness of this vital research field in a variety of directions.  Conference Title: 2nd International Conference on Modern Trends in Engineering Technology and ManagementConference Acronyms: ICMEM 2023Conference Date: 4th-6th May 2023Conference Location: Hybrid ModeConference Organizer: SNIT Adoor, Kerala, Indi

    Deep Underground Neutrino Experiment (DUNE), Far Detector Technical Design Report, Volume II DUNE Physics

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    The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay -- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. DUNE is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. Volume II of this TDR, DUNE Physics, describes the array of identified scientific opportunities and key goals. Crucially, we also report our best current understanding of the capability of DUNE to realize these goals, along with the detailed arguments and investigations on which this understanding is based. This TDR volume documents the scientific basis underlying the conception and design of the LBNF/DUNE experimental configurations. As a result, the description of DUNE's experimental capabilities constitutes the bulk of the document. Key linkages between requirements for successful execution of the physics program and primary specifications of the experimental configurations are drawn and summarized. This document also serves a wider purpose as a statement on the scientific potential of DUNE as a central component within a global program of frontier theoretical and experimental particle physics research. Thus, the presentation also aims to serve as a resource for the particle physics community at large

    Deep Underground Neutrino Experiment (DUNE) Near Detector Conceptual Design Report

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    The Deep Underground Neutrino Experiment (DUNE) is an international, world-class experiment aimed at exploring fundamental questions about the universe that are at the forefront of astrophysics and particle physics research. DUNE will study questions pertaining to the preponderance of matter over antimatter in the early universe, the dynamics of supernovae, the subtleties of neutrino interaction physics, and a number of beyond the Standard Model topics accessible in a powerful neutrino beam. A critical component of the DUNE physics program involves the study of changes in a powerful beam of neutrinos, i.e., neutrino oscillations, as the neutrinos propagate a long distance. The experiment consists of a near detector, sited close to the source of the beam, and a far detector, sited along the beam at a large distance. This document, the DUNE Near Detector Conceptual Design Report (CDR), describes the design of the DUNE near detector and the science program that drives the design and technology choices. The goals and requirements underlying the design, along with projected performance are given. It serves as a starting point for a more detailed design that will be described in future documents.This report describes the conceptual design of the DUNE near detecto
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