6 research outputs found
Optimizing Business Processes through Informatics and RPA
No full textTato diplomová práce se zabývá integrací informatiky a robotické procesní automatizace (RPA) jako strategií pro optimalizaci podnikových procesů. Poskytuje komplexní analýzu základů, nástrojů a metodologií RPA a ukazuje, jak lze RPA efektivně kombinovat s informatikou za účelem zvýšení efektivity, snížení provozních nákladů a podpory rozhodování založeného na datech. Práce obsahuje praktickou případovou studii zaměřenou na automatizaci identifikace externích služeb v souborech UiPath XAML, vyvinutou ve spolupráci se společností Pointee Interactive s.r.o. Důraz je kladen na praktické využití RPA v různých odvětvích a metodologické rámce nutné pro úspěšnou implementaci.This thesis explores the integration of Informatics and Robotic Process Automation (RPA) as a strategy for optimizing business processes. It provides a comprehensive analysis of RPA fundamentals, tools, and methodologies, and demonstrates how RPA can be effectively combined with informatics to enhance efficiency, reduce operational costs, and support data-driven decision-making. The thesis includes a practical case study focused on automating the identification of external services in UiPath XAML files, developed in collaboration with Pointee Interactive s.r.o. This work emphasizes the real-world applications of RPA in various sectors and the methodological frameworks necessary for successful implementation
Methyl-2-arylidene hydrazinecarbodithioates: synthesis and biological activity
No full textMethyl-2-arylidene hydrazine-carbodithioate has not been of particular interest to researchers even though its metal complexes are extensively reported on due to their biological activity. This study examined the cytostatic and antiviral activity of twelve methyl-2-arylidene hydrazinecarbodithioates reported by many researchers as intermediates for the synthesis of thiosemicarbazides and the preparation of their metal complexes. Compounds IIc, IIi, and IIl with tridentate ligand features were found to have the lowest IC50 value (6.5 μM, ≈ 1 μM, and 0.8 μM, respectively) against HL60 human promyelocytic leukemia cells. They were also most inhibitory to human embryonic lung (HEL) fibroblast proliferation (5.3 μM, 17 μM, and 2.6 μM). Compound IIc and IIl show antiviral activity against wild-type herpes simplex virus (HSV), varicella zoster virus (VZV), and acyclovirresistant HSV; however, these activities were observed at concentrations at which the compounds also markedly inhibit HL60 and HEL cell proliferation.sponsorship: The author acknowledges the University Grants Commission (UGC) & All-India Council for Technical Education (AICTE), India, for financial support (JRF) to the first author and the GOA (no. 10/014) of the KU Leuven; Sophisticated Instrumentation Facility (SAIF) of the Central Drug Research Institute (CDRI), Lucknow, for enabling the use of the facility for spectral characterisation of compounds. We thank Mrs. Leentje Persoons, Mrs. Frieda De Meyer, Mrs. Lies Van den Heurck, Mr. Steven Carmans, Mrs. Anita Camps, Mrs. Kristien Erven and Mr. Kris Uyttersprot for excellent technical assistance. (University Grants Commission (UGC), All-India Council for Technical Education (AICTE), India, GOA of the KU Leuven|10/014)status: Publishe
Mult Scler
No full textBackground: Investigating the degeneration of specific thalamic nuclei in multiple sclerosis (MS) remains challenging. Methods: White-matter-nulled (WMn) MPRAGE, MP-FLAIR, and standard T1-weighted magnetic resonance imaging (MRI) were performed on MS patients (n = 15) and matched controls (n = 12). Thalamic lesions were counted in individual sequences and lesion contrast-to-noise ratio (CNR) was measured. Volumes of 12 thalamic nuclei were measured using an automatic segmentation pipeline specifically developed for WMn-MPRAGE. Results: WMn-MPRAGE showed more thalamic MS lesions (n = 35 in 9 out of 15 patients) than MP-FLAIR (n = 25) and standard T1 (n = 23), which was associated with significant improvement of CNR (p < 0.0001). MS patients had whole thalamus atrophy (p = 0.003) with lower volumes found for the anteroventral (p < 0.001), the pulvinar (p < 0.0001), and the habenular (p = 0.004) nuclei. Conclusion: WMn-MPRAGE and automatic thalamic segmentation can highlight thalamic MS lesions and measure patterns of focal thalamic atrophy. © The Author(s), 2019.Translational Research and Advanced Imaging LaboratoryBordeaux Region Aquitaine Initiative for Neuroscienc
Author Correction: Combinatorial expression of GPCR isoforms affects signalling and drug responses
No full textMult Scler
No full textObjectives: Investigating differential vulnerability of thalamic nuclei in multiple sclerosis (MS). Methods: In a secondary analysis of prospectively collected datasets, we pooled 136 patients with MS or clinically isolated syndrome and 71 healthy controls all scanned with conventional 3D-T1 and white-matter-nulled magnetization-prepared rapid gradient echo (WMn-MPRAGE) and tested for cognitive performance. T1-based thalamic segmentation was compared with the reference WMn-MPRAGE method. Volumes of thalamic nuclei were compared according to clinical phenotypes and cognitive profile. Results: T1- and WMn-MPRAGE provided comparable segmentations (0.84 ± 0.13 < volume-similarity-index < 0.95 ± 0.03). Medial and posterior thalamic groups were significantly more affected than anterior and lateral groups. Cognitive impairment related to volume loss of the anterior group. Conclusion: Thalamic nuclei closest to the third ventricle are more affected, with cognitive consequences. © The Author(s), 2022
