170,068 research outputs found
Paesaggi della memoria: l'Italia di Antonio Dal Masetto e Mempo Giardinelli
No full textIl contributo analizza la rappresentazione simbolica del rapporto con le origini pre- emigratorie nell'opera degli scrittori argentini Antonio Dal Masetto (La tierra incomparable, , Oscuramente fuerte es la vida) e Mempo Giardinelli (Santo Oficio de la Memoria)
AN ESTIMATE OF THE SEDIMENTS VOLUME ENTRAINABLE BY DEBRIS FLOW ALONG STROBEL AND SOUTH PEZORÌES CHANNELS AT FIAMES (DOLOMITES, ITALY)
No full textThe area of Fiames is located on a narrow and flat valley, 2 km north to Cortina d’Ampezzo, and is bounded on the right side by the
Pomagagnon and Pezorìes peaks. At the transition between rock vertical cliffs and talus, about twenty debris channels originate and affect the
talus till the bottom of the valley. The Strobel and South Pezorìes channels were recently routed by debris flows in 2004 and 2006. Field surveys,
topographical and geo-morphological measurements were carried out to recognize the sediments volume that the debris flow can entrain during
triggering and routing phases. The estimate of the erodible sediment volume was obtained through the measurements of the geo-morphological
and sediments features of source areas including their locations (channel bank or bottom). The resultant estimate can help in the design of the
input debris flow hydrographs for dynamic modelling of debris flow and retain basins
Late-onset bursts evoked by mossy fiber bundle stimulation in unipolar brush cells: evidence for the involvement of H-and TRP-currents
No full text20) Francesca Locatelli
Post doc
University of Pavia
[email protected]
Late-onset bursts evoked by mossy fiber bundle stim
ulation in unipolar brush cells: evidence
for the involvement of H- and TRP-currents
Francesca Locatelli
1
, Luisa Bottà
1
, Francesca Prestori
1
, Sergio Masetto
1
, Egidio D’Angelo
1,2
1
Department of Neuroscience, University of Pavia, I
taly
2
Brain Connectivity Center (BCC), IRCCS C. Mondino,
Pavia, Italy
Synaptic transmission at central synapses has usual
ly short latency and graded amplitude, thereby
regulating threshold crossing and the probability o
f action potential generation. In the granular laye
r
of vestibulo-cerebellum, the unipolar brush cells (
UBCs) receive a giant synapse generating a
stereotyped EPSP-burst complex with early-onset (~
2 ms) and high reliability. By using patch-
clamp recordings in cerebellar slices of the rat ve
stibulo-cerebellum, we found that mossy fiber
bundle stimulation also evoked (in ~85% of cases) a
late-onset burst (after tens to hundreds
milliseconds) independent from EPSP generation. Dif
ferent from the early-onset, the late-onset
burst delay decreased and its duration increased by
raising stimulation intensity or the number of
impulses. Though depending on synaptic activity, th
e late-onset response was insensitive to APV,
NBQX and MCPG perfusion and did not therefore depen
d on conventional glutamatergic
transmission mechanisms. The late-onset response wa
s initiated by a slow depolarizing ramp driven
by activation of an H-current (sensitive to ZD7288-
and Cs
+
) and of a TRP-current (sensitive to
SKF96365), while the HVA and LVA Ca
2+
-currents (sensitive to nimodipine and mibefradil)
played a negligible role. The late-onset burst was
occluded by intracellular cAMP. These results
indicate that afferent activity can regulate H- and
TRP-current gating in UBCs generating
synaptically-driven EPSP-independent responses, in
which the delay rather than amplitude is graded
with the intensity of the input pattern. This modal
ity of synaptic transmission may play an
important role for regulating UBC activation and gr
anular layer functions in the vestibulo-
cerebellum
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
A Multi-Language Comparison of Influences on Author Verification using Character N-Grams
No full textWe create a new multi-language corpus for author verification based on Wikipedia talkpages, and evaluate the influence that differences in topic and time have on character n-gram author profiles. Topic alignment between two texts is found to increase author verification precision, and an authors writing style is found to change over time, but not more significantly after 3 years than after 1 year.Information ArchitectureWISElectrical Engineering, Mathematics and Computer Scienc
Longitudinal evolution of the immune suppressive glioma microenvironment in different synchronous lesions during treatment
No full textThe role of immune suppression in glioma progression has been clearly established.1 We and others have recently demonstrated that myeloid cells play a major role in the tumor microenvironment of glioblastoma (GBM) patients,2,3 and that not only bone marrow-derived macrophages (BMDMs) have a higher intrinsic immune suppressive ability compared to resident microglial cells (MG), but also that this ability greatly increases going from the periphery to the tumor core.3 In lower grade gliomas (grades II and III), a much lower amount of BMDM is present, devoid of immune suppressive ability.3 We present here a longitudinal analysis of the immune infiltrate in a patient with a synchronous occurrence of GBM in the left temporal lobe, and a low-grade glioma (LGG) in the right frontal lobe, with discordant isocitrate dehydrogenase (IDH)-mutational status,4 followed by two GBM relapse
Teor e composição do óleo essencial de inflorescências e folhas de Lavandula dentata L. em diferentes estádios de desenvolvimento floral e épocas de colheita.
No full textO óleo essencial de Lavandula dentata L. possui importância econômica devido à utilização nas indústrias farmacêutica, cosmética e de higiene pessoal. O presente trabalho teve como objetivo avaliar o teor e a composição do óleo essencial de inflorescências e folhas de lavanda em diferentes estádios de desenvolvimento. O delineamento experimental foi inteiramente casualizado em esquema fatorial 2 x 3, sendo três estádios de desenvolvimento floral (botão, pré-antese/antese e senescente) e duas épocas de colheita (janeiro e abril), com cinco repetições. As amostras de óleo essencial foram obtidas por hidrodestilação, sendo os constituintes analisados por cromatografia em fase gasosa acoplada à espectrometria de massas (CG/EM). Houve interação entre os fatores épocas de colheita e desenvolvimento floral no teor de óleo essencial das inflorescências, sendo observada média superior em botões florais colhidos em janeiro. Os estádios de desenvolvimento não alteraram o teor do óleo essencial das folhas. Os estádios de desenvolvimento influenciaram nos teores dos constituintes dos óleos essenciais das inflorescências e folhas. No óleo essencial em estádio de flor senescente da colheita de abril, observou-se teor elevado de 1,8-cineol, enquanto nos demais estádios de desenvolvimento os teores foram menores em ambas as épocas de colheita. Teores elevados de cânfora foram observados nos estádios de pré-antese/antese e senescente, na colheita de janeiro. O óleo essencial das folhas apresentou teor superior de 1,8-cineol em ramos com flores em estádio de pré-antese/antese. Os teores de cânfora e fenchona foram superiores em ramos contendo botões. O óleo essencial das folhas de ramos com botões e flores senescentes apresentou teor superior de linalol em relação ao óleo essencial das inflorescências
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